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至今，GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次，处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果，再次证明GenScript 有能力帮助业内科学家Make research easy.

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Manipulating turn residues on de novo designed β-hairpin peptides for selectivity against drug-resistant bacteria

Authors: Nhan D T Tram, Vanitha Selvarajan, Alister Boags, Devika Mukherjee, Jan K Marzinek, Bernadette Cheng, Zi-Chen Jiang, Pascal Goh, Jun-Jie Koh, Jeanette W P Teo, Peter J Bond, Pui Lai Rachel Ee

Journal: Acta Biomater

PubMed ID: 34506975

Doi: 10.1016/j.actbio.2021.09.004

Products & Services: Molecular Biology Tools

Ferulic Acid Metabolites Attenuate LPS-Induced Inflammatory Response in Enterocyte-like Cells

Authors: Gabriele Serreli, Micaela Rita Naitza, Sonia Zodio, Vera Piera Leoni, Martina Spada, Maria Paola Melis, Anna Boronat, Monica Deiana

Journal: Nutrients

PubMed ID: 34579029

Doi: 10.3390/nu13093152

Products & Services: Proteins, Expression, Isolation and Analysis

Transcriptome Reprogramming of Tomato Orchestrate the Hormone Signaling Network of Systemic Resistance Induced by

Authors: Jagmohan Singh, Rashmi Aggarwal, Bishnu Maya Bashyal, K Darshan, Pooja Parmar, M S Saharan, Zakir Hussain, Amolkumar U Solanke

Journal: Front Plant Sci

PubMed ID: 34630468

Doi: 10.3389/fpls.2021.721193

Products & Services: Molecular Biology Tools

Structure and function of aerotolerant, multiple-turnover THI4 thiazole synthases

Authors: Jaya Joshi, Qiang Li, Jorge D García-García, Bryan J Leong, You Hu, Steven D Bruner, Andrew D Hanson

Journal: Biochem J

PubMed ID: 34409984

Doi: 10.1042/BCJ20210565

Products & Services: Bacterial Expression

Targeting the VCP-binding motif of ataxin-3 improves phenotypes in Drosophila models of Spinocerebellar Ataxia Type 3

Authors: Sean L Johnson, Kozeta Libohova, Jessica R Blount, Alyson L Sujkowski, Matthew V Prifti, Wei-Ling Tsou, Sokol V Todi

Journal: Neurobiol Dis

PubMed ID: 34563642

Doi: 10.1016/j.nbd.2021.105516

Products & Services: Gene Synthesis

Semliki Forest Virus Chimeras with Functional Replicase Modules from Related Alphaviruses Survive by Adaptive Mutations in Functionally Important Hot Spots

Authors: Mona Teppor, Eva Žusinaite, Liis Karo-Astover, Ailar Omler, Kai Rausalu, Valeria Lulla, Aleksei Lulla, Andres Merits

Journal: J Virol

PubMed ID: 34319778

Doi: 10.1128/JVI.00973-21

Products & Services: Gene Synthesis

A Plant-Produced Virus-Like Particle Displaying Envelope Protein Domain III Elicits an Immune Response Against West Nile Virus in Mice

Authors: Jennifer Stander, Aleyo Chabeda, Edward P Rybicki, Ann E Meyers

Journal: Front Plant Sci

PubMed ID: 34589108

Doi: 10.3389/fpls.2021.738619

Products & Services: Codon Optimization

Immunoprotection evaluation of the recombinant N-terminal domain of Cys-loop receptors against Rhipicephalus (Boophilus) microplus tick infestation

Authors: Moisés Martínez Velázquez, Carla Patricia Barragán Álvarez, José Miguel Flores Fernández, Rodolfo Esteban Lagunes Quintanilla, Edgar Castro Saines, Patricia Berenice Ramírez Rodríguez, Sara Elisa Herrera Rodríguez, Rodolfo Hernández Gutiérrez, Abel Gutiérrez Ortega, Ángel H Álvarez

Journal: Parasite

PubMed ID: 34533454

Doi: 10.1051/parasite/2021064

Products & Services: Plasmid DNA Preparation

Knockdown of miR‑205‑5p alleviates the inflammatory response in allergic rhinitis by targeting B‑cell lymphoma 6

Authors: Shuang Zhang, Sihan Lin, Qiaofei Tang, Zhiyong Yan

Journal: Mol Med Rep

PubMed ID: 34558634

Doi: 10.3892/mmr.2021.12458

Products & Services: Mutant Libraries

Rapid antibody testing for SARS-CoV-2 vaccine response in pediatric healthcare workers

Authors: Theodore W Heyming, Diane Nugent, Aprille Tongol, Chloe Knudsen-Robbins, Janet Hoang, John Schomberg, Kellie Bacon, Bryan Lara, Terence Sanger

Journal: Int J Infect Dis

PubMed ID: 34601142

Doi: 10.1016/j.ijid.2021.09.065

Products & Services: Proteins, Expression, Isolation and Analysis

Development and characterization of a unique anti-IgE mouse monoclonal antibody cross-reactive between human and canine IgE

Authors: Akiko Kumagai, Takuya Nara, Mizuho Uematsu, Yoko Kakinuma, Takashi Saito, Kenichi Masuda

Journal: Immun Inflamm Dis

PubMed ID: 34533288

Doi: 10.1002/iid3.531

Products & Services: Gene Synthesis

Precise Characterization of Gene Using Cpf1-Based Enrichment and Oxford Nanopore Technologies

Authors: Wei Lu, Xinhui Lan, Tong Zhang, Hao Sun, Sanyuan Ma, Qingyou Xia

Journal: Insects

PubMed ID: 34564273

Doi: 10.3390/insects12090832

Products & Services: Synthetic sgRNA and crRNA Service

Developing and characterizing a single-domain antibody (nanobody) against human cytotoxic T-lymphocyte-associated protein 4 (hCTLA-4)

Authors: Nazli Sotoudeh, Zahra Noormohammadi, Mahdi Habibi-Anbouhi, Fatemeh Kazemi-Lomedasht, Mahdi Behdani

Journal: Iran J Basic Med Sci

PubMed ID: 35083014

Doi: 10.22038/IJBMS.2021.57774.12851

Products & Services: DNA Sequencing

A strategy combining 3D-DNA Walker and CRISPR-Cas12a trans-cleavage activity applied to MXene based electrochemiluminescent sensor for SARS-CoV-2 RdRp gene detection

Authors: Kai Zhang, Zhenqiang Fan, Yue Huang, Yuedi Ding, Minhao Xie

Journal: Talanta

PubMed ID: 34635250

Doi: 10.1016/j.talanta.2021.122868

Products & Services: Gene Synthesis

PEAK1 promotes invasion and metastasis and confers drug resistance in breast cancer

Authors: Xingang Wang, Yan Zheng, Yu Wang

Journal: Clin Exp Med

PubMed ID: 34554318

Doi: 10.1007/s10238-021-00761-5

Products & Services: Custom Vector Construction

The Novel Nucleoside Analogue ProTide NUC-7738 Overcomes Cancer Resistance Mechanisms and in a First-In-Human Phase I Clinical Trial

Authors: Hagen Schwenzer, Erica De Zan, Mustafa Elshani, Ruud van Stiphout, Mary Kudsy, Josephine Morris, Valentina Ferrari, In Hwa Um, James Chettle, Farasat Kazmi, Leticia Campo, Alistair Easton, Sebastian Nijman, Michaela Serpi, Stefan Symeonides, Ruth Plummer, David J Harrison, Gareth Bond, Sarah P Blagden

Journal: Clin Cancer Res

PubMed ID: 34497073

Doi: 10.1158/1078-0432.CCR-21-1652

Products & Services: Plasmid DNA Preparation

Emergent RNA-RNA interactions can promote stability in a facultative phototrophic endosymbiosis

Authors: Benjamin H Jenkins, Finlay Maguire, Guy Leonard, Joshua D Eaton, Steven West, Benjamin E Housden, David S Milner, Thomas A Richards

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34521754

Doi: 10.1073/pnas.2108874118

Products & Services: Plasmid DNA Preparation

Cyclical phosphorylation of LRAP35a and CLASP2 by GSK3β and CK1δ regulates EB1-dependent MT dynamics in cell migration

Authors: Shumei Chia, Thomas Leung, Ivan Tan

Journal: Cell Rep

PubMed ID: 34525355

Doi: 10.1016/j.celrep.2021.109687

Products & Services: Proteins, Expression, Isolation and Analysis

Analysis of the Role of N-Linked Glycosylation in Cell Surface Expression, Function, and Binding Properties of SARS-CoV-2 Receptor ACE2

Authors: Raymond Rowland, Alberto Brandariz-Nuñez

Journal: Microbiol Spectr

PubMed ID: 34494876

Doi: 10.1128/Spectrum.01199-21

Products & Services: Stable Cell Lines

The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1

Authors: Yue Xi, Yanping Li, Pengfei Xu, Sihan Li, Zhengsheng Liu, Hung-Chun Tung, Xinran Cai, Jingyuan Wang, Haozhe Huang, Menglin Wang, Meishu Xu, Songrong Ren, Song Li, Min Zhang, Yong J Lee, Leaf Huang, Da Yang, Jinhan He, Zhiying Huang, Wen Xie

Journal: Sci Adv

PubMed ID: 34516906

Doi: 10.1126/sciadv.abg9241

Products & Services: Plasmid DNA Preparation

Impact of glgA1, glgA2 or glgC overexpression on growth and glycogen production in Synechocystis sp PCC 6803

Authors: Sandra Mittermair, Gergely Lakatos, Cecilia Nicoletti, Karolína Ranglová, João Câmara Manoel, Tomáš Grivalský, Daniyar Malikuly Kozhan, Jiří Masojídek, Juliane Richter

Journal: J Biotechnol

PubMed ID: 34481001

Doi: 10.1016/j.jbiotec.2021.08.012

Products & Services: Proteins, Expression, Isolation and Analysis

Endoglycan (PODXL2) is proteolytically processed by ADAM10 (a disintegrin and metalloprotease 10) and controls neurite branching in primary neurons

Authors: Hung-En Hsia, Johanna Tüshaus, Xiao Feng, Laura I Hofmann, Benedikt Wefers, Denise K Marciano, Wolfgang Wurst, Stefan F Lichtenthaler

Journal: FASEB J

PubMed ID: 34390512

Doi: 10.1096/fj.202100475R

Products & Services: Proteins, Expression, Isolation and Analysis

Switchable immune modulator for tumor-specific activation of anticancer immunity

Authors: Yu Zhao, Yu-Qing Xie, Simon Van Herck, Sina Nassiri, Min Gao, Yugang Guo, Li Tang

Journal: Sci Adv

PubMed ID: 34516776

Doi: 10.1126/sciadv.abg7291

Products & Services: Peptide Synthesis

A structural view onto disease-linked mutations in the human neutral amino acid exchanger ASCT1

Authors: Pavlo Stehantsev, Artem Stetsenko, Mariia Nemchinova, Nanda Gowtham Aduri, Siewert J Marrink, Cornelius Gati, Albert Guskov

Journal: Comput Struct Biotechnol J

PubMed ID: 34630942

Doi: 10.1016/j.csbj.2021.09.015

Products & Services: Mammalian Expression

Mucosal IgA response elicited by intranasal immunization of Lactobacillus plantarum expressing surface-displayed RBD protein of SARS-CoV-2

Authors: Letian Li, Maopeng Wang, Jiayi Hao, Jicheng Han, Tingting Fu, Jieying Bai, Mingyao Tian, Ningyi Jin, Guangze Zhu, Chang Li

Journal: Int J Biol Macromol

PubMed ID: 34499954

Doi: 10.1016/j.ijbiomac.2021.08.232

Products & Services: Monoclonal Antibody Services

Selective autophagic receptor NbNBR1 prevents NbRFP1-mediated UPS-dependent degradation of βC1 to promote geminivirus infection

Authors: Tingting Zhou, Mingzhen Zhang, Pan Gong, Fangfang Li, Xueping Zhou

Journal: PLoS Pathog

PubMed ID: 34570833

Doi: 10.1371/journal.ppat.1009956

Products & Services: Polyclonal Antibody Services

A new carbohydrate-active oligosaccharide dehydratase is involved in the degradation of ulvan

Authors: Marcus Bäumgen, Theresa Dutschei, Daniel Bartosik, Christoph Suster, Lukas Reisky, Nadine Gerlach, Christian Stanetty, Marko D Mihovilovic, Thomas Schweder, Jan-Hendrik Hehemann, Uwe T Bornscheuer

Journal: J Biol Chem

PubMed ID: 34547290

Doi: 10.1016/j.jbc.2021.101210

Products & Services: PCR Cloning and Subcloning

A bioluminescent and homogeneous SARS-CoV-2 spike RBD and hACE2 interaction assay for antiviral screening and monitoring patient neutralizing antibody levels

Authors: Juliano Alves, Laurie Engel, Renata de Vasconcelos Cabral, Eduardo L Rodrigues, Liane de Jesus Ribeiro, Luiza M Higa, Orlando da Costa Ferreira Júnior, Terezinha Marta P P Castiñeiras, Isabela de Carvalho Leitão, Amilcar Tanuri, Said A Goueli, Hicham Zegzouti

Journal: Sci Rep

PubMed ID: 34531417

Doi: 10.1038/s41598-021-97330-3

Products & Services: Catalog Antibody

Oncogenic Truncations of ASXL1 Enhance a Motif for BRD4 ET-Domain Binding

Authors: Abigail E Burgess, Torsten Kleffmann, Peter D Mace

Journal: J Mol Biol

PubMed ID: 34536441

Doi: 10.1016/j.jmb.2021.167242

Products & Services: Gene Synthesis

Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens

Authors: Andrew J Monteith, Jeanette M Miller, C Noel Maxwell, Walter J Chazin, Eric P Skaar

Journal: Sci Adv

PubMed ID: 34516771

Doi: 10.1126/sciadv.abj2101

Products & Services: Endotoxin Detection & Removal System

Large chromosomal segment deletions by CRISPR/LbCpf1-mediated multiplex gene editing in soybean

Authors: Kaixuan Duan, Yuanyuan Cheng, Jing Ji, Chenchen Wang, Yongshu Wei, Yuanchao Wang

Journal: J Integr Plant Biol

PubMed ID: 34331750

Doi: 10.1111/jipb.13158

Products & Services: Plasmid DNA Preparation

Transcription factors Krüppel-like factor 4 and paired box 5 regulate the expression of the Grainyhead-like genes

Authors: Grzegorz Kotarba, Agnieszka Taracha-Wisniewska, Michal Miller, Michal Dabrowski, Tomasz Wilanowski

Journal: PLoS ONE

PubMed ID: 34570823

Doi: 10.1371/journal.pone.0257977

Products & Services: Plasmid DNA Preparation

Expression, biochemical and structural characterization of high-specific-activity β-amylase from Bacillus aryabhattai GEL-09 for application in starch hydrolysis

Authors: Xuguo Duan, Qiuyu Zhu, Xinyi Zhang, Zhenyan Shen, Yue Huang

Journal: Microb Cell Fact

PubMed ID: 34537082

Doi: 10.1186/s12934-021-01649-5

Products & Services: Plasmid DNA Preparation

Tracing Transmission of Sin Nombre Virus and Discovery of Infection in Multiple Rodent Species

Authors: Samuel M Goodfellow, Robert A Nofchissey, Kurt C Schwalm, Joseph A Cook, Jonathan L Dunnum, Yan Guo, Chunyan Ye, Gregory J Mertz, Kartik Chandran, Michelle Harkins, Daryl B Domman, Darrell L Dinwiddie, Steven B Bradfute

Journal: J Virol

PubMed ID: 34549977

Doi: 10.1128/JVI.01534-21

Products & Services: Plasmid DNA Preparation

The BES1/BZR1-family transcription factor MpBES1 regulates cell division and differentiation in Marchantia polymorpha

Authors: Martin A Mecchia, Mariano García-Hourquet, Fidel Lozano-Elena, Ainoa Planas-Riverola, David Blasco-Escamez, Mar Marquès-Bueno, Santiago Mora-García, Ana I Caño-Delgado

Journal: Curr Biol

PubMed ID: 34529936

Doi: 10.1016/j.cub.2021.08.050

Products & Services: Plasmid DNA Preparation

Development of High Affinity Calcitonin Analog Fragments Targeting Extracellular Domains of Calcitonin Family Receptors

Authors: Sangmin Lee

Journal: Biomolecules

PubMed ID: 34572577

Doi: 10.3390/biom11091364

Products & Services: Peptide Synthesis

Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations

Authors: Ryuta Baba, Kenji Oki, Celso E Gomez-Sanchez, Yu Otagaki, Kiyotaka Itcho, Kazuhiro Kobuke, Takaya Kodama, Gaku Nagano, Haruya Ohno, Masayasu Yoneda, Noboru Hattori

Journal: Mol Cell Endocrinol

PubMed ID: 34520814

Doi: 10.1016/j.mce.2021.111456

Products & Services: PCR Cloning and Subcloning

Phycobilin heterologous production from the Rhodophyta Porphyridium cruentum

Authors: Erika Juliana Obando Montoya, Sonia Dorion, Lucía Atehortua-Garcés, Jean Rivoal

Journal: J Biotechnol

PubMed ID: 34500003

Doi: 10.1016/j.jbiotec.2021.09.001

Products & Services: PCR Cloning and Subcloning

Genetic Diversity and Population Structure of Affecting Chickpea in Ethiopia

Authors: Gezahegne Getaneh, Tadele Tefera, Fikre Lemessa, Seid Ahmed, Tarekegn Fite, Jandouwe Villinger

Journal: J Fungi (Basel)

PubMed ID: 34682241

Doi: 10.3390/jof7100820

Products & Services: Nucleic Acid Purification & Analysis

Genetic and phenotypic heterogeneity in KIAA0753-related ciliopathies

Authors: Katherine A Inskeep, Yuri A Zarate, Danielle Monteil, Jurgen Spranger, Dan Doherty, Rolf W Stottmann, K Nicole Weaver

Journal: Am J Med Genet A

PubMed ID: 34523780

Doi: 10.1002/ajmg.a.62497

Products & Services: Mutagenesis Services

Development of A Neonatal Mouse Model for Coxsackievirus B1 Antiviral Evaluation

Authors: Zhichao Yin, Yuanyuan Wu, Rui Zhu, Longfa Xu, Yu Lin, Hongwei Yang, Wenkun Fu, Qiongzi Huang, Dongqing Zhang, Jue Wang, Wei Wang, Yingbin Wang, Tong Cheng, Ningshao Xia

Journal: Virol Sin

PubMed ID: 34581960

Doi: 10.1007/s12250-021-00444-1

Products & Services: Monoclonal Antibody Services

Immunological Response Against SARS-COV-2 After BNT162b2 Vaccine Administration Is Impaired in Allogeneic but Not in Autologous Stem Cell Transplant Recipients

Authors: Martina Chiarucci, Sara Paolasini, Alessandro Isidori, Barbara Guiducci, Federica Loscocco, Maria Capalbo, Giuseppe Visani

Journal: Front Oncol

PubMed ID: 34552880

Doi: 10.3389/fonc.2021.737300

Products & Services: Molecular Biology Reagents

Correction to: Quantitative comparison of PD-L1 IHC assays against NIST standard reference material 1934

Authors: Seshi R Sompuram, Emina E Torlakovic, Nils A 't Hart, Kodela Vani, Steven A Bogen

Journal: Mod Pathol

PubMed ID: 34493826

Doi: 10.1038/s41379-021-00898-4

Products & Services: Mammalian Expression

Phase separation and toxicity of C9orf72 poly(PR) depends on alternate distribution of arginine

Authors: Chen Chen, Yoshiaki Yamanaka, Koji Ueda, Peiying Li, Tamami Miyagi, Yuichiro Harada, Sayaka Tezuka, Satoshi Narumi, Masahiro Sugimoto, Masahiko Kuroda, Yuhei Hayamizu, Kohsuke Kanekura

Journal: J Cell Biol

PubMed ID: 34499080

Doi: 10.1083/jcb.202103160

Products & Services: Mammalian Expression

Seroepidemiology of Infection in the General Population of Northern China: The Jidong Community Cohort Study

Authors: Jingwei Shui, Dongjie Xie, Jianhui Zhao, Cailing Ao, Hongqing Lin, Yuanhao Liang, Haiying Wang, Yingchun Dai, Shixing Tang

Journal: Front Microbiol

PubMed ID: 34650533

Doi: 10.3389/fmicb.2021.729016

Products & Services: Mammalian Expression

A bimolecular fluorescence complementation flow cytometry screen for membrane protein interactions

Authors: Florian Schmitz, Jessica Glas, Richard Neutze, Kristina Hedfalk

Journal: Sci Rep

PubMed ID: 34584201

Doi: 10.1038/s41598-021-98810-2

Products & Services: Mammalian Expression

A versatile genetic engineering toolkit for E coli based on CRISPR-prime editing

Authors: Yaojun Tong, Tue S Jørgensen, Christopher M Whitford, Tilmann Weber, Sang Yup Lee

Journal: Nat Commun

PubMed ID: 34471126

Doi: 10.1038/s41467-021-25541-3

Products & Services: GenParts™ DNA Fragments

Valorization of lignin components into gallate by integrated biological hydroxylation, O-demethylation, and aryl side-chain oxidation

Authors: Chenggu Cai, Zhaoxian Xu, Huarong Zhou, Sitong Chen, Mingjie Jin

Journal: Sci Adv

PubMed ID: 34516898

Doi: 10.1126/sciadv.abg4585

Products & Services: GenParts™ DNA Fragments

Oriented in situ immobilization of a functional tyrosinase on microcrystalline cellulose effectively incorporates DOPA residues in bioengineered mussel adhesive protein

Authors: Suhyeok Kim, Gaeun Bae, Mincheol Shin, Eungsu Kang, Tae Yoon Park, Yoo Seong Choi, Hyung Joon Cha

Journal: Biotechnol J

PubMed ID: 34536060

Doi: 10.1002/biot.202100216

Products & Services: DNA Sequencing

Location and expression kinetics of Tc24 in different life stages of Trypanosoma cruzi

Authors: Leroy Versteeg, Rakesh Adhikari, Cristina Poveda, Maria Jose Villar-Mondragon, Kathryn M Jones, Peter J Hotez, Maria Elena Bottazzi, Edwin Tijhaar, Jeroen Pollet

Journal: PLoS Negl Trop Dis

PubMed ID: 34478444

Doi: 10.1371/journal.pntd.0009689

Products & Services: DNA Sequencing

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