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Therapeutic Potential of HLA-I Polyreactive mAbs Mimicking the HLA-I Polyreactivity and Immunoregulatory Functions of IVIg

Authors: Mepur H Ravindranath, Fatiha El Hilali, Edward J Filippone

Journal: Vaccines (Basel)

PubMed ID: 34205517

Doi: 10.3390/vaccines9060680

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Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1 and BCR-ABL1

Authors: Afsar Ali Mian, Isabella Haberbosch, Hazem Khamaisie, Abed Agbarya, Larissa Pietsch, Elizabeh Eshel, Dally Najib, Claudia Chiriches, Oliver Gerhard Ottmann, Oliver Hantschel, Ricardo M Biondi, Martin Ruthardt, Jamal Mahajna

Journal: Ann Hematol

PubMed ID: 34110462

Doi: 10.1007/s00277-020-04357-z

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Type II alveolar cell MHCII improves respiratory viral disease outcomes while exhibiting limited antigen presentation

Authors: Sushila A Toulmin, Chaitali Bhadiadra, Andrew J Paris, Jeffrey H Lin, Jeremy Katzen, Maria C Basil, Edward E Morrisey, G Scott Worthen, Laurence C Eisenlohr

Journal: Nat Commun

PubMed ID: 34183650

Doi: 10.1038/s41467-021-23619-6

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IgE-activated mast cells enhance TLR4-mediated antigen-specific CD4 T cell responses

Authors: Binh L Phong, Shaina J D'Souza, Robin L Baudier, Eric Wu, Victoria E Immethun, David L Bauer, James B McLachlan

Journal: Sci Rep

PubMed ID: 33958642

Doi: 10.1038/s41598-021-88956-4

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Minimally invasive brain injections for viral-mediated transgenesis: New tools for behavioral genetics in sticklebacks

Authors: Noelle James, Alison Bell

Journal: PLoS ONE

PubMed ID: 33999965

Doi: 10.1371/journal.pone.0251653

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A vaccine inducing solely cytotoxic T lymphocytes fully prevents Zika virus infection and fetal damage

Authors: Frank Gambino, Wanbo Tai, Denis Voronin, Yi Zhang, Xiujuan Zhang, Juan Shi, Xinyi Wang, Ning Wang, Lanying Du, Liang Qiao

Journal: Cell Rep

PubMed ID: 33979612

Doi: 10.1016/j.celrep.2021.109107

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S-acylation of P2K1 mediates extracellular ATP-induced immune signaling in Arabidopsis

Authors: Dongqin Chen, Fengsheng Hao, Huiqi Mu, Nagib Ahsan, Jay J Thelen, Gary Stacey

Journal: Nat Commun

PubMed ID: 33980819

Doi: 10.1038/s41467-021-22854-1

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Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency

Authors: Seula Shin, Hao Zhou, Chenxi He, Yanjun Wei, Yunfei Wang, Takashi Shingu, Ailiang Zeng, Shaobo Wang, Xin Zhou, Hongtao Li, Qiang Zhang, Qinling Mo, Jiafu Long, Fei Lan, Yiwen Chen, Jian Hu

Journal: Nat Commun

PubMed ID: 34021134

Doi: 10.1038/s41467-021-22782-0

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Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis

Authors: Xin Zhou, Seula Shin, Chenxi He, Qiang Zhang, Matthew N Rasband, Jiangong Ren, Congxin Dai, Rocío I Zorrilla-Veloz, Takashi Shingu, Liang Yuan, Yunfei Wang, Yiwen Chen, Fei Lan, Jian Hu

Journal: Elife

PubMed ID: 33942715

Doi: 10.7554/eLife.60467

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The human tRNA-guanine transglycosylase displays promiscuous nucleobase preference but strict tRNA specificity

Authors: Claire Fergus, Mashael Al-Qasem, Michelle Cotter, Ciara M McDonnell, Emiliano Sorrentino, Franciane Chevot, Karsten Hokamp, Mathias O Senge, John M Southern, Stephen J Connon, Vincent P Kelly

Journal: Nucleic Acids Res

PubMed ID: 34009357

Doi: 10.1093/nar/gkab289

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