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The aminosterol Claramine inhibits β-secretase 1-mediated insulin receptor cleavage
Authors: Bénédicte Gaborit, Roland Govers, Alexandre Altié, Jean Michel Brunel, Pierre Morange, Franck Peiretti
Journal: J Biol Chem
PubMed ID: 34029592
Doi: 10.1016/j.jbc.2021.100818
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Selective and noncovalent targeting of RAS mutants for inhibition and degradation
Authors: Kai Wen Teng, Steven T Tsai, Takamitsu Hattori, Carmine Fedele, Akiko Koide, Chao Yang, Xuben Hou, Yingkai Zhang, Benjamin G Neel, John P O'Bryan, Shohei Koide
Journal: Nat Commun
PubMed ID: 33976200
Doi: 10.1038/s41467-021-22969-5
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In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activity
Authors: Lyndsay R Watkins, Cesare Orlandi
Journal: Br J Pharmacol
PubMed ID: 33784795
Doi: 10.1111/bph.15468
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Rituximab and Canakinumab Use During Lactation: No Detectable Serum Levels in Breastfed Infants
Authors: Nicole Bosshard, Astrid Zbinden, Klara Kristin Eriksson, Frauke Förger
Journal: Rheumatol Ther
PubMed ID: 33999372
Doi: 10.1007/s40744-021-00313-z
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Neither gonadotropin nor cumulus cell expansion is needed for the maturation of competent porcine oocytes in vitro
Authors: Bethany K Redel, Lee D Spate, Ye Yuan, Clifton N Murphy, R Michael Roberts, Randall S Prather
Journal: Biol Reprod
PubMed ID: 33962465
Doi: 10.1093/biolre/ioab090
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Cross-reactive coronavirus antibodies with diverse epitope specificities and Fc effector functions
Authors: Andrea R Shiakolas, Kevin J Kramer, Daniel Wrapp, Simone I Richardson, Alexandra Schäfer, Steven Wall, Nianshuang Wang, Katarzyna Janowska, Kelsey A Pilewski, Rohit Venkat, Robert Parks, Nelia P Manamela, Nagarajan Raju, Emilee Friedman Fechter, Clinton M Holt, Naveenchandra Suryadevara, Rita E Chen, David R Martinez, Rachel S Nargi, Rachel E Sutton, Julie E Ledgerwood, Barney S Graham, Michael S Diamond, Barton F Haynes, Priyamvada Acharya, Robert H Carnahan, James E Crowe, Ralph S Baric, Lynn Morris, Jason S McLellan, Ivelin S Georgiev
Journal: Cell Rep Med
PubMed ID: 34056628
Doi: 10.1016/j.xcrm.2021.100313
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Mechanical ventilation enhances Acinetobacter baumannii-induced lung injury through JNK pathways
Authors: Tzyy-Bin Tsay, Wan-Hsuan Chang, Ching-Mei Hsu, Lee-Wei Chen
Journal: Respir Res
PubMed ID: 34022899
Doi: 10.1186/s12931-021-01739-3
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Mitohormesis reprogrammes macrophage metabolism to enforce tolerance
Authors: Greg A Timblin, Kevin M Tharp, Breanna Ford, Janet M Winchester, Jerome Wang, Stella Zhu, Rida I Khan, Shannon K Louie, Anthony T Iavarone, Johanna Ten Hoeve, Daniel K Nomura, Andreas Stahl, Kaoru Saijo
Journal: Nat Metab
PubMed ID: 34031590
Doi: 10.1038/s42255-021-00392-w
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Integrating quantitative proteomics with accurate genome profiling of transcription factors by greenCUT&RUN
Authors: Sheikh Nizamuddin, Stefanie Koidl, Tanja Bhuiyan, Tamara V Werner, Martin L Biniossek, Alexandre M J J Bonvin, Silke Lassmann, HThMarc Timmers
Journal: Nucleic Acids Res
PubMed ID: 33524153
Doi: 10.1093/nar/gkab038
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Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway
Authors: Yen-Chen Lin, Meenakshi Sundaram Kumar, Nandini Ramesh, Eric N Anderson, Aivi T Nguyen, Boram Kim, Simon Cheung, Justin A McDonough, William C Skarnes, Rodrigo Lopez-Gonzalez, John E Landers, Nicolas L Fawzi, Ian R A Mackenzie, Edward B Lee, Jeffrey A Nickerson, David Grunwald, Udai B Pandey, Daryl A Bosco
Journal: Nat Neurosci
PubMed ID: 34059832
Doi: 10.1038/s41593-021-00859-9
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