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LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/β‑catenin pathway
Authors: Sijia Han, Xueying Jin, Tianyu Hu, Feng Chi
Journal: Oncol Rep
PubMed ID: 36799186
Doi: 10.3892/or.2023.8497
Products & Services: Stable Cell Lines   
ACE2 binding and antibody evasion in enhanced transmissibility of XBB15
Authors: Can Yue, Weiliang Song, Lei Wang, Fanchong Jian, Xiaosu Chen, Fei Gao, Zhongyang Shen, Youchun Wang, Xiangxi Wang, Yunlong Cao
Journal: Lancet Infect Dis
PubMed ID: 36746173
Doi: 10.1016/S1473-3099(23)00010-5
MTORC2 is a physiological hydrophobic motif kinase of S6 Kinase 1
Authors: Sheikh Tahir Majeed, Rabiya Majeed, Aijaz A Malik, Khurshid Iqbal Andrabi
Journal: Biochim Biophys Acta Mol Cell Res
PubMed ID: 36858209
Doi: 10.1016/j.bbamcr.2023.119449
Products & Services: Catalog Peptides   
A Physiologically Responsive Nanocomposite Hydrogel for Treatment of Head and Neck Squamous Cell Carcinoma via Proteolysis-Targeting Chimeras Enhanced Immunotherapy
Authors: Yaping Wu, Xiaowei Chang, Guizhu Yang, Li Chen, Qi Wu, Jiamin Gao, Ran Tian, Wenyun Mu, John Justin Gooding, Xin Chen, Shuyang Sun
Journal: Adv Mater
PubMed ID: 36656993
Doi: 10.1002/adma.202210787
Products & Services: Peptide Synthesis   
Functionalized biomimetic nanoparticles combining programmed death-1/programmed death-ligand 1 blockade with photothermal ablation for enhanced colorectal cancer immunotherapy.
Authors: Yuchen Xiao, Tianchuan Zhu, Qi Zeng, Qingqin Tan, Guanmin Jiang, Xi Huang
Journal: Acta Biomater
PubMed ID: 36442821
Doi: 10.1016/j.actbio.2022.11.043
Revealing the role of tunable amino acid residues in elastin-like polypeptides (ELPs)-mediated biomimetic silicification
Authors: Yue Qiu , Yuanqing Lin , Bo Zeng , Peiliang Qin , Zhiwei Yi , Guangya Zhang
Journal: Int J Biol Macromol
PubMed ID: 36539170
Doi: 10.1016/j.ijbiomac.2022.12.152
Products & Services: Gene Synthesis   
Multi-omic screening of invasive GBM cells in engineered biomaterials and patient biopsies reveals targetable transsulfuration pathway alterations
Authors: Joseph H Garcia, Erin A Akins, Saket Jain, Kayla J Wolf, Jason Zhang, Nikita Choudhary, Meeki Lad, Poojan Shukla, Sabraj Gill, Will Carson, Luis Carette, Allison Zheng, Sanjay Kumar, Manish K Aghi
Journal: biorxiv
PubMed ID: 36865128
Doi: 10.1101/2023.02.23.529575
Products & Services: Peptide Synthesis   
Phosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA damage response at telomeres
Authors: Radka Storchova, Matous Palek, Natalie Palkova, Pavel Veverka, Tomas Brom, Ctirad Hofr, Libor Macurek
Journal: Nucleic Acids Res
PubMed ID: 36651296
Doi: 10.1093/nar/gkac1269
Products & Services: Peptide Synthesis   
Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice
Authors: Matthew T Birnie, Annabel K Short, Gregory B de Carvalho, Lara Taniguchi, Benjamin G Gunn, Aidan L Pham, Christy A Itoga, Xiangmin Xu, Lulu Y Chen, Stephen V Mahler, Yuncai Chen, Tallie Z Baram
Journal: Nat Commun
PubMed ID: 36841826
Doi: 10.1038/s41467-023-36780-x
Retinoblastoma Expression and Targeting by CDK4/6 Inhibitors in Small Cell Lung Cancer
Authors: Gary Wildey, Ashley M Shay, Karen S McColl, Suzy Yoon, Mohammad A Shatat, Ahmad Perwez, Kyle B Spainhower, Adam M Kresak, MaryBeth Lipka, Michael Yang, Mohadese Behtaj, Pingfu Fu, Asrar Alahmadi, Wadad Mneimneh, Ata Abbas, Afshin Dowlati
Journal: Mol Cancer Ther
PubMed ID: 36399634
Doi: 10.1158/1535-7163.MCT-22-0365
Products & Services: Molecular Biology Reagents   
Time-Course Transcriptome Profiling Reveals Differential Resistance Responses of Tomato to a Phytotoxic Effector of the Pathogenic Oomycete
Authors: Xue Zhou, Ke Wen, Shen-Xin Huang, Yi Lu, Yang Liu, Jing-Hao Jin, Shiv D Kale, Xiao-Ren Chen
Journal: Plants (Basel)
PubMed ID: 36840230
Doi: 10.3390/plants12040883
Antagonism between Prdm16 and Smad4 specifies the trajectory and progression of pancreatic cancer
Authors: Eric Hurwitz, Parash Parajuli, Seval Ozkan, Celine Prunier, Thien Ly Nguyen, Deanna Campbell, Creighton Friend, Allyn Austin Bryan, Ting-Xuan Lu, Steven Christopher Smith, Mohammed Shawkat Razzaque, Keli Xu, Azeddine Atfi
Journal: J Cell Biol
PubMed ID: 36828547
Doi: 10.1083/jcb.202203036
Products & Services: Custom DNA/RNA Oligos   
Enhancement of Cell Adhesion by Nucleolin-Interacting Protein AFAP
Authors: Hongcheng Tang, Daxiu Zhang, Fenfen Jiang, Lifeng Yu, Hui Tang, Jiafeng Zhu, Shuyan Wu, Hua Niu
Journal: J Pers Med
PubMed ID: 36836536
Doi: 10.3390/jpm13020302
Products & Services: Plasmid DNA Preparation   
FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner
Authors: Yaguang Bi, Shuolin Liu, Xing Qin, Miyesaier Abudureyimu, Lu Wang, Rongjun Zou, Amir Ajoolabady, Wenjing Zhang, Hu Peng, Jun Ren, Yingmei Zhang
Journal: J Adv Res
PubMed ID: 36828120
Doi: 10.1016/j.jare.2023.02.012
Products & Services: Recombinant Proteins   
A cercarial invadolysin interferes with the host immune response and facilitates infection establishment of Schistosoma mansoni
Authors: Jacob R Hambrook, Patrick C Hanington
Journal: PLoS Pathog
PubMed ID: 36730464
Doi: 10.1371/journal.ppat.1010884
Products & Services: Polyclonal Antibody Services   
Microenvironment-responsive anti-PD-L1 × CD3 bispecific T-cell engager for solid tumor immunotherapy
Authors: Dingkang Liu, Lichen Bao, Haichao Zhu, Yali Yue, Jing Tian, Xiangdong Gao, Jun Yin
Journal: Journal of controlled release
PubMed ID: 36669532
Doi: 10.1016/j.jconrel.2023.01.041
Products & Services: His Tag ELISA Detection Kit   
Suppression of Tumor or Host Intrinsic CMTM6 Drives Antitumor Cytotoxicity in a PD-L1–Independent Manner
Authors: Yiru Long , Runqiu Chen , Xiaolu Yu , Yongliang Tong , Xionghua Peng , Fanglin Li , Chao Hu, Jianhua Sun , Likun Gong
Journal: Cancer Immunol Res .
PubMed ID: 36484740
Doi: 10.1158/2326-6066.CIR-22-0439
Products & Services: Recombinant Proteins   
A natriuretic peptide molecule from Vigna angularis, VaEG45, confers rust resistance by inhibiting fungal development
Authors: Weina Sun , Mengqi Yuan , Lihua Yin , Xiwang Ke , Yuhu Zuo
Journal: Plant Cell Rep .
PubMed ID: 36576553
Doi: 10.1007/s00299-022-02967-7
Products & Services: Peptide Synthesis   
Room-temperature structural studies of SARS-CoV-2 protein NendoU with an X-ray free-electron laser
Authors: Rebecca J Jernigan , Dhenugen Logeswaran , Diandra Doppler , Nirupa Nagaratnam , Mukul Sonker , Jay-How Yang , Gihan Ketawala , Jose M Martin-Garcia , Megan L Shelby , Thomas D Grant , Valerio Mariani , Alexandra Tolstikova , Michelle Z Sheikh , Mimi Cho Yung , Matthew A Coleman , Sahba Zaare , Emily K Kaschner , Mohammad Towshif Rabbani , Reza Nazari , Michele A Zacks , Brandon Hayes , Raymond G Sierra , Mark S Hunter , Stella Lisova , Alexander Batyuk , Christopher Kupitz , Sebastien Boutet , Debra T Hansen , Richard A Kirian , Marius Schmidt , Raimund Fromme , Matthias Frank , Alexandra Ros , Julian J-L Chen , Sabine Botha , Petra Fromme
Journal: Structure.
PubMed ID: 36630960
Doi: 10.1016/j.str.2022.12.009
Xeno interactions between MHC-I proteins and molecular chaperones enable ligand exchange on a broad repertoire of HLA allotypes
Authors: Yi Sun, Georgia F Papadaki, Christine A Devlin, Julia N Danon, Michael C Young, Trenton J Winters, George M Burslem, Erik Procko, Nikolaos G Sgourakis
Journal: Sci Adv
PubMed ID: 36827371
Doi: 10.1126/sciadv.ade7151
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Actin polymerisation and crosslinking drive left-right asymmetry in single cell and cell collectives
Authors: Yee Han Tee, Wei Jia Goh, Xianbin Yong, Hui Ting Ong, Jinrong Hu, Ignacius Yan Yun Tay, Shidong Shi, Salma Jalal, Samuel F H Barnett, Pakorn Kanchanawong, Wenmao Huang, Jie Yan, Yong Ann Ben Lim, Visalatchi Thiagarajan, Alex Mogilner, Alexander D Bershadsky
Journal: Nat Commun
PubMed ID: 36774346
Doi: 10.1038/s41467-023-35918-1
Establishment and validation of a plasma oncofetal chondroitin sulfated proteoglycan for pan-cancer detection
Authors: Pei-Fen Zhang, Zi-Yi Wu, Wen-Bin Zhang, Yong-Qiao He, Kexin Chen, Tong-Min Wang, Haixin Li, Hong Zheng, Dan-Hua Li, Da-Wei Yang, Ting Zhou, Chang-Mi Deng, Ying Liao, Wen-Qiong Xue, Lian-Jing Cao, Xi-Zhao Li, Jiang-Bo Zhang, Si-Qi Dong, Fang Wang, Mei-Qi Zheng, Wen-Li Zhang, Jianbing Mu, Wei-Hua Jia
Journal: Nat Commun
PubMed ID: 36746966
Doi: 10.1038/s41467-023-36374-7
Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols
Authors: Calvin Dumesnil, Lauri Vanharanta, Xavier Prasanna, Mohyeddine Omrane, Maxime Carpentier, Apoorva Bhapkar, Giray Enkavi, Veijo T Salo, Ilpo Vattulainen, Elina Ikonen, Abdou Rachid Thiam
Journal: Nat Commun
PubMed ID: 36807572
Doi: 10.1038/s41467-023-36375-6
Products & Services: Codon Optimization   
SARS-CoV-2 Main Protease Targets Host Selenoproteins and Glutathione Biosynthesis for Knockdown via Proteolysis, Potentially Disrupting the Thioredoxin and Glutaredoxin Redox Cycles
Authors: Ignacio A Gallardo, Daniel A Todd, Stella T Lima, Jonathan R Chekan, Norman H Chiu, Ethan Will Taylor
Journal: Antioxidants (Basel)
PubMed ID: 36978807
Doi: 10.3390/antiox12030559
Heteromultivalent scaffolds fabricated by biomimetic co-assembly of DNA-RNA building blocks for the multi-analysis of miRNAs
Authors: Chengjie Duan, Yan Chen, Zhiqiang Hou, Dayong Li, Jin Jiao, Weihao Sun, Yang Xiang
Journal: J Mater Chem B
PubMed ID: 36723144
Doi: 10.1039/d2tb02663e
Chikungunya Virus and Its Envelope Protein E2 Induce Hyperalgesia in Mice: Inhibition by Anti-E2 Monoclonal Antibodies and by Targeting TRPV1
Authors: Carina Z Segato-Vendrameto, Camila Zanluca, Amanda Z Zucoloto, Tiago H Zaninelli, Mariana M Bertozzi, Telma Saraiva-Santos, Camila R Ferraz, Larissa Staurengo-Ferrari, Stephanie Badaro-Garcia, Marília F Manchope, Amanda M Dionisio, Felipe A Pinho-Ribeiro, Sergio M Borghi, Ana Luiza Pamplona Mosimann, Rubia Casagrande, Juliano Bordignon, Victor Fattori, Claudia N Duarte Dos Santos, Waldiceu A Verri
Journal: Cells
PubMed ID: 36831223
Doi: 10.3390/cells12040556
Products & Services: Codon Optimization   
How Many Sirtuin Genes Are Out There? Evolution of Sirtuin Genes in Vertebrates With a Description of a New Family Member
Authors: Juan C Opazo, Michael W Vandewege, Federico G Hoffmann, Kattina Zavala, Catalina Meléndez, Charlotte Luchsinger, Viviana A Cavieres, Luis Vargas-Chacoff, Francisco J Morera, Patricia V Burgos, Cheril Tapia-Rojas, Gonzalo A Mardones
Journal: Mol Biol Evol
PubMed ID: 36656997
Doi: 10.1093/molbev/msad014
Products & Services: Plasmid DNA Preparation   
Functional analysis of 110 phosphorylation sites on the circadian clock protein FRQ identifies clusters determining period length and temperature compensation
Authors: Bin Wang, Elizabeth-Lauren Stevenson, Jay C Dunlap
Journal: G3 (Bethesda)
PubMed ID: 36537198
Doi: 10.1093/g3journal/jkac334
Products & Services: Gene Synthesis   
Selective excitation with recoupling pulse schemes uncover properties of disordered mineral phases in bone-like apatite grown with bone proteins
Authors: Irina Matlahov, Alexey Kulpanovich, Taly Iline-Vul, Merav Nadav-Tsubery, Gil Goobes
Journal: Solid State Nucl Magn Reson
PubMed ID: 36913847
Doi: 10.1016/j.ssnmr.2023.101860
Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease
Authors: Rui Zhao, Li Cao, Wen-Jun Gu, Lei Li, Zhong-Zhong Chen, Jie Xiang, Ze-Yu Zhou, Bo Xu, Wei-Dong Zang, Xiang-Yu Zhou, Jing Cao, Kun Sun, Jian-Yuan Zhao
Journal: Cell Rep Med
PubMed ID: 36809766
Doi: 10.1016/j.xcrm.2023.100953
A midposition NOTCH3 truncation in inherited cerebral small vessel disease may affect the protein interactome
Authors: Soo Jung Lee , Xiaojie Zhang , Gang Xu , Jimo Borjigin , Michael M Wang
Journal: J Biol Chem .
PubMed ID: 36470429
Doi: 10.1016/j.jbc.2022.102772
Prevalent and immunodominant CD8 T cell epitopes are conserved in SARS-CoV-2 variants
Authors: Saskia Meyer , Isaac Blaas , Ravi Chand Bollineni , Marina Delic-Sarac , Trung T Tran , Cathrine Knetter , Ke-Zheng Dai , Torfinn Støve Madssen , John T Vaage , Alice Gustavsen , Weiwen Yang , Lise Sofie Haug Nissen-Meyer , Karolos Douvlataniotis , Maarja Laos , Morten Milek Nielsen , Bernd Thiede , Arne Søraas , Fridtjof Lund-Johansen , Even H Rustad, Johanna Olweus
Journal: Cell Rep .
PubMed ID: 36656713
Doi: 10.1016/j.celrep.2023.111995
Products & Services: Peptide Synthesis   
Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor
Authors: Jia Duan , Peiyu Xu , Huibing Zhang , Xiaodong Luan , Jiaqi Yang, Xinheng He , Chunyou Mao , Dan-Dan Shen , Yujie Ji , Xi Cheng , Hualiang Jiang , Yi Jiang , Shuyang Zhang , Yan Zhang , H Eric Xu
Journal: Nat Commun .
PubMed ID: 36720854
Doi: 10.1038/s41467-023-36170-3
Wheat yellow mosaic virus NIb targets TaVTC2 to elicit broad-spectrum pathogen resistance in wheat.
Authors: Zhang Tianye, Hu Haichao, Wang Ziqiong, Feng Tianyou, Yu Lu, Jie Zhang, Gao Wenqing, Zhou Yilin, Meihao Sun, Peng Liu, Zhong Kaili, Chen ZhiHui, Jianping Chen, Wei Li, Jian Yang
Journal: Plant Biotechnology Journal
PubMed ID: 36715229
Doi: 10.1111/pbi.14019
Simultaneous capture of ISG15 conjugating and deconjugating enzymes using a semi-synthetic ISG15-Dha probe
Authors: Chuntong Li, Tian Wang, Lujun Liang, Guochao Chu, Jiachen Zhang, Wei He, Lei Liu, Jinghong Li
Journal: Science China. Chemistry
PubMed ID: 36684644
Doi: 10.1007/s11426-022-1455-x
lectrochemical and Structural Study of the Buried Tryptophan in Azurin: Effects of Hydration and Polarity on the Redox Potential of W48
Authors: Kristin Tyson, Chanin B Tangtartharakul, Matthias Zeug, Nathan Findling, Alice Haddy, Eli Hvastkovs, Jun-Yong Choe, Judy E Kim, Adam R Offenbacher
Journal: The Journal of Physical Chemistry. B
PubMed ID: 36542812
Doi: 10.1021/acs.jpcb.2c06677
Products & Services: Gene Synthesis   
Cryo-EM structures of orphan GPR21 signaling complexes
Authors: Xi Lin, Bo Chen, Yiran Wu, Yingqi Han, Ao Qi, Junyan Wang, Zhao Yang, Xiaohu Wei, Tingting Zhao, Lijie Wu, Xin Xie, Jinpeng Sun, Jie Zheng, Suwen Zhao, Fei Xu
Journal: nature communications
PubMed ID: 36639690
Doi: 10.1038/s41467-023-35882-w
Products & Services: Gene Services   
Subunit Vaccine Targeting Phosphate ABC Transporter ATP-Binding Protein, PstB, Provides Cross-Protection against Serotype 2, 7, and 9 in Mice
Authors: Zujie Yan, Xiaohui Yao, Ruyi Pan, Junjie Zhang, Xiaochun Ma, Nihua Dong, Jianchao Wei, Ke Liu, Yafeng Qiu, Katie Sealey, Hester Nichols, Michael A Jarvis, Mathew Upton, Xiangdong Li, Zhiyong Ma, Juxiang Liu, Beibei Li
Journal: Vet Sci
PubMed ID: 36669049
Doi: 10.3390/vetsci10010048
A single high-dose irradiation changes accumulation of methotrexate and gene expression levels of SLC and ABC transporters in cancer cells
Authors: Kakeru Sato, Tatsuya Seki, Asuka Mizutani, Yuka Muranaka, Shiho Hirota, Kodai Nishi, Kana Yamazaki, Ryuichi Nishii, Takeo Nakanishi, Ikumi Tamai, Keiichi Kawai, Masato Kobayashi
Journal: Front Pharmacol
PubMed ID: 36712667
Doi: 10.3389/fphar.2022.1069321
Transcriptomic exploration of the Coleopteran wings reveals insight into the evolution of novel structures associated with the beetle elytron
Authors: David M Linz, Yuichiro Hara, Kevin D Deem, Shigehiro Kuraku, Shigeo Hayashi, Yoshinori Tomoyasu
Journal: J Exp Zool B Mol Dev Evol
PubMed ID: 36617687
Doi: 10.1002/jez.b.23188
Products & Services: Molecular Biology Reagents   
Calmodulin variants associated with congenital arrhythmia impair selectivity for ryanodine receptors
Authors: Giuditta Dal Cortivo, Valerio Marino, Silvia Bianconi, Daniele Dell'Orco
Journal: Front Mol Biosci
PubMed ID: 36685279
Doi: 10.3389/fmolb.2022.1100992
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Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation
Authors: Gang Du, Linlin Zhao, Yumei Zheng, Anissa Belfetmi, Tiantian Cai, Boying Xu, Karen Heyninck, Kim Van Den Heede, Marie-Ange Buyse, Pietro Fontana, Michael Bowman, Lih-Ling Lin, Hao Wu, James Jeiwen Chou
Journal: Cell Res
PubMed ID: 36604598
Doi: 10.1038/s41422-022-00755-2
Products & Services: Plasmid DNA Preparation   
Vaccination with S, an antigen guided by SARS-CoV-2 S protein evolution, protects against challenge with viral variants in mice
Authors: Yongliang Zhao, Wenjia Ni, Simeng Liang, Lianghui Dong, Min Xiang, Zeng Cai, Danping Niu, Qiuhan Zhang, Dehe Wang, Yucheng Zheng, Zhen Zhang, Dan Zhou, Wenhua Guo, Yongbing Pan, Xiaoli Wu, Yimin Yang, Zhaofei Jing, Yongzhong Jiang, Yu Chen, Huan Yan, Yu Zhou, Ke Xu, Ke Lan
Journal: Sci Transl Med
PubMed ID: 36599007
Doi: 10.1126/scitranslmed.abo3332
Depletion of microglial BDNF increases susceptibility to the behavioral and synaptic effects of chronic unpredictable stress
Authors: Samuel C Woodburn, Helina S Asrat, James K Flurer, Hana C Schwierling, Justin L Bollinger, Lauren L Vollmer, Eric S Wohleb
Journal: Brain Behav Immun
PubMed ID: 36681359
Doi: 10.1016/j.bbi.2023.01.014
Chronic intermittent hypoxia-induced BNIP3 expression mitigates contractile dysfunction and myocardial injury in animal and cell model via modulating autophagy
Authors: Ruifang Chi, Chanjuan Chai, Gaizhen Liu, Huili Cao, Bin Yang
Journal: Hum Cell
PubMed ID: 36627546
Doi: 10.1007/s13577-022-00851-w
Products & Services: Molecular Biology Reagents   
Exploring the Expression and Function of cTyro3, a Candidate Zika Virus Receptor, in the Embryonic Chicken Brain and Inner Ear
Authors: Vashi Negi, Richard J Kuhn, Donna M Fekete
Journal: Viruses
PubMed ID: 36680287
Doi: 10.3390/v15010247
Polymorphic Alpha-Synuclein Oligomers: Characterization and Differential Detection with Novel Corresponding Antibodies
Authors: Kenya Moore, Urmi Sengupta, Nicha Puangmalai, Nemil Bhatt, Rakez Kayed
Journal: Mol Neurobiol
PubMed ID: 36707462
Doi: 10.1007/s12035-023-03211-3
A non-toxic recombinant bivalent chimeric protein rETXCSA as a potential vaccine candidate against enterotoxemia and braxy
Authors: Jige Du, Bo Liu, Tuanjie Wang, Zhen Zhu, Chunsheng Yin, Yufeng Luo, Ying Liu, Xiaoyun Chen
Journal: Vaccine
PubMed ID: 36635138
Doi: 10.1016/j.vaccine.2022.11.021
Products & Services: Molecular Biology Reagents   
Omicron variants breakthrough infection elicited higher specific memory immunity than third dose booster in healthy vaccinees
Authors: Pei Yu, Zijian Liu, Zhuoqi Zhu, Jiaqing Yang, Min Deng, Mingxiao Chen, Changchun Lai, Weiya Kong, Shilong Xiong, Li Wan, Weikang Mai, Lu Chen, Yu Lei, Shahzad Akbar Khan, Jianfeng Ruan, An Kang, Xuguang Guo, Qiang Zhou, Wenrui Li, Zheng Chen, Yuemei Liang, Pingchao Li, Lei Zhang, Tianxing Ji
Journal: Virol Sin
PubMed ID: 36603767
Doi: 10.1016/j.virs.2022.12.008
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