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Curcumin downregulates expression of opioid-related nociceptin receptor gene (OPRL1) in isolated neuroglia cells.

Phytomedicine. 2018; 
Seo EJ, Efferth T, Panossian A.
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摘要

Curcumin (CC) exerts polyvalent pharmacological actions and multi-target effects, including pain relief and anti-nociceptive activity. In combination with Boswellia serrata extract (BS), curcumin shows greater efficacy in knee osteoarthritis management, presumably due to synergistic interaction of the ingredients.,To elucidate the molecular mechanisms underlying the analgesic activity of curcumin and its synergistic interaction with BS.,We performed gene expression profiling by transcriptome-wide mRNA sequencing in human T98G neuroglia cells treated with CC (Curamed), BS, and the combination of CC and BS (CC-BS; Curamin), followed by interactive pathways analysis of the regulated genes.,Treatment with CC and wi... More

关键词

Boswellia; Curcumin; Nociception; OPRL1; Opioid receptor ORL1; Pain