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LncRNA DUXAP10 Upregulation and the Hedgehog Pathway Activation Are Critically Involved in Chronic Cadmium Exposure-Induced Cancer Stem Cell-Like Property
Authors: Hsuan-Pei Lin, Zhishan Wang, Chengfeng Yang
Journal: Toxicol Sci
PubMed ID: 34373904
Doi: 10.1093/toxsci/kfab099
Products & Services: PCR Cloning and Subcloning   
Divergent degeneration of creA antitoxin genes from minimal CRISPRs and the convergent strategy of tRNA-sequestering CreT toxins
Authors: Feiyue Cheng, Rui Wang, Haiying Yu, Chao Liu, Jun Yang, Hua Xiang, Ming Li
Journal: Nucleic Acids Res
PubMed ID: 34551428
Doi: 10.1093/nar/gkab821
Products & Services: PCR and Cloning   
The Formation of Melanocyte Apoptotic Bodies in Vitiligo and the Relocation of Vitiligo Autoantigens under Oxidative Stress
Authors: Jun Tian, Yaojun Wang, Ming Ding, Yue Zhang, Jiaoni Chi, Tao Wang, Bin Jiao, Zhe Jian, Xiuli Yi, Ye Huang, Ling Liu, Kai Li, Jiaxi Chen, Gang Wang, Tianwen Gao, Chunying Li, Qiang Li
Journal: Oxid Med Cell Longev
PubMed ID: 34745423
Doi: 10.1155/2021/7617839
Products & Services: Nucleic Acid Purification & Analysis   
Loss of Function Glucose-Dependent Insulinotropic Polypeptide Receptor Variants Are Associated With Alterations in BMI, Bone Strength and Cardiovascular Outcomes
Authors: Hüsün Sheyma Kizilkaya, Kimmie Vestergaard Sørensen, Camilla J Kibsgaard, Laerke Smidt Gasbjerg, Alexander S Hauser, Alexander Hovard Sparre-Ulrich, Niels Grarup, Mette M Rosenkilde
Journal: Front Cell Dev Biol
PubMed ID: 34760890
Doi: 10.3389/fcell.2021.749607
Products & Services: Mutant Libraries   
Turnover of diacylglycerol kinase 4 by cytoplasmic acidification induces vacuole morphological change and nuclear DNA degradation in the early stage of pear self-incompatibility response
Authors: Xiao-Xiong Kong, Jia-Wei Mei, Jing Zhang, Xiao Liu, Ju-You Wu, Chun-Lei Wang
Journal: J Integr Plant Biol
PubMed ID: 34655280
Doi: 10.1111/jipb.13180
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Genome-wide analysis of the maize superoxide dismutase (SOD) gene family reveals important roles in drought and salt responses
Authors: Jing Liu, Lijuan Xu, Jian Shang, Xiaolin Hu, Haitao Yu, Hongying Wu, Wenben Lv, Yang Zhao
Journal: Genet Mol Biol
PubMed ID: 34606562
Doi: 10.1590/1678-4685-GMB-2021-0035
Products & Services: Molecular Biology Tools   
Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension
Authors: Su-Jeong Kim, Anjali Devgan, Brendan Miller, Sam Mool Lee, Hiroshi Kumagai, Kenneth A Wilson, Gabriella Wassef, Richard Wong, Hemal H Mehta, Pinchas Cohen, Kelvin Yen
Journal: Biochim Biophys Acta Gen Subj
PubMed ID: 34624450
Doi: 10.1016/j.bbagen.2021.130017
Products & Services: Mammalian Expression   
Signal inhibitory receptor on leukocytes-1 recognizes bacterial and endogenous amphipathic α-helical peptides
Authors: Matevž Rumpret, Helen J von Richthofen, Maarten van der Linden, Geertje H A Westerlaken, Cami Talavera Ormeño, Jos A G van Strijp, Meytal Landau, Huib Ovaa, Nina M van Sorge, Linde Meyaard
Journal: FASEB J
PubMed ID: 34533845
Doi: 10.1096/fj.202100812R
Products & Services: Mammalian Expression   
fucosylation of CPN20 by SPINDLY Derepresses Abscisic Acid Signaling During Seed Germination and Seedling Development
Authors: Lin Liang, Qi Wang, Zihao Song, Yaxin Wu, Qing Liang, Qingsong Wang, Jinli Yang, Ying Bi, Wen Zhou, Liu-Min Fan
Journal: Front Plant Sci
PubMed ID: 34712252
Doi: 10.3389/fpls.2021.724144
Products & Services: Mammalian Expression   
A glutamate concentration-biased allosteric modulator potentiates NMDA-induced ion influx in neurons
Authors: Blaise M Costa, Lina Cortés Kwapisz, Brittney Mehrkens, Douglas N Bledsoe, Bryanna N Vacca, Tullia V Johnston, Rehan Razzaq, Dhanasekaran Manickam, Bradley G Klein
Journal: Pharmacol Res Perspect
PubMed ID: 34476911
Doi: 10.1002/prp2.859
Products & Services: Mammalian Expression   
Optimal flexibility of the linker region of Zika virus NS5 methyltransferase-polymerase is critical for virus replication
Authors: Charlotte Flory, Kitti Wing Ki Chan, Amanda Makha Bifani, Milly Ming Ju Choy, Julien Lescar, Eng Eong Ooi, Norbert Tautz, Subhash G Vasudevan
Journal: Antiviral Res
PubMed ID: 34699863
Doi: 10.1016/j.antiviral.2021.105194
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The function of twister ribozyme variants in non-LTR retrotransposition in Schistosoma mansoni
Authors: Getong Liu, Hengyi Jiang, Wenxia Sun, Jun Zhang, Dongrong Chen, Alastair I H Murchie
Journal: Nucleic Acids Res
PubMed ID: 34551436
Doi: 10.1093/nar/gkab818
Products & Services: GenParts™ DNA Fragments   
Enhanced prime editing systems by manipulating cellular determinants of editing outcomes
Authors: Peter J Chen, Jeffrey A Hussmann, Jun Yan, Friederike Knipping, Purnima Ravisankar, Pin-Fang Chen, Cidi Chen, James W Nelson, Gregory A Newby, Mustafa Sahin, Mark J Osborn, Jonathan S Weissman, Britt Adamson, David R Liu
Journal: Cell
PubMed ID: 34653350
Doi: 10.1016/j.cell.2021.09.018
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Alkaline phosphatase attenuates LPS-induced liver injury by regulating the miR-146a-related inflammatory pathway
Authors: Haoming Wu, Yang Wang, Qianqian Yao, Linlin Fan, Lu Meng, Nan Zheng, Huiying Li, Jiaqi Wang
Journal: Int Immunopharmacol
PubMed ID: 34634739
Doi: 10.1016/j.intimp.2021.108149
Products & Services: Endotoxin Detection & Removal System   
Incorporating health co-benefits into technology pathways to achieve China's 2060 carbon neutrality goal: a modelling study
Authors: Shihui Zhang, Kangxin An, Jin Li, Yuwei Weng, Shaohui Zhang, Shuxiao Wang, Wenjia Cai, Can Wang, Peng Gong
Journal: Lancet Planet Health
PubMed ID: 34758346
Doi: 10.1016/S2542-5196(21)00252-7
Products & Services: DNA Sequencing   
GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis
Authors: Jonathan M Goodwin, Ward G Walkup, Kirsty Hooper, Taoyingnan Li, Chieko Kishi-Itakura, Aylwin Ng, Timothy Lehmberg, Archana Jha, Sravya Kommineni, Katherine Fletcher, Jorge Garcia-Fortanet, Yaya Fan, Qing Tang, Menghao Wei, Asmita Agrawal, Sagar R Budhe, Sreekanth R Rouduri, Dan Baird, Jeff Saunders, Janna Kiselar, Mark R Chance, Andrea Ballabio, Brent A Appleton, John H Brumell, Oliver Florey, Leon O Murphy
Journal: Sci Adv
PubMed ID: 34597140
Doi: 10.1126/sciadv.abj2485
Products & Services: Custom Vector Construction   
Identification of a MarR subfamily that regulates arsenic resistance genes
Authors: Yanshuang Yu, Jichen Chen, Yuanping Li, Jinxuan Liang, Zhenchen Xie, Renwei Feng, Hend A Alwathnani, Barry P Rosen, Anne Grove, Jian Chen, Christopher Rensing
Journal: Appl Environ Microbiol
PubMed ID: 34613763
Doi: 10.1128/AEM.01588-21
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Functional Characterization of a New Bifunctional Terpene Synthase LpNES1 from a Medicinal Plant Laggera pter odonta
Authors: Zhan-Ku Shi, Xiao-Wei Gong, Jiang-Yuan Zhao, Ming-Gang Li, Xiu-Lin Han, Meng-Liang Wen
Journal: J Oleo Sci
PubMed ID: 34645748
Doi: 10.5650/jos.ess21172
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NMR study of macro domains (MDs) from betacoronavirus: backbone resonance assignments of SARS-CoV and MERS-CoV MDs in the free and the ADPr-bound state
Authors: Aikaterini C Tsika, Nikolaos K Fourkiotis, Periklis Charalampous, Angelo Gallo, Georgios A Spyroulias
Journal: Biomol NMR Assign
PubMed ID: 34686999
Doi: 10.1007/s12104-021-10052-5
Products & Services: Custom Vector Construction   
I-SceI and customized meganucleases-mediated genome editing in tomato and oilseed rape
Authors: Benoit Danilo, Émilie Montes, Héloïse Archambeau, Maryse Lodé, Mathieu Rousseau-Gueutin, Anne-Marie Chèvre, Marianne Mazier
Journal: Transgenic Res
PubMed ID: 34632562
Doi: 10.1007/s11248-021-00287-2
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Identification of novel positive allosteric modulators of GLP1R that stimulate its interaction with ligands and G subunits
Authors: Sumin Kang, Nam Hyuk Kim, Yeon Gyu Yu
Journal: Biochem Biophys Res Commun
PubMed ID: 34739856
Doi: 10.1016/j.bbrc.2021.10.071
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AKIRIN2 controls the nuclear import of proteasomes in vertebrates
Authors: Melanie de Almeida, Matthias Hinterndorfer, Hanna Brunner, Irina Grishkovskaya, Kashish Singh, Alexander Schleiffer, Julian Jude, Sumit Deswal, Robert Kalis, Milica Vunjak, Thomas Lendl, Richard Imre, Elisabeth Roitinger, Tobias Neumann, Susanne Kandolf, Michael Schutzbier, Karl Mechtler, Gijs A Versteeg, David Haselbach, Johannes Zuber
Journal: Nature
PubMed ID: 34711951
Doi: 10.1038/s41586-021-04035-8
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Inhibition of 11β-HSD1 Ameliorates Cognition and Molecular Detrimental Changes after Chronic Mild Stress in SAMP8 Mice
Authors: Dolors Puigoriol-Illamola, Júlia Companys-Alemany, Kris McGuire, Natalie Z M Homer, Rosana Leiva, Santiago Vázquez, Damian J Mole, Christian Griñán-Ferré, Mercè Pallàs
Journal: Pharmaceuticals (Basel)
PubMed ID: 34681264
Doi: 10.3390/ph14101040
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Intronic variants of MITF (rs7623610) and CREB1 (rs10932201) genes may enhance splicing efficiency in human melanoma cell line
Authors: Juliana Carron, Caroline Torricelli, Janet Keller Silva, Lilian de Oliveira Coser, Carmen Silvia Passos Lima, Gustavo Jacob Lourenço
Journal: Mutat Res
PubMed ID: 34710701
Doi: 10.1016/j.mrfmmm.2021.111763
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A Novel Actinobacterial Cutinase Containing a Non-Catalytic Polymer-Binding Domain
Authors: Kofi Abokitse, Stephan Grosse, Hannes Leisch, Christopher R Corbeil, Florence Perrin-Sarazin, Peter C K Lau
Journal: Appl Environ Microbiol
PubMed ID: 34705546
Doi: 10.1128/AEM.01522-21
Products & Services: Codon Optimization   
Creation of a synthesis-friendly inflammation-inducible promoter suitable for cell therapy
Authors: Anish Jadav, Kevin Truong
Journal: Integr Biol (Camb)
PubMed ID: 34632498
Doi: 10.1093/intbio/zyab015
Products & Services: Codon Optimization   
Engineering the Prenyltransferase Domain of a Bifunctional Assembly-Line Terpene Synthase
Authors: Trey A Ronnebaum, Samuel A Eaton, Emily A E Brackhahn, David W Christianson
Journal: Biochemistry
PubMed ID: 34609847
Doi: 10.1021/acs.biochem.1c00600
Products & Services: Codon Optimization   
The pentatricopeptide repeat protein EMB1270 interacts with CFM2 to splice specific group II introns in Arabidopsis chloroplasts
Authors: Li Zhang, Jingli Chen, Liqun Zhang, Ying Wei, Yajuan Li, Xinyun Xu, Hui Wu, Zhong-Nan Yang, Jirong Huang, Fenhong Hu, Weihua Huang, Yong-Lan Cui
Journal: J Integr Plant Biol
PubMed ID: 34427970
Doi: 10.1111/jipb.13165
Products & Services: Codon Optimization   
Multiple nanocages of a cyanophage small heat shock protein with icosahedral and octahedral symmetries
Authors: Sreeparna Biswas, Priyanka Garg, Somnath Dutta, Kaza Suguna
Journal: Sci Rep
PubMed ID: 34697325
Doi: 10.1038/s41598-021-00172-2
Products & Services: Codon Optimization   
An intrinsically disordered nascent protein interacts with specific regions of the ribosomal surface near the exit tunnel
Authors: Valeria Guzman-Luna, Andrew M Fuchs, Anna J Allen, Alexios Staikos, Silvia Cavagnero
Journal: Commun Biol
PubMed ID: 34716402
Doi: 10.1038/s42003-021-02752-4
Products & Services: Codon Optimization   
N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate
Authors: Leah Gottlieb, Lin Guo, James Shorter, Ronen Marmorstein
Journal: J Biol Chem
PubMed ID: 34732320
Doi: 10.1016/j.jbc.2021.101363
Products & Services: Catalog Peptides   
Development of peptides targeting receptor binding site of the envelope glycoprotein to contain the West Nile virus infection
Authors: Patrícia Mertinková, Evelína Mochnáčová, Katarína Bhide, Amod Kulkarni, Zuzana Tkáčová, Jana Hruškovicová, Mangesh Bhide
Journal: Sci Rep
PubMed ID: 34635758
Doi: 10.1038/s41598-021-99696-w
Products & Services: Catalog Peptides   
Roles of virulence regulator ToxR in viable but non-culturable formation by controlling reactive oxygen species resistance in pathogen Vibrio alginolyticus
Authors: Mengqing Zhou, Yuping Huang, Yuanxing Zhang, Qiyao Wang, Yue Ma, Shuai Shao
Journal: Microbiol Res
PubMed ID: 34700184
Doi: 10.1016/j.micres.2021.126900
Products & Services: Catalog Antibody   
Early IgG / IgA response in hospitalized COVID-19 patients is associated with a less severe disease
Authors: Giorgio Fedele, Gianluca Russo, Ilaria Schiavoni, Pasqualina Leone, Eleonora Olivetta, Valentina Perri, Maria Antonella Zingaropoli, Maria Rosa Ciardi, Patrizia Pasculli, Claudio Maria Mastroianni, Paola Stefanelli
Journal: Diagn Microbiol Infect Dis
PubMed ID: 34742119
Doi: 10.1016/j.diagmicrobio.2021.115586
Products & Services: Catalog Antibody   
and its outer protein Amuc_1100 regulates tryptophan metabolism in colitis
Authors: Zhenyang Gu, Wenlong Pei, Yonghua Shen, Lijuan Wang, Jun Zhu, Yi Zhang, Shengxian Fan, Qian Wu, Lei Li, Zhan Zhang
Journal: Food Funct
PubMed ID: 34532729
Doi: 10.1039/d1fo02172a
Products & Services: Catalog Antibody   
Interaction of Amyloid-β-(1-42) Peptide and Its Aggregates with Lipid/Water Interfaces Probed by Vibrational Sum-Frequency Generation Spectroscopy
Authors: S Strazdaite, S J Roeters, A Sakalauskas, T Sneideris, J Kirschner, K B Pedersen, B Schiøtt, F Jensen, T Weidner, V Smirnovas, G Niaura
Journal: J Phys Chem B
PubMed ID: 34597059
Doi: 10.1021/acs.jpcb.1c04882
Guillain-Barré syndrome after coronavirus disease 2019 vaccine: A temporal association
Authors: Gustavo Figueiredo da Silva, Caroline Figueiredo da Silva, Raddib Eduardo Noleto da Nobrega Oliveira, Fabiana Romancini, Rafael Marques Mendes, Amanda Locks, Maria Francisca Moro Longo, Carla Heloisa Cabral Moro, Alexandre Luiz Longo, Vera Lucia Braatz
Journal: Clin Exp Neuroimmunol
PubMed ID: 34900000
Doi: 10.1111/cen3.12678
Products & Services: Catalog Antibody   
Characterization of backbone dynamics using solution NMR spectroscopy to discern the functional plasticity of structurally analogous proteins
Authors: Ashish A Kawale, Björn M Burmann
Journal: STAR Protoc
PubMed ID: 34761231
Doi: 10.1016/j.xpro.2021.100919
Products & Services: Gene Synthesis   
The Weak Small RNA-Binding Activity of the 2b Proteins of Subgroup II Cucumber Mosaic Virus Strains Is Insufficient for RNA Silencing Suppression
Authors: Yingying Gao, Jinrui Yang, Xiaobei Zhang, Aizhong Chen, Zhouhang Gu, Zhiyou Du
Journal: Front Microbiol
PubMed ID: 34745069
Doi: 10.3389/fmicb.2021.760937
Products & Services: Gene Synthesis   
A Novel Rice Curl Dwarf-Associated Picornavirus Encodes a 3C Serine Protease Recognizing Uncommon EPT/S Cleavage Sites
Authors: Tianze Zhang, Chenyang Li, Mengji Cao, Dan Wang, Qi Wang, Yi Xie, Shibo Gao, Shuai Fu, Xueping Zhou, Jianxiang Wu
Journal: Front Microbiol
PubMed ID: 34721366
Doi: 10.3389/fmicb.2021.757451
Products & Services: Gene Synthesis   
Mutations Suppressing the Lack of Prepilin Peptidase Provide Insights Into the Maturation of the Major Pilin Protein in Cyanobacteria
Authors: Markéta Linhartová, Petra Skotnicová, Kaisa Hakkila, Martin Tichý, Josef Komenda, Jana Knoppová, Joan F Gilabert, Victor Guallar, Taina Tyystjärvi, Roman Sobotka
Journal: Front Microbiol
PubMed ID: 34712217
Doi: 10.3389/fmicb.2021.756912
Products & Services: Custom DNA/RNA Oligos   
Cationic Channel TRPV2 Overexpression Promotes Resistance to Cisplatin-Induced Apoptosis in Gastric Cancer Cells
Authors: Simona Laurino, Pellegrino Mazzone, Vitalba Ruggieri, Pietro Zoppoli, Giovanni Calice, Antonella Lapenta, Mario Ciuffi, Orazio Ignomirelli, Giulia Vita, Alessandro Sgambato, Sabino Russi, Geppino Falco
Journal: Front Pharmacol
PubMed ID: 34671260
Doi: 10.3389/fphar.2021.746628
Products & Services: Gene Synthesis   
Effectively auto-regulated adsorption and recovery of rare earth elements via an engineered E coli
Authors: Xiaoman Xie, Xirui Tan, Yiyan Yu, Yunchong Li, Pengbo Wang, Yuanhao Liang, Yunjun Yan
Journal: J Hazard Mater
PubMed ID: 34775317
Doi: 10.1016/j.jhazmat.2021.127642
Products & Services: Gene Synthesis   
Effect of Amelotin on Bone Growth in the Murine Calvarial Defect Model
Authors: Daiki Tanaka, Yuichi Ikeda, Eri Ikeda, Mako Yokose, Bernhard Ganss, Takanori Iwata
Journal: Ann Biomed Eng
PubMed ID: 34608582
Doi: 10.1007/s10439-021-02867-z
A Tetratricopeptide Repeat Scaffold Couples Signal Detection to OdhI Phosphorylation in Metabolic Control by the Protein Kinase PknG
Authors: María-Natalia Lisa, Adrià Sogues, Nathalie Barilone, Meike Baumgart, Magdalena Gil, Martín Graña, Rosario Durán, Ricardo M Biondi, Marco Bellinzoni, Michael Bott, Pedro M Alzari
Journal: MBio
PubMed ID: 34607462
Doi: 10.1128/mBio.01717-21
Products & Services: PCR and Cloning   
p53 Transactivation Domain Mediates Binding and Phase Separation with Poly-PR/GR
Authors: Sinem Usluer, Emil Spreitzer, Benjamin Bourgeois, Tobias Madl
Journal: Int J Mol Sci
PubMed ID: 34768862
Doi: 10.3390/ijms222111431
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Low-bias ncRNA libraries using ordered two-template relay: Serial template jumping by a modified retroelement reverse transcriptase
Authors: Heather E Upton, Lucas Ferguson, Morayma M Temoche-Diaz, Xiao-Man Liu, Sydney C Pimentel, Nicholas T Ingolia, Randy Schekman, Kathleen Collins
Journal: Proc Natl Acad Sci U S A
PubMed ID: 34649994
Doi: 10.1073/pnas.2107900118
Products & Services: ORF cDNA Clones/MolecularCloud   
Impact of C-terminal truncations in the Arabidopsis Rab escort protein (REP) on REP-Rab interaction and plant fertility
Authors: Małgorzata Gutkowska, Magdalena Kaus-Drobek, Marta Hoffman-Sommer, Magdalena Małgorzata Pamuła, Anna Daria Leja, Małgorzata Perycz, Małgorzata Lichocka, Agnieszka Witek, Magdalena Wojtas, Michał Dadlez, Ewa Swiezewska, Liliana Surmacz
Journal: Plant J
PubMed ID: 34592024
Doi: 10.1111/tpj.15519
Products & Services: Monoclonal Antibody Services   
Ambient Temperature Stable, Scalable COVID-19 Polymer Particle Vaccines Induce Protective Immunity
Authors: Shuxiong Chen, Benjamin Evert, Adetayo Adeniyi, Mercè Salla-Martret, Linda H-L Lua, Victoria Ozberk, Manisha Pandey, Michael F Good, Andreas Suhrbier, Peter Halfmann, Yoshihiro Kawaoka, Bernd H A Rehm
Journal: Adv Healthc Mater
PubMed ID: 34716678
Doi: 10.1002/adhm.202102089
Products & Services: Recombinant Proteins   
The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome
Authors: Ivo A Hendriks, Sara C Buch-Larsen, Evgeniia Prokhorova, Jonas D Elsborg, Alexandra K L F S Rebak, Kang Zhu, Dragana Ahel, Claudia Lukas, Ivan Ahel, Michael L Nielsen
Journal: Nat Commun
PubMed ID: 34625544
Doi: 10.1038/s41467-021-26172-4
Products & Services: PCR and Cloning   

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