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Neutralizing antibodies reveal cryptic vulnerabilities and interdomain crosstalk in the porcine deltacoronavirus spike protein

Authors: Wenjuan Du, Oliver Debski-Antoniak, Dubravka Drabek, Rien van Haperen, Melissa van Dortmondt, Joline van der Lee, Ieva Drulyte, Frank J M van Kuppeveld, Frank Grosveld, Daniel L Hurdiss, Berend-Jan Bosch

Journal: Nat Commun

PubMed ID: 38909062

Doi: 10.1038/s41467-024-49693-0

Products & Services: DNA Sequencing

Down-regulation of SLC14A1 in prostate cancer activates CDK1/CCNB1 and mTOR pathways and promotes tumor progression

Authors: Jianbin Ma, Kaihua Xue, Yifan Jiang, Xinyang Wang, Dalin He, Peng Guo

Journal: Sci Rep

PubMed ID: 38942821

Doi: 10.1038/s41598-024-66020-1

Products & Services: Molecular Biology Reagents

Protein disulfide isomerase is essential for spermatogenesis in mice

Authors: Yaqiong Zhang, Aizhen Yang, Zhenzhen Zhao, Fengwu Chen, Xiaofeng Yan, Yue Han, Depei Wu, Yi Wu

Journal: JCI Insight

PubMed ID: 38912589

Doi: 10.1172/jci.insight.177743

Products & Services: Proteins, Expression, Isolation and Analysis

RBD design increases the functional antibody titers elicited by SARS-CoV-2 spike vaccination

Authors: Thayne H Dickey, Nichole D Salinas, Palak Patel, Sachy Orr-Gonzalez, Tarik Ouahes, Holly McAleese, Brandi L Richardson, Myesha Singleton, Michael Murphy, Brett Eaton, Jennifer L Kwan, Michael R Holbrook, Lynn E Lambert, Niraj H Tolia

Journal: Antiviral Res

PubMed ID: 38901738

Doi: 10.1016/j.antiviral.2024.105937

Products & Services: Proteins, Expression, Isolation and Analysis

Integrated metabolomics and transcriptomics reveal that HhERF9 positively regulates salt tolerance in Hibiscus hamabo Siebold & Zuccarini

Authors: Longjie Ni, Yu Xu, Zhiquan Wang, Chaoguang Yu, Jianfeng Hua, Yunlong Yin, Huogen Li, Chunsun Gu

Journal: Plant Physiol Biochem

PubMed ID: 38879985

Doi: 10.1016/j.plaphy.2024.108843

Products & Services: Proteins, Expression, Isolation and Analysis

Human cytomegalovirus deploys molecular mimicry to recruit VPS4A to sites of virus assembly

Authors: Benjamin G Butt, Daniela Fischer, Alison R Rep, Martin Schauflinger, Clarissa Read, Thomas Böck, Manuel Hirner, Frederik Wienen, Stephen C Graham, Jens von Einem

Journal: PLoS Pathog

PubMed ID: 38900818

Doi: 10.1371/journal.ppat.1012300

Products & Services: Proteins, Expression, Isolation and Analysis

Detection of avian reovirus (ARV) by ELISA based on recombinant σB, σC and σNS full-length proteins and protein fragments

Authors: Tatiana Reichert Assunção de Matos, Ana Paula Gori Palka, Claudemir de Souza, Stenio Perdigão Fragoso, Daniela Parada Pavoni

Journal: J Med Microbiol

PubMed ID: 38935078

Doi: 10.1099/jmm.0.001836

Products & Services: Gene Synthesis

Discovery and Characterization of Two Folded Intermediates for Outer Membrane Protein TolC Biogenesis

Authors: Ayotunde Paul Ikujuni, Rik Dhar, Andres Cordova, Alexander M Bowman, Sarah Noga, Joanna S G Slusky

Journal: J Mol Biol

PubMed ID: 38871177

Doi: 10.1016/j.jmb.2024.168652

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Systematic identification and functional analysis of root meristem growth factors (RGFs) reveals role of PgRGF1 in modulation of root development and ginsenoside production in Panax ginseng

Authors: Weipeng Lian, Linfan Zhang, Chenglin Wang, Shiqi Wu, Shan He, Jinlin Lei, Yonghong Zhang, Lei You, Lanlan Zheng, Xiangyin Luo, Zhengxiu Ye, Ziyao Hu, Guodong Wang, Yun Zhu, Chen Li, Juan Liu

Journal: Int J Biol Macromol

PubMed ID: 38945337

Doi: 10.1016/j.ijbiomac.2024.133446

Products & Services: Gene Synthesis

AGC kinases OXI1 and AGC2-2 regulate camalexin secretion and disease resistance by phosphorylating transporter PDR6

Authors: Juan Han, Chang-Xin Liu, Jian Liu, Cheng-Run Wang, Shun-Chang Wang, Guopeng Miao

Journal: Plant Physiol

PubMed ID: 38535832

Doi: 10.1093/plphys/kiae186

Products & Services: Proteins, Expression, Isolation and Analysis

Seeding activity of human superoxide dismutase 1 aggregates in familial and sporadic amyotrophic lateral sclerosis postmortem neural tissues by real-time quaking-induced conversion

Authors: Justin K. Mielke, Mikael Klingeborn, Eric P. Schultz, Erin L. Markham, Emily D. Reese, Parvez Alam, Ian R. Mackenzie, Cindy V. Ly, Byron Caughey, Neil R. Cashman & Moses J. Leavens

Journal: Acta Neuropathologica

PubMed ID: 38884646

Doi: 10.1007/s00401-024-02752-8

Products & Services: DNA Sequencing

Structural insights into somatostatin receptor 5 bound with cyclic peptides

Authors: Ying-Ge Li, Xian-Yu Meng, Xiru Yang, Sheng-Long Ling, Pan Shi, Chang-Lin Tian, Fan Yang

Journal: Acta Pharmacol Sin

PubMed ID: 38926478

Doi: 10.1038/s41401-024-01314-8

Products & Services: Proteins, Expression, Isolation and Analysis

Receptor-like kinase ERECTA negatively regulates anthocyanin accumulation in grape

Authors: Bo Wang, Qianqian Pang, Yunzhi Zhou, Jungui Yang, Ehsan Sadeghnezhad, Yuanxin Cheng, Sihong Zhou, Haifeng Jia

Journal: Plant Sci

PubMed ID: 38942388

Doi: 10.1016/j.plantsci.2024.112172

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Identification, Synthesis, and In Vitro Activities of Antimicrobial Peptide from African Catfish against the Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli

Authors: Hedmon Okella , Steven Odongo , Didier Vertommen , Emmanuel Okello

Journal: Pharmaceutics

PubMed ID: 39065546

Doi: 10.3390/pharmaceutics16070850

Products & Services: Peptide Synthesis

ATM and ATR gene editing mediated by CRISPR/Cas9 in Chinese Hamster cells

Authors: Junko Maeda , Piyawan Chailapakul , Takamitsu A Kato

Journal: Mutat Res

PubMed ID: 39024734

Doi: 10.1016/j.mrfmmm.2024.111871

Products & Services: CRISPR Plasmids

Lipid-Polymer Nanoparticles Mediate Compartmentalized Delivery of Cas9 and sgRNA for Glioblastoma Vasculature and Immune Reprogramming

Authors: Huaqing Zhang, Wenxin Jiang, Tingting Song, Mingjie Song, Shengyu Liu, Jianping Zhou, Hao Cheng, Yang Ding

Journal: Adv Sci (Weinh)

PubMed ID: 38923275

Doi: 10.1002/advs.202309314

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

Puferfsh gasdermin Ea is a signifcant player in the defense against bacterial pathogens

Authors: Hang Xu, Kunpeng Qin, Kangwei Hao, Zihao Yuan & Li Sun

Journal: Marine Life Science & Technology

Doi: //doi.org/10.1007/s42995-024-00237-x

Products & Services: Proteins, Expression, Isolation and Analysis

Elucidating the role of primary and secondary sphere Zn ligands in the cyanobacterial CO uptake complex NDH-1: The essentiality of arginine in zinc coordination and catalysis

Authors: Ross M Walker, Minquan Zhang, Robert L Burnap

Journal: Biochim Biophys Acta Bioenerg

PubMed ID: 38906312

Doi: 10.1016/j.bbabio.2024.149149

Products & Services: Mutant Libraries

Intein-mediated temperature control for complete biosynthesis of sanguinarine and its halogenated derivatives in yeast

Authors: Yuanwei Gou, Dongfang Li, Minghui Zhao, Mengxin Li, Jiaojiao Zhang, Yilian Zhou, Feng Xiao, Gaofei Liu, Haote Ding, Chenfan Sun, Cuifang Ye, Chang Dong, Jucan Gao, Di Gao, Zehua Bao, Lei Huang, Zhinan Xu, Jiazhang Lian

Journal: Nat Commun

PubMed ID: 38898098

Doi: 10.1038/s41467-024-49554-w

Products & Services: Gene Synthesis

Recovery kinetics of dual AAV-mediated human otoferlin expression

Authors: Jonathan B Sellon, Kathy S So, Andrew D'Arcangelo, Sarah Cancelarich, Meghan C Drummond, Peter G Slade, Ning Pan, Tyler M Gibson, Tian Yang, Joseph C Burns, Adam T Palermo, Lars Becker

Journal: Front Mol Neurosci

PubMed ID: 38952419

Doi: 10.3389/fnmol.2024.1376128

Products & Services: Gene Synthesis

Discovery of procyanidin condensed tannins of (-)-epicatechin from Kratom, Mitragyna speciosa, as virucidal agents against SARS-CoV-2

Authors: Sanya Sureram, Nopporn Chutiwitoonchai, Tam Pooprasert, Watchara Sangsopha, Suphitcha Limjiasahapong, Narumol Jariyasopit, Yongyut Sirivatanauksorn, Sakda Khoomrung, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop

Journal: Int J Biol Macromol

PubMed ID: 38866269

Doi: 10.1016/j.ijbiomac.2024.133059

Products & Services: Catalog Antibody

Physiological roles of endocytosis and presynaptic scaffold in vesicle replenishment at fast and slow central synapses

Authors: Satyajit Mahapatra, Tomoyuki Takahashi

Journal: Elife

PubMed ID: 38829367

Doi: 10.7554/eLife.90497

Products & Services: Catalog Peptides

Identification of core techniques that enhance genome editing of human T cells expressing synthetic antigen receptors

Authors: Ju-Fang Chang, Nils Wellhausen, Nils Wolfgang Engel, Jack H Landmann, Caitlin R Hopkins, January Salas-McKee, Adham S Bear, Mehmet Emrah Selli, Sangya Agarwal, Julie Jadlowsky, Gerald P Linette, Saar Gill, Carl H June, Joseph A Fraietta, Nathan Singh

Journal: Cancer Immunol Res

PubMed ID: 38869428

Doi: 10.1158/2326-6066.CIR-24-0251

Products & Services: Molecular Biology Reagents

Macaque antibodies targeting Marburg virus glycoprotein induced by multivalent immunization

Authors: Benjamin M Janus, Ruixue Wang, Thomas E Cleveland, Matthew C Metcalf, Aaron C Lemmer, Nydia van Dyk, Sarah Jeong, Anagh Astavans, Kenneth Class, Thomas R Fuerst, Gilad Ofek

Journal: J Virol

PubMed ID: 38832790

Doi: 10.1128/jvi.00155-24

Products & Services: Gene Synthesis

One-shot design elevates functional expression levels of a voltage-gated potassium channel

Authors: Jonathan Jacob Weinstein, Chandamita Saikia, Izhar Karbat, Adi Goldenzweig, Eitan Reuveny, Sarel Jacob Fleishman

Journal: Protein Sci

PubMed ID: 38747377

Doi: 10.1002/pro.4995

Products & Services: Custom Vector Construction

The BEL1-like homeodomain protein OsBLH4 regulates rice plant height, grain number, and heading date by repressing the expression of OsGA2ox1

Authors: Chengjuan Cao, Shuaiqiang Guo, Ping Deng, Shiyi Yang, Jing Xu, Tengfei Hu, Zhijuan Hu, Di Chen, Hongsheng Zhang, Ian Paul Navea, Joong Hyoun Chin, Wenhua Zhang, Wen Jing

Journal: Plant J

PubMed ID: 38824648

Doi: 10.1111/tpj.16857

Products & Services: Molecular Biology Reagents

Ectoine enhances recombinant antibody production in Chinese hamster ovary cells by promoting cell cycle arrest

Authors: Salinthip Jarusintanakorn, Enrico Mastrobattista, Montarop Yamabhai

Journal: N Biotechnol

PubMed ID: 38945523

Doi: 10.1016/j.nbt.2024.06.006

Products & Services: Recombinant Proteins

A safe and potentiated multi-type HPV L2-E7 nanoparticle vaccine with combined prophylactic and therapeutic activity

Authors: Xueer Zhao, Yueru Zhang, Oscar Trejo-Cerro, Ecem Kaplan, Zhe Li, Femke Albertsboer, Neyla El Hammiri, Filipe Colaço Mariz, Lawrence Banks, Simone Ottonello, Martin Müller

Journal: npj Vaccines

PubMed ID: 38926425

Doi: 10.1038/s41541-024-00914-z

Products & Services: Catalog Peptides

NpeA is a secreted Type IV effector containing an N-WASP-binding short linear motif that promotes niche formation

Authors: Agostina Giménez, Mariela G Del Giudice, Paula V López, Francisco Guaimas, Hugo Sámano-Sánchez, Toby J Gibson, Lucía B Chemes, Carlos O Arregui, Juan E Ugalde, Cecilia Czibener

Journal: MBio

PubMed ID: 38847540

Doi: 10.1128/mbio.00726-24

Products & Services: Gene Synthesis

Estrogen-mediated DNMT1 and DNMT3A recruitment by EZH2 silences miR-570-3p that contributes to papillary thyroid malignancy through DPP4

Authors: Xiarong Hu, Qingyao Ye, HuanQuan Lu, Zhiming Wu, Siyuan Chen, Ruinian Zheng

Journal: Clin Epigenetics

PubMed ID: 38890707

Doi: 10.1186/s13148-024-01685-z

Products & Services: Proteins, Expression, Isolation and Analysis

Enhanced Recombinant Protein Expression in Insect Cells by Natural and Recombinant Components of Lepidoptera Hemolymph

Authors: Javier López-Vidal, Susana Martínez-Pulgarín, Diego Martínez-Alonso, Miguel Cid, José M Escribano

Journal: Viruses

PubMed ID: 38932236

Doi: 10.3390/v16060944

Products & Services: Proteins, Expression, Isolation and Analysis

CD147-K148me2-Driven Tumor Cell-Macrophage Crosstalk Provokes NSCLC Immunosuppression via the CCL5/CCR5 Axis

Authors: Ke Wang, Xiaohong Chen, Peng Lin, Jiao Wu, Qiang Huang, Zhi-Nan Chen, Jiale Tian, Hao Wang, Ye Tian, Mingyan Shi, Meirui Qian, Bengang Hui, Yumeng Zhu, Ling Li, Rui Yao, Huijie Bian, Ping Zhu, Ruo Chen, Liang Chen

Journal: Adv Sci (Weinh)

PubMed ID: 38873823

Doi: 10.1002/advs.202400611

Products & Services: Recombinant Proteins

Functional diversity among cardiolipin binding sites on the mitochondrial ADP/ATP carrier

Authors: Nanami Senoo, Dinesh K Chinthapalli, Matthew G Baile, Vinaya K Golla, Bodhisattwa Saha, Abraham O Oluwole, Oluwaseun B Ogunbona, James A Saba, Teona Munteanu, Yllka Valdez, Kevin Whited, Macie S Sheridan, Dror Chorev, Nathan N Alder, Eric R May, Carol V Robinson, Steven M Claypool

Journal: EMBO J

PubMed ID: 38839991

Doi: 10.1038/s44318-024-00132-2

Products & Services: Proteins, Expression, Isolation and Analysis

The blood-testis barrier disruption is a prerequisite for toxicant-induced peritubular macrophage increases in the testis of peripubertal rats

Authors: Xin Fang, Richa Tiwary, Vivian P Nguyen, John H Richburg

Journal: Toxicol Sci

PubMed ID: 38565259

Doi: 10.1093/toxsci/kfae043

Products & Services: Molecular Biology Reagents

Anticancer Activity of HER2-targeting CPP-PTEN-THP Chimeric Proteins

Authors: Elizeth Pioquinto-Avila, Aldo O González-Cruz, Jorge Solís-Estrada, Javier Hernández-Juarez, Isaías Balderas-Rentería, Sheila Adela Villa-Cedillo, José Juan Pérez-Trujillo, Eder Arredondo-Espinoza

Journal: Anticancer Res

PubMed ID: 38821612

Doi: 10.21873/anticanres.17062

Products & Services: Custom DNA/RNA Oligos

A ternary correlation multi-symptom network strategy based on in vivo chemical profile identification and metabolomics to explore the molecular basis of Ephedra herb against viral pneumonia

Authors: Xiaoyan Wang, Jie Mei, Fan Zhang, Miaomiao Wei, Yujun Xie, Alamusi Bayoude, Xiufeng Liu, Boli Zhang, Boyang Yu

Journal: J Sep Sci

PubMed ID: 38819782

Doi: 10.1002/jssc.202400090

Products & Services: Gene Synthesis

Mitochondrial DNA transcription and mitochondrial genome-encoded long noncoding RNA in diabetic retinopathy

Authors: Jay Kumar, Renu A Kowluru

Journal: Mitochondrion

PubMed ID: 38944370

Doi: 10.1016/j.mito.2024.101925

Products & Services: Gene Synthesis

APOE2 protects against Aβ pathology by improving neuronal mitochondrial function through ERRα signaling

Authors: Zhiyuan Ning, Ying Liu, Mengyao Wan, You Zuo, Siqi Chen, Zhongshan Shi, Yongteng Xu, Honghong Li, Ho Ko, Jing Zhang, Songhua Xiao, Daji Guo, Yamei Tang

Journal: Cell Mol Biol Lett

PubMed ID: 38867189

Doi: 10.1186/s11658-024-00600-x

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Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing

Authors: Smriti Pandey, Xin D Gao, Nicholas A Krasnow, Amber McElroy, Y Allen Tao, Jordyn E Duby, Benjamin J Steinbeck, Julia McCreary, Sarah E Pierce, Jakub Tolar, Torsten B Meissner, Elliot L Chaikof, Mark J Osborn, David R Liu

Journal: Nat Biomed Eng

PubMed ID: 38858586

Doi: 10.1038/s41551-024-01227-1

Products & Services: Molecular Biology Reagents

An Ochratoxin a DNA Aptamer-Mediated Transcriptional Regulatory Riboswitch Biosensor

Authors: Xiaoze Dong, Shuo Qi, Pengfei Ma, Hongtao Jiang, Mingwei Qin, Ning Ding, Yin Zhang, Zhouping Wang

Journal: J Agric Food Chem

PubMed ID: 38847536

Doi: 10.1021/acs.jafc.4c02968

Products & Services: Recombinant Proteins

Succinate coenzyme A ligase β-like protein from Trichinella spiralis is a potential therapeutic molecule for allergic asthma

Authors: Kalibixiati Aimulajiang, Wen Chu, Shuyi Liao, Zhaohai Wen, Rongdong He, Mingmin Lu, Lixin Xu, Xiaokai Song, Xiangrui Li, Ruofeng Yan

Journal: Immun Inflamm Dis

PubMed ID: 38888451

Doi: 10.1002/iid3.1321

Products & Services: Molecular Biology Reagents

Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in presence of CD4-mimetics

Authors: Alexandra Tauzin, Lorie Marchitto, Étienne Bélanger, Mehdi Benlarbi, Guillaume Beaudoin-Bussières, Jérémie Prévost, Derek Yang, Ta-Jung Chiu, Hung-Ching Chen, Catherine Bourassa, Halima Medjahed, Marek K Korzeniowski, Suneetha Gottumukkala, William D Tolbert, Jonathan Richard, Amos B Smith, Marzena Pazgier, Andrés Finzi

Journal: medrxiv

PubMed ID: 38883797

Doi: 10.1101/2024.06.02.24308281

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Neuronal expression of herpes simplex virus-1 VP16 protein induces pseudorabies virus escape from silencing and reactivation

Authors: Zhi-Shan Hsu, Esteban A Engel, Lynn W Enquist, Orkide O Koyuncu

Journal: J Virol

PubMed ID: 38869285

Doi: 10.1128/jvi.00561-24

Products & Services: Proteins, Expression, Isolation and Analysis

Boosting PRRSV-Specific Cellular Immunity: The Immunological Profiling of an Fc-Fused Multi-CTL Epitope Vaccine in Mice

Authors: Xinnuo Lei, Jinzhao Ban, Zhi Wu, Shinuo Cao, Mo Zhou, Li Zhang, Rui Zhu, Huipeng Lu, Shanyuan Zhu

Journal: Vet Sci

PubMed ID: 38922021

Doi: 10.3390/vetsci11060274

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Investigation of SARS-CoV-2 Infection among Companion Animals in Households with Confirmed Human COVID-19 Cases

Authors: Heather Venkat, Hayley D Yaglom, Gavriella Hecht, Andrew Goedderz, Jennifer L Ely, Michael Sprenkle, Taylor Martins, Daniel Jasso-Selles, Darrin Lemmer, Jordan Gesimondo, Irene Ruberto, Kenneth Komatsu, David M Engelthaler

Journal: Pathogens

PubMed ID: 38921764

Doi: 10.3390/pathogens13060466

Products & Services: Catalog Antibody

Astragaloside IV inhibits cell viability and glycolysis of hepatocellular carcinoma by regulating KAT2A-mediated succinylation of PGAM1

Authors: Yuanzhang Zhu, Fei Lu

Journal: BMC Cancer

PubMed ID: 38835015

Doi: 10.1186/s12885-024-12438-9

Products & Services: Molecular Biology Reagents

DNA-controlled protein fluorescence: Design of aptamer-split peptide hetero-modulator for GFP to respond to intracellular ATP levels

Authors: Ki Sung Park, Hanvit Cha, Jia Niu, Hyongsok Tom Soh, Jin Hyup Lee, Seung Pil Pack

Journal: Nucleic Acids Res

PubMed ID: 38917331

Doi: 10.1093/nar/gkae532

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Chemical modification, structure elucidation and antifungal mechanism studies of a peptide extracted from garlic (Allium sativum L)

Authors: Shuqin Li, Junyu Liu, Tingting Zhang, Jingyang Lu, Mingyue Li, Min Zhang, Haixia Chen

Journal: J Sci Food Agric

PubMed ID: 38855916

Doi: 10.1002/jsfa.13633

Products & Services: Peptide Synthesis

Cationic lipid nanoparticle-mediated delivery of a Cas9/crRNA ribonucleoprotein complex for transgene-free editing of the citrus plant genome

Authors: Lamiaa M Mahmoud, Manjul Dutt

Journal: Plant Cell Rep

PubMed ID: 38874819

Doi: 10.1007/s00299-024-03254-3

Products & Services: Proteins, Expression, Isolation and Analysis

Exploring solute binding proteins in Pseudomonas aeruginosa that bind to γ-aminobutyrate and 5-aminovalerate and their role in activating sensor kinases

Authors: Jean Paul Cerna-Vargas, Tino Krell

Journal: Microbiologyopen

PubMed ID: 38780167

Doi: 10.1002/mbo3.1415

Products & Services: Gene Synthesis

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