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PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport

Authors: Paraskevi Tziortzouda , Jolien Steyaert , Wendy Scheveneels , Adria Sicart , Katarina Stoklund Dittlau , Adriana Margarida Barbosa Correia , Thibaut Burg , Arun Pal , Andreas Hermann , Philip Van Damme , Thomas G Moens , Ludo Van Den Bosch

Journal: Acta Neuropathol

PubMed ID: 38363426

Doi: 10.1007/s00401-024-02689-y

Products & Services: Peptide Synthesis

ZSCAN10 deficiency causes a neurodevelopmental disorder with characteristic oto-facial

Authors: Lucia Laugwitz, Fubo Cheng, Stephan C Collins, Alexander Hustinx, Nicolas Navarro, Simon Welsch, Helen Cox, Tzung-Chien Hsieh, Aswinkumar Vijayananth, Rebecca Buchert, Benjamin Bender, Stephanie Efthymiou, David Murphy, Faisal Zafar, Nuzhat Rana, Ute Grasshoff, Ruth J Falb, Mona Grimmel, Annette Seibt, Wenxu Zheng, Hamid Ghaedi, Marie Thirion, Sébastien Couette, Reza Azizimalamiri, Saeid Sadeghian, Hamid Galehdari, Mina Zamani, Jawaher Zeighami, Alireza Sedaghat, Samira Molaei Ramshe, Ali Zare, Behnam Alipoor, Dirk Klee,

Journal: Brain

PubMed ID: 38386308

Doi: 10.1093/brain/awae058

Products & Services: PCR Cloning and Subcloning

Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks

Authors: Carla A Jaeger-Ruckstuhl Yun Lo, Elena Fulton , Olivia G Waltner, Tamer B Shabaneh , Sylvain Simon , Pranav V Muthuraman , Colin E Correnti , Oliver J Newsom , Ian A Engstrom , Sami B Kanaan , Shruti S Bhise , Jobelle M C Peralta , Raymond Ruff , Jason P Price , Sylvia M Stull , Andrew R Stevens , Grace Bugos, Mitchell G Kluesner , Valentin Voillet, Vishaka Muhunthan, Fionnuala Morrish, James M Olson , Raphaël Gottado , Jay F Sarthy, Steven Henikoff , Lucas B Sullivan, Scott N Furlan, Stanley R Riddell

Journal: Immunity

PubMed ID: 38354704

Doi: 10.1016/j.immuni.2024.01.011

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Local structural preferences in shaping tau amyloid polymorphism

Authors: Nikolaos Louros , Martin Wilkinson , Grigoria Tsaka , Meine Ramakers , Chiara Morelli , Teresa Garcia , Rodrigo Gallardo , Sam D'Haeyer , Vera Goossens , Dominique Audenaert , Dietmar Rudolf Thal , Ian R Mackenzie , Rosa Rademakers , Neil A Ranson , Sheena E Radford , Frederic Rousseau , Joost Schymkowitz

Journal: Nat Commun

PubMed ID: 38310108

Doi: 10.1038/s41467-024-45429-2

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Identification of closely related species in through Analysis of Whole-Genome

Authors: Guihong Qi, Lijun Hao, Yutong Gan, Tianyi Xin, Qian Lou, Wenjie Xu, Jingyuan Song

Journal: Front Microbiol

PubMed ID: 38450170

Doi: 10.3389/fmicb.2024.1323572

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Antiviral activity of immunosuppressors alone and in combination against human adenovirus and cytomegalovirus

Authors: Marta Carretero-Ledesma, Manuela Aguilar-Guisado, Judith Berastegui-Cabrera, María Balsera-Manzanero, Jerónimo Pachón, Elisa Cordero, Javier Sánchez-Céspedes

Journal: Int J Antimicrob Agents

PubMed ID: 38401774

Doi: 10.1016/j.ijantimicag.2024.107116

Products & Services: PCR Cloning and Subcloning

A phenylalanine-free recombinant nutritional protein for the dietary management of phenylketonuria

Authors: Yvonne Mücke, Natalia Jablonka, Nicole Rimann, Hiu Man Grisch-Chan, Bernhard Hoffmann, Stefan Schillberg, Beat Thöny, Stefan Rasche

Journal: J Inherit Metab Dis

PubMed ID: 38390655

Doi: 10.1002/jimd.12719

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Authors: Chenwei Wang, Jiewen Chen, Jingyao Li, Zhihong Xu, Lihong Huang, Qian Zhao, Lei Chen, Xiaolong Liang, Hai Hu, Gang Li, Chengjie Xiong, Bin Wu, Hua You, Danyi Du, Xiaoling Wang, Hongle Li, Zibing Wang, Lin Chen

Journal: J Clin Invest

PubMed ID: 38412034

Doi: 10.1172/JCI172092

Products & Services: Molecular Biology Reagents

The molecular interaction pattern of lenvatinib enables inhibition of wild-type or kinase-mutated FGFR2-driven cholangiocarcinoma

Authors: Stephan Spahn, Fabian Kleinhenz, Ekaterina Shevchenko, Aaron Stahl, Yvonne Rasen, Christine Geisler, Kristina Ruhm, Marion Klaumuenzer, Thales Kronenberger, Stefan A Laufer, Holly Sundberg-Malek, Khac Cuong Bui, Marius Horger, Saskia Biskup, Klaus Schulze-Osthoff, Markus Templin, Nisar P Malek, Antti Poso, Michael Bitzer

Journal: Nat Commun

PubMed ID: 38346946

Doi: 10.1038/s41467-024-45247-6

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Molecular Characterization of Plant Volatile Compound Interactions with Odorant-Binding Proteins

Authors: Qi Qian, Xin Guo, Lingjie Wu, Jiarong Cui, Huiying Gao, Yajun Yang, Hongxing Xu, Zhongxian Lu, Pingyang Zhu

Journal: Plants (Basel)

PubMed ID: 38498446

Doi: 10.3390/plants13040479

Products & Services: Proteins, Expression, Isolation and Analysis

Cytokine responses to major human Cytomegalovirus antigens in mouse model

Authors: Sahar Essa, Hussain A Safar, Raj Raghupathy

Journal: Cytokine

PubMed ID: 38359558

Doi: 10.1016/j.cyto.2024.156546

Products & Services: Proteins, Expression, Isolation and Analysis

A recent gibbon ape leukemia virus germline integration in a rodent from New Guinea

Authors: Saba Mottaghinia, Saskia Stenzel, Kyriakos Tsangaras, Nikolas Nikolaidis, Michael Laue, Karin Müller, Henriette Hölscher, Ulrike Löber, Gayle K McEwen, Stephen C Donnellan, Kevin C Rowe, Ken P Aplin, Christine Goffinet, Alex D Greenwood

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38305758

Doi: 10.1073/pnas.2220392121

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A Diversity Covering (DiCo) Plasmodium vivax apical membrane antigen-1 vaccine adjuvanted with RFASE/RSL10 yields high levels of growth-inhibitory antibodies

Authors: Bart W Faber, Lee M Yeoh, Liriye Kurtovic, Wim E M Mol, Martin Poelert, Elly Smits, Roberto Rodriguez Garcia, Marjolein Mandalawi-Van der Eijk, Nicole van der Werff, Annemarie Voorberg-van der Wel, Edmond J Remarque, James G Beeson, Clemens H M Kocken

Journal: Vaccine

PubMed ID: 38365484

Doi: 10.1016/j.vaccine.2024.02.029

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Cloning of three epsilon-class glutathione -transferase genes from (Graeser) (Lepidoptera: Notodontidae) and their response to tannic acid

Authors: Ling Zhang, Huizhen Tu, Fang Tang

Journal: Bull Entomol Res

PubMed ID: 38327098

Doi: 10.1017/S0007485323000718

Products & Services: Molecular Biology Reagents

Nucleocapsid protein-specific monoclonal antibodies protect mice against Crimean-Congo hemorrhagic fever virus

Authors: Aura R Garrison, Vanessa Moresco, Xiankun Zeng, Curtis R Cline, Michael D Ward, Keersten M Ricks, Scott P Olschner, Lisa H Cazares, Elif Karaaslan, Collin J Fitzpatrick, Éric Bergeron, Scott D Pegan, Joseph W Golden

Journal: Nat Commun

PubMed ID: 38409240

Doi: 10.1038/s41467-024-46110-4

Products & Services: Molecular Biology Reagents

Oral administration of a recombinant modified RBD antigen of SARS-CoV-2 as a possible immunostimulant for the care of COVID-19

Authors: Norma A Valdez-Cruz, Diego Rosiles-Becerril, Constanza E Martínez-Olivares, Enrique García-Hernández, Laura Cobos-Marín, Daniel Garzón, Francisco E López-Salas, Guadalupe Zavala, Axel Luviano, Alejandro Olvera, Alejandro Alagón, Octavio T Ramírez, Mauricio A Trujillo-Roldán

Journal: Microb Cell Fact

PubMed ID: 38321489

Doi: 10.1186/s12934-024-02320-5

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Direct observation of autoubiquitination for an integral membrane ubiquitin ligase in ERAD

Authors: Basila Moochickal Assainar, Kaushik Ragunathan, Ryan D Baldridge

Journal: Nat Commun

PubMed ID: 38351109

Doi: 10.1038/s41467-024-45541-3

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Seroprevalence of Anti-SARS-CoV-2 Antibodies in Cats during Five Waves of COVID-19 Epidemic in Thailand and Correlation with Human Outbreaks

Authors: Suporn Thongyuan, Jeeraphong Thanongsaksrikul, Potjanee Srimanote, Wallaya Phongphaew, Piyaporn Eiamcharoen, Naris Thengchaisri, Angela Bosco-Lauth, Nicola Decaro, Rungrueang Yodsheewan

Journal: Animals (Basel)

PubMed ID: 38473145

Doi: 10.3390/ani14050761

Products & Services: Molecular Biology Reagents

Production and Immunogenicity Assessment of LTp50: An -Made Chimeric Antigen Targeting S1- and S2-Epitopes from the SARS-CoV-2/BA5 Spike Protein

Authors: Alejandra Wong-Arce, Omar Gonzalez-Ortega, Andrea Romero-Maldonado, Arleth Miranda-López, Mariano García-Soto, Susan Farfán-Castro, Lourdes Betancourt-Mendiola, Samaporn Teeravechyan, Kanjana Srisutthisamphan, Mauricio Comas-García, Karla I Solís Andrade, Sergio Rosales-Mendoza

Journal: Pharmaceuticals (Basel)

PubMed ID: 38543088

Doi: 10.3390/ph17030302

Products & Services: Proteins, Expression, Isolation and Analysis

A Pseudovirus-Based Neutralization Assay for SARS-CoV-2 Variants: A Rapid, Cost-Effective, BSL-2-Based High-Throughput Assay Useful for Vaccine Immunogenicity Evaluation

Authors: Zhaohui Cai, Raj Kalkeri, Mingzhu Zhu, Shane Cloney-Clark, Benjamin Haner, Mi Wang, Bahar Osman, Dominic Dent, Sheau-Line Feng, Zach Longacre, Greg Glenn, Joyce S Plested

Journal: Microorganisms

PubMed ID: 38543552

Doi: 10.3390/microorganisms12030501

Products & Services: Codon Optimization

Characterization of antibodies targeting severe fever with thrombocytopenia syndrome virus glycoprotein Gc

Authors: Kaori Sano, Miyuki Kimura, Akiko Sataka, Hideki Hasegawa, Hideki Tani, Tadaki Suzuki

Journal: Arch Virol

PubMed ID: 38308735

Doi: 10.1007/s00705-024-05968-x

Products & Services: Proteins, Expression, Isolation and Analysis

Nanofibrous MultiDomain Peptide Hydrogels Provide T Cells a 3D, Cytocompatible Environment for Cell Expansion and Antigen-Specific Killing

Authors: Viridiana Leyva-Aranda, Shailbala Singh, Maria J Telesforo, Simon Young, Cassian Yee, Jeffrey D Hartgerink

Journal: ACS Biomater Sci Eng

PubMed ID: 38385283

Doi: 10.1021/acsbiomaterials.3c01617

Products & Services: Proteins, Expression, Isolation and Analysis

Prediction of anticancer peptides derived from the true lectins of Phoenix dactylifera and their synergetic effect with mitotane

Authors: Othman Baothman, Ehab M. M. Ali , Salman Hosawi , Emadeldin Hassan E. Konoz, Isam M. Abu Zeid, Abrar Ahmadand Hisham N. Altayb

Journal: Frontiers in pharmacology

Doi: 10.3389/fphar.2024.1322865

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GDI2 deletion alleviates neurodegeneration and memory loss in the 5xFAD mice model of Alzheimer's disease

Authors: Meitian Wang, Xiuqing He, Jie Li, Daobin Han, Pan You, Hui Yu, Luwen Wang, Bo Su

Journal: Biochim Biophys Acta Mol Basis Dis

PubMed ID: 38382624

Doi: 10.1016/j.bbadis.2024.167093

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SARS-CoV-2 Membrane protein regulates the function of Spike by inhibiting its plasma membrane localization and enzymatic activity of Furin

Authors: Qi Xiang, Jie Wu, Yuzheng Zhou, Linhao Li, Miao Tian, Guobao Li, Zheng Zhang, Yang Fu

Journal: Microbiol Res

PubMed ID: 38430890

Doi: 10.1016/j.micres.2024.127659

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Proteomic analysis of milk fat globule membrane proteins in mature human milk of women with and without gestational diabetes mellitus

Authors: Dan Yao, Cai Shen, Jingwen Yu, Jiayue Tang, Hong Zhang, Xuebing Xu, Maolin Tu, Ling-Zhi Cheong

Journal: Food Chem

PubMed ID: 38354646

Doi: 10.1016/j.foodchem.2024.138691

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ATP10A deficiency results in male-specific infertility in mice

Authors: Adriana C Norris, Eugenia M Yazlovitskaya, Tzushan Sharon Yang, Alex Mansueto, John M Stafford, Todd R Graham

Journal: Front Cell Dev Biol

PubMed ID: 38415274

Doi: 10.3389/fcell.2024.1310593

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A BET inhibitor, NHWD-870, can downregulate dendritic cells maturation via the IRF7-mediated signaling pathway to ameliorate imiquimod-induced psoriasis-like murine skin inflammation

Authors: Liping Jin, Liang Dong, Shiyao Pei, Xiang Chen, Yehong Kuang, Wangqing Chen, Wu Zhu, Mingzhu Yin

Journal: Eur J Pharmacol

PubMed ID: 38311277

Doi: 10.1016/j.ejphar.2024.176382

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Identification and characterization of the low molecular mass ferredoxins involved in central metabolism in Heliomicrobium modesticaldum

Authors: Karim A Walters, Kevin E Redding, John H Golbeck

Journal: Photosynth Res

PubMed ID: 38306001

Doi: 10.1007/s11120-023-01069-z

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Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane

Authors: Rebika Shrestha, Timothy S Carpenter, Que N Van, Constance Agamasu, Marco Tonelli, Fikret Aydin, De Chen, Gulcin Gulten, James N Glosli, Cesar A López, Tomas Oppelstrup, Chris Neale, Sandrasegaram Gnanakaran, William K Gillette, Helgi I Ingólfsson, Felice C Lightstone, Andrew G Stephen, Frederick H Streitz, Dwight V Nissley, Thomas J Turbyville

Journal: Commun Biol

PubMed ID: 38418613

Doi: 10.1038/s42003-024-05916-0

Products & Services: Proteins, Expression, Isolation and Analysis

miR-193b-5p promotes GCRV replication by inhibiting autophagy via targeting deptor in grass carp (Ctenopharyngodon idellus)

Authors: Hongyan Yu, Zheyan Chen, Qiaozhen Yu, Yubang Shen, Lang Gui, Xiaoyan Xu, Jiale Li

Journal: Fish Shellfish Immunol

PubMed ID: 38365163

Doi: 10.1016/j.fsi.2024.109453

Products & Services: Proteins, Expression, Isolation and Analysis

High-Level Biosynthesis of Chlorogenic Acid from Mixed Carbon Sources of Xylose and Glucose through a Rationally Refactored Pathway Network

Authors: Yuhui Wang, Haining Tan, Yanling Wang, Jing Liang Qin, Xinyu Zhao, Yuhan Di, Lijie Xie, Xiaojing Zhao, Ziyu Li, Guozhen Ma, Lingyan Jiang, Bin Liu, Di Huang

Journal: J Agric Food Chem

PubMed ID: 38330270

Doi: 10.1021/acs.jafc.3c08587

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Voltage-gated ion channels are expressed in the Malpighian tubules and anal papillae of the yellow fever mosquito (Aedes aegypti), and may regulate ion transport during salt and water imbalance

Authors: Serena Farrell, Jocelyne Dates, Nancy Ramirez, Hannah Hausknecht-Buss, Dennis Kolosov

Journal: J Exp Biol

PubMed ID: 38197515

Doi: 10.1242/jeb.246486

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A novel ex vivo assay to evaluate functional effectiveness of Plasmodium vivax transmission blocking vaccine using Pvs25 transgenic P. berghei

Authors: Yi Cao, Clifford T H Hayashi, Nirbhay Kumar

Journal: J Infect Dis

PubMed ID: 38408353

Doi: 10.1093/infdis/jiae102

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Cryo-EM structures of the plant plastid-encoded RNA polymerase

Authors: Xiao-Xian Wu, Wen-Hui Mu, Fan Li, Shu-Yi Sun, Chao-Jun Cui , Chanhong Kim, Fei Zhou , Yu Zhang

Journal: Cell

PubMed ID: 38428393

Doi: 10.1016/j.cell.2024.01.026

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Therapeutic potential of exosome derived from hepatocyte growth factor-overexpressing adipose mesenchymal stem cells in TGFβ1-stimulated hepatic stellate cells

Authors: Jin Wang, Weikang Ye, Ming Jiang, Yinong Zhou, Jie Zheng

Journal: Cytotechnology

PubMed ID: 38495297

Doi: 10.1007/s10616-023-00611-0

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Membrane-Associated Ubiquitin Ligase RING Finger Protein 152 Orchestrates Melanogenesis via Tyrosinase Ubiquitination

Authors: Ryota Ueda, Rina Hashimoto, Yuki Fujii, José C J M D S Menezes, Hirotaka Takahashi, Hiroyuki Takeda, Tatsuya Sawasaki, Tomonori Motokawa, Kenzo Tokunaga, Hideaki Fujita

Journal: Membranes (Basel)

PubMed ID: 38392670

Doi: 10.3390/membranes14020043

Maternal Phlorizin Intake Protects Offspring from Maternal Obesity-Induced Metabolic Disorders in Mice via Targeting Gut Microbiota to Activate the SCFA-GPR43 Pathway

Authors: Xueran Mei, Yi Li, Xiaoyu Zhang, Xiwen Zhai, Yi Yang, Zhengjuan Li, Liping Li

Journal: J Agric Food Chem

PubMed ID: 38349207

Doi: 10.1021/acs.jafc.3c06370

Products & Services: Proteins, Expression, Isolation and Analysis

Targeting deoxynivalenol for degradation by a chimeric manganese peroxidase/glutathione system

Authors: Xiaoyun Su, Shuai Wang, Xiaolu Wang, Wangli Ji, Honglian Zhang, Tao Tu, Nina Hakulinen, Huiying Luo, Wei Zhang, Huoqing Huang

Journal: Ecotoxicol Environ Saf

PubMed ID: 38394761

Doi: 10.1016/j.ecoenv.2024.116130

Inhibition of NS2B-NS3 protease from all four serotypes of dengue virus by punicalagin, punicalin and ellagic acid identified from

Authors: Fouzia Ismat, Anam Tariq, Aqsa Shaheen, Raheem Ullah, Kayode Raheem, Muhammad Muddassar, Sadia Mahboob, Wasim Abbas, Mazhar Iqbal, Moazur Rahman

Journal: J Biomol Struct Dyn

PubMed ID: 38373021

Doi: 10.1080/07391102.2024.2314258

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A sustainable strategy for biosynthesis of Rebaudioside D using a novel glycosyltransferase of Solanum tuberosum

Authors: Siyuan Ma, Yuanyuan Ma

Journal: Biotechnol J

PubMed ID: 38403450

Doi: 10.1002/biot.202300628

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Engineering styrene biosynthesis: designing a functional trans-cinnamic acid decarboxylase in Pseudomonas

Authors: Ana García-Franco, Patricia Godoy, Estrella Duque, Juan L Ramos

Journal: Microb Cell Fact

PubMed ID: 38419048

Doi: 10.1186/s12934-024-02341-0

Products & Services: Proteins, Expression, Isolation and Analysis

Structure-Based Engineering of a Sesquiterpene Cyclase to Generate an Alcohol Product: Conversion of -Isozizaene Synthase into α-Bisabolol Synthase

Authors: Samuel A Eaton, David W Christianson

Journal: Biochemistry

PubMed ID: 38420671

Doi: 10.1021/acs.biochem.3c00681

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High mechanical property silk produced by transgenic silkworms expressing the Dumpy

Authors: Xiangping Dai, Xiaogang Ye, Liangen Shi, Shihua Yu, Xinqiu Wang, Boxiong Zhong

Journal: Front Bioeng Biotechnol

PubMed ID: 38410165

Doi: 10.3389/fbioe.2024.1359587

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Development of an indirect ELISA for the serodiagnosis of canine infection by Onchocerca lupi

Authors: Maria Stefania Latrofa, Viviane Noll Louzada-Flores, Carla Maia, Maureen A Kelly, Guilherme G Verocai, Cinzia Cantacessi, Domenico Otranto

Journal: Sci Rep

PubMed ID: 38336818

Doi: 10.1038/s41598-024-53759-w

Products & Services: Proteins, Expression, Isolation and Analysis

Unravelling the reason for different binding behaviors exhibited by antibody aggregates towards preparative and analytical Protein A columns

Authors: Wanyuan Dong, Mengying Tian, Yifeng Li

Journal: Protein Expr Purif

PubMed ID: 38423157

Doi: 10.1016/j.pep.2024.106449

Products & Services: Proteins, Expression, Isolation and Analysis

Efficient preparation of high-purity and intact mesenchymal stem cell-derived extracellular vesicles

Authors: Fangfang Ni, Qingfu Zhu, Hengrui Li, Fei Liu, Hao Chen

Journal: Anal Bioanal Chem

PubMed ID: 38355844

Doi: 10.1007/s00216-024-05193-0

Products & Services: Proteins, Expression, Isolation and Analysis

Measurement of neuropeptide Y with molecularly imprinted polypyrrole on carbon fiber microelectrodes

Authors: Luis López, Kelly Lozano, John Cruz, Krystal Flores, Lauren Fernández-Vega, Lisandro Cunci

Journal: Neuropeptides

PubMed ID: 38335798

Doi: 10.1016/j.npep.2024.102413

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Single dose of a recombinant vesicular stomatitis virus-based vaccine elicits robust and durable neutralizing antibody response against Hantaan virus

Authors: Hui Zhang, He Liu , Jing Wei , Yamei Dang , Yuan Wang , Qiqi Yang , Liang Zhang , Chuantao Ye , Bin Wang , Xiaolei Jin , Linfeng Cheng , Hongwei Ma , Yangchao Dong , Yinghui Li , Yinlan Bai , Xin Lv , Yingfeng Lei , Zhikai Xu , Wei Ye , Fanglin Zhang

Journal: NPJ Vaccines .

PubMed ID: 38341504

Doi: 10.1038/s41541-024-00814-2

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An Enzyme-Cleavable Solubilizing-Tag Facilitates the Chemical Synthesis of Mirror-Image Protein

Authors: Yupeng Zheng, Baochang Zhang , Wei-Wei Shi, Xiangyu Deng, Tong-Yue Wang, Dongyang Han, Yuxiang Ren, Ziyi Yang, Yong-Kang Zhou, Jian Kuang, Zhi-Wen Wang, Shan Tang, Ji-Shen Zheng

Journal: Angew Chem Int Ed Engl .

PubMed ID: 38326236

Doi: 10.1002/ange.202318897

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