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页码: 183/1026 每页显示数量

β-Amyloid fibrils catalyze neurotransmitter degradation

Authors: Elad Arad, Avigail Baruch Leshem, Hanna Rapaport, Raz Jelinek

Journal: Chem Catalysis

Doi: 10.1016/j.checat.2021.07.005

Products & Services: Peptide Synthesis

Identification of a peptide binding to cancer antigen Kita‐kyushu lung cancer antigen 1 from a phage‐display library

Authors: Xiaoxiao Yu, Jiayao Yan,Xiaotong Chen,Jia Wei,Lixia Yu,Fangcen Liu,Lin Li,Baorui Liu

Journal: Cancer Science

PubMed ID: 34387029

Doi: 10.1111/cas.15109

Products & Services: Antibody Services Peptide Synthesis

Sequence specific integration by the family 1 casposase from Candidatus Nitrosopumilus koreensis AR1

Authors: Xiaoke Wang, Qinling Yuan, Wenxuan Zhang, Suyu, Yang, Kejing Ren,Meiling Lu,and Yibei Xiao

Journal: Nucleic Acids Research

PubMed ID: 34428286

Doi: 10.1093/nar/gkab725

Products & Services: Gene Services

Glucagon-like peptide-1 receptor controls exocytosis in chromaffin cells by increasing full-fusion events

Authors: Ayoze González-Santana, Judith Estévez-Herrera, Elizabeth P Seward, Ricardo Borges, José David Machado

Journal: Cell Rep

PubMed ID: 34433018

Doi: 10.1016/j.celrep.2021.109609

Products & Services: PCR and Cloning

Targeting RIOK2 ATPase activity leads to decreased protein synthesis and cell death in acute myeloid leukemia

Authors: Jan-Erik Messling, Karl Agger, Kasper L Andersen, Kristina Kromer, Hanna Maria Kuepper, Anders H Lund, Kristian Helin

Journal: Blood

PubMed ID: 34359076

Doi: 10.1182/blood.2021012629

Products & Services: Oligo pool

How to Sequence Therapies in Waldenström Macroglobulinemia

Authors: Shayna Sarosiek, Steven P Treon, Jorge J Castillo

Journal: Curr Treat Options Oncol

PubMed ID: 34426943

Doi: 10.1007/s11864-021-00890-9

Products & Services: Protein Reagents and Products

Evaluation of two Plasmodium vivax sexual stage antigens as transmission-blocking vaccine candidates

Authors: Yongzhe Zhang, Fei Liu, Yan Zhao, Fan Yang, Jie Bai, Xitong Jia, Wanlapa Roobsoong, Jetsumon Sattabongkot, Liwang Cui, Yaming Cao, Enjie Luo, Meilian Wang

Journal: Parasit Vectors

PubMed ID: 34399829

Doi: 10.1186/s13071-021-04909-w

Products & Services: Codon Optimization

A novel pine wood nematode effector, BxSCD1, suppresses plant immunity and interacts with an ethylene-forming enzyme in pine

Authors: Tong-Yue Wen, Xiao-Qin Wu, Long-Jiao Hu, Yi-Jun Qiu, Lin Rui, Yan Zhang, Xiao-Lei Ding, Jian-Ren Ye

Journal: Mol Plant Pathol

PubMed ID: 34396673

Doi: 10.1111/mpp.13121

Products & Services: Proteins, Expression, Isolation and Analysis

Nucleomodulin Ank13 Exploits the RaDAR Nuclear Import Pathway To Modulate Host Cell Transcription

Authors: Haley E Adcox, Amanda L Hatke, Shelby E Andersen, Sarika Gupta, Nathan B Otto, Mary M Weber, Richard T Marconi, Jason A Carlyon

Journal: MBio

PubMed ID: 34340535

Doi: 10.1128/mBio.01816-21

Products & Services: Codon Optimization

Combining functional metagenomics and glycoanalytics to identify enzymes that facilitate structural characterization of sulfated N-glycans

Authors: Léa Chuzel, Samantha L Fossa, Madison L Boisvert, Samanta Cajic, René Hennig, Mehul B Ganatra, Udo Reichl, Erdmann Rapp, Christopher H Taron

Journal: Microb Cell Fact

PubMed ID: 34419057

Doi: 10.1186/s12934-021-01652-w

Products & Services: Codon Optimization

Functional Insights into Silymarin as an Antiviral Agent against Enterovirus A71 (EV-A71)

Authors: Salima Lalani, Malihe Masomian, Chit Laa Poh

Journal: Int J Mol Sci

PubMed ID: 34445463

Doi: 10.3390/ijms22168757

Products & Services: Plasmid DNA Preparation

Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge

Authors: Kerry L Hilligan, Sivaranjani Namasivayam, Chad S Clancy, Danielle O'Mard, Sandra D Oland, Shelly J Robertson, Paul J Baker, Ehydel Castro, Nicole L Garza, Bernard A P Lafont, Reed Johnson, Franca Ronchese, Katrin D Mayer-Barber, Sonja M Best, Alan Sher

Journal: biorxiv

PubMed ID: 34494021

Doi: 10.1101/2021.08.30.458273

Products & Services: Catalog Antibody

The extracellular innate-immune effector HMGB1 limits pathogenic bacterial biofilm proliferation

Authors: Aishwarya Devaraj, Laura A Novotny, Frank H Robledo-Avila, John R Buzzo, Lauren Mashburn-Warren, Joseph A Jurcisek, Natalia O Tjokro, Santiago Partida-Sanchez, Lauren O Bakaletz, Steven D Goodman

Journal: J Clin Invest

PubMed ID: 34396989

Doi: 10.1172/JCI140527

Products & Services: Bacterial Expression

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

Authors: Aleksandar Antanasijevic, Leigh M Sewall, Christopher A Cottrell, Diane G Carnathan, Luis E Jimenez, Julia T Ngo, Jennifer B Silverman, Bettina Groschel, Erik Georgeson, Jinal Bhiman, Raiza Bastidas, Celia LaBranche, Joel D Allen, Jeffrey Copps, Hailee R Perrett, Kimmo Rantalainen, Fabien Cannac, Yuhe R Yang, Alba Torrents de la Peña, Rebeca Froes Rocha, Zachary T Berndsen, David Baker, Neil P King, Rogier W Sanders, John P Moore, Shane Crotty, Max Crispin, David C Montefiori, Dennis R Burton, William R Schief, Guido Silvestri, Andrew B Ward

Journal: Nat Commun

PubMed ID: 34376662

Doi: 10.1038/s41467-021-25087-4

Products & Services: Endotoxin Detection & Removal System

Anillin/Mid1p interacts with the ESCRT-associated protein Vps4p and mitotic kinases to regulate cytokinesis in fission yeast

Authors: Imane M Rezig, Wandiahyel G Yaduma, Gwyn W Gould, Christopher J McInerny

Journal: Cell Cycle

PubMed ID: 34382912

Doi: 10.1080/15384101.2021.1962637

Products & Services: DNA Sequencing

Dpb4 promotes resection of DNA double-strand breaks and checkpoint activation by acting in two different protein complexes

Authors: Erika Casari, Elisa Gobbini, Marco Gnugnoli, Marco Mangiagalli, Michela Clerici, Maria Pia Longhese

Journal: Nat Commun

PubMed ID: 34362907

Doi: 10.1038/s41467-021-25090-9

Products & Services: Bacterial Expression

Author Correction: Identification, characterization and control of a sequence variant in monoclonal antibody drug product: a case study

Authors: Anushikha Thakur, Rekha Nagpal, Avik Kumar Ghosh, Deepak Gadamshetty, Sirisha Nagapattinam, Malini Subbarao, Shreshtha Rakshit, Sneha Padiyar, Suma Sreenivas, Nagaraja Govindappa, Harish V Pai, Ramakrishnan Melarkode Subbaraman

Journal: Sci Rep

PubMed ID: 34462514

Doi: 10.1038/s41598-021-96916-1

Products & Services: Catalog Peptides

Comparative kinetics of SARS-CoV-2 anti-spike protein RBD IgGs and neutralizing antibodies in convalescent and naïve recipients of the BNT162b2 mRNA vaccine versus COVID-19 patients

Authors: Ioannis P Trougakos, Evangelos Terpos, Christina Zirou, Aimilia D Sklirou, Filia Apostolakou, Sentiljana Gumeni, Ioanna Charitaki, Eleni-Dimitra Papanagnou, Tina Bagratuni, Christine-Ivy Liacos, Andreas Scorilas, Eleni Korompoki, Ioannis Papassotiriou, Efstathios Kastritis, Meletios A Dimopoulos

Journal: BMC Med

PubMed ID: 34420521

Doi: 10.1186/s12916-021-02090-6

Rv0927c Inhibits NF-κB Pathway by Downregulating the Phosphorylation Level of IκBα and Enhances Mycobacterial Survival

Authors: Aihong Xia, Xin Li, Juanjuan Quan, Xiang Chen, Zhengzhong Xu, Xinan Jiao

Journal: Front Immunol

PubMed ID: 34531869

Doi: 10.3389/fimmu.2021.721370

Products & Services: Endotoxin Detection & Removal System

Cell Stress Induces Mislocalization of Transcription Factors with Mitochondrial Enrichment

Authors: Chiara Rossi, Anna Fernàndez, Pascual Torres, Omar Ramirez-Nuñez, Ana Belén Granado-Serrano, Laia Fontdevila, Mònica Povedano, Reinald Pamplona, Isidro Ferrer, Manuel Portero-Otin

Journal: Int J Mol Sci

PubMed ID: 34445555

Doi: 10.3390/ijms22168853

Products & Services: Proteins, Expression, Isolation and Analysis

Vaccine-induced ErbB (EGFR/HER2)-specific immunity in spontaneous canine cancer

Authors: Hester A Doyle, Renelle J Gee, Tyler D Masters, Christian R Gee, Carmen J Booth, Elizabeth Peterson-Roth, Raymond A Koski, Stuart C Helfand, Lauren Price, Deborah Bascombe, Dorothy Jackson, Rita Ho, Gerald R Post, Mark J Mamula

Journal: Transl Oncol

PubMed ID: 34419682

Doi: 10.1016/j.tranon.2021.101205

Products & Services: Proteins, Expression, Isolation and Analysis

Structure-Guided Creation of an Anti-HA Stalk Antibody F11 Derivative That Neutralizes Both F11-Sensitive and -Resistant Influenza A(H1N1)pdm09 Viruses

Authors: Osamu Kotani, Yasushi Suzuki, Shinji Saito, Akira Ainai, Akira Ueno, Takuya Hemmi, Kaori Sano, Koshiro Tabata, Masaru Yokoyama, Tadaki Suzuki, Hideki Hasegawa, Hironori Sato

Journal: Viruses

PubMed ID: 34578314

Doi: 10.3390/v13091733

Products & Services: Gene Synthesis

Potent prophylactic and therapeutic efficacy of recombinant human ACE2-Fc against SARS-CoV-2 infection in vivo

Authors: Zhaoyong Zhang, Eric Zeng, Lu Zhang, Weiming Wang, Yingkang Jin, Jiye Sun, Shuxiang Huang, Wenguang Yin, Jun Dai, Zhen Zhuang, Zhao Chen, Jing Sun, Airu Zhu, Fang Li, Weitao Cao, Xiaobo Li, Yongxia Shi, Mian Gan, Shengnan Zhang, Peilan Wei, Jicheng Huang, Nanshan Zhong, Guocai Zhong, Jingxian Zhao, Yanqun Wang, Weihui Shao, Jincun Zhao

Journal: Cell Discov

PubMed ID: 34385423

Doi: 10.1038/s41421-021-00302-0

Products & Services: Mutant Libraries

Impairment of Autophagic Flux Participates in the Antitumor Effects of TAT-Cx43 in Glioblastoma Stem Cells

Authors: Sara G Pelaz, Claudia Ollauri-Ibáñez, Concepción Lillo, Arantxa Tabernero

Journal: Cancers (Basel)

PubMed ID: 34503072

Doi: 10.3390/cancers13174262

Products & Services: Catalog Peptides

Genome-Wide Identification and Expression Analysis of MYB Transcription Factor Superfamily in

Authors: Tingting Zhang, Zheng Cui, Yuxin Li, Yuqian Kang, Xiqiang Song, Jian Wang, Yang Zhou

Journal: Front Genet

PubMed ID: 34512725

Doi: 10.3389/fgene.2021.714696

Products & Services: Protein Tools

SAGE1: a Potential Target Antigen for Lung Cancer T-Cell Immunotherapy

Authors: Yajing Zhang, Xiaohong Yu, Qiuping Liu, Haiping Gong, An-An Chen, Hongjun Zheng, Shi Zhong, Yi Li

Journal: Mol Cancer Ther

PubMed ID: 34465596

Doi: 10.1158/1535-7163.MCT-21-0203

Products & Services: Peptide Synthesis

Correlation between a quantitative anti-SARS-CoV-2 IgG ELISA and neutralization activity

Authors: Ramona Dolscheid-Pommerich, Eva Bartok, Marcel Renn, Beate M Kümmerer, Bianca Schulte, Ricarda M Schmithausen, Birgit Stoffel-Wagner, Hendrik Streeck, Sandra Saschenbrecker, Katja Steinhagen, Gunther Hartmann

Journal: J Med Virol

PubMed ID: 34415572

Doi: 10.1002/jmv.27287

Intracellular Accumulation of IFN-λ4 Induces ER Stress and Results in Anti-Cirrhotic but Pro-HCV Effects

Authors: Olusegun O Onabajo, Fang Wang, Mei-Hsuan Lee, Oscar Florez-Vargas, Adeola Obajemu, Chizu Tanikawa, Joselin M Vargas, Shu-Fen Liao, Ci Song, Yu-Han Huang, Chen-Yang Shen, A Rouf Banday, Thomas R O'Brien, Zhibin Hu, Koichi Matsuda, Ludmila Prokunina-Olsson

Journal: Front Immunol

PubMed ID: 34497603

Doi: 10.3389/fimmu.2021.692263

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of a GrgA-Euo-HrcA Transcriptional Regulatory Network in Chlamydia

Authors: Wurihan Wurihan, Yi Zou, Alec M Weber, Korri Weldon, Yehong Huang, Xiaofeng Bao, Chengsheng Zhu, Xiang Wu, Yaqun Wang, Zhao Lai, Huizhou Fan

Journal: mSystems

PubMed ID: 34342542

Doi: 10.1128/mSystems.00738-21

Products & Services: Plasmid DNA Preparation

Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies

Authors: Thomas Güttler, Metin Aksu, Antje Dickmanns, Kim M Stegmann, Kathrin Gregor, Renate Rees, Waltraud Taxer, Oleh Rymarenko, Jürgen Schünemann, Christian Dienemann, Philip Gunkel, Bianka Mussil, Jens Krull, Ulrike Teichmann, Uwe Groß, Volker C Cordes, Matthias Dobbelstein, Dirk Görlich

Journal: EMBO J

PubMed ID: 34302370

Doi: 10.15252/embj.2021107985

Products & Services: Recombinant Proteins

α-Synuclein kinetically regulates the nascent fusion pore dynamics

Authors: Rohith K Nellikka, Bhavya R Bhaskar, Kinjal Sanghrajka, Swapnali S Patil, Debasis Das

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34413185

Doi: 10.1073/pnas.2021742118

Products & Services: Peptide Synthesis

BB0562 is a nutritional virulence determinant with lipase activity important for Borrelia burgdorferi infection and survival in fatty acid deficient environments

Authors: Hunter W Kuhn, Amanda G Lasseter, Philip P Adams, Carlos Flores Avile, Brandee L Stone, Darrin R Akins, Travis J Jewett, Mollie W Jewett

Journal: PLoS Pathog

PubMed ID: 34415955

Doi: 10.1371/journal.ppat.1009869

Products & Services: Catalog Antibody

cAMP-dependent protein kinase regulates secretion of apical membrane antigen 1 (AMA1) in Plasmodium yoelii

Authors: Takahiro Ishizaki, Masahito Asada, Hassan Hakimi, Nattawat Chaiyawong, Yuto Kegawa, Kazuhide Yahata, Osamu Kaneko

Journal: Parasitol Int

PubMed ID: 34390881

Doi: 10.1016/j.parint.2021.102435

Products & Services: Codon Optimization

Genome-wide Analysis of Basic Helix-Loop-Helix Family Genes and Expression Analysis in Response to Drought and Salt Stresses in Sieb et Zucc

Authors: Longjie Ni, Zhiquan Wang, Zekai Fu, Dina Liu, Yunlong Yin, Huogen Li, Chunsun Gu

Journal: Int J Mol Sci

PubMed ID: 34445454

Doi: 10.3390/ijms22168748

Products & Services: Molecular Biology Tools

Cell-type and subcellular compartment-specific APEX2 proximity labeling reveals activity-dependent nuclear proteome dynamics in the striatum

Authors: V Dumrongprechachan, R B Salisbury, G Soto, M Kumar, M L MacDonald, Y Kozorovitskiy

Journal: Nat Commun

PubMed ID: 34381044

Doi: 10.1038/s41467-021-25144-y

Products & Services: Custom Vector Construction

Butyryl/Caproyl-CoA:Acetate CoA-transferase: cloning, expression and characterization of the key enzyme involved in medium-chain fatty acid biosynthesis

Authors: Qingzhuoma Yang, Shengtao Guo, Qi Lu, Yong Tao, Decong Zheng, Qinmao Zhou, Jun Liu

Journal: Biosci Rep

PubMed ID: 34338280

Doi: 10.1042/BSR20211135

Products & Services: Proteins, Expression, Isolation and Analysis

Copy number variation and expression of exportin-4 associates with severity of fibrosis in metabolic associated fatty liver disease

Authors: Mayada Metwally, Ali Bayoumi, Anis Khan, Leon A Adams, Rocio Aller, Carmelo García-Monzón, María Teresa Arias-Loste, Elisabetta Bugianesi, Luca Miele, Alisi Anna, Olivier Latchoumanin, Shuanglin Han, Shafi Alenizi, Rasha El Sharkawy, Afaf Elattar, Rocio Gallego-Durán, Janett Fischer, Thomas Berg, Christopher Liddle, Manuel Romero-Gomez, Jacob George, Mohammed Eslam

Journal: EBioMedicine

PubMed ID: 34388518

Doi: 10.1016/j.ebiom.2021.103521

Products & Services: ORF cDNA Clones/MolecularCloud

Genome-wide characterization and expression profiling of the Phospholipase C (PLC) gene family in three orchids of economic importance

Authors: Madhvi Kanchan, Thakku R Ramkumar, Jaspreet K Sembi

Journal: J Genet Eng Biotechnol

PubMed ID: 34420115

Doi: 10.1186/s43141-021-00217-z

Products & Services: Protein Tools

The nucleotide addition cycle of the SARS-CoV-2 polymerase

Authors: Subhas Chandra Bera, Mona Seifert, Robert N Kirchdoerfer, Pauline van Nies, Yibulayin Wubulikasimu, Salina Quack, Flávia S Papini, Jamie J Arnold, Bruno Canard, Craig E Cameron, Martin Depken, David Dulin

Journal: Cell Rep

PubMed ID: 34433083

Doi: 10.1016/j.celrep.2021.109650

Products & Services: Codon Optimization

Spore-Trained Dendritic Cells Enhance the Generation of Memory T Cells via ICAM1

Authors: Jian Lin, Lulu Huang, Yuchen Li, Penghao Zhang, Qinghua Yu, Qian Yang

Journal: Cells

PubMed ID: 34571913

Doi: 10.3390/cells10092267

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Protective humoral and cellular immune responses to SARS-CoV-2 persist up to 1 year after recovery

Authors: Chengqian Feng, Jingrong Shi, Qinghong Fan, Yaping Wang, Huang Huang, Fengjuan Chen, Guofang Tang, Youxia Li, Pingchao Li, Jiaojiao Li, Jianping Cui, Liliangzi Guo, Sisi Chen, Mengling Jiang, Liqiang Feng, Ling Chen, Chunliang Lei, Changwen Ke, Xilong Deng, Fengyu Hu, Xiaoping Tang, Feng Li

Journal: Nat Commun

PubMed ID: 34404803

Doi: 10.1038/s41467-021-25312-0

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A T-cell-based immunogenicity protocol for evaluating human antigen-specific responses

Authors: Cansu Cimen Bozkus, Ana Belen Blazquez, Tomohiro Enokida, Nina Bhardwaj

Journal: STAR Protoc

PubMed ID: 34458873

Doi: 10.1016/j.xpro.2021.100758

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N-acetylmannosamine-6-phosphate 2-epimerase uses a novel substrate-assisted mechanism to catalyze amino sugar epimerization

Authors: Michael J Currie, Lavanyaa Manjunath, Christopher R Horne, Phillip M Rendle, Ramaswamy Subramanian, Rosmarie Friemann, Antony J Fairbanks, Andrew C Muscroft-Taylor, Rachel A North, Renwick C J Dobson

Journal: J Biol Chem

PubMed ID: 34437902

Doi: 10.1016/j.jbc.2021.101113

Products & Services: Plasmid DNA Preparation

PGLYRP2 as a novel biomarker for the activity and lipid metabolism of systemic lupus erythematosus

Authors: Hui Li, Defang Meng, Jieting Jia, Hua Wei

Journal: Lipids Health Dis

PubMed ID: 34461924

Doi: 10.1186/s12944-021-01515-8

Products & Services: Custom DNA/RNA Oligos

Vestibular and Auditory Hair Cell Regeneration Following Targeted Ablation of Hair Cells With Diphtheria Toxin in Zebrafish

Authors: Erin Jimenez, Claire C Slevin, Luis Colón-Cruz, Shawn M Burgess

Journal: Front Cell Neurosci

PubMed ID: 34489643

Doi: 10.3389/fncel.2021.721950

Products & Services: PCR Cloning and Subcloning

Genome-Wide Identification, Expression and Functional Analysis Reveal the Involvement of FCS-Like Zinc Finger Gene Family in Submergence Response in Rice

Authors: Yamei Ma, Junliang Zhao, Hua Fu, Tifeng Yang, Jingfang Dong, Wu Yang, Luo Chen, Lian Zhou, Jian Wang, Bin Liu, Shaohong Zhang, David Edwards

Journal: Rice (N Y)

PubMed ID: 34417910

Doi: 10.1186/s12284-021-00519-3

Products & Services: Protein Tools

Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4 T-cells

Authors: Vijaya L Simhadri, Louis Hopkins, Joseph R McGill, Brian R Duke, Swati Mukherjee, Kate Zhang, Zuben E Sauna

Journal: Nat Commun

PubMed ID: 34429421

Doi: 10.1038/s41467-021-25414-9

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Impaired Cx43 gap junction endocytosis causes morphological and functional defects in zebrafish

Authors: Caitlin Hyland, Michael Mfarej, Giorgos Hiotis, Sabrina Lancaster, Noelle Novak, M Kathryn Iovine, Matthias M Falk

Journal: Mol Biol Cell

PubMed ID: 34379446

Doi: 10.1091/mbc.E20-12-0797

Influence of Fc modifications and IgG subclass on biodistribution of humanized antibodies targeting L1CAM

Authors: Sai Kiran Sharma, Maya Suzuki, Hong Xu, Joshua A Korsen, Zachary Samuels, Hongfen Guo, Brandon Nemieboka, Alessandra Piersigilli, Kimberly J Edwards, Nai-Kong Cheung, Jason S Lewis

Journal: J Nucl Med

PubMed ID: 34353869

Doi: 10.2967/jnumed.121.262383

Products & Services: Gene Synthesis

The Aneugenicity of Ketone Bodies in Colon Epithelial Cells Is Mediated by Microtubule Hyperacetylation and Is Blocked by Resveratrol

Authors: Haruka Sudo, Akira Kubo

Journal: Int J Mol Sci

PubMed ID: 34502304

Doi: 10.3390/ijms22179397

Products & Services: Mammalian Expression

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