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Lowly expressed lncRNA PVT1 suppresses proliferation and advances apoptosis of glioma cells through up-regulating microRNA-128-1-5p and inhibiting PTBP1

Brain Res Bull. 2020-06-01; 
Zheng Dahai, Chen Daliang, Lin Famu, Wan Xiang, Lu Lenian, Chen Jianmin, Xu Xiaobing
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Mutant Libraries … between PVT1 and miR-128-1-5p as well as miR-128-1-5p and PTBP1, wild type (WT) or mutant type (MUT) pmirGLO PVT1 (PVT1-WT and PVT1-MUT) and pmirGLO PTBP1 (PTBP1-WT and PTBP1-MUT) were composed by Nanjing Genscript Biotechnology Co., Ltd … Get A Quote

摘要

background: Glioma is a primary intracranial malignancy with poor prognosis, of which the pathogenesis remains to be elucidated. Therein, the aim of this study is to discuss the impacts of lncRNA plasmacytoma variant translocation 1 (PVT1)/microRNA-128-1-5p (miR-128-1-5p)/polypyrimidine tract-binding protein 1 (PTBP1) axis on the biological characteristics of glioma cells. methods: Glioma tissue samples (72 cases) and normal brain tissue samples (35 cases) were harvested. The expression of PVT1, miR-128-1-5p and PTBP1 in glioma tissues and cells was detected. Glioma cells were transfected with sh-PVT1, miR-128-1-5p mimics or miR-128-1-5p inhibitors to verify the impacts of PVT1 and miR-128-1-5p on DNA damage, c... More

关键词

Apoptosis, Glioma, Invasion, LncRNA PVT1, MicroRNA-128-1-5p, Polypyrimidine tract-binding protein 1, Proliferation