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A chemically controlled Cas9 switch enables temporal modulation of diverse effectors
Authors: Cindy T Wei, Nicholas A Popp, Omri Peleg, Rachel L Powell, Elhanan Borenstein, Dustin J Maly, Douglas M Fowler
Journal: Nat Chem Biol
PubMed ID: 36879061
Doi: 10.1038/s41589-023-01278-6
Products & Services: Codon Optimization   
Antitumor effect of neoantigen-reactive T cells combined with PD1 inhibitor therapy in mouse lung cancer
Authors: Huan Qin, Haiyan Hu, Ximing Liao, Pei Zhao, Wenjuan He, Xiaoping Su, Jiaxing Sun, Qiang Li
Journal: J Cancer Res Clin Oncol
PubMed ID: 36933035
Doi: 10.1007/s00432-023-04683-5
Products & Services: Peptide Synthesis   
SARS-CoV-2-related bat virus behavior in human-relevant models sheds light on the origin of COVID-19
Authors: Sarah Temmam, Xavier Montagutelli, Cécile Herate, Flora Donati, Béatrice Regnault, Mikael Attia, Eduard Baquero Salazar, Delphine Chretien, Laurine Conquet, Grégory Jouvion, Juliana Pipoli Da Fonseca, Thomas Cokelaer, Faustine Amara, Francis Relouzat, Thibaut Naninck, Julien Lemaitre, Nathalie Derreudre-Bosquet, Quentin Pascal, Massimiliano Bonomi, Thomas Bigot, Sandie Munier, Felix A Rey, Roger Le Grand, Sylvie van der Werf, Marc Eloit
Journal: EMBO Rep
PubMed ID: 36876574
Doi: 10.15252/embr.202256055
Products & Services: Recombinant Proteins   
Design of a stabilized RBD enables potently neutralizing SARS-CoV-2 single-component nanoparticle vaccines
Authors: Thayne H Dickey, Rui Ma, Sachy Orr-Gonzalez, Tarik Ouahes, Palak Patel, Holly McAleese, Brandi Butler, Elizabeth Eudy, Brett Eaton, Michael Murphy, Jennifer L Kwan, Nichole D Salinas, Michael R Holbrook, Lynn E Lambert, Niraj H Tolia
Journal: Cell Rep
PubMed ID: 36943870
Doi: 10.1016/j.celrep.2023.112266
Products & Services: Recombinant Proteins   
On the design of a constitutively active peptide asparaginyl ligase for facile protein conjugation
Authors: Niying Chua, Yee Hwa Wong, Abbas El Sahili, Chuan Fa Liu, Julien Lescar
Journal: FEBS Open Bio
PubMed ID: 36788723
Doi: 10.1002/2211-5463.13575
Products & Services: Peptide Synthesis   
RHINO restricts MMEJ activity to mitosis
Authors: Alessandra Brambati, Olivia Sacco, Sarina Porcella, Joshua Heyza, Mike Kareh, Jens C Schmidt, Agnel Sfeir
Journal: biorxiv
PubMed ID: 36993461
Doi: 10.1101/2023.03.16.532763
Products & Services: Recombinant Proteins   
Myosin-X recruits lamellipodin to filopodia tips
Authors: Ana Popović, Mitro Miihkinen, Sujan Ghimire, Rafael Saup, Max L B Grönloh, Neil J Ball, Benjamin T Goult, Johanna Ivaska, Guillaume Jacquemet
Journal: J Cell Sci
PubMed ID: 36861887
Doi: 10.1242/jcs.260574
Products & Services: Gene Synthesis   
Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders
Authors: Elżbieta Wątor , Piotr Wilk , Artur Biela, Michał Rawski , Krzysztof M Zak, Wieland Steinchen , Gert Bange, Sebastian Glatt , Przemysław Grudnik
Journal: Nature Communications
PubMed ID: 36973244
Doi: 10.1038/s41467-023-37305-2
Products & Services: Gene Synthesis   Gene Synthesis   
Mucus-penetrating nonviral gene vaccine processed in the epithelium for inducing advanced vaginal mucosal immune responses
Authors: Qunjie Bi, Xu Song, Yangyang Zhao, Xueyi Hu, Huan Yang, Rongrong Jin, Yu Nie
Journal: Acta Pharmacuetica Sinica.B
PubMed ID: 36970203
Doi: 10.1016/j.apsb.2022.11.004
Products & Services: Peptide Synthesis   
A riboswitch separated from its ribosome-binding site still regulates translation
Authors: Griffin M Schroeder, Olayinka Akinyemi, Jeffrey Malik, Caroline M Focht, Elizabeth M Pritchett, Cameron D Baker, James P McSally, Jermaine L Jenkins, David H Mathews, Joseph E Wedekind
Journal: Nucleic Acids Research
PubMed ID: 36762498
Doi: 10.1093/nar/gkad056.
Products & Services: Gene Synthesis   
A swapped genetic code prevents viral infections and gene transfer
Authors: Akos Nyerges, Svenja Vinke, Regan Flynn, Siân V Owen, Eleanor A Rand, Bogdan Budnik, Eric Keen, Kamesh Narasimhan, Jorge A Marchand, Maximilien Baas-Thomas, Min Liu, Kangming Chen, Anush Chiappino-Pepe, Fangxiang Hu, Michael Baym, George M Church
Journal: Nature
PubMed ID: 36922599
Doi: 10.1038/s41586-023-05824-z
Products & Services: Gene Synthesis   
New insights underlying the early events of dopaminergic dysfunction in Parkinson’s Disease
Authors: Hannah L. Dela Cruz, Esther L. Dela Cruz, Cody J. Zurhellen, Herbert T. York, Jim A. Baun, Joshua L. Dela Cruz, Jay S. Dela Cruz
Journal: biorxiv
Doi: 10.1101/2020.09.27.313957
Products & Services: Endotoxin Detection & Removal System   
The Trypanosoma brucei MISP family of invariant proteins is co-expressed with BARP as triple helical bundle structures on the surface of salivary gland forms, but is dispensable for parasite development within the tsetse vector
Authors: Aitor Casas-Sanchez, Raghavendran Ramaswamy, Samïrah Perally, Lee R Haines, Clair Rose, Marcela Aguilera-Flores, Susana Portillo, Margot Verbeelen, Shahid Hussain, Laura Smithson, Cristina Yunta, Michael J Lehane, Sue Vaughan, Jan van den Abbeele, Igor C Almeida, Martin J Boulanger, Álvaro Acosta-Serrano
Journal: PLoS Pathog
PubMed ID: 36996244
Doi: 10.1371/journal.ppat.1011269
Highly Sensitive and Selective Detection of Inorganic Phosphates in the Water Environment by Biosensors Based on Bioluminescence Resonance Energy Transfer
Authors: Jie Yu, Yan Zhang, Yanping Zhao, Xuxiang Zhang, Hongqiang Ren
Journal: Anal Chem
PubMed ID: 36942460
Doi: 10.1021/acs.analchem.2c04748
Peptides that Mimic RS repeats modulate phase separation of SRSF1, revealing a reliance on combined stacking and electrostatic interactions
Authors: Talia Fargason, Naiduwadura Ivon Upekala De Silva, Erin King, Zihan Zhang, Trenton Paul, Jamal Shariq, Steve Zaharias, Jun Zhang
Journal: Elife
PubMed ID: 36862748
Doi: 10.7554/eLife.84412
Products & Services: Molecular Biology Reagents   
Identification of HPV16 E1 and E2-specific T cells in the oropharyngeal cancer tumor microenvironment
Authors: Christine McInnis, Shilpa Bhatia, Brinda Vijaykumar, Qiaomu Tian, Yanbo Sun, Del Leistritz-Edwards, Charles T Quinn, Ravi Uppaluri, Ann Marie Egloff, Lakshmi Srinivasan, Daniel C Pregibon, Anthony J Coyle, Glenn J Hanna
Journal: J Immunother Cancer
PubMed ID: 36990508
Doi: 10.1136/jitc-2023-006721
Products & Services: Peptide Synthesis   
Interaction of SARS-CoV-2 Nucleocapsid Protein and Human RNA Helicases DDX1 and DDX3X Modulates Their Activities on Double-Stranded RNA
Authors: Camilla Lodola, Massimiliano Secchi, Virginia Sinigiani, Antonella De Palma, Rossana Rossi, Davide Perico, Pier Luigi Mauri, Giovanni Maga
Journal: Int J Mol Sci
PubMed ID: 36982856
Doi: 10.3390/ijms24065784
Products & Services: Plasmid DNA Preparation   
Genetically engineered CXCR4-modified exosomes for delivery of miR-126 mimics to macrophages alleviate periodontitis
Authors: Haotian Luo, Danying Chen, Ruoyu Li, Runze Li, Yungshan Teng, Yang Cao, Xuenong Zou, Weicai Wang, Chen Zhou
Journal: J Nanobiotechnology
PubMed ID: 36991451
Doi: 10.1186/s12951-023-01863-w
Identification of Three Human POLH Germline Variants Defective in Complementing the UV- and Cisplatin-Sensitivity of POLH-Deficient Cells
Authors: Mina Yeom, Jin-Kyung Hong, Joo-Ho Shin, Yunjong Lee, Frederick Peter Guengerich, Jeong-Yun Choi
Journal: Int J Mol Sci
PubMed ID: 36982269
Doi: 10.3390/ijms24065198
Products & Services: Custom DNA/RNA Oligos   
The Influence of Protein Charge and Molecular Weight on the Affinity of Aptamers
Authors: Alissa Drees, Tung Lam Trinh, Markus Fischer
Journal: Pharmaceuticals (Basel)
PubMed ID: 36986556
Doi: 10.3390/ph16030457
Products & Services: Custom DNA/RNA Oligos   
Dissection of Antibody Responses of Gam-COVID-Vac-Vaccinated Subjects Suggests Involvement of Epitopes Outside RBD in SARS-CoV-2 Neutralization
Authors: Maria Byazrova, Pia Gattinger, Ekaterina Astakhova, Gerhard Hofer, Musa Khaitov, Alexander Filatov, Rudolf Valenta
Journal: Int J Mol Sci
PubMed ID: 36982183
Doi: 10.3390/ijms24065104
Products & Services: Recombinant Antibody Expression   
Genome-wide identification and characterization of tomato 14–3-3 (SlTFT) genes and functional analysis of SlTFT6 under heat stress
Authors: Yunfei Liang, Fang Ma, Ruili Zhang, Wenyu Li, Jiao Dang, Huai Su, Boyu Li, Tixu Hu, Mingke Zhang, Yan Liang, Xiangqiang Zhan
Journal: Physiologia plantarum
PubMed ID: 36906839
Doi: 10.1111/ppl.13888
Products & Services: Transient Expression(INACTIVE)   
Development and Evaluation of Recombinant B-Cell Multi-Epitopes of PDHA1 and GAPDH as Subunit Vaccines against Infection in Flounder ()
Authors: Xiuzhen Sheng, Honghua Zhang, Min Liu, Xiaoqian Tang, Jing Xing, Heng Chi, Wenbin Zhan
Journal: Vaccines (Basel)
PubMed ID: 36992208
Doi: 10.3390/vaccines11030624
Products & Services: Peptide Synthesis   
To Explore the Binding Affinity of Human γ-Secretase Activating Protein (GSAP) Isoform 4 with APP-C99 Peptides
Authors: Deekshi Angira, Sonali Chaudhary, Arumugam Abiramasundari, Vijay Thiruvenkatam
Journal: ACS Omega
PubMed ID: 37065030
Doi: 10.1021/acsomega.3c01117
Identification of Filamin A Mechanobinding Partner III: SAV1 Specifically Interacts with Filamin A Mechanosensitive Domain 21
Authors: Huaguan Zhang, Zhenfeng Mao, Ziwei Yang, Fumihiko Nakamura
Journal: Biochemistry
PubMed ID: 36857526
Doi: 10.1021/acs.biochem.2c00665
Products & Services: Molecular Biology Reagents   
Virus-like Magnetic Mesoporous Silica Particles as a Universal Vaccination Platform against Pathogenic Infections
Authors: Mingyang Liu, Yan Zhao, Zhishang Shi, Jeffrey I Zink, Qilin Yu
Journal: ACS Nano
PubMed ID: 36961475
Doi: 10.1021/acsnano.3c00644
Products & Services: Gene Synthesis   
Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants
Authors: Bin Ju, Qi Zhang, Ziyi Wang, Zhen Qin Aw, Peng Chen, Bing Zhou, Ruoke Wang, Xiangyang Ge, Qining Lv, Lin Cheng, Rui Zhang, Yi Hao Wong, Huixin Chen, Haiyan Wang, Sisi Shan, Xuejiao Liao, Xuanling Shi, Lei Liu, Justin Jang Hann Chu, Xinquan Wang, Zheng Zhang, Linqi Zhang
Journal: Nat Immunol
PubMed ID: 36914890
Doi: 10.1038/s41590-023-01449-6
Products & Services: DNA Sequencing   
Mechanism of sphingolipid homeostasis revealed by structural analysis of Arabidopsis SPT-ORM1 complex
Authors: Peng Liu, Tian Xie, Xinyue Wu, Gongshe Han, Sita D Gupta, Zike Zhang, Jian Yue, Feitong Dong, Kenneth Gable, Somashekarappa Niranjanakumari, Wanyuan Li, Lin Wang, Wenchen Liu, Ruifeng Yao, Edgar B Cahoon, Teresa M Dunn, Xin Gong
Journal: SCIENCE ADVANCES
PubMed ID: 36989369
Doi: 10.1126/sciadv.adg0728
Engineered production of isoprene from the model green microalga Chlamydomonas reinhardtii
Authors: Razan Z Yahya, Gordon B Wellman, Sebastian Overmans, Kyle J Lauersen
Journal: Metab Eng Commun .
PubMed ID: 37006831
Doi: 10.1016/j.mec.2023.e00221
Products & Services: Gene Synthesis   
Epinecidin-1, a marine antifungal peptide, inhibits Botrytis cinerea and delays gray mold in postharvest peaches
Authors: Li Fan , Yingying Wei , Yi Chen , Shu Jiang , Feng Xu , Chundan Zhang , Hongfei Wang , Xingfeng Shao
Journal: Food Chem .
PubMed ID: 36191421
Doi: 10.1016/j.foodchem.2022.134419
Products & Services: Peptide Synthesis   
Fabrication of bFGF/polydopamine-loaded PEEK implants for improving soft tissue integration by upregulating Wnt/β-catenin signaling
Authors: Xiaohu Wang, Ning Ma, Li Feng, Mingkui Shen, Yaqi Zhou, Xinan Zhang, Ruichao Huang, Li Zhou, Shanfeng Ji, Yongli Lou, Zhi Zhu
Journal: Heliyon
PubMed ID: 37012909
Doi: 10.1016/j.heliyon.2023.e14800
Purification and biochemical characterization of a novel chitosanase cloned from the gene of Kitasatospora setae KM-6054 and its application in the production of chitooligosaccharides
Authors: Yinxiao Xu, Hui Wang, Benwei Zhu, Zhong Yao, Ling Jiang
Journal: World J Microbiol Biotechnol
PubMed ID: 36905451
Doi: 10.1007/s11274-023-03561-z
Regenerative marine waste towards CaCO nanoformulation for Alzheimer's therapy
Authors: Prakashkumar Nallasamy, Beema Shafreen Rajamohamed, Jeyakanthan Jeyaraman, Brindhadevi Kathirvel, Suganthy Natarajan
Journal: Environ Res
PubMed ID: 36889568
Doi: 10.1016/j.envres.2023.115631
Products & Services: Peptide Synthesis   
Enhanced Endosomal Signaling and Desensitization of GLP-1R vs GIPR in Pancreatic Beta Cells
Authors: Yusman Manchanda, Stavroula Bitsi, Shiqian Chen, Johannes Broichhagen, Jorge Bernardino de la Serna, Ben Jones, Alejandra Tomas
Journal: Endocrinology
PubMed ID: 36774542
Doi: 10.1210/endocr/bqad028
Products & Services: Molecular Biology Reagents   
DELLA functions evolved by rewiring of associated transcriptional networks
Authors: Asier Briones-Moreno, Jorge Hernández-García, Carlos Vargas-Chávez, Noel Blanco-Touriñán, Alexandros Phokas, Cristina Úrbez, Pablo D Cerdán, Juliet C Coates, David Alabadí, Miguel A Blázquez
Journal: Nat Plants
PubMed ID: 36914897
Doi: 10.1038/s41477-023-01372-6
Products & Services: Gene Synthesis   
Inflammatory stimulation of astrocytes affects the expression of miRNA-22-3p within NSCs-EVs regulating remyelination by targeting KDM3A
Authors: Tianyu Han, Peiwen Song, Zuomeng Wu, Cancan Wang, Yunlei Liu, Wang Ying, Kaixuan Li, Cailiang Shen
Journal: Stem Cell Res Ther
PubMed ID: 36959678
Doi: 10.1186/s13287-023-03284-w
Products & Services: Molecular Biology Reagents   
The force-dependent filamin A-G3BP1 interaction regulates phase-separated stress granule formation
Authors: Ziyi Feng, Zhenfeng Mao, Ziwei Yang, Xiaowei Liu, Fumihiko Nakamura
Journal: J Cell Sci
PubMed ID: 36806943
Doi: 10.1242/jcs.260684
Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel
Authors: Mingfeng Zhang, Yuanyue Shan, Duanqing Pei
Journal: nature COMMUNICATION
PubMed ID: 36928654
Doi: 10.1038/s41467-023-37204-6
Products & Services: Nucleic Acid Purification & Analysis   
Single-Molecule Interconversion between Chiral Configurations of Boronate Esters Observed in a Nanoreactor
Authors: Xiaoyu Du, Shanyu Zhang, Liying Wang, Yuqin Wang, Pingping Fan, Wendong Jia, Panke Zhang, Shuo Huang
Journal: ACS Nano
PubMed ID: 36655995
Doi: 10.1021/acsnano.2c11286
Products & Services: Plasmid DNA Preparation   
The activation mechanism and antibody binding mode for orphan GPR20
Authors: Xi Lin, Shan Jiang, Yiran Wu, Xiaohu Wei, Gye-Won Han, Lijie Wu, Junlin Liu, Bo Chen, Zhibin Zhang, Suwen Zhao, Vadim Cherezov, Fei Xu
Journal: Cell Discovery
PubMed ID: 36849514
Doi: 10.1038/s41421-023-00520-8
Products & Services: Gene Synthesis   
Barrier properties of Nup98 FG phases ruled by FG motif identity and inter-FG spacer length
Authors: Sheung Chun Ng, Abin Biswas, Trevor Huyton, Jürgen Schünemann, Simone Reber, Dirk Görlich
Journal: Nat Commun
PubMed ID: 36765044
Doi: 10.1038/s41467-023-36331-4
Safety and Immunogenicity of Betuvax-CoV-2, an RBD-Fc-Based SARS-CoV-2 Recombinant Vaccine: Preliminary Results of the First-in-Human, Randomized, Double-Blind, Placebo-Controlled Phase I/II Clinical Trial
Authors: Aleksandr V Kudriavtsev, Anna V Vakhrusheva, Nickolay A Kryuchkov, Maria E Frolova, Konstantin A Blagodatskikh, Taras V Ivanishin, Milana Djonovic, Ekaterina A Romanovskaya-Romanko, Anton N Kovalenko, Dmitry A Lioznov, Tatiana G Zubkova, Svetlana V Teplykh, Rodion A Oseshnyuk, Marina A Stukova, Artur A Isaev, Igor V Krasilnikov
Journal: Vaccines (Basel)
PubMed ID: 36851204
Doi: 10.3390/vaccines11020326
Characterization of cross-reactive monoclonal antibodies against SARS-CoV-1 and SARS-CoV-2: Implication for rational design and development of pan-sarbecovirus vaccines and neutralizing antibodies
Authors: Shibo Li, Jianbo Wu, Weiyu Jiang, Haiyan He, Yunjiao Zhou, Wei Wu, Yidan Gao, Minxiang Xie, Anqi Xia, Jiaying He, Qianqian Zhang, Yuru Han, Nan Wang, Guangqi Zhu, Qiujing Wang, Zheen Zhang, Christian T Mayer, Kang Wang, Xiangxi Wang, Junqing Wang, Zhenguo Chen, Shibo Jiang, Lei Sun, Rong Xia, Qiao Wang
Journal: J Med Virol
PubMed ID: 36573441
Doi: 10.1002/jmv.28440
Products & Services: Molecular Biology Reagents   
Acid-Responsive Immune-Enhancing Chitosan Formulation Capable of Transforming from Particle Stabilization to Polymer Chain Stabilization
Authors: Yongjuan Zou, Xiaoxuan Liu, Qiuting Chen, Hiroyuki Oku, Guanghui Ma, Jie Wu
Journal: ACS Appl Mater Interfaces
PubMed ID: 36825996
Doi: 10.1021/acsami.2c17505
Connection between MHC class II binding and aggregation propensity: The antigenic peptide 10 of as a benchmark study
Authors: Rodrigo Ochoa, Thyago R Cardim-Pires, Ricardo Sant'Anna, Pilar Cossio, Debora Foguel
Journal: Comput Struct Biotechnol J
PubMed ID: 36890879
Doi: 10.1016/j.csbj.2023.02.031
Products & Services: Molecular Biology Reagents   
Antibody isotype epitope mapping of SARS-CoV-2 Spike RBD protein: Targets for COVID-19 symptomatology and disease control
Authors: Marinela Contreras, Joaquín Vicente, José Joaquín Cerón, Silvia Martinez Subiela, José Miguel Urra, Francisco J Rodríguez-Del-Río, Elisa Ferreras-Colino, Rita Vaz-Rodrigues, Isabel G de Fernández de Mera, Sandra Antunes, Ana Domingos, Christian Gortázar, José de la Fuente
Journal: Eur J Immunol
PubMed ID: 36658749
Doi: 10.1002/eji.202250206
Products & Services: Molecular Biology Reagents   
Smartphone-based chemiluminescence detection of aflatoxin B via labelled and label-free dual sensing systems
Authors: Junning Ma, Yue Guan, Fuguo Xing, Yan Wang, Xu Li, Qiang Yu, Xiaohua Yu
Journal: Food Chem
PubMed ID: 36796268
Doi: 10.1016/j.foodchem.2023.135654
Products & Services: Molecular Biology Reagents   
Generation and characterization of an immunodeficient mouse model of mucopolysaccharidosis type II
Authors: Miles C Smith, Lalitha R Belur, Andrea D Karlen, Kelly Podetz-Pedersen, Olivia Erlanson, Kanut Laoharawee, Justin Furcich, Troy C Lund, Yun You, Davis Seelig, Beau R Webber, R Scott McIvor
Journal: Mol Genet Metab
PubMed ID: 37023503
Doi: 10.1016/j.ymgme.2023.107539
Products & Services: Gene Synthesis   
The molecular mechanism of light-induced bond formation and breakage in the cyanobacteriochrome TePixJ
Authors: Jeannette Ruf, Flavia Bindschedler, David Buhrke
Journal: Phys Chem Chem Phys
PubMed ID: 36752541
Doi: 10.1039/d2cp05856a
The molecular chaperone cysteine string protein is required for monomeric SNARE proteins to assemble in trans-complexes during human sperm acrosomal exocytosis†
Authors: Karina Flores-Montero, María Victoria Berberián, Luis Segundo Mayorga, Claudia Nora Tomes, María Celeste Ruete
Journal: Biol Reprod
PubMed ID: 36308432
Doi: 10.1093/biolre/ioac196

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