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Inhibition of NS2B-NS3 protease from all four serotypes of dengue virus by punicalagin, punicalin and ellagic acid identified from

Authors: Fouzia Ismat, Anam Tariq, Aqsa Shaheen, Raheem Ullah, Kayode Raheem, Muhammad Muddassar, Sadia Mahboob, Wasim Abbas, Mazhar Iqbal, Moazur Rahman

Journal: J Biomol Struct Dyn

PubMed ID: 38373021

Doi: 10.1080/07391102.2024.2314258

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A sustainable strategy for biosynthesis of Rebaudioside D using a novel glycosyltransferase of Solanum tuberosum

Authors: Siyuan Ma, Yuanyuan Ma

Journal: Biotechnol J

PubMed ID: 38403450

Doi: 10.1002/biot.202300628

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Engineering styrene biosynthesis: designing a functional trans-cinnamic acid decarboxylase in Pseudomonas

Authors: Ana García-Franco, Patricia Godoy, Estrella Duque, Juan L Ramos

Journal: Microb Cell Fact

PubMed ID: 38419048

Doi: 10.1186/s12934-024-02341-0

Products & Services: Proteins, Expression, Isolation and Analysis

Structure-Based Engineering of a Sesquiterpene Cyclase to Generate an Alcohol Product: Conversion of -Isozizaene Synthase into α-Bisabolol Synthase

Authors: Samuel A Eaton, David W Christianson

Journal: Biochemistry

PubMed ID: 38420671

Doi: 10.1021/acs.biochem.3c00681

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High mechanical property silk produced by transgenic silkworms expressing the Dumpy

Authors: Xiangping Dai, Xiaogang Ye, Liangen Shi, Shihua Yu, Xinqiu Wang, Boxiong Zhong

Journal: Front Bioeng Biotechnol

PubMed ID: 38410165

Doi: 10.3389/fbioe.2024.1359587

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Development of an indirect ELISA for the serodiagnosis of canine infection by Onchocerca lupi

Authors: Maria Stefania Latrofa, Viviane Noll Louzada-Flores, Carla Maia, Maureen A Kelly, Guilherme G Verocai, Cinzia Cantacessi, Domenico Otranto

Journal: Sci Rep

PubMed ID: 38336818

Doi: 10.1038/s41598-024-53759-w

Products & Services: Proteins, Expression, Isolation and Analysis

Unravelling the reason for different binding behaviors exhibited by antibody aggregates towards preparative and analytical Protein A columns

Authors: Wanyuan Dong, Mengying Tian, Yifeng Li

Journal: Protein Expr Purif

PubMed ID: 38423157

Doi: 10.1016/j.pep.2024.106449

Products & Services: Proteins, Expression, Isolation and Analysis

Efficient preparation of high-purity and intact mesenchymal stem cell-derived extracellular vesicles

Authors: Fangfang Ni, Qingfu Zhu, Hengrui Li, Fei Liu, Hao Chen

Journal: Anal Bioanal Chem

PubMed ID: 38355844

Doi: 10.1007/s00216-024-05193-0

Products & Services: Proteins, Expression, Isolation and Analysis

Measurement of neuropeptide Y with molecularly imprinted polypyrrole on carbon fiber microelectrodes

Authors: Luis López, Kelly Lozano, John Cruz, Krystal Flores, Lauren Fernández-Vega, Lisandro Cunci

Journal: Neuropeptides

PubMed ID: 38335798

Doi: 10.1016/j.npep.2024.102413

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Single dose of a recombinant vesicular stomatitis virus-based vaccine elicits robust and durable neutralizing antibody response against Hantaan virus

Authors: Hui Zhang, He Liu , Jing Wei , Yamei Dang , Yuan Wang , Qiqi Yang , Liang Zhang , Chuantao Ye , Bin Wang , Xiaolei Jin , Linfeng Cheng , Hongwei Ma , Yangchao Dong , Yinghui Li , Yinlan Bai , Xin Lv , Yingfeng Lei , Zhikai Xu , Wei Ye , Fanglin Zhang

Journal: NPJ Vaccines .

PubMed ID: 38341504

Doi: 10.1038/s41541-024-00814-2

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An Enzyme-Cleavable Solubilizing-Tag Facilitates the Chemical Synthesis of Mirror-Image Protein

Authors: Yupeng Zheng, Baochang Zhang , Wei-Wei Shi, Xiangyu Deng, Tong-Yue Wang, Dongyang Han, Yuxiang Ren, Ziyi Yang, Yong-Kang Zhou, Jian Kuang, Zhi-Wen Wang, Shan Tang, Ji-Shen Zheng

Journal: Angew Chem Int Ed Engl .

PubMed ID: 38326236

Doi: 10.1002/ange.202318897

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ECSIT facilitates memory CD8+ T cell development by mediating fumarate synthesis during viral infection and tumorigenesis

Authors: Yongbing Yang , Yanan Wang , Zhongcheng Wang , Huanyu Yan , Yi Gong , Yingchao Hu , Yuying Jiang , Shuang Wen , Feifei Xu , Bingwei Wang , Fiachra Humphries , Yun Chen , Xi Wang , Shuo Yang

Journal: Nat Cell Biol .

PubMed ID: 38326554

Doi: 10.1038/s41556-024-01351-9

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Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8

Authors: Shan Jiang , Xi Lin , Lijie Wu , Ling Wang , Yiran Wu , Ziyi Xu , Fei Xu

Journal: Sci Adv .

PubMed ID: 38306437

Doi: 10.1126/sciadv.adj7500

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HIV coinfection exacerbates HBV-induced liver fibrogenesis through a HIF-1α- and TGF-β1-dependent pathway

Authors: Min Xu , Charlotte Warner, Xiaoqiong Duan, Zhimeng Cheng, Andre J Jeyarajan, Wenting Li, Yongtao Wang , Tuo Shao , Shadi Salloum , Pei-Jer Chen , Xu Yu , Raymond T Chung , Wenyu Lin

Journal: J Hepatol

PubMed ID: 38311121

Doi: 10.1016/j.jhep.2024.01.026

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A model of human neural networks reveals NPTX2 pathology in ALS and FTLD

Authors: Marian Hruska-Plochan, Vera I Wiersma, Katharina M Betz, Izaskun Mallona, Silvia Ronchi, Zuzanna Maniecka, Eva-Maria Hock, Elena Tantardini, Florent Laferriere, Sonu Sahadevan, Vanessa Hoop, Igor Delvendahl, Manuela Pérez-Berlanga, Beatrice Gatta, Martina Panatta, Alexander van der Bourg, Dasa Bohaciakova, Puneet Sharma , Laura De Vos, Karl Frontzek , Adriano Aguzzi, Tammaryn Lashley , Mark D Robinson, Theofanis Karayannis, Martin Mueller, Andreas Hierlemann 4, Magdalini Polymenidou 13

Journal: Nature

PubMed ID: 38355792

Doi: 10.1038/s41586-024-07042-7

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Ribosomal collision is not a prerequisite for ZNF598-mediated ribosome ubiquitination and disassembly of ribosomal complexes by ASCC

Authors: Anna Miścicka, Alexander G Bulakhov, Kazushige Kuroha, Alexandra Zinoviev, Christopher U T Hellen, Tatyana V Pestova

Journal: Nucleic Acids Res

PubMed ID: 38366554

Doi: 10.1093/nar/gkae087

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Molecular mechanism of human ISG20L2 for the ITS1 clea vag e in the processing of 18S precursor ribosomal RNA

Authors: Yinliang Ma, Jiaxu Wang, Xingyi He, Yuhang Liu, Shuo Zhen, Lina An, Qian Yang, Fumin Niu, Hong Wang, Boran An, Xinyue Tai, Zhenzhen Yan, Chen Wu, Xiaoyun Yang, Xiuhua Liu

Journal: Nucleic Acids Res

PubMed ID: 38153123

Doi: 10.1093/nar/gkad1210

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Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel Na18 with a Unique Mechanism of Action

Authors: John M Gilchrist, Nien-Du Yang, Victoria Jiang, Bryan D Moyer

Journal: Mol Pharmacol

PubMed ID: 38195157

Doi: 10.1124/molpharm.123.000789

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The ETI-dependent receptor-like kinase 1 positively regulates effector-triggered immunity by stabilizing NLR-required for cell death 4 in Nicotiana benthamiana

Authors: Yujing Sun, Fan Liu, Mengzhu Zeng, Xinjie Zhang, Ying Cui, Zhaodan Chen, Lei Wang, Yuanpeng Xu, Jinbin Wu, Shengya Guo, Xian Dong, Suomeng Dong, Yan Wang, Yuanchao Wang

Journal: New Phytol

PubMed ID: 38362937

Doi: 10.1111/nph.19596

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Safety and immunogenicity of CoronaVac in healthy adults: A prospective observational multicenter real-world study in Henan Province, China

Authors: Benchen Rao, Ling Wang, Mengzhao Yang, Hong Luo, Junyi Sun, Shanshuo Liu, Haiyu Wang, Xuemei Wang, Lei Li, Chengyu Yuan, Zujiang Yu, Zhigang Ren

Journal: Virulence

PubMed ID: 38326274

Doi: 10.1080/21505594.2024.2310450

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Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia

Authors: Wonjae Sung, Min-Young Noh, Minyeop Nahm, Yong Sung Kim, Chang-Seok Ki, Young-Eun Kim, Hee-Jin Kim, Seung Hyun Kim

Journal: J Neuroinflammation

PubMed ID: 38347588

Doi: 10.1186/s12974-024-03039-1

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Ultrasound Imaging of Tumor Vascular CD93 with MMRN2 Modified Microbubbles for Immune Microenvironment Prediction

Authors: Dingyi Wang, Changyang Xing, Yuan Liang, Chen Wang, Ping Zhao, Xiao Liang, Qiuyang Li, Lijun Yuan

Journal: Adv Mater

PubMed ID: 38270289

Doi: 10.1002/adma.202310421

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Structural and mechanistic characterization of bifunctional heparan sulfate N-deacetylase-N-sulfotransferase 1

Authors: Courtney J Mycroft-West, Sahar Abdelkarim, Helen M E Duyvesteyn, Neha S Gandhi, Mark A Skidmore, Raymond J Owens, Liang Wu

Journal: Nat Commun

PubMed ID: 38351061

Doi: 10.1038/s41467-024-45419-4

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Unveiling the Dynamic Self-Assembly of a Recombinant Dragline-Silk-Mimicking Protein

Authors: Dongqing Wu, Anamaria Koscic, Sonja Schneider, Romeo C A Dubini, Diana C Rodriguez Camargo, Sabine Schneider, Petra Rovó

Journal: Biomacromolecules

PubMed ID: 38343096

Doi: 10.1021/acs.biomac.3c01239

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Characterization of cleavage patterns and assembly of N-terminally modified GII6 norovirus VP1 proteins

Authors: Jie Ma, Jinjin Liu, Yuqi Huo

Journal: Arch Virol

PubMed ID: 38386207

Doi: 10.1007/s00705-024-05973-0

Products & Services: Proteins, Expression, Isolation and Analysis

The Role of Hyaluronan/Receptor for Hyaluronan-Mediated Motility Interactions in the Modulation of Macrophage Polarization and Cartilage Repair

Authors: Emilia Bianchini, Yun Jin Ashley Sin, You Jin Lee, Charles Lin, Utkarsh Anil, Cassie Hamill, Mary K Cowman, Thorsten Kirsch

Journal: Am J Pathol

PubMed ID: 38403161

Doi: 10.1016/j.ajpath.2024.01.020

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Erdr1 Drives Macrophage Programming via Dynamic Interplay with YAP1 and Mid1

Authors:

Journal: Immunohorizons

PubMed ID: 38392560

Doi: 10.4049/immunohorizons.2400004

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Integrating network pharmacology and experimental models to identify notoginsenoside R1 ameliorates atherosclerosis by inhibiting macrophage NLRP3 inflammasome activation

Authors: Jingyue Yu, Jinyu Hu, Margaret Baldini, Huan Lei, Lei Li, Shanshan Luo, Jielian Wu, Xupin Liu, Dan Shan, Yanfei Xie, Haihong Fang, Jun Yu

Journal: J Nat Med

PubMed ID: 38409483

Doi: 10.1007/s11418-023-01776-w

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Inhibition of AMPK activation in sensu stricto limits the parasite's glucose metabolism and survival

Authors: Mingzhi Yan, Hui Liu, Yansen Su, Xiaojuan Bi, Ning Yang, Renyong Lin, Guodong Lü

Journal: Antimicrob Agents Chemother

PubMed ID: 38349157

Doi: 10.1128/aac.01202-23

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Filamin A Is a Prognostic Serum Biomarker for Differentiating Benign Prostatic Hyperplasia from Prostate Cancer in Caucasian and African American Men

Authors: Nischal Mahaveer Chand, Poornima K Tekumalla, Matt T Rosenberg, Albert Dobi, Amina Ali, Gregory M Miller, Juan J Aristizabal-Henao, Elder Granger, Stephen J Freedland, Mark D Kellogg, Shiv Srivastava, David G McLeod, Niven R Narain, Michael A Kiebish

Journal: Cancers (Basel)

PubMed ID: 38398103

Doi: 10.3390/cancers16040712

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Newcastle disease virus regulates its replication by instigating oxidative stress-driven Sirtuin 7 production

Authors: Kamal Shokeen, Sachin Kumar

Journal: J Gen Virol

PubMed ID: 38376490

Doi: 10.1099/jgv.0.001961

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Structure of the p53 degradation complex from HPV16

Authors: John C K Wang, Hannah T Baddock, Amirhossein Mafi, Ian T Foe, Matthew Bratkowski, Ting-Yu Lin, Zena D Jensvold, Magdalena Preciado López, David Stokoe, Dan Eaton, Qi Hao, Aaron H Nile

Journal: Nat Commun

PubMed ID: 38418456

Doi: 10.1038/s41467-024-45920-w

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SOX9 Induces Orbital Fibroblast Activation in Thyroid Eye Disease Via MAPK/ERK1/2 Pathway

Authors: Min Zhou, Bingying Lin, Pengsen Wu, Yu Ke, Siyu Huang, Fan Zhang, Xiangqing Hei, Zhen Mao, Xingyi Li, Pengxia Wan, Tingting Chen, Huasheng Yang, Danping Huang

Journal: Invest Ophthalmol Vis Sci

PubMed ID: 38345552

Doi: 10.1167/iovs.65.2.25

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The Humanization and Maturation of an Anti-PrPc Antibody

Authors: Cheng Zhang, Fanlei Ran, Lei Du, Xiaohui Wang, Lei Liu, Jinming Liu, Quan Chen, Yang Cao, Lijun Bi, Haiying Hang

Journal: Bioengineering (Basel)

PubMed ID: 38534516

Doi: 10.3390/bioengineering11030242

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Preorganized cyclic modules facilitate the self-assembly of protein nanostructures

Authors: Jaka Snoj, Fabio Lapenta, Roman Jerala

Journal: Chem Sci

PubMed ID: 38455016

Doi: 10.1039/d3sc06658d

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Development of a live-attenuated chimeric vaccine against the emerging Usutu virus

Authors: Zheng-Jian Wang, Rong-Rong Zhang, Mei Wu, Hui Zhao, Xiao-Feng Li, Qing Ye, Cheng-Feng Qin

Journal: Vaccine

PubMed ID: 38310016

Doi: 10.1016/j.vaccine.2024.01.077

Products & Services: Proteins, Expression, Isolation and Analysis

Exploring the Impact of Primer-Template Mismatches on PCR Performance of DNA Polymerases Varying in Proofreading Activity

Authors: Ke Huang, Jilei Zhang, Jing Li, Haixiang Qiu, Lanjing Wei, Yi Yang, Chengming Wang

Journal: Genes (Basel)

PubMed ID: 38397205

Doi: 10.3390/genes15020215

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Ultrasound-mediated gene delivery specifically targets liver sinusoidal endothelial cells for sustained FVIII expression in hemophilia A mice

Authors: Savannah M Lawton, Megan A Manson, Meng-Ni Fan, Ting-Yen Chao, Chun-Yu Chen, Peter Kim, Carley Campbell, Xiaohe Cai, Amber Vander Kooi, Carol H Miao

Journal: Mol Ther

PubMed ID: 38341614

Doi: 10.1016/j.ymthe.2024.02.010

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of Candidate Expansin Genes Associated with Seed Weight in Pomegranate ( L)

Authors: Chunyan Liu, Haoyu Zhao, Jiyu Li, Zhen Cao, Bo Deng, Xin Liu, Gaihua Qin

Journal: Genes (Basel)

PubMed ID: 38397202

Doi: 10.3390/genes15020212

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Cooperativity between Cas9 and hyperactive AID establishes broad and diversifying mutational footprints in base editors

Authors: Kiara N Berríos, Aleksia Barka, Jasleen Gill, Juan C Serrano, Peter F Bailer, Jared B Parker, Niklaus H Evitt, Kiran S Gajula, Junwei Shi, Rahul M Kohli

Journal: Nucleic Acids Res

PubMed ID: 38261989

Doi: 10.1093/nar/gkae024

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Poly-γ-glutamylation of biomolecules

Authors: Ghader Bashiri, Esther M M Bulloch, William R Bramley, Madison Davidson, Stephanie M Stuteley, Paul G Young, Paul W R Harris, Muhammad S H Naqvi, Martin J Middleditch, Michael Schmitz, Wei-Chen Chang, Edward N Baker, Christopher J Squire

Journal: Nat Commun

PubMed ID: 38346985

Doi: 10.1038/s41467-024-45632-1

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Cross-Phosphorylation between AgrC Histidine Kinase and the Noncognate Response Regulator Lmo1172 in under Benzalkonium Chloride Stress

Authors: Tao Yu, Xiaojie Jiang, Xiaobo Xu, Ping Xu, Shuxing Qiu, Junlei Yin, David P Hamilton, Xiaobing Jiang

Journal: Microorganisms

PubMed ID: 38399796

Doi: 10.3390/microorganisms12020392

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A quaternary ammonium-based nanosystem enables delivery of CRISPR/Cas9 for cancer therapy

Authors: Mengzhu Zhang, Siyu Sun, Xiao Liang, Zengguang Liu, Jiaxin Yin, Quanshun Li, Shengcai Yang

Journal: Biomater Sci

PubMed ID: 38240497

Doi: 10.1039/d3bm01629c

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Enhancing sensitivity of qPCR assays targeting Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae by using a mutant Taq DNA polymerase

Authors: Selin Nar Otgun, Canan Zohre Ketre Kolukirik, Nuriye Unal Sahin, Mustafa Kolukirik, Gozde Girgin Ozgumus, Meral Turan, Mert Elmas, Selcuk Kilic

Journal: J Microbiol Methods

PubMed ID: 38360298

Doi: 10.1016/j.mimet.2024.106899

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Nanobody-Mediated Dualsteric Engagement of the Angiotensin Receptor Broadens Biased Ligand Pharmacology

Authors: Nayara Braga Emidio , Brandi M Small , Amanda R Keller , Ross W Cheloha , Laura M Wingler

Journal: Mol Pharmacol

PubMed ID: 38164609

Doi: 10.1124/molpharm.123.000797

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DNA polymerase iota promotes EMT and metastasis of esophageal squamous cell carcinoma by interacting with USP7 to stabilize HIF-1α

Authors: Aidi Gao, Mingxia Zhang, Shuang Qi Zhu, Shitao Zou, Hengrui Chen, Xiaoqin Li, Chao He, Liangsu Zhou, Yan Mei, Weiqun Ding, Jundong Zhou, Yue Zhou, Yuandong Cao

Journal: Cell Death Dis

PubMed ID: 38402183

Doi: 10.1038/s41419-024-06552-6

Products & Services: Proteins, Expression, Isolation and Analysis

UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment

Authors: Yin Li, Manling Jiang, Ling Aye, Li Luo, Yong Zhang, Fengkai Xu, Yongqi Wei, Dan Peng, Xiang He, Jie Gu, Xiaofang Yu, Guoping Li, Di Ge, Chunlai Lu

Journal: Nat Commun .

PubMed ID: 38331898

Doi: 10.1038/s41467-024-45340-w

Products & Services: Proteins, Expression, Isolation and Analysis

Cepharanthine analogs mining and genomes of Stephania accelerate anti-coronavirus drug discovery

Authors: Liang Leng, Zhichao Xu, Bixia Hong, Binbin Zhao, Ya Tian, Can Wang, Lulu Yang, Zhongmei Zou, Lingyu Li, Ke Liu, Wanjun Peng, Jiangning Liu, Zhoujie An, Yalin Wang, Baozhong Duan, Zhigang Hu, Chuan Zheng, Sanyin Zhang, Xiaodong Li, Maochen Li, Zhaoyu Liu, Zenghao Bi, Tianxing He, Baimei Liu, Huahao Fan, Chi Song, Yigang Tong, Shilin Chen

Journal: Nat Commun .

PubMed ID: 38378731

Doi: 10.1038/s41467-024-45690-5

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Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore

Authors: Yasmeen J Solano , Michael P Everett , Kelly S Dang , Jude Abueg , Philip D Kiser

Journal: Nature Chemical Biology

PubMed ID: 38355721

Doi: 10.1038/s41589-024-01554-z

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Unraveling the Catalytic Mechanism of Taxadiene-5α-hydroxylase from Crystallography and Computational Analyses

Authors: Xitong Song, Qian Wang, Xiaoxi Zhu, Wenhan Fang, Xiaonan Liu, Chao Shi, Zhenzhan Chang, Huifeng Jiang, and Binju Wang

Journal: ACS Catal

Doi: doi.org/10.1021/acscatal.3c05807

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