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Soluble CD4 and low molecular weight CD4-mimetic compounds sensitize cells to be killed by anti-HIV cytotoxic immunoconjugates

J Virol. 2023-09;

Seth H Pincus, Megan Stackhouse, Connie Watt, Kelli Ober, Frances M Cole, Hung-Ching Chen, Amos B Smith Iii, Tami Peters

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Proteins, Expression, Isolation and Analysis	… serum that was precleared on protein G-agarose (GenScript, Piscataway, NJ USA) to remove residual IgG. The IgG in the clarified supernatant was purified on protein G-agarose. …	Get A Quote

摘要

HIV infection can be effectively treated to prevent the development of AIDS, but it cannot be cured. We have attached poisons to anti-HIV antibodies to kill the infected cells that persist even after years of effective antiviral therapy. Here we show that the killing of infected cells can be markedly enhanced by the addition of soluble forms of the HIV receptor CD4 or by mimics of CD4.