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Finding Ways to Relax: A Revisionistic Analysis of the Chemistry of GTP Cyclohydrolase II

Authors: Madison M Smith, Brett A Beaupre, Dariush C Fourozesh, Kathleen M Meneely, Audrey L Lamb, Graham R Moran

Journal: Biochemistry

PubMed ID: 34569786

Doi: 10.1021/acs.biochem.1c00511

Products & Services: Plasmid DNA Preparation

Identifying Distinct Structural Features of the SARS-CoV-2 Spike Protein Fusion Domain Essential for Membrane Interaction

Authors: Daniel Birtles, Jinwoo Lee

Journal: Biochemistry

PubMed ID: 34570469

Doi: 10.1021/acs.biochem.1c00543

Products & Services: Plasmid DNA Preparation

LvCPG2 facilitated WSSV infection by interaction with VP26 and VP28

Authors: Xing-Chao Ren, Qing-Hui Liu

Journal: Fish Shellfish Immunol

PubMed ID: 34562580

Doi: 10.1016/j.fsi.2021.09.019

Products & Services: Plasmid DNA Preparation

Serum Complement Activation by C4BP-IgM Fusion Protein Can Restore Susceptibility to Antibiotics in

Authors: Serena Bettoni, Karolina Maziarz, M Rhia L Stone, Mark A T Blaskovich, Jan Potempa, Maria Luiza Bazzo, Magnus Unemo, Sanjay Ram, Anna M Blom

Journal: Front Immunol

PubMed ID: 34539665

Doi: 10.3389/fimmu.2021.726801

Products & Services: Peptide Synthesis

Evolutionary study of maize dwarf mosaic virus using nearly complete genome sequences acquired by next-generation sequencing

Authors: Dulanjani Wijayasekara, Akhtar Ali

Journal: Sci Rep

PubMed ID: 34552152

Doi: 10.1038/s41598-021-98299-9

Products & Services: PCR and Cloning

Adipokinetic hormone (AKH), energy budget and their effect on feeding and gustatory processes of foraging honey bees

Authors: Gabriela de Brito Sanchez, Anna Expósito Muñoz, Li Chen, Weifone Huang, Songkun Su, Martin Giurfa

Journal: Sci Rep

PubMed ID: 34526585

Doi: 10.1038/s41598-021-97851-x

Products & Services: ORF cDNA Clones/MolecularCloud

Effect of γ-aminobutyric Acid on Phenolics Metabolism in Barley Seedlings under Low NaCl Treatment

Authors: Mian Wang, Yahui Zhu, Pei Wang, Zhenxin Gu, Runqiang Yang

Journal: Antioxidants (Basel)

PubMed ID: 34573053

Doi: 10.3390/antiox10091421

Products & Services: Nucleic Acid Purification & Analysis

Probing multiple enzymatic methylation events in real time with NMR spectroscopy

Authors: Emery T Usher, Kevin E W Namitz, Michael S Cosgrove, Scott A Showalter

Journal: Biophys J

PubMed ID: 34592262

Doi: 10.1016/j.bpj.2021.09.034

Products & Services: Mutant Libraries

Single-molecule optical tweezers reveals folding steps of the domain swapping mechanism of a protein

Authors: Andres Bustamante, Rodrigo Rivera, Martin Floor, Jorge Babul, Mauricio Baez

Journal: Biophys J

PubMed ID: 34555362

Doi: 10.1016/j.bpj.2021.09.026

Products & Services: Mutant Libraries

TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth

Authors: Tsz-Yin Chan, Christina M Egbert, Julia E Maxson, Adam Siddiqui, Logan J Larsen, Kristina Kohler, Eranga Roshan Balasooriya, Katie L Pennington, Tsz-Ming Tsang, Madison Frey, Erik J Soderblom, Huimin Geng, Markus Müschen, Tetyana V Forostyan, Savannah Free, Gaelle Mercenne, Courtney J Banks, Jonard Valdoz, Clifford J Whatcott, Jason M Foulks, David J Bearss, Thomas O'Hare, David C S Huang, Kenneth A Christensen, James Moody, Steven L Warner, Jeffrey W Tyner, Joshua L Andersen

Journal: Nat Commun

PubMed ID: 34504101

Doi: 10.1038/s41467-021-25622-3

Products & Services: Mutagenesis Services

Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia

Authors: Reina Bassil, Kenneth Shields, Kevin Granger, Ivan Zein, Shirley Ng, Ben Chih

Journal: Nat Commun

PubMed ID: 34471104

Doi: 10.1038/s41467-021-25344-6

Products & Services: Molecular Biology Reagents

Generation of stable cell lines using readthrough expression from lentiviral integration

Authors: Anish Jadav, Kevin Truong

Journal: Biotechnol Lett

PubMed ID: 34533680

Doi: 10.1007/s10529-021-03186-y

Products & Services: GenParts™ DNA Fragments

Expression of the ISPpu9 transposase of Pseudomonas putida KT2440 is regulated by two small RNAs and the secondary structure of the mRNA 5'-untranslated region

Authors: Guillermo Gómez-García, Angel Ruiz-Enamorado, Luis Yuste, Fernando Rojo, Renata Moreno

Journal: Nucleic Acids Res

PubMed ID: 34379788

Doi: 10.1093/nar/gkab672

Products & Services: GenParts™ DNA Fragments

Discovery of novel glycoside hydrolases from C-glycoside-degrading bacteria using sequence similarity network analysis

Authors: Bin Wei, Ya-Kun Wang, Jin-Biao Yu, Si-Jia Wang, Yan-Lei Yu, Xue-Wei Xu, Hong Wang

Journal: J Microbiol

PubMed ID: 34554454

Doi: 10.1007/s12275-021-1292-4

Products & Services: GenParts™ DNA Fragments

Viral suppressor of RNA silencing in vascular plants also interferes with the development of the bryophyte Physcomitrella patens

Authors: Eeva M Marttinen, Mikko T Lehtonen, Nico van Gessel, Ralf Reski, Jari P T Valkonen

Journal: Plant Cell Environ

PubMed ID: 34564869

Doi: 10.1111/pce.14194

Products & Services: DNA Sequencing

DcCCD4 catalyzes the degradation of α-carotene and β-carotene to affect carotenoid accumulation and taproot color in carrot

Authors: Tong Li, Yuan-Jie Deng, Jie-Xia Liu, Ao-Qi Duan, Hui Liu, Ai-Sheng Xiong

Journal: Plant J

PubMed ID: 34547154

Doi: 10.1111/tpj.15498

Products & Services: DNA Sequencing

Synthetic SARS-CoV-2 Spike-Based DNA Vaccine Elicits Robust and Long-Lasting Th1 Humoral and Cellular Immunity in Mice

Authors: Sawsan S Alamri, Khalid A Alluhaybi, Rowa Y Alhabbab, Mohammad Basabrain, Abdullah Algaissi, Sarah Almahboub, Mohamed A Alfaleh, Turki S Abujamel, Wesam H Abdulaal, M-Zaki ElAssouli, Rahaf H Alharbi, Mazen Hassanain, Anwar M Hashem

Journal: Front Microbiol

PubMed ID: 34557174

Doi: 10.3389/fmicb.2021.727455

Products & Services: DNA Sequencing

Molecular mechanism of interactions between ACAD9 and binding partners in mitochondrial respiratory complex I assembly

Authors: Chuanwu Xia, Baoying Lou, Zhuji Fu, Al-Walid Mohsen, Anna L Shen, Jerry Vockley, Jung-Ja P Kim

Journal: iScience

PubMed ID: 34646991

Doi: 10.1016/j.isci.2021.103153

Products & Services: DNA Sequencing

Infection Kinetics and Transmissibility of a Reanimated Dengue Virus Serotype 4 Identified Originally in Wild From Florida

Authors: Jasmine B Ayers, Xuping Xie, Heather Coatsworth, Caroline J Stephenson, Christy M Waits, Pei-Yong Shi, Rhoel R Dinglasan

Journal: Front Microbiol

PubMed ID: 34630357

Doi: 10.3389/fmicb.2021.734903

Products & Services: DNA Sequencing

A novel thermostable prokaryotic fucoidan active sulfatase PsFucS1 with an unusual quaternary hexameric structure

Authors: Maria Dalgaard Mikkelsen, Hang Thi Thuy Cao, Thomas Roret, Nanna Rhein-Knudsen, Jesper Holck, Van Thi Thanh Tran, Thuan Thi Nguyen, Vy Ha Nguyen Tran, Mateusz Jakub Lezyk, Jan Muschiol, Thinh Duc Pham, Mirjam Czjzek, Anne S Meyer

Journal: Sci Rep

PubMed ID: 34593864

Doi: 10.1038/s41598-021-98588-3

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Hsa-circ_0003420 induces apoptosis in acute myeloid leukemia stem cells and impairs stem cell properties

Authors: Guoqiang Lin, Yingying Fei, Yanming Zhang

Journal: Immunopharmacol Immunotoxicol

PubMed ID: 34477035

Doi: 10.1080/08923973.2021.1963272

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Propofol induces the ferroptosis of colorectal cancer cells by downregulating STAT3 expression

Authors: Xining Zhao, Fei Chen

Journal: Oncol Lett

PubMed ID: 34589146

Doi: 10.3892/ol.2021.13028

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Exendin-4 Pretreatment Attenuates Kainic Acid-Induced Hippocampal Neuronal Death

Authors: Yu-Jeong Ahn, Hyun-Joo Shin, Eun-Ae Jeong, Hyeong-Seok An, Jong-Youl Lee, Hye-Min Jang, Kyung-Eun Kim, Jaewoong Lee, Meong-Cheol Shin, Gu-Seob Roh

Journal: Cells

PubMed ID: 34685508

Doi: 10.3390/cells10102527

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Mechanisms of irreversible aquaporin-10 inhibition by organogold compounds studied by combined biophysical methods and atomistic simulations

Authors: Catarina Pimpão, Darren Wragg, Riccardo Bonsignore, Brech Aikman, Per Amstrup Pedersen, Stefano Leoni, Graça Soveral, Angela Casini

Journal: Metallomics

PubMed ID: 34468767

Doi: 10.1093/mtomcs/mfab053

Products & Services: Codon Optimization

Structure of the human marker of self 5-transmembrane receptor CD47

Authors: Gustavo Fenalti, Nicolas Villanueva, Mark Griffith, Barbra Pagarigan, Sirish Kaushik Lakkaraju, Richard Y-C Huang, Nadia Ladygina, Alok Sharma, David Mikolon, Mahan Abbasian, Jeffrey Johnson, Haralambos Hadjivassiliou, Dan Zhu, Philip P Chamberlain, Ho Cho, Kandasamy Hariharan

Journal: Nat Commun

PubMed ID: 34471125

Doi: 10.1038/s41467-021-25475-w

Products & Services: Codon Optimization

Neuromedin B receptor stimulation of Cav32 T-type Ca channels in primary sensory neurons mediates peripheral pain hypersensitivity

Authors: Yuan Zhang, Zhiyuan Qian, Dongsheng Jiang, Yufang Sun, Shangshang Gao, Xinghong Jiang, Hua Wang, Jin Tao

Journal: Theranostics

PubMed ID: 34646374

Doi: 10.7150/thno.62255

Products & Services: Peptide Synthesis

Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra

Authors: Salinthip Jarusintanakorn, Chutima Phechkrajang, Putthiporn Khongkaew, Enrico Mastrobattista, Montarop Yamabhai

Journal: Anal Bioanal Chem

PubMed ID: 34476523

Doi: 10.1007/s00216-021-03549-4

Products & Services: Proteins, Expression, Isolation and Analysis

Cellular retinoid-binding proteins transfer retinoids to human cytochrome P450 27C1 for desaturation

Authors: Sarah M Glass, F Peter Guengerich

Journal: J Biol Chem

PubMed ID: 34480899

Doi: 10.1016/j.jbc.2021.101142

Products & Services: Mutagenesis Services

Nasal Immunization With Small Molecule Mast Cell Activators Enhance Immunity to Co-Administered Subunit Immunogens

Authors: Brandi T Johnson-Weaver, Hae Woong Choi, Hang Yang, Josh A Granek, Cliburn Chan, Soman N Abraham, Herman F Staats

Journal: Front Immunol

PubMed ID: 34566991

Doi: 10.3389/fimmu.2021.730346

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Preclinical development of a bispecific TNFα/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease

Authors: Kevin J Roberts, Marion F Cubitt, Timothy M Carlton, Lurdes Rodrigues-Duarte, Luana Maggiore, Ray Chai, Simon Clare, Katherine Harcourt, Thomas T MacDonald, Keith P Ray, Anna Vossenkämper, Michael R West, J Scott Crowe

Journal: Sci Rep

PubMed ID: 34593832

Doi: 10.1038/s41598-021-97236-0

Products & Services: Monoclonal Antibody Services

Conformational rearrangements enable iterative backbone N-methylation in RiPP biosynthesis

Authors: Fredarla S Miller, Kathryn K Crone, Matthew R Jensen, Sudipta Shaw, William R Harcombe, Mikael H Elias, Michael F Freeman

Journal: Nat Commun

PubMed ID: 34504067

Doi: 10.1038/s41467-021-25575-7

Products & Services: Bacterial Expression

Structural insights into the activation of human calcium-sensing receptor

Authors: Xiaochen Chen, Lu Wang, Qianqian Cui, Zhanyu Ding, Li Han, Yongjun Kou, Wenqing Zhang, Haonan Wang, Xiaomin Jia, Mei Dai, Zhenzhong Shi, Yuying Li, Xiyang Li, Yong Geng

Journal: Elife

PubMed ID: 34467854

Doi: 10.7554/eLife.68578

Products & Services: Catalog Peptides

Molecular basis for ATPase-powered substrate translocation by the Lon AAA+ protease

Authors: Shanshan Li, Kan-Yen Hsieh, Shih-Chieh Su, Grigore D Pintilie, Kaiming Zhang, Chung-I Chang

Journal: J Biol Chem

PubMed ID: 34563541

Doi: 10.1016/j.jbc.2021.101239

Products & Services: Proteins, Expression, Isolation and Analysis

Newt regeneration genes regulate Wingless signaling to restore patterning in eye

Authors: Abijeet Singh Mehta, Prajakta Deshpande, Anuradha Venkatakrishnan Chimata, Panagiotis A Tsonis, Amit Singh

Journal: iScience

PubMed ID: 34746690

Doi: 10.1016/j.isci.2021.103166

Products & Services: ORF cDNA Clones/MolecularCloud

One Health Investigation of SARS-CoV-2 Infection and Seropositivity among Pets in Households with Confirmed Human COVID-19 Cases-Utah and Wisconsin, 2020

Authors: Grace W Goryoka, Caitlin M Cossaboom, Radhika Gharpure, Patrick Dawson, Cassandra Tansey, John Rossow, Victoria Mrotz, Jane Rooney, Mia Torchetti, Christina M Loiacono, Mary L Killian, Melinda Jenkins-Moore, Ailam Lim, Keith Poulsen, Dan Christensen, Emma Sweet, Dallin Peterson, Anna L Sangster, Erin L Young, Kelly F Oakeson, Dean Taylor, Amanda Price, Tair Kiphibane, Rachel Klos, Darlene Konkle, Sanjib Bhattacharyya, Trivikram Dasu, Victoria T Chu, Nathaniel M Lewis, Krista Queen, Jing Zhang, Anna Uehara, Elizabeth A Dietrich, Suxiang Tong, Hannah L Kirking, Jeffrey B Doty, Laura S Murrell, Jessica R Spengler, Anne Straily, Ryan Wallace, Casey Barton Behravesh

Journal: Viruses

PubMed ID: 34578394

Doi: 10.3390/v13091813

Products & Services: Serology SARS-Cov-2 detection kits

Profiles of spp Isolated from the Rhizosphere of Suaeda glauca and Their Potential to Promote Plant Growth and Suppress Fungal Phytopathogens

Authors: Ping Lu, Ke Jiang, Ya-Qiao Hao, Wan-Ying Chu, Yu-Dong Xu, Jia-Yao Yang, Jia-Le Chen, Guo-Hong Zeng, Zhou-Hang Gu, Hong-Xin Zhao

Journal: J Microbiol Biotechnol

PubMed ID: 34261851

Doi: 10.4014/jmb.2105.05010

Products & Services: Recombinant Antibody Expression

Highly Specific Memory B Cells Generation after the 2nd Dose of BNT162b2 Vaccine Compensate for the Decline of Serum Antibodies and Absence of Mucosal IgA

Authors: Eva Piano Mortari, Cristina Russo, Maria Rosaria Vinci, Sara Terreri, Ane Fernandez Salinas, Livia Piccioni, Claudia Alteri, Luna Colagrossi, Luana Coltella, Stefania Ranno, Giulia Linardos, Marilena Agosta, Christian Albano, Chiara Agrati, Concetta Castilletti, Silvia Meschi, Paolo Romania, Giuseppe Roscilli, Emiliano Pavoni, Vincenzo Camisa, Annapaola Santoro, Rita Brugaletta, Nicola Magnavita, Alessandra Ruggiero, Nicola Cotugno, Donato Amodio, Marta Luisa Ciofi Degli Atti, Daniela Giorgio, Nicoletta Russo, Guglielmo Salvatori, Tiziana Corsetti, Franco Locatelli, Carlo Federico Perno, Salvatore Zaffina, Rita Carsetti

Journal: Cells

PubMed ID: 34685521

Doi: 10.3390/cells10102541

Products & Services: Recombinant Antibody Expression

Structures of foot-and-mouth disease virus with bovine neutralizing antibodies reveal the determinant of intra-serotype cross-neutralization

Authors: Yong He, Kun Li, Li Wang, Zixian Sun, Yimei Cao, Pinghua Li, Pu Sun, Huifang Bao, Shasha Zhou, Sheng Wang, Xingwen Bai, Xuerong Liu, Lixia Zhao, Xiuli Fan, Zaixin Liu, Zengjun Lu, Cheng Yang, Zhiyong Lou

Journal: J Virol

PubMed ID: 34586859

Doi: 10.1128/JVI.01308-21

Products & Services: Proteins, Expression, Isolation and Analysis

Biocatalytic synthesis of 2-O-α-D-glucopyranosyl-L-ascorbic acid using an extracellular expressed α-glucosidase from Oryza sativa

Authors: Xuelian Qi, Junlan Shao, Yinchu Cheng, Xiaoying He, Yan Li, Honghua Jia, Ming Yan

Journal: Biotechnol J

PubMed ID: 34392609

Doi: 10.1002/biot.202100199

Products & Services: Proteins, Expression, Isolation and Analysis

Desialylation of O-glycans activates von Willebrand factor by destabilizing its autoinhibitory module

Authors: Kayleigh M Voos, Wenpeng Cao, Nicholas A Arce, Emily R Legan, Yingchun Wang, Asif Shajahan, Parastoo Azadi, Pete Lollar, Xiaohui Frank Zhang, Renhao Li

Journal: J Thromb Haemost

PubMed ID: 34529349

Doi: 10.1111/jth.15528

Products & Services: Proteins, Expression, Isolation and Analysis

Up-regulation of MELK by E2F1 promotes the proliferation in cervical cancer cells

Authors: Hongzhi Sun, Hongmei Ma, Hao Zhang, Minjun Ji

Journal: Int J Biol Sci

PubMed ID: 34671205

Doi: 10.7150/ijbs.62517

Products & Services: Proteins, Expression, Isolation and Analysis

Recombinant adenovirus expressing the fusion protein PD1PVR improves CD8 T cell-mediated antitumor efficacy with long-term tumor-specific immune surveillance in hepatocellular carcinoma

Authors: Hailin Zhang, Yonghui Zhang, Jie Dong, Shuguang Zuo, Gang Meng, Junhua Wu, Jiwu Wei

Journal: Cell Oncol (Dordr)

PubMed ID: 34491549

Doi: 10.1007/s13402-021-00633-w

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Knockdown of lncRNA TUG1 protects lens epithelial cells from oxidative stress-induced injury by regulating miR-196a-5p expression in age-related cataracts

Authors: Qimin Shen, Tian Zhou

Journal: Exp Ther Med

PubMed ID: 34630641

Doi: 10.3892/etm.2021.10721

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Seroprevalence and detection of Trypanosoma cruzi in dogs living in a non-endemic area for Chagas disease in the legal Amazon region, Brazil

Authors: Thaliane França Costa, Ana Vitória Verde Oliveira Rocha, Leandro Macedo Miranda, Larissa Fernanda Soares Lima, Fred Luciano Neves Santos, Ângelo Antônio Oliveira Silva, Fernando Almeida-Souza, Anaiá da Paixão Sevá, Aline Diniz Cabral, Márcia Aparecida Sperança, Francisco Borges Costa, Rita de Maria Seabra Nogueira, Andréa Pereira da Costa

Journal: Vet Parasitol Reg Stud Reports

PubMed ID: 34879958

Doi: 10.1016/j.vprsr.2021.100648

Products & Services: Proteins, Expression, Isolation and Analysis

Novel Homologs of Isopentenyl Phosphate Kinase Reveal Class-Wide Substrate Flexibility

Authors: Vikas Kumar , Bryce P Johnson , Dustin A Dimas , Shanteri Singh

Journal: ChemCatChem

PubMed ID: 34630731

Doi: 10.1002/cctc.202100595

Products & Services: Gene Synthesis

Cytoplasmic and nuclear Sw-5b NLR act both independently and synergistically to confer full host defense against tospovirus infection

Authors: Hongyu Chen , Xin Qian , Xiaojiao Chen , Tongqing Yang , Mingfeng Feng , Jing Chen , Ruixiang Cheng , Hao Hong , Ying Zheng , Yuzhen Mei , Danyu Shen , Yi Xu , Min Zhu , Xin Shun Ding , Xiaorong Tao

Journal: New Phytol

PubMed ID: 34096619

Doi: 10.1111/nph.17535

Products & Services: Gene Synthesis

Assessment of IsPETase-Assisted Depolymerization of Terephthalate Aromatic Polyesters and the Effect of the Thioredoxin Fusion Domain

Authors: Paula Wagner-Egea ,Virginia Tosi ,Ping Wang ,Carl Grey,Baozhong Zhang and Javier A. Linares-Pastén

Journal: applied sciences

Doi: 10.3390/app11188315

Products & Services: Gene Synthesis

Protein Production and Purification of a Codon-Optimized Human NGN3 Transcription Factor from E coli

Authors: Gloria Narayan, Akriti Agrawal, Neha Joshi, Ranadeep Gogoi, Shirisha Nagotu, Rajkumar P Thummer

Journal: Protein J

PubMed ID: 34550497

Doi: 10.1007/s10930-021-10020-x

Products & Services: Mammalian Expression

Atypical laminin spots and pull-generated microtubule-actin projections mediate Drosophila wing adhesion

Authors: Tianhui Sun, Yuzhao Song, Dequn Teng, Yanan Chen, Jianli Dai, Mengqi Ma, Wei Zhang, José C Pastor-Pareja

Journal: Cell Rep

PubMed ID: 34496252

Doi: 10.1016/j.celrep.2021.109667

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A novel intronic circular RNA, circGNG7, inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82

Authors: Houyu Ju, Zhenrong Hu, Dongliang Wei, Jinyun Huang, Xinyi Zhang, Mengyu Rui, Zhi Li, Xiaomeng Zhang, Jingzhou Hu, Wei Guo, Guoxin Ren

Journal: Cancer Commun (Lond)

PubMed ID: 34498800

Doi: 10.1002/cac2.12213

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