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The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι

Authors: Yiwen Zhang, Yingshi Chen, Yuzhuang Li, Feng Huang, Baohong Luo, Yaochang Yuan, Baijin Xia, Xiancai Ma, Tao Yang, Fei Yu, Jun Liu, Bingfeng Liu, Zheng Song, Jingliang Chen, Shumei Yan, Liyang Wu, Ting Pan, Xu Zhang, Rong Li, Wenjing Huang, Xin He, Fei Xiao, Junsong Zhang, Hui Zhang

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34021074

Doi: 10.1073/pnas.2024202118

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A stealth antigen SPESP1, which is epigenetically silenced in tumors, is a suitable target for cancer immunotherapy

Authors: Akemi Kosaka, Yuki Yajima, Mayumi Hatayama, Katsuya Ikuta, Takaaki Sasaki, Noriko Hirai, Syunsuke Yasuda, Marino Nagata, Ryusuke Hayashi, Shohei Harabuchi, Kenzo Ohara, Mizuho Ohara, Takumi Kumai, Kei Ishibashi, Yui Hirata-Nozaki, Toshihiro Nagato, Kensuke Oikawa, Yasuaki Harabuchi, Esteban Celis, Toshikatsu Okumura, Yoshinobu Ohsaki, Hiroya Kobayashi, Takayuki Ohkuri

Journal: Cancer Sci

PubMed ID: 34009705

Doi: 10.1111/cas.14973

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Targeted Radionuclide Therapy Using Auger Electron Emitters: The Quest for the Right Vector and the Right Radionuclide

Authors: Malick Bio Idrissou, Alexandre Pichard, Bryan Tee, Tibor Kibedi, Sophie Poty, Jean-Pierre Pouget

Journal: Pharmaceutics

PubMed ID: 34209637

Doi: 10.3390/pharmaceutics13070980

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Contingency and chance erase necessity in the experimental evolution of ancestral proteins

Authors: Victoria Cochran Xie, Jinyue Pu, Brian Ph Metzger, Joseph W Thornton, Bryan C Dickinson

Journal: Elife

PubMed ID: 34061027

Doi: 10.7554/eLife.67336

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Order and disorder-An integrative structure of the full-length human growth hormone receptor

Authors: Noah Kassem, Raul Araya-Secchi, Katrine Bugge, Abigail Barclay, Helena Steinocher, Adree Khondker, Yong Wang, Aneta J Lenard, Jochen Bürck, Cagla Sahin, Anne S Ulrich, Michael Landreh, Martin Cramer Pedersen, Maikel C Rheinstädter, Per Amstrup Pedersen, Kresten Lindorff-Larsen, Lise Arleth, Birthe B Kragelund

Journal: Sci Adv

PubMed ID: 34193419

Doi: 10.1126/sciadv.abh3805

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Atherosclerosis-associated hepatic secretion of VLDL but not PCSK9 is dependent on cargo receptor protein Surf4

Authors: Bingxiang Wang, Yishi Shen, Lei Zhai, Xiaodan Xia, Hong-Mei Gu, Maggie Wang, Yongfang Zhao, Xiaole Chang, Adekunle Alabi, Sijie Xing, Shijun Deng, Boyan Liu, Guiqing Wang, Shucun Qin, Da-Wei Zhang

Journal: J Lipid Res

PubMed ID: 34118252

Doi: 10.1016/j.jlr.2021.100091

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A newly identified linear epitope on non-RBD region of SARS-CoV-2 spike protein improves the serological detection rate of COVID-19 patients

Authors: Yunwen Zhang, Zhengrong Yang, Sicheng Tian, Baisheng Li, Tiejian Feng, Jianfan He, Min Jiang, Xiujuan Tang, Shujiang Mei, Hao Li, Yifan Zhong, Guilian Li, Mingyuan Tang, Sijing Liu, Tian Tang, Chuan Wang, Xiaohui Wang

Journal: BMC Microbiol

PubMed ID: 34174835

Doi: 10.1186/s12866-021-02241-y

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Therapeutic Potential of HLA-I Polyreactive mAbs Mimicking the HLA-I Polyreactivity and Immunoregulatory Functions of IVIg

Authors: Mepur H Ravindranath, Fatiha El Hilali, Edward J Filippone

Journal: Vaccines (Basel)

PubMed ID: 34205517

Doi: 10.3390/vaccines9060680

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Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1 and BCR-ABL1

Authors: Afsar Ali Mian, Isabella Haberbosch, Hazem Khamaisie, Abed Agbarya, Larissa Pietsch, Elizabeh Eshel, Dally Najib, Claudia Chiriches, Oliver Gerhard Ottmann, Oliver Hantschel, Ricardo M Biondi, Martin Ruthardt, Jamal Mahajna

Journal: Ann Hematol

PubMed ID: 34110462

Doi: 10.1007/s00277-020-04357-z

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Type II alveolar cell MHCII improves respiratory viral disease outcomes while exhibiting limited antigen presentation

Authors: Sushila A Toulmin, Chaitali Bhadiadra, Andrew J Paris, Jeffrey H Lin, Jeremy Katzen, Maria C Basil, Edward E Morrisey, G Scott Worthen, Laurence C Eisenlohr

Journal: Nat Commun

PubMed ID: 34183650

Doi: 10.1038/s41467-021-23619-6

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