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Development of a biosensor based on a new marine luciferase fused to an affibody to assess Her2 expression in living cells

Authors: Laura Rodríguez de la Fuente, Irene Golán Cancela, Ánxela M Estévez-Salguero, Pablo Iglesias, José A Costoya

Journal: Anal Chim Acta

PubMed ID: 35934341

Doi: 10.1016/j.aca.2022.340084

Products & Services: PCR Cloning and Subcloning

Longitudinal profile of neutralizing and binding antibodies in vaccinated and convalescent COVID-19 cohorts by chemiluminescent immunoassays

Authors: Xiaowen Dou, Enyun Wang, Ruiwei Jiang, Min Li, Dan Xiong, Baoqing Sun, Xiuming Zhang

Journal: Immun Inflamm Dis

PubMed ID: 35634960

Doi: 10.1002/iid3.612

Pore-Forming Cardiotoxin VVA2 (Volvatoxin A2) Variant I82E/L86K Is an Atypical Duplex-Specific Nuclease

Authors: Jia-Qi Lu, Jia-Wen Shou, Ka-Ching Lo, Yun-Sang Tang, Wei-Wei Shi, Pang-Chui Shaw

Journal: Toxins (Basel)

PubMed ID: 35737053

Doi: 10.3390/toxins14060392

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An epitope-optimized human H3N2 influenza vaccine induces broadly protective immunity in mice and ferrets

Authors: Brianna L Bullard, Jennifer DeBeauchamp, Matthew J Pekarek, Erika Petro-Turnquist, Peter Vogel, Richard J Webby, Eric A Weaver

Journal: npj Vaccines

PubMed ID: 35739199

Doi: 10.1038/s41541-022-00492-y

Products & Services: Mammalian Expression

SpG and SpRY variants expand the CRISPR toolbox for genome editing in zebraﬁsh

Authors: Fang Liang, Yu Zhang, Lin Li, Yexin Yang, Ji-Feng Fei, Yanmei Liu, Wei Qin

Journal: Nat Commun

PubMed ID: 35701400

Doi: 10.1038/s41467-022-31034-8

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Structure−Function Analysis of a Quinone-Dependent Dehydrogenase Capable of Deoxynivalenol Detoxification

Authors: Hua Yang , Ruxue Yan , Yue Li , Zhaoxin Lu , Xiaomei Bie , Haizhen Zhao , Fengxia Lu , Meirong Chen

Journal: J Agric Food Chem

PubMed ID: 35613468

Doi: 10.1021/acs.jafc.2c01083

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Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx

Authors: Tae Gun Kang, Kee Woong Kwon, Kyungsoo Kim, Insuk Lee, Myeong Joon Kim, Sang-Jun Ha, Sung Jae Shin

Journal: Nat Commun

PubMed ID: 35672321

Doi: 10.1038/s41467-022-30914-3

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Recapitulating early human development with 8C-like cells

Authors: Xiu Yu, Shiqi Liang, Manqi Chen, Hanwen Yu, Ruiqi Li, Yuliang Qu, Xuhui Kong, Ruirui Guo, Rongyan Zheng, Zsuzsanna Izsvák, Chuanbo Sun, Mingzhu Yang, Jichang Wang

Journal: Cell Rep

PubMed ID: 35732112

Doi: 10.1016/j.celrep.2022.110994

Products & Services: Proteins, Expression, Isolation and Analysis

Insights Into the Effect of Rice Stripe Virus P2 on Rice Defense by Comparative Proteomic Analysis

Authors: Zihang Yang, Hehong Zhang, Xiaoxiang Tan, Zhongyan Wei, Caiyi Wen, Zongtao Sun, Bingjian Sun, Jianping Chen

Journal: Front Microbiol

PubMed ID: 35747367

Doi: 10.3389/fmicb.2022.897589

Products & Services: Gene Synthesis

Construction of a synthetic Saccharomyces cerevisiae pan-genome neo-chromosome

Authors: Dariusz R Kutyna, Cristobal A Onetto, Thomas C Williams, Hugh D Goold, Ian T Paulsen, Isak S Pretorius, Daniel L Johnson, Anthony R Borneman

Journal: Nat Commun

PubMed ID: 35750675

Doi: 10.1038/s41467-022-31305-4

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Investigation of Product Ions Generated by 193 nm Ultraviolet Photodissociation of Peptides and Proteins Containing Disulfide Bonds

Authors: Luis A Macias, Jennifer S Brodbelt

Journal: J Am Soc Mass Spectrom

PubMed ID: 35736955

Doi: 10.1021/jasms.2c00124

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Biochemical, structural, and functional studies reveal that MAB_4324c from Mycobacterium abscessus is an active tandem repeat N-acetyltransferase

Authors: Husam M A B Alsarraf, Kien Lam Ung, Matt D Johansen, Juliette Dimon, Vincent Olieric, Laurent Kremer, Mickaël Blaise

Journal: FEBS Lett

PubMed ID: 35470425

Doi: 10.1002/1873-3468.14360

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Structural analysis of LpqY, a substrate-binding protein from the SugABC transporter of Mycobacterium tuberculosis, provides insights into its trehalose specificity

Authors: Dipika Sharma, Mandeep Singh, Punit Kaur, Uddipan Das

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35775983

Doi: 10.1107/S2059798322005290

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Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors

Authors: Jiayue Su, Desheng Liu, Fan Yang, Mei-Qing Zuo, Chang Li, Meng-Qiu Dong, Shan Sun, Sen-Fang Sui

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35733257

Doi: 10.1073/pnas.2200158119

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Increased resistance of SARS-CoV-2 Lambda variant to antibody neutralization

Authors: Huimin Guo, Qing Fan, Shuo Song, Senlin Shen, Bing Zhou, Haiyan Wang, Lin Cheng, Xiangyang Ge, Bin Ju, Zheng Zhang

Journal: JOURNAL OF CLINICAL VIROLOGY

PubMed ID: 35461042

Doi: 10.1016/j.jcv.2022.105162

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Histidine Ligated Iron-Sulfur Peptides

Authors: Luca Valer, Daniele Rossetto, Taylor Parkkila, Lorenzo Sebastianelli, Graziano Guella, Amber L Hendricks, James A Cowan, Lingzi Sang, Sheref S Mansy

Journal: Chembiochem

PubMed ID: 35674331

Doi: 10.1002/cbic.202200202

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Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease

Authors: Nikhil Panicker, Tae-In Kam, Hu Wang, Stewart Neifert, Shih-Ching Chou, Manoj Kumar, Saurav Brahmachari, Aanishaa Jhaldiyal, Jared T Hinkle, Fatih Akkentli, Xiaobo Mao, Enquan Xu, Senthilkumar S Karuppagounder, Eric T Hsu, Sung-Ung Kang, Olga Pletnikova, Juan Troncoso, Valina L Dawson, Ted M Dawson

Journal: Neuron

PubMed ID: 35654037

Doi: 10.1016/j.neuron.2022.05.009

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Towards a general approach for tailoring the hydrophobic binding site of phenylalanine ammonia-lyases

Authors: Souad Diana Tork, Mădălina Elena Moisă, Lilla Cserepes, Alina Filip, Levente Csaba Nagy, Florin Dan Irimie, László Csaba Bencze

Journal: Sci Rep

PubMed ID: 35739148

Doi: 10.1038/s41598-022-14585-0

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The Effects of Qinghao-Kushen and Its Active Compounds on the Biological Characteristics of Liver Cancer Cells

Authors: Jingmin Ji, Zhiqin Zhang, Qing Peng, Liyuan Hao, Yinglin Guo, Yu Xue, Yiwei Liu, Caige Li, Xinli Shi

Journal: Evid Based Complement Alternat Med

PubMed ID: 35722140

Doi: 10.1155/2022/8763510

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Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes

Authors: Lucy C Walters, Daniel Rozbesky, Karl Harlos, Max Quastel, Hong Sun, Sebastian Springer, Robert P Rambo, Fiyaz Mohammed, E Yvonne Jones, Andrew J McMichael, Geraldine M Gillespie

Journal: Cell Rep

PubMed ID: 35705051

Doi: 10.1016/j.celrep.2022.110959

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Microfluidic T Cell Selection by Cellular Avidity

Authors: Julian F Ashby, Julien Schmidt, Neelima Kc, Armand Kurum, Caroline Koch, Alexandre Harari, Li Tang, Sam H Au

Journal: Adv Healthc Mater

PubMed ID: 35657072

Doi: 10.1002/adhm.202200169

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Successful Preservation of Native BCR::ABL1 in Chronic Myeloid Leukemia Primary Leukocytes Reveals a Reduced Kinase Activity

Authors: Christian Boni, Massimiliano Bonifacio, Marzia Vezzalini, Luigi Scaffidi, Luisa Tomasello, Laurie L Parker, Diego Boscarino, Dino Paladin, Mauro Krampera, Claudio Sorio

Journal: Front Oncol

PubMed ID: 35756686

Doi: 10.3389/fonc.2022.904510

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The Use of Endo-Cellulase and Endo-Xylanase for the Extraction of Apple Pectins as Factors Modifying Their Anticancer Properties and Affecting Their Synergy with the Active Form of Irinotecan

Authors: Jerzy Maksymowicz, Anna Palko-Łabuz, Beata Sobieszczańska, Mateusz Chmielarz, Mirosława Ferens-Sieczkowska, Magdalena Skonieczna, Agnieszka Wikiera, Olga Wesołowska, Kamila Środa-Pomianek

Journal: Pharmaceuticals (Basel)

PubMed ID: 35745651

Doi: 10.3390/ph15060732

Products & Services: Recombinant Proteins

Individual and Synergistic Anti-Coronavirus Activities of SOCS1/3 Antagonist and Interferon α1 Peptides

Authors: Chulbul M Ahmed, Tristan R Grams, David C Bloom, Howard M Johnson, Alfred S Lewin

Journal: Front Immunol

PubMed ID: 35799776

Doi: 10.3389/fimmu.2022.902956

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Comparative Characterization of Different Molecular Formats of Bispecific Antibodies Targeting EGFR and PD-L1

Authors: Nishant Mohan, Atul Agrawal, Yi Shen, Katie L Winarski, Yukinori Endo, Milos Dokmanovic, Deborah Schmiel, Jiwen Zheng, David S Rotstein, Lorraine C Pelosof, Wen Jin Wu

Journal: Pharmaceutics

PubMed ID: 35890277

Doi: 10.3390/pharmaceutics14071381

Products & Services: Plasmid DNA Preparation

SASH1 knockdown suppresses TRAF6 ubiquitination to regulate hemangioma progression by mediating EZH2 degradation

Authors: Xueyuan Yu, Nuonuo Cong, Xiangyu Liu, Rui Wang, Daxu Li

Journal: Exp Cell Res

PubMed ID: 35772492

Doi: 10.1016/j.yexcr.2022.113270

Products & Services: Proteins, Expression, Isolation and Analysis

Inhibition of histone acetyltransferase GCN5 by a transcription factor FgPacC controls fungal adaption to host-derived iron stress

Authors: Qin Gu, Yujie Wang, Xiaozhen Zhao, Bingqin Yuan, Mengxuan Zhang, Zheng Tan, Xinyue Zhang, Yun Chen, Huijun Wu, Yuming Luo, Nancy P Keller, Xuewen Gao, Zhonghua Ma

Journal: Nucleic Acids Res

PubMed ID: 35687128

Doi: 10.1093/nar/gkac498

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Immunogenicity of Varicella Zoster Virus DNA Vaccines Encoding Glycoprotein E and Immediate Early Protein 63 in Mice

Authors: Jie Liu, Junyang Lin, Linjun Cai, Jie Sun, Xue Ding, Cenrong Wang, Yanchun Wu, Xiaoling Gao, Weiheng Su, Chunlai Jiang

Journal: Viruses

PubMed ID: 35746685

Doi: 10.3390/v14061214

Products & Services: Mammalian Expression

LncRNA RAD51-AS1 Regulates Human Bone Marrow Mesenchymal Stem Cells via Interaction with YBX1 to Ameliorate Osteoporosis

Authors: Beichen Li, Jing Wang, Fangrong Xu, Qinjue Wang, Quan Liu, Guantong Wang, Dengshun Miao, Qiang Sun

Journal: Stem Cell Rev Rep

PubMed ID: 35727431

Doi: 10.1007/s12015-022-10408-x

Products & Services: Proteins, Expression, Isolation and Analysis

Investigating the specificity of endothelin-traps as a potential therapeutic tool for endothelin-1 related disorders

Authors: Arjun Jain, Kristof Bozovicar, Vidhi Mehrotra, Tomaz Bratkovic, Martin H Johnson, Ira Jha

Journal: World J Diabetes

PubMed ID: 35800412

Doi: 10.4239/wjd.v13.i6.434

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Arabidopsis HOPS subunit VPS41 carries out plant-specific roles in vacuolar transport and vegetative growth

Authors: Dong Jiang, Yilin He, Xiangui Zhou, Zhiran Cao, Lei Pang, Sheng Zhong, Liwen Jiang, Ruixi Li

Journal: Plant Physiol

PubMed ID: 35417008

Doi: 10.1093/plphys/kiac167

Products & Services: Proteins, Expression, Isolation and Analysis

A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine

Authors: Jeeva Subbiah, Judy Oh, Ki-Hye Kim, Chong-Hyun Shin, Bo Ryoung Park, Noopur Bhatnagar, Baik-Lin Seong, Bao-Zhong Wang, Sang-Moo Kang

Journal: npj Vaccines

PubMed ID: 35768475

Doi: 10.1038/s41541-022-00498-6

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Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses

Authors: Ghizlane Maarifi, Marie-France Martin, Abderezak Zebboudj, Aude Boulay, Pierre Nouaux, Juliette Fernandez, Justine Lagisquet, Dominique Garcin, Raphael Gaudin, Nathalie J Arhel, Sébastien Nisole

Journal: Cell Chem Biol

PubMed ID: 35728599

Doi: 10.1016/j.chembiol.2022.05.009

Products & Services: Recombinant Proteins

Sequence-specific H, C and N backbone NMR assignments for the N-terminal IgV-like domain (D1) and full extracellular region (D1D2) of PD-L1

Authors: Kayleigh Walker, Lorna C Waters, Geoff Kelly, Frederick W Muskett, Mark D Carr

Journal: Biomol NMR Assign

PubMed ID: 35675028

Doi: 10.1007/s12104-022-10092-5

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Rapid decline in vaccine-boosted neutralizing antibodies against SARS-CoV-2 Omicron variant

Authors: Kirsten E Lyke, Robert L Atmar, Clara Dominguez Islas, Christine M Posavad, Daniel Szydlo, Rahul Paul Chourdhury, Meagan E Deming, Amanda Eaton, Lisa A Jackson, Angela R Branche, Hana M El Sahly, Christina A Rostad, Judith M Martin, Christine Johnston, Richard E Rupp, Mark J Mulligan, Rebecca C Brady, Robert W Frenck, Martín Bäcker, Angelica C Kottkamp, Tara M Babu, Kumaravel Rajakumar, Srilatha Edupuganti, David Dobrzynski, Rhea N Coler, Janet I Archer, Sonja Crandon, Jillian A Zemanek, Elizabeth R Brown, Kathleen M Neuzil, David S Stephens, Diane J Post, Seema U Nayak, Mehul S Suthar, Paul C Roberts, John H Beigel, David C Montefiori

Journal: Cell Rep Med

PubMed ID: 35798000

Doi: 10.1016/j.xcrm.2022.100679

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Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-2

Authors: Maria Martinez-Molledo, Emmanuel Nji, Nicolas Reyes

Journal: Nat Struct Mol Biol

PubMed ID: 35710838

Doi: 10.1038/s41594-022-00786-8

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Allosteric Communication in the Multifunctional and Redox NQO1 Protein Studied by Cavity-Making Mutations

Authors: Juan Luis Pacheco-Garcia, Dmitry S Loginov, Ernesto Anoz-Carbonell, Pavla Vankova, Rogelio Palomino-Morales, Eduardo Salido, Petr Man, Milagros Medina, Athi N Naganathan, Angel L Pey

Journal: Antioxidants (Basel)

PubMed ID: 35740007

Doi: 10.3390/antiox11061110

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Pharmacological Modulation of Melanocortin 1 Receptor Signaling by Mrap Proteins in

Authors: Xiaolu Tai, Yaqun Zhang, Jindong Yao, Xuan Li, Jun Liu, Jiazhen Han, Jianjun Lyu, Gufa Lin, Chao Zhang

Journal: Front Endocrinol (Lausanne)

PubMed ID: 35795143

Doi: 10.3389/fendo.2022.892407

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Deletion of COM donor and acceptor domains and the interaction between modules in bacillomycin D produced by

Authors: Ziyan Lv, Wenjie Ma, Ping Zhang, Zhaoxin Lu, Libang Zhou, Fanqiang Meng, Zuwei Wang, Xiaomei Bie

Journal: Synth Syst Biotechnol

PubMed ID: 35782484

Doi: 10.1016/j.synbio.2022.05.007

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Altered gut microbiota and metabolites profile are associated with reduced bone metabolism in ethanol-induced osteoporosis

Authors: Zhao Liu, Xilin Xu, Yiwei Shen, Yuanyuan Hao, Wenwen Cui, Wenyan Li, Xin Zhang, Hang Lv, Xiaodong Li, Yunlong Hou, Xiaofeng Zhang

Journal: Cell Prolif

PubMed ID: 35688648

Doi: 10.1111/cpr.13245

Products & Services: Proteins, Expression, Isolation and Analysis

Pre-existing immunity modulates responses to mRNA boosters

Authors: Tanushree Dangi, Sarah Sanchez, Min Han Lew, Lavanya Visvabharathy, Justin Richner, Igor J Koralnik, Pablo Penaloza-MacMaster

Journal: biorxiv

PubMed ID: 35794898

Doi: 10.1101/2022.06.27.497248

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mRNA Booster Vaccination Enhances Antibody Responses against SARS-CoV2 Omicron Variant in Individuals Primed with mRNA or Inactivated Virus Vaccines

Authors: Biyan Zhang, Jianxin Huo, Yuhan Huang, Shuan Yong Teo, Kaibo Duan, Yanfeng Li, Lim Kai Toh, Kong Peng Lam, Shengli Xu

Journal: Vaccines (Basel)

PubMed ID: 35891221

Doi: 10.3390/vaccines10071057

RNA Polymerase II Transcription in : TFIIB from Can Replace the Transcriptional Functions of Fission Yeast TFIIB In Vivo and In Vitro

Authors: Diego A Rojas, Fabiola Urbina, Aldo Solari, Edio Maldonado

Journal: Int J Mol Sci

PubMed ID: 35743306

Doi: 10.3390/ijms23126865

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Dynamic transcriptome profiling reveals essential roles of the receptor tyrosine kinases (RTK) family in feather development of duck

Authors: H Liu, Q Xu, Y Xi, S Ma, J Wang, L Bai, C Han, H He, L Li

Journal: Br Poult Sci

PubMed ID: 35383522

Doi: 10.1080/00071668.2022.2061839

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Immunological characteristics of MAV/06 strain of varicella-zoster virus vaccine in an animal model

Authors: Duckhyang Shin, Younchul Shin, Eunmi Kim, Hyojung Nam, Haiyan Nan, Jaewoo Lee

Journal: BMC Immunol

PubMed ID: 35658899

Doi: 10.1186/s12865-022-00503-6

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The optimal docking strength for reversibly tethered kinases

Authors: Mateusz Dyla, Nicolás S González Foutel, Daniel E Otzen, Magnus Kjaergaard

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35696590

Doi: 10.1073/pnas.2203098119

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Preclinical study of formulated recombinant nucleocapsid protein, the receptor binding domain of the spike protein, and truncated spike (S1) protein as vaccine candidates against COVID-19 in animal models

Authors: Shahram Nazarian, Gholamreza Olad, Raziyeh Abdolhamidi, Mohammad Javad Motamedi, Rouhollah Kazemi, Emad Kordbacheh, Alireza Felagari, Hanieh Olad, Ali Ahmadi, Alireza Bahiraee, Parisa Farahani, Leila Haghighi, Faezeh Hassani, Vahideh Hajhassan, Mona Nadi, Abdolkarim Sheikhi, Jafar Salimian, Jafar Amani

Journal: Mol Immunol

PubMed ID: 35802999

Doi: 10.1016/j.molimm.2022.06.007

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Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells

Authors: Daniel A Michelson, Koji Hase, Tsuneyasu Kaisho, Christophe Benoist, Diane Mathis

Journal: Cell

PubMed ID: 35714609

Doi: 10.1016/j.cell.2022.05.018

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Novel Mutations Associated With Epilepsy and Impacts on Neuronal Excitability

Authors: Changning Xie, Fangyun Liu, Hailan He, Fang He, Leilei Mao, Xiaole Wang, Fei Yin, Jing Peng

Journal: Front Mol Neurosci

PubMed ID: 35845605

Doi: 10.3389/fnmol.2022.870182

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Betaine Alleviates High-Fat Diet-Induced Disruptionof Hepatic Lipid and Iron Homeostasis in Mice

Authors: Yanlin Li, Wenduo Jiang, Yue Feng, Lei Wu, Yimin Jia, Ruqian Zhao

Journal: Int J Mol Sci

PubMed ID: 35682942

Doi: 10.3390/ijms23116263

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