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Therapeutic effects of human urocortin-1, -2 and -3 in intracerebral hemorrhage of rats.

Neuropeptides. 2015; 
LiewHock-Kean,HuangLi-Chuan,YangHui-I,PengHsiao-Fen,LiKuo-Wei,TsaiAndy Po-Yi,ChenShin-Yuan,KuoJon-Son,PangCheng-Y
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Biochemicals … group Coupling reagents 1-Hydroxy-7-azabenzotriazole (HOAt) and O-(7- azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HATU) were purchased from GenScript Corporation (Piscataway, NJ, USA) … Get A Quote

摘要

Urocortin exerts neuroprotective effects in intracerebral hemorrhage (ICH) of rats. For pre-clinical trial, we intended to study the neuroprotective efficacy of human UCN (hUCN)-1, -2 and -3 in treating ICH rats. ICH was induced by infusing bacterial collagenase VII (0.23 U in sterile saline) to the striatum. The hUCN-1, -2, and -3 were administrated (2.5μg/kg, i.p.) at 1h after ICH insult, respectively. Neurological deficits were evaluated by modified Neurological Severity Scores. Brain edema and hematoma expansion was evaluated by coronal T2-WI and DWI magnetic resonance imaging on 1, 3, 6, 24, and 56h after ICH insult. Blood-brain barrier permeability was evaluated by Evans blue assay on... More

关键词

Brain edema,Brain lesion,Intracerebral hemorrhage (ICH),Neuroprotection,Urocor