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页码: 185/1026 每页显示数量

Optimising PHBV biopolymer production in haloarchaea via CRISPRi-mediated redirection of carbon flux

Authors: Lin Lin, Junyu Chen, Ruchira Mitra, Quanxiu Gao, Feiyue Cheng, Tong Xu, Zhenqiang Zuo, Hua Xiang, Jing Han

Journal: Commun Biol

PubMed ID: 34433872

Doi: 10.1038/s42003-021-02541-z

Products & Services: Gene Synthesis

RhoC Modulates Cell Junctions and Type I Interferon Response in Aggressive Breast Cancers

Authors: Hannah G Abraham, Peter J Ulintz, Laura Goo, Joel A Yates, Andrew C Little, Liwei Bao, Zhifen Wu, Sofia D Merajver

Journal: Front Oncol

PubMed ID: 34513691

Doi: 10.3389/fonc.2021.712041

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Expressing Type I Interferon From Atlantic Salmon Enhances the Innate Antiviral Immune Response and

Authors: Carlos Muñoz, Josue González-Lorca, Mick Parra, Sarita Soto, Natalia Valdes, Ana María Sandino, Rodrigo Vargas, Alex González, Mario Tello

Journal: Front Immunol

PubMed ID: 34475871

Doi: 10.3389/fimmu.2021.696781

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Identifying the Basis for VirS/VirR Two-Component Regulatory System Control of Clostridium perfringens Beta-Toxin Production

Authors: Iman Mehdizadeh Gohari, Jihong Li, Bruce A McClane

Journal: J Bacteriol

PubMed ID: 34228498

Doi: 10.1128/JB.00279-21

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A novel RNA detection technique for point-of-care identification of pathogens

Authors: Mekbib Astatke, Olivia Tiburzi, Amy Connolly

Journal: J Immunoassay Immunochem

PubMed ID: 34355634

Doi: 10.1080/15321819.2021.1955380

Products & Services: Gene Synthesis

Genome editing with CRISPR/Cas9 in Pinus radiata (D. Don)

Authors: Charleson Poovaiah, Lorelle Phillips, Barbara Geddes, Cathie Reeves, Mathias Sorieul and Glenn Thorlby

Journal: BMC Plant Biology

PubMed ID: 34376154

Doi: 10.1186/s12870-021-03143-x

Products & Services: Gene Synthesis

GRB2 enforces homology-directed repair initiation by MRE11.

Authors: Zu Ye, Shengfeng Xu, Yin Shi, Albino Bacolla, Aleem Syed, Davide Moiani, Chi-Lin Tsai, Qiang Shen, Guang Peng, Paul G Leonard, Darin E Jones, Bin Wang, John A Tainer, Zamal Ahmed

Journal: Sci Adv

Doi: 10.1126/sciadv.abe9254

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Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor

Authors: Yue Wang, Shimeng Guo, Youwen Zhuang, Ying Yun, Peiyu Xu, Xinheng He, Jia Guo, Wanchao Yin, H Eric Xu, Xin Xie, Yi Jiang

Journal: Nat Commun.

PubMed ID: 34417468

Doi: 10.1038/s41467-021-25364-2

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An EZH2-dependent transcriptional complex promotes aberrant epithelial remodelling after injury

Authors: Huy Q Le, Matthew A Hill, Ines Kollak, Martina Keck, Victoria Schroeder, Johannes Wirth, Wioletta Skronska-Wasek, Eva Schruf, Benjamin Strobel, Heiko Stahl, Franziska E Herrmann, Alexandre R Campos, Jun Li, Karsten Quast, Dagmar Knebel, Coralie Viollet, Matthew J Thomas, David Lamb, James P Garnett

Journal: EMBO Rep

PubMed ID: 34224201

Doi: 10.15252/embr.202152785

Products & Services: Gene Synthesis

Comprehensive Proteome and Lysine Acetylome Analysis Reveals the Widespread Involvement of Acetylation in Cold Resistance of Pepper ( L)

Authors: Zhoubin Liu, Jingshuang Song, Wu Miao, Bozhi Yang, Zhuqing Zhang, Wenchao Chen, Fangjun Tan, Huan Suo, Xiongze Dai, Xuexiao Zou, Lijun Ou

Journal: Front Plant Sci

PubMed ID: 34512705

Doi: 10.3389/fpls.2021.730489

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Human Cystathionine γ-Lyase Is Inhibited by -Nitrosation: A New Crosstalk Mechanism between NO and HS

Authors: Dalila G F Fernandes, João Nunes, Catarina S Tomé, Karim Zuhra, João M F Costa, Alexandra M M Antunes, Alessandro Giuffrè, João B Vicente

Journal: Antioxidants (Basel)

PubMed ID: 34573023

Doi: 10.3390/antiox10091391

Products & Services: Mutagenesis Services

DSB-3 reveals conservation and divergence among protein complexes promoting meiotic double-strand breaks

Authors: Albert W Hinman, Hsin-Yi Yeh, Baptiste Roelens, Kei Yamaya, Alexander Woglar, Henri-Marc G Bourbon, Peter Chi, Anne M Villeneuve

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34389685

Doi: 10.1073/pnas.2109306118

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Immune responses in COVID-19 respiratory tract and blood reveal mechanisms of disease severity

Authors: Wuji Zhang, Brendon Chua, Kevin Selva, Lukasz Kedzierski, Thomas Ashhurst, Ebene Haycroft, Suzanne Shoffner, Luca Hensen, David Boyd, Fiona James, Effie Mouhtouris, Jason Kwong, Kyra Chua, George Drewett, Ana Copaescu, Julie Dobson, Louise Rowntree, Jennifer Habel, Lilith Allen, Hui-Fern Koay, Jessica Neil, Matthew Gartner, Christina Lee, Patiyan Andersson, Torsten Seemann, Norelle Sherry, Fatima Amanat, Florian Krammer, Sarah Londrigan, Linda Wakim, Nicholas King, Dale Godfrey, Laura Mackay, Paul Thomas, Suellen Nicholson, Kelly Arnold, Amy Chung, Natasha Holmes, Olivia Smibert, Jason Trubiano, Claire Gordon, Thi Nguyen, Katherine Kedzierska

Journal: Res Sq

PubMed ID: 34462740

Doi: 10.21203/rs.3.rs-802084/v1

Products & Services: Proteins, Expression, Isolation and Analysis

SARS-CoV-2 Isolates Show Impaired Replication in Human Immune Cells but Differential Ability to Replicate and Induce Innate Immunity in Lung Epithelial Cells

Authors: Miao Jiang, Pekka Kolehmainen, Laura Kakkola, Sari Maljanen, Krister Melén, Teemu Smura, Ilkka Julkunen, Pamela Österlund

Journal: Microbiol Spectr

PubMed ID: 34378952

Doi: 10.1128/Spectrum.00774-21

Products & Services: Mammalian Expression

A newly characterized malaria antigen on erythrocyte and merozoite surfaces induces parasite inhibitory antibodies

Authors: Ian C Michelow, Sangshin Park, Shu-Whei Tsai, Bonnie Rayta, Charisse Flerida A Pasaje, Sara Nelson, Angela M Early, Anne P Frosch, George Ayodo, Dipak K Raj, Christina E Nixon, Christian P Nixon, Sunthorn Pond-Tor, Jennifer F Friedman, Michal Fried, Patrick E Duffy, Karine G Le Roch, Jacquin C Niles, Jonathan D Kurtis

Journal: J Exp Med

PubMed ID: 34342640

Doi: 10.1084/jem.20200170

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Interaction of Human C5a with the Major Peptide Fragments of C5aR1: Direct Evidence in Support of "Two-Site" Binding Paradigm

Authors: Aurosikha Das, Lalita Mohan Behera, Soumendra Rana

Journal: ACS Omega

PubMed ID: 34514259

Doi: 10.1021/acsomega.1c03400

Products & Services: GenParts™ DNA Fragments

compensates for in mice in the amino-terminal acetylation pathway

Authors: Hyae Yon Kweon, Mi-Ni Lee, Max Dorfel, Seungwoon Seo, Leah Gottlieb, Thomas PaPazyan, Nina McTiernan, Rasmus Ree, David Bolton, Andrew Garcia, Michael Flory, Jonathan Crain, Alison Sebold, Scott Lyons, Ahmed Ismail, Elaine Marchi, Seong-Keun Sonn, Se-Jin Jeong, Sejin Jeon, Shinyeong Ju, Simon J Conway, Taesoo Kim, Hyun-Seok Kim, Cheolju Lee, Tae-Young Roh, Thomas Arnesen, Ronen Marmorstein, Goo Taeg Oh, Gholson J Lyon

Journal: Elife

PubMed ID: 34355692

Doi: 10.7554/eLife.65952

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Conformational equilibria in allosteric control of Hsp70 chaperones

Authors: Wei Wang, Qinglian Liu, Qun Liu, Wayne A Hendrickson

Journal: Mol Cell

PubMed ID: 34453889

Doi: 10.1016/j.molcel.2021.07.039

Products & Services: Proteins, Expression, Isolation and Analysis

Activated Alpha 2-Macroglobulin Is a Novel Mediator of Mesangial Cell Profibrotic Signaling in Diabetic Kidney Disease

Authors: Jackie Trink, Renzhong Li, Yaseelan Palarasah, Stéphan Troyanov, Thomas E Andersen, Johannes J Sidelmann, Mark D Inman, Salvatore V Pizzo, Bo Gao, Joan C Krepinsky

Journal: Biomedicines

PubMed ID: 34572299

Doi: 10.3390/biomedicines9091112

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Long Non-Coding RNA TRG-AS1 Promoted Proliferation and Invasion of Lung Cancer Cells Through the miR-224-5p/SMAD4 Axis

Authors: Mengyan Zhang, Weiguo Zhu, Mansour Haeryfar, Sumei Jiang, Xiang Jiang, Wei Chen, Jiancheng Li

Journal: Onco Targets Ther

PubMed ID: 34408438

Doi: 10.2147/OTT.S297336

Products & Services: Gene Synthesis

Objective Measurements Associated with the Preferred Eating Qualities of Fermented Salamis

Authors: Jihan Kim, Scott Knowles, Raise Ahmad, Li Day

Journal: Foods

PubMed ID: 34574113

Doi: 10.3390/foods10092003

Products & Services: Stable Cell Lines

Ion Transport Activity Assay for Microbial Rhodopsin Expressed in Cells

Authors: Masae Konno, Keiichi Inoue, Hideki Kandori

Journal: Bio Protoc

PubMed ID: 34458409

Doi: 10.21769/BioProtoc.4115

Products & Services: Bacterial Expression

Insertion of prpoD_rpoS fragment enhances expression of recombinant protein by dps auto-inducible promoter in Escherichia coli

Authors: Dina Mulyanti, Sundani Nurono Soewandhi, Catur Riani

Journal: Mol Biol Rep

PubMed ID: 34342815

Doi: 10.1007/s11033-021-06562-z

Products & Services: Plasmid DNA Preparation

Hydrolysis of a second Asp-Pro site at the N-terminus of NOTCH3 in inherited vascular dementia

Authors: Xiaojie Zhang, Soo Jung Lee, Michael M Wang

Journal: Sci Rep

PubMed ID: 34446744

Doi: 10.1038/s41598-021-96679-9

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A micro-peptide encoded by HOXB-AS3 promotes the proliferation and viability of oral squamous cell carcinoma cell lines by directly binding with IGF2BP2 to stabilize c-Myc

Authors: Fei Leng, Yan-Yu Miu, Yi Zhang, Hao Luo, Xiao-Li Lu, Hui Cheng, Zhi-Guo Zheng

Journal: Oncol Lett

PubMed ID: 34457052

Doi: 10.3892/ol.2021.12958

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Platelet-derived growth factor (PDGF)-BB protects dopaminergic neurons via activation of Akt/ERK/CREB pathways to upregulate tyrosine hydroxylase

Authors: Huan Chen, Yan Teng, Xingmin Chen, Zhihao Liu, Fan Geng, Yanzhuo Liu, Haisong Jiang, Ziyan Wang, Lu Yang

Journal: CNS Neurosci Ther

PubMed ID: 34346167

Doi: 10.1111/cns.13708

Products & Services: Mammalian Expression

Evidence for UV-green dichromacy in the basal hymenopteran Sirex noctilio (Siricidae)

Authors: Quentin Guignard, Johannes Spaethe, Bernard Slippers, Martin Strube-Bloss, Jeremy D Allison

Journal: Sci Rep

PubMed ID: 34341410

Doi: 10.1038/s41598-021-95107-2

Products & Services: Molecular Biology Tools

Engineering analysis of multienzyme cascade reactions for 3'-sialyllactose synthesis

Authors: Sabine Schelch, Manuel Eibinger, Stefanie Gross Belduma, Barbara Petschacher, Jürgen Kuballa, Bernd Nidetzky

Journal: Biotechnol Bioeng

PubMed ID: 34289079

Doi: 10.1002/bit.27898

Products & Services: Bacterial Expression

Does Differential Receptor Distribution Underlie Variable Responses to a Neuropeptide in the Lobster Cardiac System?

Authors: Audrey J Muscato, Patrick Walsh, Sovannarath Pong, Alixander Pupo, Roni J Gross, Andrew E Christie, J Joe Hull, Patsy S Dickinson

Journal: Int J Mol Sci

PubMed ID: 34445418

Doi: 10.3390/ijms22168703

Products & Services: Proteins, Expression, Isolation and Analysis

Genome-Wide Identification and Characterization of KNOTTED-Like Homeobox (KNOX) Homologs in Garlic ( L) and Their Expression Profilings Responding to Exogenous Cytokinin and Gibberellin

Authors: Siyu Zhang, Yupeng Pan, Chengchen Zhi, Yujie Zheng, Xi'ao Wang, Xiaxia Li, Zhihui Cheng

Journal: Int J Mol Sci

PubMed ID: 34502163

Doi: 10.3390/ijms22179237

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Inhibition of NOD1 Attenuates Neonatal Hypoxia-Ischemia Induced Long-Term Cognitive Impairments in Mice Through Modulation of Autophagy-Related Proteins

Authors: Fang Liu, Mingyu Shao, Feng Xu, Fang Rong

Journal: Neuropsychiatr Dis Treat

PubMed ID: 34421301

Doi: 10.2147/NDT.S314884

Products & Services: Recombinant Proteins

Rapid CRISPR/Cas9 Editing of Genotype IX African Swine Fever Virus Circulating in Eastern and Central Africa

Authors: Hussein M Abkallo, Nicholas Svitek, Bernard Oduor, Elias Awino, Sonal P Henson, Samuel O Oyola, Stephen Mwalimu, Nacrya Assad-Garcia, Walter Fuchs, Sanjay Vashee, Lucilla Steinaa

Journal: Front Genet

PubMed ID: 34527025

Doi: 10.3389/fgene.2021.733674

Products & Services: Plasmid DNA Preparation

Three-layered control of mRNA poly(A) tail synthesis in

Authors: Matti Turtola, M Cemre Manav, Ananthanarayanan Kumar, Agnieszka Tudek, Seweryn Mroczek, Paweł S Krawczyk, Andrzej Dziembowski, Manfred Schmid, Lori A Passmore, Ana Casañal, Torben Heick Jensen

Journal: Genes Dev

PubMed ID: 34385261

Doi: 10.1101/gad.348634.121

Products & Services: Bacterial Expression

Inhibition of Three Citrus Pathogenic Fungi by Peptide PAF56 Involves Cell Membrane Damage

Authors: Wenjun Wang, Guirong Feng, Xindan Li, Changqing Ruan, Jian Ming, Kaifang Zeng

Journal: Foods

PubMed ID: 34574141

Doi: 10.3390/foods10092031

Products & Services: Catalog Peptides

CRISPR-mediated Labeling of Cells in Chick Embryos Based on Selectively Expressed Genes

Authors: Masahito Yamagata, Joshua R Sanes

Journal: Bio Protoc

PubMed ID: 34458399

Doi: 10.21769/BioProtoc.4105

Products & Services: Recombinant Proteins

Butyryl/Caproyl-CoA:Acetate CoA-transferase: cloning, expression and characterization of the key enzyme involved in medium-chain fatty acid biosynthesis

Authors: Qingzhuoma Yang, Shengtao Guo, Qi Lu, Yong Tao, Decong Zheng, Qinmao Zhou, Jun Liu

Journal: Biosci Rep

PubMed ID: 34338280

Doi: 10.1042/BSR20211135

Products & Services: Proteins, Expression, Isolation and Analysis

Sulfated glycosaminoglycans and low-density lipoprotein receptor mediate the cellular entry of Clostridium novyi alpha-toxin

Authors: Yao Zhou, Diyin Li, Jianhua Luo, Aizhong Chen, Xingxing Li, Zhenrui Pan, Li Wan, Liuqing He, Danyang Li, Yanyan Li , Min Dong, Liang Tao

Journal: Cell Res

PubMed ID: 33972749

Doi: 10.1038/s41422-021-00510-z

Products & Services: Gene Synthesis

Secreted Expression of mRNA-Encoded Truncated ACE2 Variants for SARS-CoV-2 via Lipid-Like Nanoassemblies

Authors: Min Li, Sanpeng Li, Yixuan Huang, Haixia Chen, Songya Zhang, Zhicheng Zhang, Weigang Wu, Xiaobin Zeng, Boping Zhou, Bin Li

Journal: Adv Mater

PubMed ID: 34278613

Doi: 10.1002/adma.202101707

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3D culture system to study collective migration in mammary organoid epithelium

Authors: Yunzhe Lu, Ruolan Deng, Huanyang You, Pengfei Lu

Journal: STAR Protoc

PubMed ID: 34485944

Doi: 10.1016/j.xpro.2021.100778

Products & Services: Recombinant Proteins

Dominant-negative actions of a dopamine transporter variant identified in patients with parkinsonism and neuropsychiatric disease

Authors: Freja Herborg,Kathrine L. Jensen,Sasha Tolstoy,Natascha V. Arends,Leonie P. Posselt,Aparna Shekar, Jenny I Aguilar, Viktor K. Lund, Kevin Erreger,Mattias Rickhag,Matthew D. Lycas,Markus N. Lonsdale,Troels Rahbek-Clemmensen,Andreas T. Sørensen,Amy H. Newman,Annemette Løkkegaard,Ole Kjaerulff,Thomas Werge,Lisbeth B. Møller,Heinrich J.G. Matthies, Aurelio Galli, Lena E. Hjermind,6 and Ulrik Gether

Journal: JCI Insight

PubMed ID: 34375312

Doi: 10.1172/jci.insight.151496.

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Ty1 integrase is composed of an active N-terminal domain and a large disordered C-terminal module dispensable for its activity in vitro

Authors: Phong Quoc Nguyen , Christine Conesa , Elise Rabut , Gabriel Bragagnolo , Célia Gouzerh , Carlos Fernández-Tornero , Pascale Lesage , Juan Reguera and Jol Acker

Journal: Journal of Biological Chemistry

PubMed ID: 34416236

Doi: 10.1016/j.jbc.2021.101093

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Serological Testing for COVID-19, Immunological Surveillance, and Exploration of Protective Antibodies

Authors: Luis A Peroni, Jessica M Toscaro, Camila Canateli, Celisa C C Tonoli, Renata R de Olivera, Celso E Benedetti, Lais D Coimbra, Alexandre Borin Pereira, Rafael E Marques, José L Proença-Modena, Gabriel C Lima, Renata Viana, Jessica B Borges, Hui Tzu Lin-Wang, Cely S Abboud, Carlos Gun, Kleber G Franchini, Marcio C Bajgelman

Journal: Front Immunol

PubMed ID: 34489923

Doi: 10.3389/fimmu.2021.635701

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Recognition of Multiple Hybrid Insulin Peptides by a Single Highly Diabetogenic T-Cell Receptor

Authors: Daniel Parras, Patricia Solé, Thomas Delong, Pere Santamaría, Pau Serra

Journal: Front Immunol

PubMed ID: 34527002

Doi: 10.3389/fimmu.2021.737428

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Evolution and Antigenic Advancement of N2 Neuraminidase of Swine Influenza A Viruses Circulating in the United States following Two Separate Introductions from Human Seasonal Viruses

Authors: Bryan S Kaplan, Tavis K Anderson, Jennifer Chang, Jefferson Santos, Daniel Perez, Nicola Lewis, Amy L Vincent

Journal: J Virol

PubMed ID: 34379513

Doi: 10.1128/JVI.00632-21

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A Methyltransferase-Defective Vesicular Stomatitis Virus-Based SARS-CoV-2 Vaccine Candidate Provides Complete Protection against SARS-CoV-2 Infection in Hamsters

Authors: Mijia Lu, Yuexiu Zhang, Piyush Dravid, Anzhong Li, Cong Zeng, Mahesh Kc, Sheetal Trivedi, Himanshu Sharma, Supranee Chaiwatpongsakorn, Ashley Zani, Adam Kenney, Chuanxi Cai, Chengjin Ye, Xueya Liang, Jianming Qiu, Luis Martinez-Sobrido, Jacob S Yount, Prosper N Boyaka, Shan-Lu Liu, Mark E Peeples, Amit Kapoor, Jianrong Li

Journal: J Virol

PubMed ID: 34379509

Doi: 10.1128/JVI.00592-21

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Shrimp Plasma CREG Is a Hemocyte Activation Factor

Authors: Zhiqi Huang, Peng Yang, Fan Wang

Journal: Front Immunol.

PubMed ID: 34484206

Doi: 10.3389/fimmu.2021.707770

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The component of the mA writer complex VIRMA is implicated in aggressive tumor phenotype, DNA damage response and cisplatin resistance in germ cell tumors

Authors: Vera Miranda-Gonçalves, João Lobo, Catarina Guimarães-Teixeira, Daniela Barros-Silva, Rita Guimarães, Mariana Cantante, Isaac Braga, Joaquina Maurício, Christoph Oing, Friedemann Honecker, Daniel Nettersheim, Leendert H J Looijenga, Rui Henrique, Carmen Jerónimo

Journal: J Exp Clin Cancer Res

PubMed ID: 34446080

Doi: 10.1186/s13046-021-02072-9

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Treatment-emergent and trajectory-based peripheral gene expression markers of antidepressant response

Authors: Laura M Fiori, Massimiliano Orri, Zahia Aouabed, Jean François Théroux, Rixing Lin, Corina Nagy, Benicio N Frey, Raymond W Lam, Glenda M MacQueen, Roumen Milev, Daniel J Müller, Sagar V Parikh, Susan Rotzinger, Rudolf Uher, Jane A Foster, Sidney H Kennedy, Gustavo Turecki

Journal: Transl Psychiatry

PubMed ID: 34420030

Doi: 10.1038/s41398-021-01564-8

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Peptides derived from viral glycoprotein Gc Inhibit infection of severe fever with thrombocytopenia syndrome virus

Authors: Chengfeng Gao, Yufeng Yu, Chunxia Wen, Zhifeng Li, Menghuai Sun, Shu Gao, Shuhan Lin, Shenjiao Wang, Peng Zou, Zheng Xing

Journal: Antiviral Res

PubMed ID: 34411654

Doi: 10.1016/j.antiviral.2021.105164

Products & Services: Proteins, Expression, Isolation and Analysis

Activation of Local and Systemic Defence Responses by Flg22 Is Dependent on Daytime and Ethylene in Intact Tomato Plants

Authors: Zalán Czékus, András Kukri, Kamirán Áron Hamow, Gabriella Szalai, Irma Tari, Attila Ördög, Péter Poór

Journal: Int J Mol Sci

PubMed ID: 34361121

Doi: 10.3390/ijms22158354

Products & Services: Proteins, Expression, Isolation and Analysis

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