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Attenuated Replication of Lassa Virus Vaccine Candidate ML29 in STAT-1-/- Mice.

Pathogens. 2019; 
Johnson DM,, Jokinen JD,, Lukashevich IS,.
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Monoclonal Antibody Services After washing, cells were treated with either polyclonal monkey-anti-ML29 antibody (1:400), monoclonal mouse-anti-LASV/JOS-NP, 1:100 (GenScript, Piscataway, NJ, USA) or polyclonal rabbit-anti-LASV-GP 1:400 (IBT Bioservices, Rockville, MD, USA) followed by HRP linked appropriate secondary antibody. Get A Quote

摘要

Lassa virus (LASV), a highly prevalent mammalian arenavirus endemic in West Africa, can cause Lassa fever (LF), which is responsible for thousands of deaths annually. LASV is transmitted to humans from naturally infected rodents. At present, there is not an effective vaccine nor treatment. The genetic diversity of LASV is the greatest challenge for vaccine development. The reassortant ML29 carrying the L segment from the nonpathogenic Mopeia virus (MOPV) and the S segment from LASV is a vaccine candidate under current development. ML29 demonstrated complete protection in validated animal models against a Nigerian strain from clade II, which was responsible for the worst outbreak on record in 2018. This study de... More

关键词

Lassa virus; Lassa virus vaccine; ML29 vaccine; Mopeia virus; STAT-1-/- mice; interfering particles