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The Combined Use of Phenothiazines and Statins Strongly Affects Doxorubicin-Resistance, Apoptosis, and Cox-2 Activity in Colon Cancer Cells.

Int J Mol Sci. 2019-03; 
Środa-PomianekKamila, MichalakKrystyna, Palko-ŁabuzAnna, UrygaAnna, ŚwiątekPiotr, MajkowskiMichał, Wesołowska
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Stable Cell Line Development Services … calibration curve that was prepared previously. 4.6. Caspase 3 Activation Assay. Caspase-3 activation was estimated with the use of a commercially available kit (GenScript, Piscataway, NJ, USA). The cells were seeded (800,000 … Get A Quote

摘要

Since none of the multidrug resistance (MDR) modulators tested so far found their way into clinic, a novel approach to overcome the MDR of cancer cells has been proposed. The combined use of two MDR modulators of dissimilar mechanisms of action was suggested to benefit from the synergy between them. The effect of three phenothiazine derivatives that were used as single agents and in combination with simvastatin on cell growth, apoptosis induction, activity, and expression of cyclooxygenase-2 (COX-2) in doxorubicin-resistant colon cancer cells (LoVo/Dx) was investigated. Treatment of LoVo/Dx cells by phenothiazine derivatives combined with simvastatin resulted in an increase of doxorubicin cytotoxicity a... More

关键词

ABCB1 (P-glycoprotein),apoptosis,cancer combination therapy,cancer multidrug resistance,cyclooxygenase-2 (COX-2),phenothiazine derivatives,simvast