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Balance between Protection and Pathogenic Response to Aerosol Challenge with (Mtb) in Mice Vaccinated with TriFu64, a Fusion Consisting of Three Mtb Antigens

Vaccines (Basel). 2021-05; 
Sadaf Sulman, Benjamin O Savidge, Kawther Alqaseer, Mrinal K Das, Neda Nezam Abadi, John E Pearl, Obolbek Turapov, Galina V Mukamolova, M Waheed Akhtar, Andrea May Cooper
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Bacterial Expression The level of bacterial LPS in the protein preparations was evaluated by Limulus amoebocyte lysate assay (ToxinSensor, GenScript USA Inc., Piscataway, NJ, USA). Get A Quote

摘要

Tuberculosis vaccines capable of reducing disease worldwide have proven difficult to develop. BCG is effective in limiting childhood disease, but adult TB is still a major public health issue. Development of new vaccines requires identification of antigens that are both spatially and temporally available throughout infection, and immune responses to which reduce bacterial burden without increasing pathologic outcomes. Subunit vaccines containing antigen require adjuvants to drive appropriate long-lived responses. We generated a triple-antigen fusion containing the virulence-associated EsxN (Rv1793), the PPE42 (Rv2608), and the latency associated Rv2628 to investigate the balance between bacterial reduction and ... More

关键词

antigen, tuberculosis, vaccine, weight loss