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Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities
Authors: Nakamura-Bencomo S, Gutierrez DA, Robles-Escajeda E, Iglesias-Figueroa B, Siqueiros-Cendón TS, Espinoza-Sánchez EA, Arévalo-Gallegos S, Aguilera RJ, Rascón-Cruz Q, Varela-Ramirez A
Journal: Investigational new drugs
PubMed ID: 33063290
Doi: 10.1007/s10637-020-01020-2
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Natural killer cell receptors regulate responses of HLA-E-restricted T cells
Authors: Lucy C Sullivan, Thi H O Nguyen, Christopher M Harpur, Sanda Stankovic, Abbie R Kanagarajah, Marios Koutsakos, Philippa M Saunders, Zhangying Cai, James A Gray, Jacqueline M L Widjaja, Jie Lin, Gabriella Pietra, Maria Cristina Mingari, Lorenzo Moretta, Jerome Samir, Fabio Luciani, Glen P Westall, Karl J Malmberg, Katherine Kedzierska, Andrew G Brooks
Journal: Sci Immunol
PubMed ID: 33893172
Doi: 10.1126/sciimmunol.abe9057
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Ultrasound-responsive nutlin-loaded nanoparticles for combined chemotherapy and piezoelectric treatment of glioblastoma cells
Authors: Carlotta Pucci, Attilio Marino, Özlem Şen, Daniele De Pasquale, Martina Bartolucci, Nerea Iturrioz-Rodríguez, Nicoletta di Leo, Giuseppe de Vito, Doriana Debellis, Andrea Petretto, Gianni Ciofani
Journal: Acta Biomater
PubMed ID: 33894347
Doi: 10.1016/j.actbio.2021.04.005
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Structural basis for an exceptionally strong preference for asparagine residue at the S2 subsite of Stenotrophomonas maltophilia dipeptidyl peptidase 7
Authors: Akihiro Nakamura, Yoshiyuki Suzuki, Yasumitsu Sakamoto, Saori Roppongi, Chisato Kushibiki, Natsuri Yonezawa, Masato Takahashi, Yosuke Shida, Hiroaki Gouda, Takamasa Nonaka, Nobutada Tanaka, Wataru Ogasawara
Journal: Sci Rep
PubMed ID: 33846449
Doi: 10.1038/s41598-021-86965-x
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Reduced Nucleoprotein Availability Impairs Negative-Sense RNA Virus Replication and Promotes Host Recognition
Authors: Benjamin E Nilsson-Payant, Daniel Blanco-Melo, Skyler Uhl, Beatriz Escudero-Pérez, Silke Olschewski, Patricia Thibault, Maryline Panis, Maria Rosenthal, César Muñoz-Fontela, Benhur Lee, Benjamin R tenOever
Journal: J Virol
PubMed ID: 33568513
Doi: 10.1128/JVI.02274-20
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Synergistic Activation of Antitumor Immunity by a Particulate Therapeutic Vaccine
Authors: Junhua Mai, Zhaoqi Li, Xiaojun Xia, Jingxin Zhang, Jun Li, Haoran Liu, Jianliang Shen, Maricela Ramirez, Feng Li, Zheng Li, Kenji Yokoi, Xuewu Liu, Elizabeth A Mittendorf, Mauro Ferrari, Haifa Shen
Journal: Adv Sci (Weinh)
PubMed ID: 34194942
Doi: 10.1002/advs.202100166
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Myeloid-derived suppressor cells support remyelination in a murine model of multiple sclerosis by promoting oligodendrocyte precursor cell survival, proliferation, and differentiation
Authors: Melero-Jerez C,Fernández-Gómez B,Lebrón-Galán R,Ortega MC,Sánchez-de Lara I,Ojalvo AC,Clemente D,de Castro F
Journal: Glia
PubMed ID: 33217041
Doi: 10.1002/glia.23936
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Intradermal delivery of a synthetic DNA vaccine protects macaques from Middle East respiratory syndrome coronavirus
Authors: Ami Patel, Emma L Reuschel, Ziyang Xu, Faraz I Zaidi, Kevin Y Kim, Dana P Scott, Janess Mendoza, Stephanie Ramos, Regina Stoltz, Friederike Feldmann, Atsushi Okumura, Kimberly Meade-White, Elaine Haddock, Tina Thomas, Rebecca Rosenke, Jamie Lovaglio, Patrick W Hanley, Greg Saturday, Kar Muthumani, Heinz Feldmann, Laurent M Humeau, Kate E Broderick, David B Weiner
Journal: JCI Insight
PubMed ID: 33886507
Doi: 10.1172/jci.insight.146082
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H3K36 methylation reprograms gene expression to drive early gametocyte development in Plasmodium falciparum
Authors: Jessica Connacher, Gabrielle A Josling, Lindsey M Orchard, Janette Reader, Manuel Llinás, Lyn-Marié Birkholtz
Journal: Epigenetics Chromatin
PubMed ID: 33794978
Doi: 10.1186/s13072-021-00393-9
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Dynamic allostery controls the peptide sensitivity of the Ly49C natural killer receptor
Authors: Jiaqi Ma, Cory M Ayres, Lance M Hellman, Jason R Devlin, Brian M Baker
Journal: J Biol Chem
PubMed ID: 33891944
Doi: 10.1016/j.jbc.2021.100686
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