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MiR-326 sponges TET2 triggering imbalance of Th17/Treg differentiation to exacerbate pyroptosis of hepatocytes in concanavalin A-induced autoimmune hepatitis

Authors: Genglin Zhang, Sensen Wu, Guangtao Xia

Journal: Hepatology

PubMed ID: 38043702

Doi: 10.1016/j.aohep.2023.101183

Products & Services: Codon Optimization

Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4-induced brain pathology

Authors: Brendan Miller, Su-Jeong Kim, Kevin Cao, Hemal H Mehta, Neehar Thumaty, Hiroshi Kumagai, Tomomitsu Iida, Cassandra McGill, Christian J Pike, Kamila Nurmakova, Zachary A Levine, Patrick M Sullivan, Kelvin Yen, Nilüfer Ertekin-Taner, Gil Atzmon, Nir Barzilai, Pinchas Cohen

Journal: Cell

PubMed ID: 38520065

Doi: 10.1111/acel.14153

Products & Services: Gene Synthesis

A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins

Authors: Xiuxiu Lu, Monika Chandravanshi, Venkata R Sabbasani, Snehal Gaikwad, V Keith Hughitt, Nana Gyabaah-Kessie, Bradley T Scroggins, Sudipto Das, Wazo Myint, Michelle E Clapp, Charles D Schwieters, Marzena A Dyba, Derek L Bolhuis, Janusz W Koscielniak, Thorkell Andresson, Michael J Emanuele, Nicholas G Brown, Hiroshi Matsuo, Raj Chari, Deborah E Citrin, Beverly A Mock, Rolf E Swenson, Kylie J Walters

Journal: Nature

PubMed ID: 38509117

Doi: 10.1038/s41467-024-46644-7

Products & Services: Plasmid DNA Preparation

Development of a colloidal gold immunochromatographic strip for rapid detection of avian coronavirus infectious bronchitis virus

Authors: Chang-Run Zhao, Li-Ting Lin, Jin-Wen Tang, Yu Zhang, Wen Zhang, Ji-Ming Chen, Ping Wei, Teng Huang, Tian-Chao Wei, Mei-Lan Mo

Journal: Poult Sci

PubMed ID: 38574460

Doi: 10.1016/j.psj.2024.103648.

Products & Services: Proteins, Expression, Isolation and Analysis

A common protein C inhibitor exosite partially controls the heparin induced activation and inhibition of serine proteases

Authors: Urfi Siddiqui, Abdul Burhan Khan, Tahif Ahmad, Ahmed Abdur Rehman, Mohamad Aman Jairajpuri

Journal: Int J Biol Macromol

PubMed ID: 38521329

Doi: 10.1016/j.ijbiomac.2024.131065

Products & Services: PCR Cloning and Subcloning

OsWRKY78 regulates panicle exsertion via gibberellin signaling pathway in rice

Authors: Enyang Mei, Mingliang He, Min Xu, Jiaqi Tang, Jiali Liu, Yingxiang Liu, Zhipeng Hong, Xiufeng Li, Zhenyu Wang, Qingjie Guan, Xiaojie Tian, Qingyun Bu

Journal: J Integr Plant Biol

PubMed ID: 38470298

Doi: 10.1111/jipb.13636

Products & Services: Proteins, Expression, Isolation and Analysis

Structural basis for RAD18 regulation by MAGEA4 and its implications for RING ubiquitin ligase binding by MAGE family proteins

Authors: Simonne Griffith-Jones, Lucía Álvarez, Urbi Mukhopadhyay, Sarah Gharbi, Mandy Rettel, Michael Adams, Janosch Hennig, Sagar Bhogaraju

Journal: EMBO J

PubMed ID: 38448672

Doi: 10.1038/s44318-024-00058-9

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Saikosaponin d protects pancreatic acinar cells against cerulein-induced pyroptosis through alleviating mitochondrial damage and inhibiting cGAS-STING pathway

Authors: Hui Chen, Xirong Lu, Beiqi Xu, Gang Cheng, Yuyi Li, Dan Xie

Journal: J Appl Toxicol

PubMed ID: 38462915

Doi: 10.1002/jat.4594

Products & Services: Gene Synthesis

Enhancing precision medicine: Bispecific antibody-mediated targeted delivery of lipid nanoparticles for potential cancer therapy

Authors: Yue Zhang, Xiaoyan Gu, Lili Huang, Yani Yang, Jun He

Journal: Int J Pharm

PubMed ID: 38467208

Doi: 10.1016/j.ijpharm.2024.123990

Products & Services: Molecular Biology Tools

Construction by artificial intelligence and immunovalidation of hypoallergenic mite allergen Der f 36 vaccine

Authors: Qiao-Zhi Qin, Jian Tang, Cai-Yun Wang, Zhi-Qiang Xu, Man Tian

Journal: Front Immunol

PubMed ID: 38601166

Doi: 10.3389/fimmu.2024.1325998

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An oncolytic vaccinia virus encoding hyaluronidase reshapes the extracellular matrix to enhance cancer chemotherapy and immunotherapy

Authors: Shibing Wang, Yuxin Li, Chuning Xu, Jie Dong, Jiwu Wei

Journal: J Immunother Cancer

PubMed ID: 38458640

Doi: 10.1136/jitc-2023-008431

Products & Services: Recombinant Proteins

CAR-engineered lymphocyte persistence is governed by a FAS ligand/FAS auto-regulatory circuit

Authors: Fei Yi, Tal Cohen, Natalie Zimmerman, Friederike Dündar, Paul Zumbo, Razan Eltilib, Erica J Brophy, Hannah Arkin, Judith Feucht, Michael V Gormally, Christopher S Hackett, Korbinian N Kropp, Inaki Etxeberria, Smita S Chandran, Jae H Park, Katharine C Hsu, Michel Sadelain, Doron Betel, Christopher A Klebanoff

Journal: biorxiv

PubMed ID: 38464085

Doi: 10.1101/2024.02.26.582108

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Biochemical and structural analysis of N-myristoyltransferase mediated protein tagging

Authors: Paul Monassa , Frédéric Rivière , Cyril Dian , Frédéric Frottin , Carmela Giglione , Thierry Meinnel

Journal: Methods Enzymol .

PubMed ID: 37230587

Doi: 10.1016/bs.mie.2023.02.016

Products & Services: Peptide Synthesis

Kinetic and catalytic features of N-myristoyltransferases

Authors: Frédéric Rivière , Paul Monassa , Carmela Giglione , Thierry Meinnel

Journal: Methods Enzymol .

PubMed ID: 37230588

Doi: 10.1016/bs.mie.2023.02.018

Products & Services: Peptide Synthesis

A next generation peripherally restricted Cavα2δ-1 ligand with inhibitory action on Cav22 channels and utility in neuropathic pain

Authors: Franz Kricek, Christine Ruf, Premji Meghani, Ivana A Souza, Maria A Gandini, Gerald W Zamponi, George Skouteris

Journal: Biomed Pharmacother

PubMed ID: 38531121

Doi: 10.1016/j.biopha.2024.116472

Products & Services: Molecular Biology Reagents

Oxysterol 25-hydroxycholesterol activation of ferritinophagy inhibits the development of squamous intraepithelial lesion of cervix in HPV-positive patients

Authors: Tianming Wang, Min Gong, Yingfei Lu, Chengcheng Zhao, Ling Ling, Jianquan Chen, Rong Ju

Journal: Cell Death Discov

PubMed ID: 38472192

Doi: 10.1038/s41420-024-01899-3

Products & Services: Proteins, Expression, Isolation and Analysis

Influence of Mutations and N-Glycosylation Sites in the Receptor-Binding Domain (RBD) and the Membrane Protein of SARS-CoV-2 Variants of Concern on Antibody Binding in ELISA

Authors: Mandy Schwarze, Daniela Volke, Juan Camilo Rojas Echeverri, Robin Schick, Nicole Lakowa, Thomas Grünewald, Johannes Wolf, Stephan Borte, Markus Scholz, Andor Krizsan, Ralf Hoffmann

Journal: Biology (Basel)

PubMed ID: 38666819

Doi: 10.3390/biology13040207

Products & Services: Proteins, Expression, Isolation and Analysis

Study on the Thermal Stability of the Sweet-Tasting Protein Brazzein Based on Its Structure-Sweetness Relationship

Authors: Jingnan Zuo, Wei Zheng, Nian Shi, Rong Song, Fei Han, Chen Yang, Jingwen Li, Chao Peng, Bin Li, Yijie Chen

Journal: J Agric Food Chem

PubMed ID: 38526016

Doi: 10.1021/acs.jafc.3c09616

Products & Services: Gene Synthesis

Involvement of TGFBI-TAGLN axis in cancer stem cell property of head and neck squamous cell carcinoma

Authors: Motoharu Sarubo, Yasuhiro Mouri, Akira Moromizato, Azusa Yamada, Shengjan Jin, Wenhua Shao, Hiroko Hagita, Keiko Miyoshi, Yasusei Kudo

Journal: Sci Rep

PubMed ID: 38514830

Doi: 10.1038/s41598-024-57478-0

Products & Services: Molecular Biology Reagents

AIRE is expressed in breast cancer TANs and TAMs to regulate the extrinsic apoptotic pathway and inflammation

Authors: Eva Källberg, Meliha Mehmeti-Ajradini, Frida Björk Gunnarsdottir, Marcus Göransson, Caroline Bergenfelz, Roni Allaoui Fredriksson, Catharina Hagerling, Martin E Johansson, Charlotte Welinder, Karin Jirström, Karin Leandersson

Journal: J Leukoc Biol

PubMed ID: 38060995

Doi: 10.1093/jleuko/qiad152

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Identification of mA RNA methylation genes in and expression profiling in response to different developmental and environmental stimuli

Authors: Mahbub Hasan, Zakia Sultana Nishat, Md Soyib Hasan, Tanvir Hossain, Ajit Ghosh

Journal: Biochem Biophys Rep

PubMed ID: 38511186

Doi: 10.1016/j.bbrep.2024.101677

Products & Services: Proteins, Expression, Isolation and Analysis

Atrogin-1 promotes muscle homeostasis by regulating levels of endoplasmic reticulum chaperone BiP

Authors: Avnika A Ruparelia, Margo Montandon, Jo Merriner, Cheng Huang, Siew Fen Lisa Wong, Carmen Sonntag, Justin P Hardee, Gordon S Lynch, Lee B Miles, Ashley Siegel, Thomas E Hall, Ralf B Schittenhelm, Peter D Currie

Journal: JCI Insight

PubMed ID: 38530354

Doi: 10.1172/jci.insight.167578

Products & Services: Molecular Biology Reagents

Mucosal tumor vaccination delivering endogenous tumor antigens protects against pulmonary breast cancer metastases

Authors: Friederike Oltmanns, Ana Vieira Antão, Pascal Irrgang, Vera Viherlehto, Leticia Jörg, Anna Schmidt, Jannik T Wagner, Michael Rückert, Ann-Sophie Flohr, Carol Imanuel Geppert, Benjamin Frey, Wibke Bayer, Claudia Gravekamp, Matthias Tenbusch, Udo Gaipl, Dennis Lapuente

Journal: J Immunother Cancer

PubMed ID: 38458636

Doi: 10.1136/jitc-2023-008652

Products & Services: Peptide Synthesis

Oxygen Activation in Aromatic Ring Cleaving Salicylate Dioxygenase: Detection of Reaction Intermediates with a Nitro-substituted Substrate Analog

Authors: Qian Wang, Hanbin Li, Uran Bujupi, Janosch Gröning, Andreas Stolz, Angelo Bongiorno, Rupal Gupta

Journal: Chembiochem

PubMed ID: 38363551

Doi: 10.1002/cbic.202400023

Products & Services: Molecular Biology Reagents

Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection

Authors: Julie Rageul , Natalie Lo , Amy L Phi , Jinal A Patel , Jennifer J Park , Hyungjin Kim

Journal: Cell Rep

PubMed ID: 38393943

Doi: 10.1016/j.celrep.2024.113845

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Bacillus cereus cereolysin O induces pyroptosis in an undecapeptide-dependent manner

Authors: Yujian Wang, Jingchang Luo, Xiaolu Guan , Yan Zhao , Li Sun

Journal: Cell Death Discov

PubMed ID: 38458999

Doi: 10.1038/s41420-024-01887-7

Products & Services: Proteins, Expression, Isolation and Analysis

The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb

Authors: Ran Feng, Feng Liu, Ruofei Li, Zhifen Zhou, Zhuoheng Lin, Song Lin, Shengcheng Deng, Yingying Li, Baoting Nong, Ying Xia, Zhiyi Li, Xiaoqin Zhong, Shuhan Yang, Gang Wan, Wenbin Ma, Su Wu, Zhou Songyang

Journal: Cell Research

PubMed ID: 38448650

Doi: 10.1038/s41422-024-00938-z

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Structural analysis of phosphoribosyltransferase-mediated cell wall precursor synthesis in Mycobacterium tuberculosis

Authors: Shan Gao, Fangyu Wu, Sudagar S Gurcha, Sarah M Batt, Gurdyal S Besra, Zihe Rao, Lu Zhang

Journal: Nature

PubMed ID: 38491273

Doi: 10.1038/s41564-024-01643-8

Products & Services: Proteins, Expression, Isolation and Analysis

Persistent immune imprinting occurs after vaccination with the COVID-19 XBB.1.5 mRNA booster in humans

Authors: M Alejandra Tortorici, Amin Addetia, Albert J Seo, Jack Brown, Kaiti Sprouse, Jenni Logue, Erica Clark, Nicholas Franko, Helen Chu, David Veesler

Journal: Immunity

PubMed ID: 38490197

Doi: 10.1016/j.immuni.2024.02.016

Products & Services: Plasmid DNA Preparation

Specific protein-RNA interactions are mostly preserved in biomolecular condensates

Authors: Tebbe de Vries, Mihajlo Novakovic, Yinan Ni, Izabela Smok, Clara Inghelram, Maria Bikaki, Chris P Sarnowski, Yaning Han, Leonidas Emmanouilidis, Giacomo Padroni, Alexander Leitner, Frédéric H-T Allain

Journal: SCIENCE ADVANCES

PubMed ID: 38446881

Doi: 10.1126/sciadv.adm7435

Products & Services: PCR Cloning and Subcloning

A uniquely efficacious type of CFTR corrector with complementary mode of action

Authors: Valentina Marchesin, Lucile Monnier, Peter Blattmann, Florent Chevillard, Christine Kuntz, Camille Forny, Judith Kamper, Rolf Studer, Alexandre Bossu, Eric A Ertel, Oliver Nayler, Christine Brotschi, Jodi T Williams, John Gatfield

Journal: SCIENCE ADVANCES

PubMed ID: 38427726

Doi: 10.1126/sciadv.adk1814

Products & Services: PCR Cloning and Subcloning

FUS reads histone H3K36me3 to regulate alternative polyadenylation

Authors: Junqi Jia, Haonan Fan, Xinyi Wan, Yuan Fang, Zhuoning Li, Yin Tang, Yanjun Zhang, Jun Huang, Dong Fang

Journal: Nucleic Acids Research

PubMed ID: 38499486

Doi: 10.1093/nar/gkae184

Products & Services: Proteins, Expression, Isolation and Analysis

An optimised protocol for the expression and purification of adenovirus core protein VII

Authors: Ajani Athukorala, Karla J Helbig, Brian P McSharry, Jade K Forwood, Subir Sarker

Journal: J Virol Methods

PubMed ID: 38432358

Doi: 10.1016/j.jviromet.2024.114907

Products & Services: Molecular Biology Reagents

A pattern recognition receptor interleukin-1 receptor is involved in reproductive immunity in Macrobrachium nipponense ovary

Authors: Haifu Wan, Lei Yu, Xiaodong Cui, Shuai Guo, Shumei Mu, Xianjiang Kang

Journal: Fish Shellfish Immunol

PubMed ID: 38479568

Doi: 10.1016/j.fsi.2024.109481

Products & Services: Recombinant Proteins

Genetic fusion of CCL11 to antigens enhances antigenicity in nucleic acid vaccines and eradicates tumor mass through optimizing T-cell response

Authors: Hailong Qi, Zhongjie Sun, Tianle Gao, Yanling Yao, Yu Wang, Weiwei Li, Xudong Wang, Xiaofang Wang, Defang Liu, Jian-Dong Jiang

Journal: Mol Cancer

PubMed ID: 38459592

Doi: 10.1186/s12943-024-01958-4

Products & Services: Proteins, Expression, Isolation and Analysis

MicroRNA-223-3p downregulates the inflammatory response in preeclampsia placenta via targeting NLRP3

Authors: Xueqiong Liu, Zhiyue Li, Dan Lu

Journal: BMC Pregnancy Childbirth

PubMed ID: 38448875

Doi: 10.1186/s12884-024-06371-9

Products & Services: Gene Synthesis

Absence of specific autoantibodies in patients with narcolepsy type 1 as indicated by an unbiased random peptide-displayed phage screening

Authors: Thi-Tuyet Trinh Tran, Thi-Hong Nhung Nguyen, Yves Dauvilliers, Roland Liblau, Xuan-Hung Nguyen

Journal: PLoS ONE

PubMed ID: 38442093

Doi: 10.1371/journal.pone.0297625

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A new trivalent recombinant protein for type 2 diabetes mellitus with oral delivery potential: design, expression, and experimental validation

Authors: Maryam Ehsasatvatan, Bahram Baghban Kohnehrouz

Journal: J Biomol Struct Dyn

PubMed ID: 38468545

Doi: 10.1080/07391102.2024.2329290

Products & Services: Molecular Biology Reagents

Bactericera cockerelli Picorna-like Virus and Three New Viruses Found Circulating in Populations of Potato/Tomato Psyllids ()

Authors: Jennifer Dahan, Gardenia E Orellana, Kaleigh B Wald, Erik J Wenninger, W Rodney Cooper, Alexander V Karasev

Journal: Viruses

PubMed ID: 38543780

Doi: 10.3390/v16030415

Products & Services: PCR Cloning and Subcloning

Continuous evolution of compact protein degradation tags regulated by selective molecular glues

Authors: Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine A Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu

Journal: Science

PubMed ID: 38484051

Doi: 10.1126/science.adk4422

Products & Services: Proteins, Expression, Isolation and Analysis

Long-term antigen-specific immune response by an oncolytic adenovirus encoding SP-SA-E7-4-1BBL in HPV-16 cancer model

Authors: Alejandra G Martinez-Perez, Rodolfo Garza-Morales, Maria de J Loera-Arias, Sheila A Villa-Cedillo, Aracely Garcia-Garcia, Humberto Rodriguez-Rocha, Orlando E Flores-Maldonado, Jesus Valdes, Jose J Perez-Trujillo, Odila Saucedo-Cardenas

Journal: Mol Biol Rep

PubMed ID: 38460043

Doi: 10.1007/s11033-024-09303-0

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Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals

Authors: Jimena Pérez-Vargas, Gabriel Lemieux, Connor A H Thompson, Antoine Désilets, Siobhan Ennis, Guang Gao, Danielle G Gordon, Annika Lea Schulz, Masahiro Niikura, Ivan Robert Nabi, Mel Krajden, Pierre-Luc Boudreault, Richard Leduc, François Jean

Journal: Antiviral Res

PubMed ID: 38548023

Doi: 10.1016/j.antiviral.2024.105869

Products & Services: Molecular Biology Reagents

Preclinical Development of a Novel Epitope-based DNA Vaccine Candidate against SARS-CoV-2 and Evaluation of Immunogenicity in BALB/c Mice

Authors: Kanwal Khalid, Hui Xuan Lim, Ayaz Anwar, Soon Hao Tan, Jung Shan Hwang, Seng-Kai Ong, Chit Laa Poh

Journal: AAPS PharmSciTech

PubMed ID: 38472523

Doi: 10.1208/s12249-024-02778-x

Products & Services: Proteins, Expression, Isolation and Analysis

HTRA1 disaggregates α-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species

Authors: Sheng Chen, Anuradhika Puri, Braxton Bell, Joseph Fritsche, Hector H Palacios, Maurie Balch, Macy L Sprunger, Matthew K Howard, Jeremy J Ryan, Jessica N Haines, Gary J Patti, Albert A Davis, Meredith E Jackrel

Journal: Nat Commun

PubMed ID: 38499535

Doi: 10.1038/s41467-024-46538-8

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Endothelial β-catenin upregulation and Y142 phosphorylation drive diabetic angiogenesis via upregulating KDR/HDAC9

Authors: Zhenfeng Chen, Bingqi Lin, Xiaodan Yao, Jie Weng, Jinlian Liu, Qi He, Ke Song, Chuyu Zhou, Zirui Zuo, Xiaoxia Huang, Zhuanhua Liu, Qiaobing Huang, Qiulin Xu, Xiaohua Guo

Journal: Cell Commun Signal

PubMed ID: 38491522

Doi: 10.1186/s12964-024-01566-1

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Reactive Oxygen Species-Responsive Nanoparticles Toward Extracellular Matrix Normalization for Pancreatic Fibrosis Regression

Authors: Liang Qi, Bo-Wen Duan, Hui Wang, Yan-Jun Liu, Han Han, Meng-Meng Han, Lei Xing, Hu-Lin Jiang, Stephen J Pandol, Ling Li

Journal: Adv Sci (Weinh)

PubMed ID: 38483920

Doi: 10.1002/advs.202401254

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Highly sensitive spatial transcriptomics using FISHnCHIPs of multiple co-expressed genes

Authors: Xinrui Zhou , Wan Yi Seow, Norbert Ha, Teh How Cheng, Lingfan Jiang, Jeeranan Boonruangkan, Jolene Jie Lin Goh, Shyam Prabhakar, Nigel Chou, Kok Hao Chen Affiliations expand

Journal: Nat Commun

PubMed ID: 38491027

Doi: s41467-024-46669-y

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Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography

Authors: Kaylen R Meeks, Juan Ji , Mykola V Protopopov , Olga O Tarkhanova , Yurii S Moroz , John J Tanner

Journal: J Chem Inf Model

PubMed ID: 38411104

Doi: 10.1021/acs.jcim.3c01879

Products & Services: Molecular Biology Reagents

Exploring functional genes' correlation with ()-equol concentration and new daidzein racemase identification

Authors: Yun-Fei Hu, Shu Luo, Sheng-Qi Wang, Ke-Xin Chen, Wei-Xuan Zhong, Bai-Yuan Li, Lin-Yan Cao, Hua-Hai Chen, Ye-Shi Yin

Journal: Appl Environ Microbiol

PubMed ID: 38501861

Doi: 10.1128/aem.00007-24

Products & Services: Molecular Biology Reagents

Morusin Alleviates Aortic Valve Calcification by Inhibiting Valve Interstitial Cell Senescence Through Ccnd1/Trim25/Nrf2 Axis

Authors: Zongtao Liu, Kan Wang, Chen Jiang, Yuqi Chen, Fayuan Liu, Minghui Xie, Wai Yen Yim, Dingyi Yao, Xingyu Qian, Shiqi Chen, Jiawei Shi, Kang Xu, Yixuan Wang, Nianguo Dong

Journal: Adv Sci (Weinh)

PubMed ID: 38502885

Doi: 10.1002/advs.202307319

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