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Microsomal triglyceride transfer protein regulates intracellular lipolysis in adipocytes independent of its lipid transfer activity

Metabolism. 2022-10; 
Sujith Rajan, Peter Hofer, Amanda Christiano, Matthew Stevenson, Louis Ragolia, Eugenia Villa-Cuesta, Susan K Fried, Raymond Lau, Collin Braithwaite, Rudolf Zechner, Gary J Schwartz, M Mahmood Hussain
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Catalog Peptides … eluted using 100 μM FLAG peptide (Genscript) in 2 mL PBS. … their blood before and 15 min after injections. A-Mttp −/− mice … different FFA levels before the injections, we subtracted the … Get A Quote

摘要

background: The triglyceride (TG) transfer activity of microsomal triglyceride transfer protein (MTP) is essential for lipoprotein assembly in the liver and intestine; however, its function in adipose tissue, which does not assemble lipoproteins, is unknown. Here we have elucidated the function of MTP in adipocytes. results: We demonstrated that MTP is present on lipid droplets in human adipocytes. Adipose-specific MTP deficient (A-Mttp) male and female mice fed an obesogenic diet gained less weight than Mttp mice, had less fat mass, smaller adipocytes and were insulin sensitive. A-Mttp mice showed higher energy expenditure than Mttp mice. During a cold challenge, A-Mttp mice maintained higher body temperature ... More

关键词

ATGL, Free fatty acids, HSL, Obesity, Protein-protein interactions, Thermogenesis