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页码: 162/1026 每页显示数量

A Chemical Strategy for Intracellular Arming of an Endogenous Broad-Spectrum Antiviral Nucleotide

Authors: Kellan T Passow, Haley S Caldwell, Kiet A Ngo, Jamie J Arnold, Nicole M Antczak, Anoop Narayanan, Joyce Jose, Shana J Sturla, Craig E Cameron, Alexander T Ciota, Daniel A Harki

Journal: J Med Chem

PubMed ID: 34661397

Doi: 10.1021/acs.jmedchem.1c01481

Products & Services: Custom DNA/RNA Oligos

Mutational analysis of TlyA from Brachyspira hampsonii reveals two key residues conserved in pathogenic bacteria responsible for oligomerization and hemolytic activity

Authors: Brandon A Keith, John C S Harding, Matthew E Loewen

Journal: Biochim Biophys Acta Gen Subj

PubMed ID: 34715264

Doi: 10.1016/j.bbagen.2021.130045

Products & Services: Codon Optimization

Repeating Aspartic Acid Residues Prefer Turn-like Conformations in the Unfolded State: Implications for Early Protein Folding

Authors: Bridget Milorey, Harald Schwalbe, Nichole O'Neill, Reinhard Schweitzer-Stenner

Journal: J Phys Chem B

PubMed ID: 34619031

Doi: 10.1021/acs.jpcb.1c06472

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Systemic and mucosal immune profiling in asymptomatic and symptomatic SARS-CoV-2-infected individuals reveal unlinked immune signatures

Authors: Supriya Ravichandran, Gabrielle Grubbs, Juanjie Tang, Youri Lee, Chang Huang, Hana Golding, Surender Khurana

Journal: Sci Adv

PubMed ID: 34644111

Doi: 10.1126/sciadv.abi6533

Products & Services: Mutagenesis Services

Synthetic virology: the experts speak

Authors:

Journal: Nat Biotechnol

PubMed ID: 34599304

Doi: 10.1038/s41587-021-01078-0

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Generation of recombinant vaccinia virus and analysis of virus-induced cell death

Authors: Zhijun Liu, Kidong Kang, Francis Ka-Ming Chan

Journal: STAR Protoc

PubMed ID: 34661172

Doi: 10.1016/j.xpro.2021.100871

Products & Services: Gene Synthesis

Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period

Authors: Wen-Heng Ji, Dan-Dan Li, Dan-Ping Wei, Ai-Qin Gu, Ying Yang, Jing-Pian Peng

Journal: Front Immunol

PubMed ID: 34712245

Doi: 10.3389/fimmu.2021.763067

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ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota

Authors: Hao Zhong, Jian Wang, Muhammad Adnan Hafeez, Rongfa Guan, Fengqin Feng

Journal: Front Nutr

PubMed ID: 34805244

Doi: 10.3389/fnut.2021.754222

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Natural diversity provides a broad spectrum of cyanobacteriochrome-based diguanylate cyclases

Authors: Matthew Blain-Hartung, Nathan C Rockwell, J Clark Lagarias

Journal: Plant Physiol

PubMed ID: 34608946

Doi: 10.1093/plphys/kiab240

Products & Services: Gene Synthesis

Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation

Authors: Aneta J Lenard, Saskia Hutten, Qishun Zhou, Sinem Usluer, Fangrong Zhang, Benjamin M R Bourgeois, Dorothee Dormann, Tobias Madl

Journal: Front Mol Biosci

PubMed ID: 34738012

Doi: 10.3389/fmolb.2021.689687

Products & Services: Gene Synthesis

Human serum albumin fusion protein as therapeutics for targeting amyloid beta in Alzheimer's diseases

Authors: Sookhee Bang, Jeong Kuen Song, Seung-Wook Shin, Kwan Hee Lee

Journal: Neurosci Lett

PubMed ID: 34673147

Doi: 10.1016/j.neulet.2021.136298

Products & Services: Gene Synthesis

Inhibition of viral suppressor of RNAi proteins by designer peptides protects from enteroviral infection in vivo

Authors: Yuan Fang , Zezhong Liu , Yang Qiu , Jing Kong, Yuhong Fu, Yujie Liu , Chong Wang , Jia Quan , Qian Wang , Wei Xu , Lei Yin , Jie Cui , Yi Xu , Stephen Curry , Shibo Jiang , Lu Lu , Xi Zhou

Journal: Immunity

PubMed ID: 34555337

Doi: 10.1016/j.immuni.2021.08.027

Products & Services: Peptide Synthesis

The Bacterial Amyloids Phenol Soluble Modulins from Catalyze Alpha-Synuclein Aggregation

Authors: Caroline Haikal, Lei Ortigosa-Pascual, Zahra Najarzadeh, Katja Bernfur, Alexander Svanbergsson, Daniel E Otzen, Sara Linse, Jia-Yi Li

Journal: Int J Mol Sci

PubMed ID: 34769023

Doi: 10.3390/ijms222111594

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Drug Repurposing for the SARS-CoV-2 Papain-Like Protease

Authors: Chia-Chuan Cho, Shuhua G Li, Tyler J Lalonde, Kai S Yang, Ge Yu, Yuchen Qiao, Shiqing Xu, Wenshe Ray Liu

Journal: ChemMedChem

PubMed ID: 34423563

Doi: 10.1002/cmdc.202100455

Products & Services: Proteins, Expression, Isolation and Analysis

Guillain-Barré Syndrome Associated with COVID-19 Vaccination

Authors: Shih-Chieh Shao, Chien-Ho Wang, Kai-Cheng Chang, Ming-Jui Hung, Hui-Yu Chen, Shu-Chen Liao

Journal: Emerg Infect Dis

PubMed ID: 34648420

Doi: 10.3201/eid2712.211634

Products & Services: Proteins, Expression, Isolation and Analysis

Comparative transcriptome analysis uncovers cell wall reorganization and repressed cell division during cotton fiber initiation

Authors: Wenyuan Liu, Yanjia Lv, Xiaoyue Li, Zongqin Feng, Lichen Wang

Journal: BMC Dev Biol

PubMed ID: 34715791

Doi: 10.1186/s12861-021-00247-3

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Reprogramming the metabolism of PCC 6803 by regulating the plastoquinone biosynthesis

Authors: Jianhua Fan, Dongqing Zhou, Cheng Chen, Ju Wu, Hui Wu

Journal: Synth Syst Biotechnol

PubMed ID: 34754966

Doi: 10.1016/j.synbio.2021.10.004

Products & Services: Codon Optimization

A BK channel-targeted peptide induces age-dependent improvement in behavioral and neural sound representation

Authors: Elliott J Brecht, Luisa L Scott, Bo Ding, Xiaoxia Zhu, Joseph P Walton

Journal: Neurobiol Aging

PubMed ID: 34861480

Doi: 10.1016/j.neurobiolaging.2021.10.014

Products & Services: Proteins, Expression, Isolation and Analysis

Overexpression of the Ginkgo biloba WD40 gene GbLWD1-like improves salt tolerance in transgenic Populus

Authors: Yue Xin, Yaqiong Wu, Xin Han, Li-An Xu

Journal: Plant Sci

PubMed ID: 34763876

Doi: 10.1016/j.plantsci.2021.111092

Products & Services: Bacterial Expression

WSB1 regulates c-Myc expression through -catenin signaling and forms a feedforward circuit

Authors: Xiaomeng Gao, Jieqiong You, Yanling Gong, Meng Yuan, Haiying Zhu, Liang Fang, Hong Zhu, Meidan Ying, Qiaojun He, Bo Yang, Ji Cao

Journal: Acta Pharm Sin B

PubMed ID: 35530152

Doi: 10.1016/j.apsb.2021.10.021

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Prior infection with SARS-CoV-2 boosts and broadens Ad26COV2S immunogenicity in a variant-dependent manner

Authors: Roanne Keeton, Simone I Richardson, Thandeka Moyo-Gwete, Tandile Hermanus, Marius B Tincho, Ntombi Benede, Nelia P Manamela, Richard Baguma, Zanele Makhado, Amkele Ngomti, Thopisang Motlou, Mathilda Mennen, Lionel Chinhoyi, Sango Skelem, Hazel Maboreke, Deelan Doolabh, Arash Iranzadeh, Ashley D Otter, Tim Brooks, Mahdad Noursadeghi, James C Moon, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Jonathan Blackburn, Nei-Yuan Hsiao, Carolyn Williamson, Catherine Riou, Ameena Goga, Nigel Garrett, Linda-Gail Bekker, Glenda Gray, Ntobeko A B Ntusi, Penny L Moore, Wendy A Burgers

Journal: Cell Host Microbe

PubMed ID: 34688376

Doi: 10.1016/j.chom.2021.10.003

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An inducible -Cre mouse model to monitor and manipulate -highly-expressing senescent cells

Authors: Binsheng Wang, Lichao Wang, Nathan S Gasek, Yueying Zhou, Taewan Kim, Chun Guo, Evan R Jellison, Laura Haynes, Sumit Yadav, Tamar Tchkonia, George A Kuchel, James L Kirkland, Ming Xu

Journal: Nat Aging

PubMed ID: 35024619

Doi: 10.1038/s43587-021-00107-6

Products & Services: GenParts™ DNA Fragments

Cowpea Mosaic Virus Nanoparticle Vaccine Candidates Displaying Peptide Epitopes Can Neutralize the Severe Acute Respiratory Syndrome Coronavirus

Authors: Oscar A Ortega-Rivera, Sourabh Shukla, Matthew D Shin, Angela Chen, Veronique Beiss, Miguel A Moreno-Gonzalez, Yi Zheng, Alex E Clark, Aaron F Carlin, Jonathan K Pokorski, Nicole F Steinmetz

Journal: ACS Infect Dis

PubMed ID: 34672530

Doi: 10.1021/acsinfecdis.1c00410

Products & Services: Peptide Synthesis

Polymersomes as Stable Nanocarriers for a Highly Immunogenic and Durable SARS-CoV-2 Spike Protein Subunit Vaccine

Authors: Jian Hang Lam, Amit K Khan, Thomas A Cornell, Teck Wan Chia, Regine J Dress, Wen Wang William Yeow, Nur Khairiah Mohd-Ismail, Shrinivas Venkataraman, Kim Tien Ng, Yee-Joo Tan, Danielle E Anderson, Florent Ginhoux, Madhavan Nallani

Journal: ACS Nano

PubMed ID: 34618423

Doi: 10.1021/acsnano.1c01243

Products & Services: Recombinant Antibody Expression

Hantaviruses use the endogenous host factor P58IPK to combat the PKR antiviral response

Authors: Zekun Wang, Songyang Ren, Qiming Li, Austin D Royster, Lei Lin, Sichen Liu, Safder S Ganaie, Jianming Qiu, Sheema Mir, Mohammad A Mir

Journal: PLoS Pathog

PubMed ID: 34653226

Doi: 10.1371/journal.ppat.1010007

Products & Services: PCR and Cloning

Enzymatic extraction improves intracellular protein recovery from the industrial carrageenan seaweed revealed by quantitative, subcellular protein profiling: A high potential source of functional food ingredients

Authors: Simon Gregersen, Anne-Sofie Havgaard Kongsted, Rikke Brønnum Nielsen, Søren Storck Hansen, Frederik Andersen Lau, Jacob Bisgaard Rasmussen, Susan Løvstad Holdt, Charlotte Jacobsen

Journal: Food Chem X

PubMed ID: 34746746

Doi: 10.1016/j.fochx.2021.100137

Products & Services: Proteins, Expression, Isolation and Analysis

Ethylene Induced by Sound Stimulation Enhances Anthocyanin Accumulation in Grape Berry Skin through Direct Upregulation of UDP-Glucose: Flavonoid 3--Glucosyltransferase

Authors: Mone Yamazaki, Akari Ishida, Yutaka Suzuki, Yoshinao Aoki, Shunji Suzuki, Shinichi Enoki

Journal: Cells

PubMed ID: 34685779

Doi: 10.3390/cells10102799

Products & Services: PCR and Cloning

Reconstitution of Caveolin-1 into Artificial Lipid Membrane: Characterization by Transmission Electron Microscopy and Solid-State Nuclear Magnetic Resonance

Authors: Yanli Zhang, Xinyan Zhang, Wenru Kong, Shuqi Wang

Journal: Molecules

PubMed ID: 34684779

Doi: 10.3390/molecules26206201

Products & Services: Bacterial Expression

Using Continuous Directed Evolution to Improve Enzymes for Plant Applications

Authors: Jorge D García-García, Kristen Van Gelder, Jaya Joshi, Ulschan Bathe, Bryan J Leong, Steven D Bruner, Chang C Liu, Andrew D Hanson

Journal: Plant Physiol

PubMed ID: 34718794

Doi: 10.1093/plphys/kiab500

Products & Services: Recombinant Antibody Expression

A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

Authors: Allison J Greaney, Tyler N Starr, Rachel T Eguia, Andrea N Loes, Khadija Khan, Farina Karim, Sandile Cele, John E Bowen, Jennifer K Logue, Davide Corti, David Veesler, Helen Y Chu, Alex Sigal, Jesse D Bloom

Journal: biorxiv

PubMed ID: 34671768

Doi: 10.1101/2021.10.12.464114

Products & Services: Proteins, Expression, Isolation and Analysis

Recombinant expression of insoluble enzymes in Escherichia coli: a systematic review of experimental design and its manufacturing implications

Authors: Suraj Mital, Graham Christie, Duygu Dikicioglu

Journal: Microb Cell Fact

PubMed ID: 34717620

Doi: 10.1186/s12934-021-01698-w

Products & Services: PCR and Cloning

Bivalent individualization during chromosome territory formation in Drosophila spermatocytes by controlled condensin II protein activity and additional force generators

Authors: Luisa Vernizzi, Christian F Lehner

Journal: PLoS Genet

PubMed ID: 34669718

Doi: 10.1371/journal.pgen.1009870

Products & Services: GenParts™ DNA Fragments

Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells

Authors: Hillary H Le, Suleyman S Cinaroglu, Elise C Manalo, Aysegul Ors, Michelle M Gomes, Burcin Duan Sahbaz, Karla Bonic, Carlos A Origel Marmolejo, Arnaud Quentel, Justin S Plaut, Taryn E Kawashima, E Sila Ozdemir, Sanjay V Malhotra, Yavuz Ahiska, Ugur Sezerman, Gunseli Bayram Akcapinar, Joshua C Saldivar, Emel Timucin, Jared M Fischer

Journal: EBioMedicine

PubMed ID: 34689087

Doi: 10.1016/j.ebiom.2021.103646

Products & Services: Proteins, Expression, Isolation and Analysis

Stabilized coronavirus spike stem elicits a broadly protective antibody

Authors: Ching-Lin Hsieh, Anne P Werner, Sarah R Leist, Laura J Stevens, Ester Falconer, Jory A Goldsmith, Chia-Wei Chou, Olubukola M Abiona, Ande West, Kathryn Westendorf, Krithika Muthuraman, Ethan J Fritch, Kenneth H Dinnon, Alexandra Schäfer, Mark R Denison, James D Chappell, Ralph S Baric, Barney S Graham, Kizzmekia S Corbett, Jason S McLellan

Journal: Cell Rep

PubMed ID: 34710354

Doi: 10.1016/j.celrep.2021.109929

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Robust Neutralizing Antibody Responses 6 Months Post Vaccination with BNT162b2: A Prospective Study in 308 Healthy Individuals

Authors: Evangelos Terpos, Vangelis Karalis, Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou, Sentiljana Gumeni, Panagiotis Malandrakis, Eleni-Dimitra Papanagnou, Efstathios Kastritis, Ioannis P Trougakos, Meletios A Dimopoulos

Journal: Life (Basel)

PubMed ID: 34685448

Doi: 10.3390/life11101077

Characterization of oleosin genes from forage sorghum in Arabidopsis and yeast reveals their role in storage lipid stability

Authors: Rabishankar Ojha, Simranjit Kaur, Kshitija Sinha, Kirti Chawla, Sumandeep Kaur, Harish Jadhav, Manmehar Kaur, Rupam Kumar Bhunia

Journal: Planta

PubMed ID: 34655341

Doi: 10.1007/s00425-021-03744-8

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Sortase-mediated segmental labeling: A method for segmental assignment of intrinsically disordered regions in proteins

Authors: Kristina V Boyko, Erin A Rosenkranz, Derrick M Smith, Heather L Miears, Melissa Oueld Es Cheikh, Micah Z Lund, Jeffery C Young, Patrick N Reardon, Mark Okon, Serge L Smirnov, John M Antos

Journal: PLoS ONE

PubMed ID: 34710113

Doi: 10.1371/journal.pone.0258531

Products & Services: Plasmid DNA Preparation

Exosomal transfer of miR-769-5p promotes osteosarcoma proliferation and metastasis by targeting DUSP16

Authors: Wanshun Liu, Binyu Wang, Ao Duan, Kai Shen, Qi Zhang, Xiaolu Tang, Yongzhong Wei, Jian Tang, Sheng Zhang

Journal: Cancer Cell Int

PubMed ID: 34663350

Doi: 10.1186/s12935-021-02257-4

Products & Services: Mutant Libraries

Effect of inactivated influenza vaccination on human coronavirus infection: Secondary analysis of a randomized trial in Hutterite colonies

Authors: Andrew T Chen, Hannah D Stacey, Art Marzok, Pardeep Singh, Jann Ang, Matthew S Miller, Mark Loeb

Journal: Vaccine

PubMed ID: 34756613

Doi: 10.1016/j.vaccine.2021.10.021

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Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces

Authors: Jazmine P Hallinan, Lindsey A Doyle, Betty W Shen, Mesfin M Gewe, Brittany Takushi, Madison A Kennedy, Della Friend, James M Roberts, Philip Bradley, Barry L Stoddard

Journal: Commun Biol

PubMed ID: 34716407

Doi: 10.1038/s42003-021-02766-y

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Manual Acupuncture at ST37 Modulates TRPV1 in Rats with Acute Visceral Hyperalgesia via Phosphatidylinositol 3-Kinase/Akt Pathway

Authors: Caiyi Chen, Zhi Yu, Dong Lin, Xuan Wang, Xuejun Zhang, Feng Ji, Lingling He, Bin Xu

Journal: Evid Based Complement Alternat Med

PubMed ID: 34646326

Doi: 10.1155/2021/5561999

Products & Services: Proteins, Expression, Isolation and Analysis

Micronucleus production, activation of DNA damage response and cGAS-STING signaling in syncytia induced by SARS-CoV-2 infection

Authors: He Ren, Chaobing Ma, Haoran Peng, Bo Zhang, Lulin Zhou, Yan Su, Xiaoyan Gao, Hongyan Huang

Journal: Biol Direct

PubMed ID: 34674770

Doi: 10.1186/s13062-021-00305-7

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Zinc Influx Restricts Enterovirus D68 Replication

Authors: Shunan Liu, Xia Cao, Haoran Guo, Wei Wei

Journal: Front Microbiol

PubMed ID: 34721351

Doi: 10.3389/fmicb.2021.748546

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High mechanical property silk produced by transgenic silkworms expressing the spidroins PySp1 and ASG1

Authors: Xiaoli Tang, Xiaogang Ye, Xiaoxiao Wang, Shuo Zhao, Meiyu Wu, Jinghua Ruan, Boxiong Zhong

Journal: Sci Rep

PubMed ID: 34697320

Doi: 10.1038/s41598-021-00029-8

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Immunological Response to COVID-19 Vaccination in Ovarian Cancer Patients Receiving PARP Inhibitors

Authors: Michalis Liontos, Evangelos Terpos, Christos Markellos, Flora Zagouri, Alexandros Briasoulis, Ioanna Katsiana, Efthymia Skafida, Oraianthi Fiste, Elena Kunadis, Angeliki Andrikopoulou, Maria Kaparelou, Konstantinos Koutsoukos, Maria Gavriatopoulou, Efstathios Kastritis, Ioannis P Trougakos, Meletios-Athanasios Dimopoulos

Journal: Vaccines (Basel)

PubMed ID: 34696256

Doi: 10.3390/vaccines9101148

Identification of Novel, Immunogenic HLA-DR-Presented Prevotella copri Peptides in Patients With Rheumatoid Arthritis

Authors: Annalisa Pianta, Geena Chiumento, Kristina Ramsden, Qi Wang, Klemen Strle, Sheila Arvikar, Catherine E Costello, Allen C Steere

Journal: Arthritis Rheumatol

PubMed ID: 34042327

Doi: 10.1002/art.41807

Products & Services: Bacterial Expression

Anticancer properties of colicin E7 against colon cancer

Authors: Morovat Taherikalani, Sobhan Ghafourian

Journal: Prz Gastroenterol

PubMed ID: 34976246

Doi: 10.5114/pg.2021.109622

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Biophysical Characterization of Iron-Sulfur Proteins

Authors: Bhanu P Jagilinki, Irina Paluy, Alexei M Tyryshkin, Vikas Nanda, Dror Noy

Journal: Bio Protoc

PubMed ID: 34761074

Doi: 10.21769/BioProtoc.4202

Products & Services: Plasmid DNA Preparation

Microscopic Screening of Cyclodextrin Channel Blockers by DiffusiOptoPhysiology

Authors: Xiaoyu Du, Yuqin Wang, Shanyu Zhang, Pingping Fan, Shuanghong Yan, Panke Zhang, Hong-Yuan Chen, Shuo Huang

Journal: Anal Chem

PubMed ID: 34641671

Doi: 10.1021/acs.analchem.1c02775

Products & Services: Plasmid DNA Preparation

A Strategy for Selective Deletion of Autoimmunity-Related T Cells by pMHC-Targeted Delivery

Authors: Shalom D Goldberg, Nathan Felix, Michael McCauley, Ryan Eberwine, Lou Casta, Kathleen Haskell, Tricia Lin, Elizabeth Palovick, Donna Klein, Lori Getts, Robert Getts, Mimi Zhou, Pratima Bansal-Pakala, Vadim Dudkin

Journal: Pharmaceutics

PubMed ID: 34683962

Doi: 10.3390/pharmaceutics13101669

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