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Enhanced transglycosylation activity of an Endo-F3 mutant by ligand-directed localization

Authors: Xiangman Zou, Zhi Liu, Liya Liu, Wei Shi, Wanzhen Li, Zifen Guo, Feng Tang, Wei Huang

Journal: Org Biomol Chem

PubMed ID: 35166761

Doi: 10.1039/d2ob00030j

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Quantifying Neutralizing Antibodies in Patients with COVID-19 by a Two-Variable Generalized Additive Model

Authors: Kuan-Ting Liu, Yu-Nong Gong, Chung-Guei Huang, Peng-Nien Huang, Kar-Yee Yu, Hou-Chen Lee, Sun-Che Lee, Huan-Jung Chiang, Yu-An Kung, Yueh-Te Lin, Mei-Jen Hsiao, Po-Wei Huang, Sheng-Yu Huang, Hsin-Tai Wu, Chih-Ching Wu, Rei-Lin Kuo, Kuan-Fu Chen, Chuan-Tien Hung, Kasopefoluwa Y Oguntuyo, Christian S Stevens, Shreyas Kowdle, Hsin-Ping Chiu, Benhur Lee, Guang-Wu Chen, Shin-Ru Shih

Journal: mSphere

PubMed ID: 35107336

Doi: 10.1128/msphere.00883-21

Products & Services: Molecular Biology Reagents

Charge-Modulated Accessibility of Tyrosine Residues for Silk-Elastin Copolymer Cross-Linking

Authors: Constancio Gonzalez-Obeso, Fredrik G Backlund, David L Kaplan

Journal: Biomacromolecules

PubMed ID: 35113522

Doi: 10.1021/acs.biomac.1c01192

Products & Services: Custom DNA/RNA Oligos

SARS-CoV-2 neutralizing capacity among blood donors without prior COVID-19 symptomatic history vs blood donors with prior COVID-19 symptomatic history: A comparative study

Authors: Ushasree Ravula, Srinivasa Rao Chunchu, Srujaleswari Mooli, Ravi Naik, Pandu Ranga Rao Sarangapati

Journal: Transfus Clin Biol

PubMed ID: 35167958

Doi: 10.1016/j.tracli.2022.02.004

Melanocortin receptor agonists suppress experimental autoimmune uveitis

Authors: Tat Fong Ng, Kaleb Dawit, Andrew W Taylor

Journal: Exp Eye Res

PubMed ID: 35196505

Doi: 10.1016/j.exer.2022.108986

Products & Services: Mammalian Expression

Impact of the clinically approved Petasites hybridus extract Ze 339 on intestinal mechanisms involved in the handling of histamine

Authors: Lina G Mettler, Karin Brecht, Veronika Butterweck, Henriette E Meyer Zu Schwabedissen

Journal: Biomed Pharmacother

PubMed ID: 35149385

Doi: 10.1016/j.biopha.2022.112698

Products & Services: Proteins, Expression, Isolation and Analysis

IL-4 plays an essential role in DnaJ-ΔA146Ply-mediated immunoprotection against Streptococcus pneumoniae in mice

Authors: Yi Hu, Lian Li, Wenchun Xu, Kaifeng Wu, Jiangming Xiao, Yang Peng, Yusi Liu, Yibing Yin, Xuemei Zhang

Journal: Mol Immunol

PubMed ID: 35114487

Doi: 10.1016/j.molimm.2022.01.010

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The interplay of viral loads, clinical presentation, and serological responses in SARS-CoV-2 - Results from a prospective cohort of outpatient COVID-19 cases

Authors: Kerstin Puchinger, Noemi Castelletti, Raquel Rubio-Acero, Christof Geldmacher, Tabea M Eser, Flora Deák, Ivana Paunovic, Abhishek Bakuli, Elmar Saathoff, Alexander von Meyer, Alisa Markgraf, Philine Falk, Jakob Reich, Friedrich Riess, Philipp Girl, Katharina Müller, Katja Radon, Jessica Michelle Guggenbuehl Noller, Roman Wölfel, Michael Hoelscher, Inge Kroidl, Andreas Wieser, Laura Olbrich

Journal: Virology

PubMed ID: 35245784

Doi: 10.1016/j.virol.2022.02.002

Knockdown of long non‑coding RNA DDX11‑AS1 inhibits the proliferation, migration and paclitaxel resistance of breast cancer cells by upregulating microRNA‑497 expression

Authors: Meng Liang, Beibei Zhu, Min Wang, Ju Jin

Journal: Mol Med Rep

PubMed ID: 35169864

Doi: 10.3892/mmr.2022.12639

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Knockdown of long non‑coding RNA DDX11‑AS1 inhibits the proliferation, migration and paclitaxel resistance of breast cancer cells by upregulating microRNA‑497 expression

Authors: Meng Liang, Beibei Zhu, Min Wang, Ju Jin

Journal: Mol Med Rep

PubMed ID: 35169864

Doi: 10.3892/mmr.2022.12639

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Biochemical Screening of Potent Zika Virus Protease Inhibitors

Authors: Camila Coelho, Gloria Gallo, Leon Hardy, Maria Elena Bottazzi, Claudia Campos, Martin Würtele

Journal: ChemMedChem

PubMed ID: 35104396

Doi: 10.1002/cmdc.202100695

Products & Services: Proteins, Expression, Isolation and Analysis

Long noncoding RNASEH1-AS1 exacerbates the progression of non-small cell lung cancer by acting as a ceRNA to regulate microRNA-516a-5p/FOXK1 and thereby activating the Wnt/β-catenin signaling pathway

Authors: Chan Zhang, Jian Huang, Ke Lou, Hui Ouyang

Journal: Cancer Med

PubMed ID: 35166053

Doi: 10.1002/cam4.4509

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Circular dichroism spectroscopic assessment of structural changes upon protein thermal unfolding at contrasting pH: Comparison with molecular dynamics simulations

Authors: Ponciano García-Gutiérrez, Menandro Camarillo-Cadena, Liliana I Vera-Robles, Rafael A Zubillaga, Andrés Hernández-Arana

Journal: Spectrochim Acta A Mol Biomol Spectrosc

PubMed ID: 35245803

Doi: 10.1016/j.saa.2022.121039

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Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines

Authors: Noëmi Johanna Roos, Riccardo Vincenzo Mancuso, Gerda Mawududzi Sanvee, Jamal Bouitbir, Stephan Krähenbühl

Journal: Food Chem Toxicol

PubMed ID: 35182693

Doi: 10.1016/j.fct.2022.112869

Products & Services: Proteins, Expression, Isolation and Analysis

Molecular characterization of the serotonergic transporter from the cestode Echinococcus granulosus: pharmacology and potential role in the nervous system

Authors: Federico Camicia, Hugo R Vaca, Ines Guarnaschelli, Uriel Koziol, Ole V Mortensen, Andreia C K Fontana

Journal: Parasitol Res

PubMed ID: 35169884

Doi: 10.1007/s00436-022-07466-y

Products & Services: Mammalian Expression

Molecular characterization of the serotonergic transporter from the cestode Echinococcus granulosus: pharmacology and potential role in the nervous system

Authors: Federico Camicia, Hugo R Vaca, Ines Guarnaschelli, Uriel Koziol, Ole V Mortensen, Andreia C K Fontana

Journal: Parasitol Res

PubMed ID: 35169884

Doi: 10.1007/s00436-022-07466-y

Products & Services: Mammalian Expression

Alterations in calmodulin-cardiac ryanodine receptor molecular recognition in congenital arrhythmias

Authors: Giuditta Dal Cortivo , Carlo Giorgio Barracchia , Valerio Marino , Mariapina D'Onofrio , Daniele Dell'Orco

Journal: Cell Mol Life Sci

PubMed ID: 35133504

Doi: 10.1007/s00018-022-04165-w

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The Structure of the Arabidopsis PEX4-PEX22 Peroxin Complex—Insights Into Ubiquitination at the Peroxisomal Membrane

Authors: Melissa S Traver , Sarah E Bradford , Jose Luis Olmos Jr , Zachary J Wright , Mitchell D Miller , Weijun Xu , George N Phillips Jr , Bonnie Bartel

Journal: Front Cell Dev Biol

PubMed ID: 35300425

Doi: 10.3389/fcell.2022.838923

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A continuous assay set to screen and characterize novel protein N-acetyltransferases unveils rice GNAT2 activity

Authors: Thomas Asensio , Cyril Dian , Jean-Baptiste Boyer , Frédéric Rivière, Thierry Meinnel , Carmela Giglione

Journal: Front Plant Sci

PubMed ID: 35273627

Doi: 10.3389/fpls.2022.832144

Products & Services: Peptide Synthesis

Exploring Noncovalent Protease Inhibitors for the Treatment of Severe Acute Respiratory Syndrome and Severe Acute Respiratory Syndrome-Like Coronaviruses

Authors: Brendan T Freitas, Daniil A Ahiadorme, Rahul S Bagul, Ian A Durie, Samir Ghosh, Jarvis Hill, Naomi E Kramer, Jackelyn Murray, Brady M O'Boyle, Emmanuel Onobun, Michael G Pirrone, Justin D Shepard, Suzanne Enos, Yagya P Subedi, Kapil Upadhyaya, Ralph A Tripp, Brian S Cummings, David Crich, Scott D Pegan

Journal: ACS Infect Dis

PubMed ID: 35199517

Doi: 10.1021/acsinfecdis.1c00631

Products & Services: PCR Cloning and Subcloning

Biochemical and Biophysical Characterisation of the Hepatitis E Virus Guanine-7-Methyltransferase

Authors: Preeti Hooda, Mohd Ishtikhar, Shweta Saraswat, Pooja Bhatia, Deepali Mishra, Aditya Trivedi, Rajkumar Kulandaisamy, Soumya Aggarwal, Manoj Munde, Nemat Ali, Abdullah F AlAsmari, Mohd A Rauf, Krishna K Inampudi, Deepak Sehgal

Journal: Molecules

PubMed ID: 35268608

Doi: 10.3390/molecules27051505

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DCHS1, Lix1L, and the Septin Cytoskeleton: Molecular and Developmental Etiology of Mitral Valve Prolapse

Authors: Kelsey S Moore, Reece Moore, Diana B Fulmer, Lilong Guo, Cortney Gensemer, Rebecca Stairley, Janiece Glover, Tyler C Beck, Jordan E Morningstar, Rachel Biggs, Rupak Muhkerjee, Alexander Awgulewitsch, Russell A Norris

Journal: J Cardiovasc Dev Dis

PubMed ID: 35200715

Doi: 10.3390/jcdd9020062

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Comprehensive mapping of SARS-CoV-2 peptide epitopes for development of a highly sensitive serological test for total and neutralizing antibodies

Authors: Garima Kumar, Sarah Sterrett, Lucinda Hall, Edlue Tabengwa, Kazuhito Honjo, Michael Larimer, Randall S Davis, Paul A Goepfert, Benjamin M Larimer

Journal: Protein Eng Des Sel

PubMed ID: 35174857

Doi: 10.1093/protein/gzab033

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Systematic profiling of antigen bias in humoral response against SARS-CoV-2

Authors: Nana Wei, Qiujing Wang, Zhibing Lin, Liyun Xu, Zheen Zhang, Yan Wang, Zhejuan Yang, Lue Li, Tingxiao Zhao, Lu Wang, Haifei Lou, Mingfang Han, Mingliang Ma, Yaosheng Jiang, Jinmiao Lu, Shilan Zhu, Li Cui, Shibo Li

Journal: Virus Res

PubMed ID: 35176329

Doi: 10.1016/j.virusres.2022.198711

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Non-Invasive Monitoring for Rejection in Kidney Transplant Recipients After SARS-CoV-2 mRNA Vaccination

Authors: Ayman Al Jurdi, Rodrigo B Gassen, Thiago J Borges, Zhabiz Solhjou, Frank E Hullekes, Isadora T Lape, Orhan Efe, Areej Alghamdi, Poojan Patel, John Y Choi, Mostafa T Mohammed, Brigid Bohan, Vikram Pattanayak, Ivy Rosales, Paolo Cravedi, Camille N Kotton, Jamil R Azzi, Leonardo V Riella

Journal: Front Immunol

PubMed ID: 35281011

Doi: 10.3389/fimmu.2022.838985

miR-145-5p inhibits the proliferation of glioma stem cells by targeting translationally controlled tumor protein

Authors: Qiujian Zhang, Zhe Cheng, Lei Shi, Gengsheng Mao

Journal: J Cancer

PubMed ID: 35371310

Doi: 10.7150/jca.65543

Products & Services: Proteins, Expression, Isolation and Analysis

A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination

Authors: Sarah F Andrews, Julie E Raab, Jason Gorman, Rebecca A Gillespie, Crystal S F Cheung, Reda Rawi, Lauren Y Cominsky, Jeffrey C Boyington, Adrian Creanga, Chen-Hsiang Shen, Darcy R Harris, Adam S Olia, Alexandra F Nazzari, Tongqing Zhou, Katherine V Houser, Grace L Chen, John R Mascola, Barney S Graham, Masaru Kanekiyo, Julie E Ledgerwood, Peter D Kwong, Adrian B McDermott

Journal: Nat Med

PubMed ID: 35115707

Doi: 10.1038/s41591-021-01636-8

Products & Services: Recombinant Antibody Expression

Enrofloxacin Promotes Plasmid-Mediated Conjugation Transfer of Fluoroquinolone-Resistance Gene

Authors: Yue Zhao, Zhengzheng Cao, Luqing Cui, Tianyu Hu, Kaixuan Guo, Fan Zhang, Xiangru Wang, Zhong Peng, Quan Liu, Menghong Dai

Journal: Front Microbiol

PubMed ID: 35250901

Doi: 10.3389/fmicb.2021.773664

Products & Services: Proteins, Expression, Isolation and Analysis

A Triple Gene-Deleted Pseudorabies Virus-Vectored Subunit PCV2b and CSFV Vaccine Protects Pigs against PCV2b Challenge and Induces Serum Neutralizing Antibody Response against CSFV

Authors: Selvaraj Pavulraj, Katrin Pannhorst, Rhett W Stout, Daniel B Paulsen, Mariano Carossino, Denise Meyer, Paul Becher, Shafiqul I Chowdhury

Journal: Vaccines (Basel)

PubMed ID: 35214763

Doi: 10.3390/vaccines10020305

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Selective Detection of Serogroup 1 and 5 with a Digital Photocorrosion Biosensor Using Antimicrobial Peptide-Antibody Sandwich Strategy

Authors: M Amirul Islam, Walid M Hassen, Ishika Ishika, Azam F Tayabali, Jan J Dubowski

Journal: Biosensors (Basel)

PubMed ID: 35200365

Doi: 10.3390/bios12020105

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Molecular basis of receptor binding and antibody neutralization of Omicron

Authors: Qin Hong, Wenyu Han, Jiawei Li, Shiqi Xu, Yifan Wang, Cong Xu, Zuyang Li, Yanxing Wang, Chao Zhang, Zhong Huang, Yao Cong

Journal: Nature

PubMed ID: 35228716

Doi: 10.1038/s41586-022-04581-9

Products & Services: Mammalian Expression

Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress

Authors: Mark Stoneley, Robert F Harvey, Thomas E Mulroney, Ryan Mordue, Rebekah Jukes-Jones, Kelvin Cain, Kathryn S Lilley, Ritwick Sawarkar, Anne E Willis

Journal: Mol Cell

PubMed ID: 35180429

Doi: 10.1016/j.molcel.2022.01.019

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Far-Red Light Triggered Production of Bispecific T Cell Engagers (BiTEs) from Engineered Cells for Antitumor Application

Authors: Cuilin Zhang, Yingjun Shi, Lingjie Wu, Chenyi Wang, Naishun Liao, Fei Wang, Bixing Zhao, Yingchao Wang, Xiaolong Liu

Journal: ACS Synth Biol

PubMed ID: 35113526

Doi: 10.1021/acssynbio.1c00523

Products & Services: Proteins, Expression, Isolation and Analysis

The small heat shock protein HSPB5 attenuates the severity of lupus nephritis in lupus-prone mice

Authors: Spencer Iner Thomas Berg, Justin Knapp, Marsela Braunstein, Cody Shirriff

Journal: Autoimmunity

PubMed ID: 35137667

Doi: 10.1080/08916934.2022.2027921

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Highly Stable Buffer-Based Zinc Oxide/Reduced Graphene Oxide Nanosurface Chemistry for Rapid Immunosensing of SARS-CoV-2 Antigens

Authors: Fatemeh Haghayegh, Razieh Salahandish, Mohsen Hassani, Amir Sanati-Nezhad

Journal: ACS Appl Mater Interfaces

PubMed ID: 35172574

Doi: 10.1021/acsami.1c24475

Products & Services: Proteins, Expression, Isolation and Analysis

Development of a Nanoparticle Multiepitope DNA Vaccine against Virulent Infectious Bronchitis Virus Challenge

Authors: Yifeng Qin, Qingyuan Teng, Delan Feng, Yu Pei, Ye Zhao, Guozhong Zhang

Journal: J Immunol

PubMed ID: 35217582

Doi: 10.4049/jimmunol.2100909

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Higher SARS-CoV-2 Spike Binding Antibody Levels and Neutralization Capacity 6 Months after Heterologous Vaccination with AZD1222 and BNT162b2

Authors: Brigitte Müller-Hilke, Franz Mai, Michael Müller, Johann Volzke, Emil C Reisinger

Journal: Vaccines (Basel)

PubMed ID: 35214780

Doi: 10.3390/vaccines10020322

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Development of a Test Card Based on Colloidal Gold Immunochromatographic Strips for Rapid Detection of Antibodies against Theileria equi and Babesia caballi

Authors: Guangpu Yang, Kewei Chen, Wei Guo, Zhe Hu, Ting Qi, Diqiu Liu, Yaoxin Wang, Cheng Du, Xiaojun Wang

Journal: Microbiol Spectr

PubMed ID: 35196786

Doi: 10.1128/spectrum.02411-21

Products & Services: Proteins, Expression, Isolation and Analysis

Genome-wide identification and characterization of aquaporins in mangrove plant Kandelia obovata and its role in response to the intertidal environment

Authors: Zejun Guo, Dongna Ma, Jing Li, Mingyue Wei, Ludan Zhang, Lichun Zhou, Xiaoxuan Zhou, Shanshan He, Lin Wang, Yingjia Shen, Qingshun Quinn Li, Hai-Lei Zheng

Journal: Plant Cell Environ

PubMed ID: 35141923

Doi: 10.1111/pce.14286

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SARS-CoV-2 Infectivity and Antibody Titer Reduction for 6 Months After Second Dose of BNT162b2 mRNA Vaccine in Healthcare Workers: A Prospective Cohort Study

Authors: Namhee Kim, Sue Shin, Dohsik Minn, Seungman Park, Dongheui An, Jae Hyeon Park, Eun Youn Roh, Jong Hyun Yoon, Hyunwoong Park

Journal: J Infect Dis

PubMed ID: 35104871

Doi: 10.1093/infdis/jiac035

SARS-CoV-2 Infectivity and Antibody Titer Reduction for 6 Months After Second Dose of BNT162b2 mRNA Vaccine in Healthcare Workers: A Prospective Cohort Study

Authors: Namhee Kim, Sue Shin, Dohsik Minn, Seungman Park, Dongheui An, Jae Hyeon Park, Eun Youn Roh, Jong Hyun Yoon, Hyunwoong Park

Journal: J Infect Dis

PubMed ID: 35104871

Doi: 10.1093/infdis/jiac035

Biochemical Screening of Potent Zika Virus Protease Inhibitors

Authors: Camila Coelho, Gloria Gallo, Leon Hardy, Maria Elena Bottazzi, Claudia Campos, Martin Würtele

Journal: ChemMedChem

PubMed ID: 35104396

Doi: 10.1002/cmdc.202100695

Products & Services: Proteins, Expression, Isolation and Analysis

RNA modifications stabilize the tertiary structure of tRNAfMet by locally increasing conformational dynamics

Authors: Thomas Biedenbänder, Vanessa de Jesus, Martina Schmidt-Dengler, Mark Helm, Björn Corzilius, Boris Fürtig

Journal: Nucleic Acids Res

PubMed ID: 35137185

Doi: 10.1093/nar/gkac040

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PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation

Authors: Prasidda Khadka, Zachary J Reitman, Sophie Lu, Graham Buchan, Gabrielle Gionet, Frank Dubois, Diana M Carvalho, Juliann Shih, Shu Zhang, Noah F Greenwald, Travis Zack, Ofer Shapira, Kristine Pelton, Rachel Hartley, Heather Bear, Yohanna Georgis, Spandana Jarmale, Randy Melanson, Kevin Bonanno, Kathleen Schoolcraft, Peter G Miller, Alexandra L Condurat, Elizabeth M Gonzalez, Kenin Qian, Eric Morin, Jaldeep Langhnoja, Leslie E Lupien, Veronica Rendo, Jeromy Digiacomo, Dayle Wang, Kevin Zhou, Rushil Kumbhani, Maria E Guerra Garcia, Claire E Sinai, Sarah Becker, Rachel Schneider, Jayne Vogelzang, Karsten Krug, Amy Goodale, Tanaz Abid, Zohra Kalani, Federica Piccioni, Rameen Beroukhim, Nicole S Persky, David E Root, Angel M Carcaboso, Benjamin L Ebert, Christine Fuller, Ozgun Babur, Mark W Kieran, Chris Jones, Hasmik Keshishian, Keith L Ligon, Steven A Carr, Timothy N Phoenix, Pratiti Bandopadhayay

Journal: Nat Commun

PubMed ID: 35105861

Doi: 10.1038/s41467-022-28198-8

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Non-ionic detergent assists formation of supercharged nanodiscs and insertion of membrane proteins

Authors: Frederik G Tidemand, Sara Blemmer, Nicolai T Johansen, Lise Arleth, Martin Cramer Pedersen

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 35182589

Doi: 10.1016/j.bbamem.2022.183884

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Development of an efficient and precise adenine base editor (ABE) with expanded target range in allotetraploid cotton (Gossypium hirsutum)

Authors: Guanying Wang, Zhongping Xu, Fuqiu Wang, Yuefan Huang, Yanfeng Xin, Sijia Liang, Bo Li, Huan Si, Lin Sun, Qiongqiong Wang, Xiao Ding, Xiangqian Zhu, Luo Chen, Lu Yu, Keith Lindsey, Xianlong Zhang, Shuangxia Jin

Journal: BMC Biol

PubMed ID: 35164736

Doi: 10.1186/s12915-022-01232-3

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Enzymatic activity of glycosyltransferase GLT8D1 promotes human glioblastoma cell migration

Authors: Elena I Ilina, Camille Cialini, Dietlind L Gerloff, Maitane Duarte Garcia-Escudero, Céline Jeanty, Marie-Laëtitia Thézénas, Antoine Lesur, Vincent Puard, François Bernardin, Alina Moter, Anne Schuster, Monika Dieterle, Anna Golebiewska, Jean-Jacques Gérardy, Gunnar Dittmar, Simone P Niclou, Tanja Müller, Michel Mittelbronn

Journal: iScience

PubMed ID: 35198895

Doi: 10.1016/j.isci.2022.103842

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Characterization and Interaction Analysis of the Secondary Cell Wall Synthesis-Related Transcription Factor in Lamb

Authors: Peizhen Chen, Rong Li, Lingzhi Zhu, Qingqing Hao, Sheng Yao, Jiahe Liu, Kongshu Ji

Journal: Int J Mol Sci

PubMed ID: 35216196

Doi: 10.3390/ijms23042079

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Structure of a thylakoid-anchored contractile injection system in multicellular cyanobacteria

Authors: Gregor L Weiss, Fabian Eisenstein, Ann-Katrin Kieninger, Jingwei Xu, Hannah A Minas, Milena Gerber, Miki Feldmüller, Iris Maldener, Karl Forchhammer, Martin Pilhofer

Journal: Nat Microbiol

PubMed ID: 35165386

Doi: 10.1038/s41564-021-01055-y

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CD19-targeted BiTE expression by an oncolytic vaccinia virus significantly augments therapeutic efficacy against B-cell lymphoma

Authors: Wen Lei, Qian Ye, Yuanyuan Hao, Jie Chen, Yu Huang, Liu Yang, Shibing Wang, Wenbin Qian

Journal: Blood Cancer J

PubMed ID: 35228544

Doi: 10.1038/s41408-022-00634-4

Products & Services: Plasmid DNA Preparation

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