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Low-dose 2-deoxy glucose stabilises tolerogenic dendritic cells and generates potent in vivo immunosuppressive effects
Authors: Christofi M, Le Sommer S, Mölzer C, Klaska IP, Kuffova L, Forrester JV
Journal: Cellular and molecular life sciences : CMLS
PubMed ID: 33074350
Doi: 10.1007/s00018-020-03672-y
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X-box binding protein 1-mediated COL4A1s secretion regulates communication between vascular smooth muscle and stem/progenitor cells
Authors: Angshumonik Angbohang, Lei Huang, Yi Li, Yue Zhao, Yijie Gong, Yi Fu, Chenfeng Mao, Jose Morales, Peiyi Luo, Mazdak Ehteramyan, Yingtang Gao, Andriana Margariti, Wenduo Gu, Min Zhang, Alberto Smith, Ajay M Shah, Tong Li, Wei Kong, Lingfang Zeng
Journal: J Biol Chem
PubMed ID: 33722606
Doi: 10.1016/j.jbc.2021.100541
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Adult astrocytes from reptiles are resistant to proinflammatory activation via sustaining Vav1 expression
Authors: Nan Du, Hui Li, Chunshuai Sun, Bingqiang He, Ting Yang, Honghua Song, Yingjie Wang, Yongjun Wang
Journal: J Biol Chem
PubMed ID: 33705794
Doi: 10.1016/j.jbc.2021.100527
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Design of Alphavirus Virus-Like Particles Presenting Circumsporozoite Junctional Epitopes That Elicit Protection against Malaria
Authors: Joseph R Francica, Wei Shi, Gwo-Yu Chuang, Steven J Chen, Lais Da Silva Pereira, S Katie Farney, Barbara J Flynn, Li Ou, Tyler Stephens, Yaroslav Tsybovsky, Lawrence T Wang, Alexander Anderson, Zoltan Beck, Marlon Dillon, Azza H Idris, Nicholas Hurlburt, Tracy Liu, Baoshan Zhang, Carl R Alving, Gary R Matyas, Marie Pancera, John R Mascola, Peter D Kwong, Robert A Seder
Journal: Vaccines (Basel)
PubMed ID: 33803622
Doi: 10.3390/vaccines9030272
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The Crystal Structure of Calmodulin Bound to the Cardiac Ryanodine Receptor (RyR2) at Residues Phe4246-Val4271 Reveals a Fifth Calcium Binding Site
Authors: Qinhong Yu, David E Anderson, Ramanjeet Kaur, Andrew J Fisher, James B Ames
Journal: Biochemistry
PubMed ID: 33754699
Doi: 10.1021/acs.biochem.1c00152
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Soluble Spike DNA Vaccine Provides Long-Term Protective Immunity against SARS-CoV-2 in Mice and Nonhuman Primates
Authors: Yong Bok Seo, You Suk Suh, Ji In Ryu, Hwanhee Jang, Hanseul Oh, Bon-Sang Koo, Sang-Hwan Seo, Jung Joo Hong, Manki Song, Sung-Joo Kim, Young Chul Sung
Journal: Vaccines (Basel)
PubMed ID: 33804981
Doi: 10.3390/vaccines9040307
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RGS12 is a novel tumor suppressor in osteosarcoma that inhibits YAP-TEAD1-Ezrin signaling
Authors: Yang Li, Min Liu, Shuting Yang, Ashley M Fuller, T S Karin Eisinger-Mathason, Shuying Yang
Journal: Oncogene
PubMed ID: 33686240
Doi: 10.1038/s41388-020-01599-z
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Functional elucidation of TfuA in peptide backbone thioamidation
Authors: Andi Liu, Yuanyuan Si, Shi-Hui Dong, Nilkamal Mahanta, Haley N Penkala, Satish K Nair, Douglas A Mitchell
Journal: Nat Chem Biol
PubMed ID: 33707784
Doi: 10.1038/s41589-021-00771-0
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Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling
Authors: Ross A Robinson, Samuel C Griffiths, Lieke L van de Haar, Tomas Malinauskas, Eljo Y van Battum, Pavol Zelina, Rebekka A Schwab, Dimple Karia, Lina Malinauskaite, Sara Brignani, Marleen H van den Munkhof, Özge Düdükcü, Anna A De Ruiter, Dianne M A Van den Heuvel, Benjamin Bishop, Jonathan Elegheert, A Radu Aricescu, R Jeroen Pasterkamp, Christian Siebold
Journal: Cell
PubMed ID: 33740419
Doi: 10.1016/j.cell.2021.02.045
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Y06014 is a selective BET inhibitor for the treatment of prostate cancer
Authors: Tian-Bang Wu, Qiu-Ping Xiang, Chao Wang, Chun Wu, Cheng Zhang, Mao-Feng Zhang, Zhao-Xuan Liu, Yan Zhang, Lin-Jiu Xiao, Yong Xu
Journal: Acta Pharmacol Sin
PubMed ID: 33654218
Doi: 10.1038/s41401-021-00614-7
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