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Novel PGC-1/ATF5 Axis Partly Activates UPR and Mediates Cardioprotective Role of Tetrahydrocurcumin in Pathological Cardiac Hypertrophy

Oxid Med Cell Longev. 2020-12; 
Bing Zhang, Yanzhen Tan, Zhengbin Zhang, Pan Feng, Wenyuan Ding, Qian Wang, Hongliang Liang, Weixun Duan, Xiaowu Wang, Shiqiang Yu, Jincheng Liu, Dinghua Yi, Yang Sun, Wei Yi
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摘要

Mitochondrial unfolding protein response (UPR) effectively resists the pathological cardiac hypertrophy and improves the mitochondrial function. However, the specific activation mechanism and drugs that can effectively activate UPR in the cardiac muscle are yet to be elucidated. The aim of this study was to determine the regulation role of UPR on preventing pathological cardiac hypertrophy by tetrahydrocurcumin (THC) and explore its underlying molecular mechanism. Male C57BL/6J wild-type (WT) mice were divided into a control group and subjected to sham treatment for 4 weeks, and a test group which was subjected to transverse aortic constriction (TAC) surgery. Animals in the control and test group were orally ad... More

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