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A critical path to producing high quality, reproducible data from quantitative western blot experiments
Authors: Sean C Taylor, Luciana K Rosselli-Murai, Bélinda Crobeddu, Isabelle Plante
Journal: Sci Rep
PubMed ID: 36266411
Doi: 10.1038/s41598-022-22294-x
Protein kinase C beta relieves autism-like behavior in EN2 knockout mice via upregulation of the FTO/PGC-1α/UCP1 axis
Authors: Xingyu Song, Qibo Hu, Xiaoheng Xu, Wei Pan
Journal: J Biochem Mol Toxicol
PubMed ID: 36239013
Doi: 10.1002/jbt.23236
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Energy landscape reshaped by strain-specific mutations underlies epistasis in NS1 evolution of influenza A virus
Authors: Iktae Kim, Alyssa Dubrow, Bryan Zuniga, Baoyu Zhao, Noah Sherer, Abhishek Bastiray, Pingwei Li, Jae-Hyun Cho
Journal: Nat Commun
PubMed ID: 36182933
Doi: 10.1038/s41467-022-33554-9
GITRL impairs the immunosuppressive function of MDSCs via PTEN-mediated signaling pathway in experimental Sjögren syndrome
Authors: Jie Tian, Beibei Zhang, Qingfang Yuan, Xueqing Sun, Na Peng, Bo Zhu, Chang Liu, Xiaoran Wang, Man Han, Meng Cao, Fan Xiao, Shengjun Wang, Ke Rui, Liwei Lu
Journal: Inflamm Res
PubMed ID: 36301339
Doi: 10.1007/s00011-022-01660-5
Discovery and functional characterization of the oncogenicity and targetability of a novel gene fusion in pediatric angiosarcoma
Authors: Payal Jain, Sudarshan Iyer, Joshua Straka, Lea F Surrey, Jennifer Pogoriler, Harry Han, Tiffany Smith, Christine Busch, Elizabeth Fox, Marilyn Li, Angela J Waanders, Adam Resnick, Monika A Davare
Journal: Cold Spring Harb Mol Case Stud
PubMed ID: 36307212
Doi: 10.1101/mcs.a006222
Products & Services: Plasmid DNA Preparation   
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction
Authors: John T Happ, Corvin D Arveseth, Jessica Bruystens, Daniela Bertinetti, Isaac B Nelson, Cristina Olivieri, Jingyi Zhang, Danielle S Hedeen, Ju-Fen Zhu, Jacob L Capener, Jan W Bröckel, Lily Vu, C C King, Victor L Ruiz-Perez, Xuecai Ge, Gianluigi Veglia, Friedrich W Herberg, Susan S Taylor, Benjamin R Myers
Journal: Nat Struct Mol Biol
PubMed ID: 36202993
Doi: 10.1038/s41594-022-00838-z
Products & Services: Gene Synthesis   
Evasion of cGAS and TRIM5 defines pandemic HIV
Authors: Lorena Zuliani-Alvarez, Morten L Govasli, Jane Rasaiyaah, Chris Monit, Stephen O Perry, Rebecca P Sumner, Simon McAlpine-Scott, Claire Dickson, K M Rifat Faysal, Laura Hilditch, Richard J Miles, Frederic Bibollet-Ruche, Beatrice H Hahn, Till Boecking, Nikos Pinotsis, Leo C James, David A Jacques, Greg J Towers
Journal: Nat Microbiol
PubMed ID: 36289397
Doi: 10.1038/s41564-022-01247-0
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Comparison of the kinetics and magnitude of antibody responses to different SARS-CoV-2 proteins in Sinopharm/BBIBP-CorV vaccinees following the BNT162b2 booster or natural infection
Authors: Chandima Jeewandara, Inoka Sepali Aberathna, Shashika Dayarathna, Thashmi Nimasha, Thushali Ranasinghe, Jeewantha Jayamali, Achala Kamaladasa, Maneshka Karunanada, Lahiru Perera, Graham S Ogg, Gathsaurie Neelika Malavige
Journal: PLoS ONE
PubMed ID: 36227884
Doi: 10.1371/journal.pone.0274845
Products & Services: Catalog Antibody   
Susceptibility to SARS-CoV-2 omicron following ChAdOx1 nCoV-19 and BNT162b2 versus CoronaVac vaccination
Authors: Jia Xin Chua, Lindy Gillian Durrant, Yin Ling Chok, Oi Ming Lai
Journal: iScience
PubMed ID: 36277260
Doi: 10.1016/j.isci.2022.105379
Products & Services: Recombinant Proteins   
Cancer stem cell antigen nanodisc cocktail elicits anti-tumor immune responses in melanoma
Authors: Marisa E Aikins, You Qin, Hannah E Dobson, Alireza Hassani Najafabadi, Kexing Lyu, Yao Xu, Ying Xin, Anna Schwendeman, Max S Wicha, Alfred E Chang, Qiao Li, James J Moon
Journal: J Control Release
PubMed ID: 36206945
Doi: 10.1016/j.jconrel.2022.09.061
Products & Services: Peptide Synthesis   
Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library
Authors: Devan J Shell, Justin M Rectenwald, Peter H Buttery, Rebecca L Johnson, Caroline A Foley, Shiva K R Guduru, Mélanie Uguen, Juanita Sanchez Rubiano, Xindi Zhang, Fengling Li, Jacqueline L Norris-Drouin, Matthew Axtman, P Brian Hardy, Masoud Vedadi, Stephen V Frye, Lindsey I James, Kenneth H Pearce
Journal: SLAS Discov
PubMed ID: 36272689
Doi: 10.1016/j.slasd.2022.10.003
Products & Services: Recombinant Proteins   
Sex Difference Leads to Differential Gene Expression Patterns and Therapeutic Efficacy in Mucopolysaccharidosis IVA Murine Model Receiving AAV8 Gene Therapy
Authors: Matthew Piechnik, Paige C Amendum, Kazuki Sawamoto, Molly Stapleton, Shaukat Khan, Nidhi Fnu, Victor Álvarez, Angelica Maria Herreño Pachon, Olivier Danos, Joseph T Bruder, Subha Karumuthil-Melethil, Shunji Tomatsu
Journal: Int J Mol Sci
PubMed ID: 36293546
Doi: 10.3390/ijms232012693
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External quality assessment of SARS-CoV-2 serology in European expert laboratories, April 2021
Authors: Ramona Mögling, Francesca Colavita, Johan Reimerink, Angeliki Melidou, Katrin Leitmeyer, Maria Keramarou, Daniele Lapa, Massimo Francalancia, Jean-Luc Murk, Ann Vossen, Fabrizio Carletti, Boris Hogema, Adam Meijer, Liesbet Deprez, Antonino di Caro, Concetta Castilletti, Chantal Bem Reusken
Journal: Euro Surveill
PubMed ID: 36268736
Doi: 10.2807/1560-7917.ES.2022.27.42.2101057
Products & Services: Catalog Antibody   
Multidomain peptide hydrogel adjuvants elicit strong bias towards humoral immunity
Authors: Brett H Pogostin, Marina H Yu, Alon R Azares, Erin M Euliano, Cheuk Sun Edwin Lai, Gabriel Saenz, Samuel X Wu, Adam C Farsheed, Sarah M Melhorn, Tyler P Graf, Darren G Woodside, Jeffrey D Hartgerink, Kevin J McHugh
Journal: Biomater Sci
PubMed ID: 36102692
Doi: 10.1039/d2bm01242a
Structural basis of interleukin-17B receptor in complex with a neutralizing antibody for guiding humanization and affinity maturation
Authors: Wen-Hsin Lee, Xiaorui Chen, I-Ju Liu, Jiin-Horng Lee, Chun-Mei Hu, Han-Chung Wu, Sheng-Kai Wang, Wen-Hwa Lee, Che Ma
Journal: Cell Rep
PubMed ID: 36288706
Doi: 10.1016/j.celrep.2022.111555
Products & Services: Mammalian Expression   
Identification of human MHC-I HPV18 E6/E7-specific CD8 + T cell epitopes and generation of an HPV18 E6/E7-expressing adenosquamous carcinoma in HLA-A2 transgenic mice
Authors: Shiwen Peng, Deyin Xing, Louise Ferrall, Ya-Chea Tsai, Chien-Fu Hung, T-C Wu
Journal: J Biomed Sci
PubMed ID: 36224625
Doi: 10.1186/s12929-022-00864-5
Products & Services: Peptide Synthesis   
Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma
Authors: Tilman L B Hölting, Florencia Cidre-Aranaz, Dana Matzek, Bastian Popper, Severin J Jacobi, Cornelius M Funk, Florian H Geyer, Jing Li, Ignazio Piseddu, Bruno L Cadilha, Stephan Ledderose, Jennifer Zwilling, Shunya Ohmura, David Anz, Annette Künkele, Frederick Klauschen, Thomas G P Grünewald, Maximilian M L Knott
Journal: Mol Cancer
PubMed ID: 36229873
Doi: 10.1186/s12943-022-01641-6
Products & Services: Recombinant Proteins   
Active Pharmaceutical Ingredient Uptake by Zebrafish (Danio rerio) Oct2 (slc22a2) Transporter Expressed in Xenopus laevis Oocytes
Authors: Elisabeth D Chang, Stewart F Owen, Christer Hogstrand, Nic R Bury
Journal: Environ Toxicol Chem
PubMed ID: 36102855
Doi: 10.1002/etc.5480
Products & Services: Gene Synthesis   
Author Correction: Omicron BA4/BA5 escape neutralizing immunity elicited by BA1 infection
Authors: Khadija Khan, Farina Karim, Yashica Ganga, Mallory Bernstein, Zesuliwe Jule, Kajal Reedoy, Sandile Cele, Gila Lustig, Daniel Amoako, Nicole Wolter, Natasha Samsunder, Aida Sivro, James Emmanuel San, Jennifer Giandhari, Houriiyah Tegally, Sureshnee Pillay, Yeshnee Naidoo, Matilda Mazibuko, Yoliswa Miya, Nokuthula Ngcobo, Nithendra Manickchund, Nombulelo Magula, Quarraisha Abdool Karim, Anne von Gottberg, Salim S Abdool Karim, Willem Hanekom, Bernadett I Gosnell, Richard J Lessells, Tulio de Oliveira, Mahomed-Yunus S Moosa, Alex Sigal
Journal: Nat Commun
PubMed ID: 36229444
Doi: 10.1038/s41467-022-33371-0
Products & Services: Monoclonal Antibody Services   
MnO Nanozyme-Mediated CRISPR-Cas12a System for the Detection of SARS-CoV-2
Authors: Lina Wu, Xinjie Wang, Xiangchuan Wu, Shiqi Xu, Ming Liu, Xizhong Cao, Taishan Tang, Xingxu Huang, He Huang
Journal: ACS Appl Mater Interfaces
PubMed ID: 36301087
Doi: 10.1021/acsami.2c14497
Products & Services: Molecular Biology Tools   
FAD-Deficient P187S mutation of NAD(P)H:quinone oxidoreductase 1 (NQO1*2) binds and accelerates β-amyloid aggregation
Authors: Sudipta Panja, David Siegel, Simonetta Camandola, Rafael de Cabo, David Ross, Krishna Mallela
Journal: Biosci Rep
PubMed ID: 36281795
Doi: 10.1042/BSR20220643
Products & Services: Click Peptide Services   
A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology
Authors: Benjamin F N Campbell, Antje Dittmann, Birgit Dreier, Andreas Plückthun, Shiva K Tyagarajan
Journal: Elife
PubMed ID: 36314779
Doi: 10.7554/eLife.80895
Products & Services: Recombinant Antibody Expression   
Sequential Deletions of Interferon Inhibitors MGF110-9L and MGF505-7R Result in Sterile Immunity against the Eurasia Strain of Africa Swine Fever
Authors: Mingyang Ding, Wen Dang, Huanan Liu, Keshan Zhang, Fan Xu, Hong Tian, Huaguo Huang, Zhengwang Shi, Yongjie Sunkang, Xiaodong Qin, Yong Zhang, Haixue Zheng
Journal: J Virol
PubMed ID: 36197109
Doi: 10.1128/jvi.01192-22
Products & Services: Custom DNA/RNA Oligos   
miR-124-3p Delivered Using Exosomes Attenuates the Keratinocyte Response to IL-17A Stimulation in Psoriasis
Authors: Simin Liu, Jian Gong
Journal: Oxid Med Cell Longev
PubMed ID: 36275890
Doi: 10.1155/2022/6264474
Products & Services: Custom Vector Construction   
Peroxynitrite in the tumor microenvironment changes the profile of antigens allowing escape from cancer immunotherapy
Authors: Evgenii N Tcyganov, Emilio Sanseviero, Douglas Marvel, Thomas Beer, Hsin-Yao Tang, Peter Hembach, David W Speicher, Qianfei Zhang, Laxminarasimha R Donthireddy, Ali Mostafa, Sabina Tsyganova, Vladimir Pisarev, Terri Laufer, Dmitriy Ignatov, Soldano Ferrone, Christiane Meyer, Hélène Maby-El Hajjami, Daniel E Speiser, Sooner Altiok, Scott Antonia, Xiaowei Xu, Wei Xu, Cathy Zheng, Lynn M Schuchter, Ravi K Amaravadi, Tara C Mitchell, Giorgos C Karakousis, Zhe Yuan, Luis J Montaner, Esteban Celis, Dmitry I Gabrilovich
Journal: Cancer Cell
PubMed ID: 36220073
Doi: 10.1016/j.ccell.2022.09.001
Products & Services: Peptide Synthesis   
Chitosan and chitosan oligosaccharide influence digestibility of whey protein isolate through electrostatic interaction
Authors: Linlin Wang, Lilong Wang, Chengrong Wen, Nan Wang, Chunhong Yan, Caihong Shen, Shuang Song
Journal: Int J Biol Macromol
PubMed ID: 36191784
Doi: 10.1016/j.ijbiomac.2022.09.258
Deciphering the Alphabet of Disorder-Glu and Asp Act Differently on Local but Not Global Properties
Authors: Mette Ahrensback Roesgaard, Jeppe E Lundsgaard, Estella A Newcombe, Nina L Jacobsen, Francesco Pesce, Emil E Tranchant, Søren Lindemose, Andreas Prestel, Rasmus Hartmann-Petersen, Kresten Lindorff-Larsen, Birthe B Kragelund
Journal: Biomolecules
PubMed ID: 36291634
Doi: 10.3390/biom12101426
Products & Services: Mutagenesis Services   
Identifying a novel role for the master regulator Tal1 in the Endothelial to Hematopoietic Transition
Authors: Yasmin Natalia Serina Secanechia, Isabelle Bergiers, Matt Rogon, Christian Arnold, Nicolas Descostes, Stephanie Le, Natalia López-Anguita, Kerstin Ganter, Chrysi Kapsali, Lea Bouilleau, Aaron Gut, Auguste Uzuotaite, Ayshan Aliyeva, Judith B Zaugg, Christophe Lancrin
Journal: Sci Rep
PubMed ID: 36217016
Doi: 10.1038/s41598-022-20906-0
Products & Services: Gene Synthesis   
Amphiphile-CpG vaccination induces potent lymph node activation and COVID-19 immunity in mice and non-human primates
Authors: Lochana M Seenappa, Aniela Jakubowski, Martin P Steinbuck, Erica Palmer, Christopher M Haqq, Crystal Carter, Jane Fontenot, Francois Villinger, Lisa K McNeil, Peter C DeMuth
Journal: npj Vaccines
PubMed ID: 36307453
Doi: 10.1038/s41541-022-00560-3
Products & Services: Catalog Peptides   
Allosteric regulation of glycogen breakdown by the second messenger cyclic di-GMP
Authors: Maria A Schumacher, Mirka E Wörmann, Max Henderson, Raul Salinas, Andreas Latoscha, Mahmoud M Al-Bassam, Kumar Siddharth Singh, Elaine Barclay, Katrin Gunka, Natalia Tschowri
Journal: Nat Commun
PubMed ID: 36192422
Doi: 10.1038/s41467-022-33537-w
Products & Services: PCR Cloning and Subcloning   
HCV Infection Increases the Expression of ACE2 Receptor, Leading to Enhanced Entry of Both HCV and SARS-CoV-2 into Hepatocytes and a Coinfection State
Authors: Tom Domovitz, Samer Ayoub, Michal Werbner, Joel Alter, Lee Izhaki Tavor, Yfat Yahalom-Ronen, Evgeny Tikhonov, Tomer Meirson, Yaakov Maman, Nir Paran, Tomer Israely, Moshe Dessau, Meital Gal-Tanamy
Journal: Microbiol Spectr
PubMed ID: 36314945
Doi: 10.1128/spectrum.01150-22
Products & Services: Plasmid DNA Preparation   
Accelerated DNA vaccine regimen provides protection against Crimean-Congo hemorrhagic fever virus challenge in a macaque model
Authors: David W Hawman, Kimberly Meade-White, Shanna Leventhal, Sofia Appelberg, Gustaf Ahlén, Negin Nikouyan, Chad Clancy, Brian Smith, Patrick Hanley, Jamie Lovaglio, Ali Mirazimi, Matti Sällberg, Heinz Feldmann
Journal: Mol Ther
PubMed ID: 36184852
Doi: 10.1016/j.ymthe.2022.09.016
Products & Services: Catalog Peptides   
Safety, efficacy, and DIVA feasibility on a novel live attenuated classical swine fever marker vaccine candidate
Authors: Chao Tong, Huanhuan Liu, Jiaying Wang, Yanyong Sun, Ning Chen
Journal: Vaccine
PubMed ID: 36328881
Doi: 10.1016/j.vaccine.2022.10.035
Products & Services: Gene Synthesis   
Neutralizing and interfering human antibodies define the structural and mechanistic basis for antigenic diversion
Authors: Palak N Patel, Thayne H Dickey, Christine S Hopp, Ababacar Diouf, Wai Kwan Tang, Carole A Long, Kazutoyo Miura, Peter D Crompton, Niraj H Tolia
Journal: Nat Commun
PubMed ID: 36202833
Doi: 10.1038/s41467-022-33336-3
Products & Services: Mammalian Expression   
Recent reconfiguration of an ancient developmental gene regulatory network in Heliocidaris sea urchins
Authors: Phillip L Davidson, Haobing Guo, Jane S Swart, Abdull J Massri, Allison Edgar, Lingyu Wang, Alejandro Berrio, Hannah R Devens, Demian Koop, Paula Cisternas, He Zhang, Yaolei Zhang, Maria Byrne, Guangyi Fan, Gregory A Wray
Journal: Nat Ecol Evol
PubMed ID: 36266460
Doi: 10.1038/s41559-022-01906-9
Products & Services: PCR Cloning and Subcloning   
Construction of a bioluminescence-based assay for bitter taste receptors (TAS2Rs)
Authors: Shi Min Tan, Wei-Guang Seetoh
Journal: Sci Rep
PubMed ID: 36271274
Doi: 10.1038/s41598-022-21678-3
Products & Services: Mammalian Expression   
Characteristics of a new carotenoid cleavage dioxygenase NtCCD10 derived from Nicotiana tabacum
Authors: Fan Li, Xiaowei Gong, Yupeng Liang, Lijuan Peng, Xiulin Han, Mengliang Wen
Journal: Planta
PubMed ID: 36251100
Doi: 10.1007/s00425-022-04013-y
Products & Services: Plasmid DNA Preparation   
CRISPR/Cas Precisely Regulated DNA-Templated Silver Nanocluster Fluorescence Sensor for Meat Adulteration Detection
Authors: Jiahui Chen, Jianghua Liu, Di Wu, Ruiyuan Pan, Jian Chen, Yongning Wu, Mingquan Huang, Guoliang Li
Journal: J Agric Food Chem
PubMed ID: 36288511
Doi: 10.1021/acs.jafc.2c04500
Autophagy Regulates Osteogenic Differentiation of Human Periodontal Ligament Stem Cells Induced by Orthodontic Tension
Authors: Junyi Zheng, Bowen Xu, Kai Yang
Journal: Stem Cells Int
PubMed ID: 36248255
Doi: 10.1155/2022/2983862
Crystal structure of the collagen prolyl 4-hydroxylase (C-P4H) catalytic domain complexed with PDI: Toward a model of the C-P4H αβ tetramer
Authors: Abhinandan V Murthy, Ramita Sulu, Andrey Lebedev, Antti M Salo, Kati Korhonen, Rajaram Venkatesan, Hongmin Tu, Ulrich Bergmann, Janne Jänis, Mikko Laitaoja, Lloyd W Ruddock, Johanna Myllyharju, M Kristian Koski, Rik K Wierenga
Journal: J Biol Chem
PubMed ID: 36265586
Doi: 10.1016/j.jbc.2022.102614
Products & Services: Codon Optimization   
Development of Enzymatic Depletion Methods for Preparation of Small Extracellular Vesicles with Long Blood-Circulation Half-Life
Authors: Yuki Kobayashi, Shimpei Kitamura, Yuki Takahashi, Yoshinobu Takakura
Journal: Pharm Res
PubMed ID: 36195822
Doi: 10.1007/s11095-022-03405-9
Targeting SARS-CoV-2 infection through CAR-T-like bispecific T cell engagers incorporating ACE2
Authors: Mikail Dogan, Lina Kozhaya, Lindsey Placek, Fatih Karabacak, Mesut Yigit, Derya Unutmaz
Journal: Clin Transl Immunology
PubMed ID: 36285327
Doi: 10.1002/cti2.1421
A non-canonical RNA-binding domain of the Fragile X protein, FMRP, elicits translational repression independent of mRNA G-quadruplexes
Authors: MaKenzie R Scarpitti, Julia E Warrick, Evelyn L Yoder, Michael G Kearse
Journal: J Biol Chem
PubMed ID: 36328245
Doi: 10.1016/j.jbc.2022.102660
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Genome-Wide Identification and Functional Analysis of the Gene Family Responding to Multiple Stressors in
Authors: Mei Zhang, Zhengfeng Wang, Shuguang Jian
Journal: Genes (Basel)
PubMed ID: 36360226
Doi: 10.3390/genes13111988
Products & Services: Protein Tools   
The synergism of lytic polysaccharide monooxygenases with lichenase and their co-immobilization on silica nanospheres for green conversion of lichen biomass
Authors: Lixi Cai, Ying Zheng, Yunmeng Chu, Yuanqing Lin, Lixing Liu, Guangya Zhang
Journal: Front Nutr
PubMed ID: 36337671
Doi: 10.3389/fnut.2022.970540
Products & Services: Gene Synthesis   
Mannose and Hyaluronic Acid Dual-Modified Iron Oxide Enhances Neoantigen-Based Peptide Vaccine Therapy by Polarizing Tumor-Associated Macrophages
Authors: Ying Nie , Lu Shi , Yanan Zhang , Yunfei Guo , Hongchen Gu
Journal: Cancers
PubMed ID: 36291890
Doi: /10.3390/cancers14205107
Products & Services: Peptide Synthesis   
Structural basis of TRPV3 inhibition by an antagonist
Authors: Junping Fan, Linghan Hu, Zongwei Yue, Daohong Liao, Fusheng Guo, Han Ke, Daohua Jiang, Yong Yang, Xiaoguang Lei
Journal: Nat Chem Biol
PubMed ID: 36302896
Doi: 10.1038/s41589-022-01166-5
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Neutralizing Antibody Responses Among Residents and Staff of Long-Term Care Facilities in the State of New Jersey During the First Wave of the COVID-19 Pandemic
Authors: Stephen M Friedman, Jieliang Li, Pauline Thomas, Manisha Gurumurthy, Richard Siderits, Anna Nepomich, Edward Lifshitz
Journal: J Community Health
PubMed ID: 36197535
Doi: 10.1007/s10900-022-01142-z
Outliers Matter-Correlation between S1 IgG SARS-CoV-2 Antibodies and Neutralizing SARS-CoV-2 Antibodies
Authors: Berthold Hocher, Anne Schönbrunn, Xin Chen, Bernhard K Krämer, Volker von Baehr
Journal: Microorganisms
PubMed ID: 36296343
Doi: 10.3390/microorganisms10102067
Insertion of circularly permuted cyan fluorescent protein into the ligand-binding domain of inositol 1,4,5-trisphosphate receptor for enhanced FRET upon binding of fluorescent ligand
Authors: Azmeree Jahan, Mst Tahmina Akter, Kiwamu Takemoto, Tai Oura, Akiko Shitara, Shingo Semba, Akihiro Nezu, Satoshi Suto, Takeharu Nagai, Akihiko Tanimura
Journal: Cell Calcium
PubMed ID: 36335765
Doi: 10.1016/j.ceca.2022.102668
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