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Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in inadvertently vaccinated healthy children

Authors: Eder Gatti Fernandes, Giselle Ibette Silva López-Lopes, Valeria Oliveira Silva, Rosemeire Yamashiro, Karen Cristina Rolim Madureira, Juliana Failde Gallo, José Angelo Lindoso, Helena Keico Sato, Núbia Virginia D'Avila Limeira de Araujo, Maria Ligia Bacciotte Ramos Nerger, Luis Fernando Macedo Brigido

Journal: Rev Inst Med Trop Sao Paulo

PubMed ID: 34878041

Doi: 10.1590/S1678-9946202163083

Products & Services: Protein Reagents and Products

Inhibition of micro RNA miR-122-5p prevents lipopolysaccharide-induced myocardial injury by inhibiting oxidative stress, inflammation and apoptosis via targeting GIT1

Authors: Wenliang Song, Tiening Zhang, Ni Yang, Tao Zhang, Ri Wen, Chunfeng Liu

Journal: Bioengineered

PubMed ID: 34002676

Doi: 10.1080/21655979.2021.1926201

Products & Services: Mutagenesis Services

Association between physical activity and immunogenicity of an inactivated virus vaccine against SARS-CoV-2 in patients with autoimmune rheumatic diseases

Authors: Bruno Gualano, Italo Ribeiro Lemes, Rafael Pires da Silva, Ana J Pinto, Bruna C Mazzolani, Fabiana I Smaira, Sofia M Sieczkowska, Nadia E Aikawa, Sandra G Pasoto, Ana C Medeiros-Ribeiro, Carla G S Saad, Emily F N Yuk, Clovis A Silva, Paul Swinton, Pedro C Hallal, Hamilton Roschel, Eloisa Bonfa

Journal: Brain Behav Immun

PubMed ID: 34954325

Doi: 10.1016/j.bbi.2021.12.016

Products & Services: Protein Reagents and Products

ATP2, The essential P4-ATPase of malaria parasites, catalyzes lipid-stimulated ATP hydrolysis in complex with a Cdc50 β-subunit

Authors: Anaïs Lamy, Ewerton Macarini-Bruzaferro, Thibaud Dieudonné, Alex Perálvarez-Marín, Guillaume Lenoir, Cédric Montigny, Marc le Maire, José Luis Vázquez-Ibar

Journal: Emerg Microbes Infect

PubMed ID: 33372863

Doi: 10.1080/22221751.2020.1870413

Products & Services: Recombinant Proteins

Antibody response to second dose of the BNT162b2 mRNA vaccine in the first 12 weeks in South Korea: A prospective longitudinal study

Authors: Hyun Jin Kim, Heon Jeong Yun, Jungok Kim, Sungmin Kym, Qute Choi

Journal: Vaccine

PubMed ID: 34953606

Doi: 10.1016/j.vaccine.2021.12.012

Products & Services: Protein Reagents and Products

Mucosal immune response in BNT162b2 COVID-19 vaccine recipients

Authors: Lorenzo Azzi, Daniela Dalla Gasperina, Giovanni Veronesi, Mariam Shallak, Giuseppe Ietto, Domenico Iovino, Andreina Baj, Francesco Gianfagna, Vittorio Maurino, Daniele Focosi, Fabrizio Maggi, Marco Mario Ferrario, Francesco Dentali, Giulio Carcano, Angelo Tagliabue, Lorenzo Stefano Maffioli, Roberto Sergio Accolla, Greta Forlani

Journal: EBioMedicine

PubMed ID: 34954658

Doi: 10.1016/j.ebiom.2021.103788

Products & Services: Protein Reagents and Products

Efficient discovery of potential inhibitors for SARS-CoV-2 3C-like protease from herbal extracts using a native MS-based affinity-selection method

Authors: Dafu Zhu, Haixia Su, Changqiang Ke, Chunping Tang, Matthias Witt, Ronald J Quinn, Yechun Xu, Jia Liu, Yang Ye

Journal: J Pharm Biomed Anal

PubMed ID: 34929567

Doi: 10.1016/j.jpba.2021.114538

Products & Services: Protein Reagents and Products

Gene-specific quantification of nascent transcription following targeted degradation of endogenous proteins in cultured cells

Authors: Alissa D Guarnaccia, April M Weissmiller, William P Tansey

Journal: STAR Protoc

PubMed ID: 34917979

Doi: 10.1016/j.xpro.2021.101000

Products & Services: Codon Optimization

Identification and validation of potential mRNA- microRNA- long-noncoding RNA (mRNA-miRNA-lncRNA) prognostic signature for cervical cancer

Authors: Jie Wang, Chen Zhang

Journal: Bioengineered

PubMed ID: 33682613

Doi: 10.1080/21655979.2021.1890377

Products & Services: Polyclonal Antibody Services

Generation and utility of a single-chain fragment variable monoclonal antibody platform against a baculovirus expressed recombinant receptor binding domain of SARS-CoV-2 spike protein

Authors: Reda Salem, Alaa A El-Kholy, Fatma R Waly, Dalia Ayman, Aya Sakr, Mai Hussein

Journal: Mol Immunol

PubMed ID: 34915268

Doi: 10.1016/j.molimm.2021.12.006

Products & Services: Codon Optimization

Deep mutational scanning for therapeutic antibody engineering

Authors: Kyrin R Hanning, Mason Minot, Annmaree K Warrender, William Kelton, Sai T Reddy

Journal: Trends Pharmacol Sci

PubMed ID: 34895944

Doi: 10.1016/j.tips.2021.11.010

Products & Services: Codon Optimization

Sequential dynamics of virological and serological changes in the serum of SARS-CoV-2 infected patients

Authors: Serge Ouoba, Mafumi Okimoto, Shintaro Nagashima, Yoshihiro Kitahara, Kei Miwata, Ko Ko, Bunthen E, Aya Sugiyama, Kazuaki Takahashi, Takemasa Sakaguchi, Toshiro Takafuta, Junko Tanaka

Journal: J Med Virol

PubMed ID: 34897741

Doi: 10.1002/jmv.27518

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A Pathogen-Inducible Rice NAC Transcription Factor ONAC096 Contributes to Immunity Against and pv by Direct Binding to the Promoters of , Magnaprothe oryzae, and Xanthomonas oryzaeoryzae OsRap26 OsWRKY62 OsPAL1

Authors: Hui Wang, Yan Bi, Yizhou Gao, Yuqing Yan, Xi Yuan, Xiaohui Xiong, Jiajing Wang, Jiayu Liang, Dayong Li, Fengming Song

Journal: Front Plant Sci

PubMed ID: 34956298

Doi: 10.3389/fpls.2021.802758

Products & Services: Catalog Peptides

Synergistic enzyme cocktail between levansucrase and inulosucrase for superb levan-type fructooligosaccharide synthesis

Authors: Karan Wangpaiboon, Methus Klaewkla, Thanapon Charoenwongpaiboon, Napas Vongkusolkit, Pawinee Panpetch, Kamontip Kuttiyawong, Wonnop Visessanguan, Rath Pichyangkura

Journal: Enzyme Microb Technol

PubMed ID: 34923315

Doi: 10.1016/j.enzmictec.2021.109960

Products & Services: Proteins, Expression, Isolation and Analysis

Gastrin producing syngeneic mesenchymal stem cells protect non-obese diabetic mice from type 1 diabetes

Authors: Marie-Claude Gaudreau, Radhika R Gudi, Gongbo Li, Benjamin M Johnson, Chenthamarakshan Vasu

Journal: Autoimmunity

PubMed ID: 34882054

Doi: 10.1080/08916934.2021.2012165

Products & Services: Gene Synthesis

Novel sequential immunocapture microflow LC/MS/MS approach to measuring PTH-Fc protein in human serum

Authors: Haixing Wang, Jiang Wu, Peng Pan, Thuy Nguyen, Michael Cwik, Ling Morgan

Journal: Bioanalysis

PubMed ID: 34894717

Doi: 10.4155/bio-2021-0233

Products & Services: Codon Optimization

Cryopreservation of network bioactivity and multi-lineage stromal cell differentiation potential within three-dimensional synthetic hydrogels

Authors:

Journal: Cryobiology

PubMed ID: 34922883

Doi: 10.1016/j.cryobiol.2021.12.003

Products & Services: Molecular Biology Reagents

Phosphodiesterase 8A Regulates CFTR Activity in Airway Epithelial Cells

Authors: Mark J Turner, Yukiko Sato, David Y Thomas, Kathy Abbott-Banner, John W Hanrahan

Journal: Cell Physiol Biochem

PubMed ID: 34936285

Doi: 10.33594/000000477

Products & Services: Proteins, Expression, Isolation and Analysis

Phosphodiesterase 8A Regulates CFTR Activity in Airway Epithelial Cells

Authors: Mark J Turner, Yukiko Sato, David Y Thomas, Kathy Abbott-Banner, John W Hanrahan

Journal: Cell Physiol Biochem

PubMed ID: 34936285

Doi: 10.33594/000000477

Products & Services: Proteins, Expression, Isolation and Analysis

Structural Insight into the Mechanism of PALB2 Interaction with MRG15

Authors: Jennifer Redington, Jaigeeth Deveryshetty, Lakshmi Kanikkannan, Ian Miller, Sergey Korolev

Journal: Genes (Basel)

PubMed ID: 34946951

Doi: 10.3390/genes12122002

Products & Services: Mutant Libraries

MiR-31 targets HSD17B14 and FSHR, and miR-20b targets HSD17B14 to affect apoptosis and steroid hormone metabolism of porcine ovarian granulosa cells

Authors: Siyuan Gao, Jing Zhao, Qinglei Xu, Yanli Guo, Mingzheng Liu, Chunlei Zhang, Allan P Schinckel, Bo Zhou

Journal: Theriogenology

PubMed ID: 34959084

Doi: 10.1016/j.theriogenology.2021.12.014

Products & Services: Proteins, Expression, Isolation and Analysis

COVID-19 mRNA booster vaccines elicit strong protection against SARS-CoV-2 Omicron variant in patients with cancer

Authors: Cong Zeng, John P Evans, Karthik Chakravarthy, Panke Qu, Sarah Reisinger, No-Joon Song, Mark P Rubinstein, Peter G Shields, Zihai Li, Shan-Lu Liu

Journal: Cancer Cell

PubMed ID: 34986328

Doi: 10.1016/j.ccell.2021.12.014

Products & Services: PCR Cloning and Subcloning

A metabolic labeling protocol to enrich myristoylated proteins from

Authors: Xin Gong, Yanwen Feng, Hongyun Tang

Journal: STAR Protoc

PubMed ID: 34917984

Doi: 10.1016/j.xpro.2021.101013

Products & Services: Proteins, Expression, Isolation and Analysis

BIX-01294 enhances the effect of chemotherapy on colorectal cancer by inhibiting the expression of stemness genes

Authors: Shikang Liu, Yihang Jiang, Hua Yang, Zhongke Hua, Yu Han, Cai Zhou, Shuling Xu, Shenglan Nie, Gaixia Xu, Xingsheng Shu, Xiaomei Wang

Journal: Biochem Biophys Res Commun

PubMed ID: 34979318

Doi: 10.1016/j.bbrc.2021.12.089

Products & Services: Recombinant Proteins

Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2

Authors: Lihong Liu, Sho Iketani, Yicheng Guo, Jasper F-W Chan, Maple Wang, Liyuan Liu, Yang Luo, Hin Chu, Yiming Huang, Manoj S Nair, Jian Yu, Kenn K-H Chik, Terrence T-T Yuen, Chaemin Yoon, Kelvin K-W To, Honglin Chen, Michael T Yin, Magdalena E Sobieszczyk, Yaoxing Huang, Harris H Wang, Zizhang Sheng, Kwok-Yung Yuen, David D Ho

Journal: Nature

PubMed ID: 35016198

Doi: 10.1038/s41586-021-04388-0

Products & Services: Catalog Antibody

Widely heterogeneous humoral and cellular immunity after mild SARS-CoV-2 infection in a homogeneous population of healthy young men

Authors: Nina Le Bert, Wan Ni Chia, Wei Yee Wan, Alvin Kuo Jing Teo, Samuel Zeng-Rong Chong, Nicole Tan, Doreen Soek Chin Tan, Adeline Chia, Iain Beehuat Tan, Kamini Kunasegaran, Qin Xuan Chua, Mohammad Yazid Abdad, Aven Shan Hua Ng, Shawn Vasoo, Julian Xiao-Li Ang, Mao Sheng Lee, Louisa Sun, Jinyan Fang, Feng Zhu, Alex R Cook, Tar Choon Aw, Jingxiang Huang, Clarence Tam, Fong Sin Lee, Hannah Clapham, Enan Jun-Kang Goh, Monica Socheata Suor Peou, Shiow Pin Tan, Siew Kim Ong, Lin-Fa Wang, Antonio Bertoletti, Li Yang Hsu, Biauw Chi Ong

Journal: Emerg Microbes Infect

PubMed ID: 34709140

Doi: 10.1080/22221751.2021.1999777

Safety evaluation of the mouse TCRα - transduced T cell product in preclinical models in vivo and in vitro

Authors: Anastasiia Kalinina, Alexandra Bruter, Nadezhda Persiyantseva, Yulia Silaeva, Maria Zamkova, Ludmila Khromykh, Dmitry Kazansky

Journal: Biomed Pharmacother

PubMed ID: 34915667

Doi: 10.1016/j.biopha.2021.112480

Products & Services: Molecular Biology Reagents

Nanopore-based measurement of the interaction of P450cam monooxygenase and putidaredoxin at the single-molecule level

Authors: Hui Chen, Yao Lin, Yi-Tao Long, Shelley D Minteer, Yi-Lun Ying

Journal: Faraday Discuss

PubMed ID: 34889330

Doi: 10.1039/d1fd00042j

Products & Services: Plasmid DNA Preparation

Functional Characterization of Spinocerebellar Ataxia Associated Dynorphin A Mutant Peptides

Authors: Andreas Lieb, Germana Thaler, Barbara Fogli, Olga Trovato, Mitja Amon Posch, Teresa Kaserer, Luca Zangrandi

Journal: Biomedicines

PubMed ID: 34944698

Doi: 10.3390/biomedicines9121882

Products & Services: Catalog Peptides

Modifications of IL-6 by Hypochlorous Acids: Effects on Receptor Binding

Authors: Lori I Robins, Erika K Keim, Deborah B Robins, John S Edgar, John S Meschke, Philip R Gafken, Jeffrey F Williams

Journal: ACS Omega

PubMed ID: 34984290

Doi: 10.1021/acsomega.1c05297

Products & Services: Gene Synthesis

Rapid kinetics of calcium dissociation from plant calmodulin and calmodulin-like proteins and effect of target peptides

Authors: Francesca Troilo, Marco Pedretti, Carlo Travaglini-Allocatelli, Alessandra Astegno, Adele Di Matteo

Journal: Biochem Biophys Res Commun

PubMed ID: 34974297

Doi: 10.1016/j.bbrc.2021.12.077

Products & Services: Peptide Synthesis

An engineered oncolytic vaccinia virus encoding a single-chain variable fragment against TIGIT induces effective antitumor immunity and synergizes with PD-1 or LAG-3 blockade

Authors: Shuguang Zuo, Min Wei, Tiancheng Xu, Lingkai Kong, Bohao He, Shiqun Wang, Shibing Wang, Junhua Wu, Jie Dong, Jiwu Wei

Journal: J Immunother Cancer

PubMed ID: 34949694

Doi: 10.1136/jitc-2021-002843

Products & Services: GenParts™ DNA Fragments

The impact of benzo[a]pyrene on murine allergic airway inflammation via epigenetic remodeling

Authors: Xihua Wang, Shuyuan Guan, Lingbin Sun, Zhongliang Dai

Journal: Environ Toxicol Pharmacol

PubMed ID: 34883242

Doi: 10.1016/j.etap.2021.103782

Products & Services: Proteins, Expression, Isolation and Analysis

Adenovirus-mediated RNA interference against herpes simplex virus infection in vitro

Authors: Lin Chen, Zhi-Qiang Pan, Chang-Bin Zhai

Journal: Folia Histochem Cytobiol

PubMed ID: 34905214

Doi: 10.5603/FHC.a2021.0031

Products & Services: GenParts™ DNA Fragments

A unique NLRC4 receptor from echinoderms mediates Vibrio phagocytosis via rearrangement of the cytoskeleton and polymerization of F-actin

Authors: Kaiyu Chen, Siyuan Zhang, Yina Shao, Ming Guo, Weiwei Zhang, Chenghua Li

Journal: PLoS Pathog

PubMed ID: 34898657

Doi: 10.1371/journal.ppat.1010145

Products & Services: Recombinant Antibody Expression

A unique NLRC4 receptor from echinoderms mediates Vibrio phagocytosis via rearrangement of the cytoskeleton and polymerization of F-actin

Authors: Kaiyu Chen, Siyuan Zhang, Yina Shao, Ming Guo, Weiwei Zhang, Chenghua Li

Journal: PLoS Pathog

PubMed ID: 34898657

Doi: 10.1371/journal.ppat.1010145

Products & Services: Recombinant Antibody Expression

Convergent phenotypic evolution of rhodopsin for dim-light sensing across deep-diving vertebrates

Authors: Yu Xia , Yimeng Cui , Aishan Wang , Fangnan Liu , Hai Chi , Joshua H T Potter , Joseph Williamson , Xiaolan Chen , Stephen J Rossiter , Yang Liu

Journal: Mol Biol Evol

PubMed ID: 34463769

Doi: 10.1093/molbev/msab262

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Comparison of SARS-CoV-2 Antibody Response 4 Weeks After Homologous vs Heterologous Third Vaccine Dose in Kidney Transplant Recipients: A Randomized Clinical Trial

Authors: Roman Reindl-Schwaighofer, Andreas Heinzel, Manuel Mayrdorfer, Rhea Jabbour, Thomas M Hofbauer, Anne Merrelaar, Michael Eder, Florina Regele, Konstantin Doberer, Paul Spechtl, Constantin Aschauer, Maximilian Koblischke, Christopher Paschen, Farsad Eskandary, Karin Hu, Barbara Öhler, Arshdeep Bhandal, Sabine Kleibenböck, Rahel I Jagoditsch, Bianca Reiskopf, Florian Heger, Gregor Bond, Georg A Böhmig, Robert Strassl, Lukas Weseslindtner, Alexander Indra, Judith H Aberle, Michael Binder, Rainer Oberbauer

Journal: JAMA Intern Med

PubMed ID: 34928302

Doi: 10.1001/jamainternmed.2021.7372

Products & Services: Protein Reagents and Products

Bio inspired growth factor loaded self assembling peptide nano hydrogel for chronic wound healing

Authors: E Santhini, R Parthasarathy, M Shalini, S Dhivya, L Amalorpava Mary, V Vijaya Padma

Journal: Int J Biol Macromol

PubMed ID: 34920072

Doi: 10.1016/j.ijbiomac.2021.12.026

Products & Services: Catalog Antibody

Induction of Th1 and Th2 in the protection against SARS-CoV-2 through mucosal delivery of an adenovirus vaccine expressing an engineered spike protein

Authors: Nai-Hsiang Chung, Ying-Chin Chen, Shiu-Ju Yang, Yu-Ching Lin, Horng-Yunn Dou, Lily Hui-Ching Wang, Ching-Len Liao, Yen-Hung Chow

Journal: Vaccine

PubMed ID: 34952759

Doi: 10.1016/j.vaccine.2021.12.024

Products & Services: Insect Expression

SARS-CoV-2 recombinant proteins stimulate distinct cellular and humoral immune response profiles in samples from COVID-19 convalescent patients

Authors: Laís Teodoro da Silva, Marina Mazzilli Ortega, Bruna Tiaki Tiyo, Isabelle Freire Tabosa Viana, Tayná Evily de Lima, Tania Regina Tozetto-Mendoza, Luanda Mara da Silva Oliveira, Franciane Mouradian Emidio Teixeira, Roberto Dias Lins, Alexandre de Almeida, Maria Cassia Mendes-Correa, Alberto Jose da Silva Duarte, Telma Miyuki Oshiro

Journal: Clinics (Sao Paulo)

PubMed ID: 34878034

Doi: 10.6061/clinics/2021/e3548

Products & Services: Protein Reagents and Products

Porcine Genome-Wide CRISPR Screen Identifies the Golgi Apparatus Complex Protein COG8 as a Pivotal Regulator of Influenza Virus Infection

Authors: Ao Zhou, Wenhua Zhang, Xia Dong, Bin Tang

Journal: CRISPR J

PubMed ID: 34935491

Doi: 10.1089/crispr.2021.0054

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Anisotropic Rod-Shaped Particles Influence Injectable Granular Hydrogel Properties and Cell Invasion

Authors: Taimoor H Qazi, Jingyu Wu, Victoria G Muir, Shoshana Weintraub, Sarah E Gullbrand, Daeyeon Lee, David Issadore, Jason A Burdick

Journal: Adv Mater

PubMed ID: 34932833

Doi: 10.1002/adma.202109194

Products & Services: Peptide Synthesis

Development of competitive and noncompetitive immunoassays for clothianidin with high sensitivity and specificity using phage-displayed peptides

Authors: Tianyang You, Yuan Ding, He Chen, Guangyue Song, Lianrun Huang, Minghua Wang, Xiude Hua

Journal: J Hazard Mater

PubMed ID: 34896720

Doi: 10.1016/j.jhazmat.2021.128011

Products & Services: Mutant Libraries

A New Testing Platform Using Fingerstick Blood for Quantitative Antibody Response Evaluation after SARS-CoV-2 Vaccination

Authors: Jinwei Du, Dayu Zhang, Joseph A Pathakamuri, Daniel Kuebler, Ying Yang, Yulia Loginova, Eric Chu, Roberta Madej, Jocelyn V Neves, Brianna Singer, Holly Radke, Naomi Spencer, Elizabeth Rizk, Aiguo Zhang, Chuanyi M Lu, Michael Y Sha

Journal: Emerg Microbes Infect

PubMed ID: 34951566

Doi: 10.1080/22221751.2021.2023328

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Rapid directed molecular evolution of fluorescent proteins in mammalian cells

Authors: Siranush Babakhanova, Erica E Jung, Kazuhiko Namikawa, Hanbin Zhang, Yangdong Wang, Oksana M Subach, Dmitry A Korzhenevskiy, Tatiana V Rakitina, Xian Xiao, Wenjing Wang, Jing Shi, Mikhail Drobizhev, Demian Park, Lea Eisenhard, Hongyun Tang, Reinhard W Köster, Fedor V Subach, Edward S Boyden, Kiryl D Piatkevich

Journal: Protein Sci

PubMed ID: 34913537

Doi: 10.1002/pro.4261

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pH Low Insertion Peptide-Modified Programmed Cell Death-Ligand 1 Potently Suppresses T-Cell Activation Under Acidic Condition

Authors: Ying Sun, Linhan Hu, Peng Yang, Min Zhang, Xinwei Wang, He Xiao, Chunxia Qiao, Jing Wang, Longlong Luo, Jiannan Feng, Yuanqiang Zheng, Yi Wang, Yanchun Shi, Guojiang Chen

Journal: Front Immunol

PubMed ID: 35003115

Doi: 10.3389/fimmu.2021.794226

Products & Services: Recombinant Antibody Expression

Construction, Investigation and Application of TEV Protease Variants with Improved Oxidative Stability

Authors: Enkhtuya Bayar, Yuanyuan Ren, Yinghua Chen, Yafang Hu, Shuncheng Zhang, Xuelian Yu, Jun Fan

Journal: J Microbiol Biotechnol

PubMed ID: 34528919

Doi: 10.4014/jmb.2106.06075

Products & Services: Plasmid DNA Preparation

Rhomboid-like Protein 5 Provided Partial Protection against Homologous Challenge in Forms of Recombinant Protein and DNA Plasmid in Chickens

Authors: Di Tian, Xiaoqian Liu, Xiangrui Li, Lixin Xu, Ruofeng Yan, Xiaokai Song

Journal: Vaccines (Basel)

PubMed ID: 35062693

Doi: 10.3390/vaccines10010032

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Selective suppression of IL-10 transcription by calcineurin in dendritic cells through inactivation of CREB

Authors: Xiuyuan Lu, Masatsugu Oh-Hora, Kiyoshi Takeda, Sho Yamasaki

Journal: Int Immunol

PubMed ID: 34953165

Doi: 10.1093/intimm/dxab112

Products & Services: Gene Synthesis

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