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CD147-K148me2-Driven Tumor Cell-Macrophage Crosstalk Provokes NSCLC Immunosuppression via the CCL5/CCR5 Axis

Authors: Ke Wang, Xiaohong Chen, Peng Lin, Jiao Wu, Qiang Huang, Zhi-Nan Chen, Jiale Tian, Hao Wang, Ye Tian, Mingyan Shi, Meirui Qian, Bengang Hui, Yumeng Zhu, Ling Li, Rui Yao, Huijie Bian, Ping Zhu, Ruo Chen, Liang Chen

Journal: Adv Sci (Weinh)

PubMed ID: 38873823

Doi: 10.1002/advs.202400611

Products & Services: Recombinant Proteins

Functional diversity among cardiolipin binding sites on the mitochondrial ADP/ATP carrier

Authors: Nanami Senoo, Dinesh K Chinthapalli, Matthew G Baile, Vinaya K Golla, Bodhisattwa Saha, Abraham O Oluwole, Oluwaseun B Ogunbona, James A Saba, Teona Munteanu, Yllka Valdez, Kevin Whited, Macie S Sheridan, Dror Chorev, Nathan N Alder, Eric R May, Carol V Robinson, Steven M Claypool

Journal: EMBO J

PubMed ID: 38839991

Doi: 10.1038/s44318-024-00132-2

Products & Services: Proteins, Expression, Isolation and Analysis

Elucidating the role of primary and secondary sphere Zn ligands in the cyanobacterial CO uptake complex NDH-1: The essentiality of arginine in zinc coordination and catalysis

Authors: Ross M Walker, Minquan Zhang, Robert L Burnap

Journal: Biochim Biophys Acta Bioenerg

PubMed ID: 38906312

Doi: 10.1016/j.bbabio.2024.149149

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Intein-mediated temperature control for complete biosynthesis of sanguinarine and its halogenated derivatives in yeast

Authors: Yuanwei Gou, Dongfang Li, Minghui Zhao, Mengxin Li, Jiaojiao Zhang, Yilian Zhou, Feng Xiao, Gaofei Liu, Haote Ding, Chenfan Sun, Cuifang Ye, Chang Dong, Jucan Gao, Di Gao, Zehua Bao, Lei Huang, Zhinan Xu, Jiazhang Lian

Journal: Nat Commun

PubMed ID: 38898098

Doi: 10.1038/s41467-024-49554-w

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Recovery kinetics of dual AAV-mediated human otoferlin expression

Authors: Jonathan B Sellon, Kathy S So, Andrew D'Arcangelo, Sarah Cancelarich, Meghan C Drummond, Peter G Slade, Ning Pan, Tyler M Gibson, Tian Yang, Joseph C Burns, Adam T Palermo, Lars Becker

Journal: Front Mol Neurosci

PubMed ID: 38952419

Doi: 10.3389/fnmol.2024.1376128

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Boosting PRRSV-Specific Cellular Immunity: The Immunological Profiling of an Fc-Fused Multi-CTL Epitope Vaccine in Mice

Authors: Xinnuo Lei, Jinzhao Ban, Zhi Wu, Shinuo Cao, Mo Zhou, Li Zhang, Rui Zhu, Huipeng Lu, Shanyuan Zhu

Journal: Vet Sci

PubMed ID: 38922021

Doi: 10.3390/vetsci11060274

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Identification of core techniques that enhance genome editing of human T cells expressing synthetic antigen receptors

Authors: Ju-Fang Chang, Nils Wellhausen, Nils Wolfgang Engel, Jack H Landmann, Caitlin R Hopkins, January Salas-McKee, Adham S Bear, Mehmet Emrah Selli, Sangya Agarwal, Julie Jadlowsky, Gerald P Linette, Saar Gill, Carl H June, Joseph A Fraietta, Nathan Singh

Journal: Cancer Immunol Res

PubMed ID: 38869428

Doi: 10.1158/2326-6066.CIR-24-0251

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Astragaloside IV inhibits cell viability and glycolysis of hepatocellular carcinoma by regulating KAT2A-mediated succinylation of PGAM1

Authors: Yuanzhang Zhu, Fei Lu

Journal: BMC Cancer

PubMed ID: 38835015

Doi: 10.1186/s12885-024-12438-9

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One-shot design elevates functional expression levels of a voltage-gated potassium channel

Authors: Jonathan Jacob Weinstein, Chandamita Saikia, Izhar Karbat, Adi Goldenzweig, Eitan Reuveny, Sarel Jacob Fleishman

Journal: Protein Sci

PubMed ID: 38747377

Doi: 10.1002/pro.4995

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DNA-controlled protein fluorescence: Design of aptamer-split peptide hetero-modulator for GFP to respond to intracellular ATP levels

Authors: Ki Sung Park, Hanvit Cha, Jia Niu, Hyongsok Tom Soh, Jin Hyup Lee, Seung Pil Pack

Journal: Nucleic Acids Res

PubMed ID: 38917331

Doi: 10.1093/nar/gkae532

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Exploring solute binding proteins in Pseudomonas aeruginosa that bind to γ-aminobutyrate and 5-aminovalerate and their role in activating sensor kinases

Authors: Jean Paul Cerna-Vargas, Tino Krell

Journal: Microbiologyopen

PubMed ID: 38780167

Doi: 10.1002/mbo3.1415

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A culture method with berbamine, a plant alkaloid, enhances CAR-T cell efficacy through modulating cellular metabolism

Authors: Shin-Ichiro Takayanagi, Sayaka Chuganji, Masahiro Tanaka, Bo Wang, Saki Hasegawa, Ken Fukumoto, Nariaki Wasano, Makoto Kakitani, Nakaba Ochiai, Yohei Kawai, Tatsuki Ueda, Akihiro Ishikawa, Yuko Kurimoto, Asami Fukui, Sanae Kamibayashi, Eri Imai, Atsushi Kunisato, Hajime Nozawa, Shin Kaneko

Journal: Commun Biol

PubMed ID: 38834758

Doi: 10.1038/s42003-024-06297-0

Products & Services: Proteins, Expression, Isolation and Analysis

Capturing totipotency in human cells through spliceosomal repression

Authors: Shiyu Li, Min Yang, Hui Shen, Li Ding, Xuehui Lyu, Kexin Lin, Jennie Ong, Peng Du

Journal: Cell

PubMed ID: 38843832

Doi: 10.1016/j.cell.2024.05.010

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NpeA is a secreted Type IV effector containing an N-WASP-binding short linear motif that promotes niche formation

Authors: Agostina Giménez, Mariela G Del Giudice, Paula V López, Francisco Guaimas, Hugo Sámano-Sánchez, Toby J Gibson, Lucía B Chemes, Carlos O Arregui, Juan E Ugalde, Cecilia Czibener

Journal: MBio

PubMed ID: 38847540

Doi: 10.1128/mbio.00726-24

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XIST dampens X chromosome activity in a SPEN-dependent manner during early human development

Authors: Charbel Alfeghaly, Gaël Castel, Emmanuel Cazottes, Madeleine Moscatelli, Eva Moinard, Miguel Casanova, Juliette Boni, Kasturi Mahadik, Jenna Lammers, Thomas Freour, Louis Chauviere, Carla Piqueras, Ruben Boers, Joachim Boers, Joost Gribnau, Laurent David, Jean-François Ouimette & Claire Rougeulle

Journal: Nat Struct Mol Biol

PubMed ID: 38834912

Doi: 10.1038/s41594-024-01325-3

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Characterization and regulation of cell cycle-independent noncanonical gene targeting

Authors: Shinta Saito & Noritaka Adachi

Journal: Nature Communications

PubMed ID: 38890315

Doi: 10.1038/s41467-024-49385-9.

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A safe and potentiated multi-type HPV L2-E7 nanoparticle vaccine with combined prophylactic and therapeutic activity

Authors: Xueer Zhao, Yueru Zhang, Oscar Trejo-Cerro, Ecem Kaplan, Zhe Li, Femke Albertsboer, Neyla El Hammiri, Filipe Colaço Mariz, Lawrence Banks, Simone Ottonello, Martin Müller

Journal: npj Vaccines

PubMed ID: 38926425

Doi: 10.1038/s41541-024-00914-z

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Molecular and structural basis of an ATPase-nuclease dual-enzyme anti-phage defense complex

Authors: Qiyin An, Yong Wang, Zhenhua Tian, Jie Han, Jinyue Li, Fumeng Liao, Feiyang Yu, Haiyan Zhao, Yancheng Wen, Heng Zhang & Zengqin Deng

Journal: Cell Research

PubMed ID: 38834762

Doi: 10.1038/s41422-024-00981-w

Products & Services: Proteins, Expression, Isolation and Analysis

Estrogen-mediated DNMT1 and DNMT3A recruitment by EZH2 silences miR-570-3p that contributes to papillary thyroid malignancy through DPP4

Authors: Xiarong Hu, Qingyao Ye, HuanQuan Lu, Zhiming Wu, Siyuan Chen, Ruinian Zheng

Journal: Clin Epigenetics

PubMed ID: 38890707

Doi: 10.1186/s13148-024-01685-z

Products & Services: Proteins, Expression, Isolation and Analysis

Enhanced Recombinant Protein Expression in Insect Cells by Natural and Recombinant Components of Lepidoptera Hemolymph

Authors: Javier López-Vidal, Susana Martínez-Pulgarín, Diego Martínez-Alonso, Miguel Cid, José M Escribano

Journal: Viruses

PubMed ID: 38932236

Doi: 10.3390/v16060944

Products & Services: Proteins, Expression, Isolation and Analysis

A quadrivalent recombinant influenza Hemagglutinin vaccine induced strong protective immune responses in animal models

Authors: Jin Feng, Yingying Du, Liyun Chen, Wenhan Su, Hailiu Wei, Aijiao Liu, Xiaojun Jiang, Jianmin Guo, Cailing Dai, Yuhua Xu, Tao Peng

Journal: Vaccine

PubMed ID: 38834431

Doi: 10.1016/j.vaccine.2024.05.056

Products & Services: Proteins, Expression, Isolation and Analysis Peptide Library Services

Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design

Authors: Manjeet Mukherjee, Philip J Day, Duncan Laverty, Juan A Bueren-Calabuig, Andrew J Woodhead, Charlotte Griffiths-Jones, Steve Hiscock, Charlotte East, Susan Boyd, Marc O'Reilly

Journal: Structure

PubMed ID: 38870939

Doi: 10.1016/j.str.2024.05.011

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Dual-Omics Approach Unveils Novel Perspective on the Quality Control of Genetically Engineered Exosomes

Authors: Christopher Olson, Konstantin Ivanov, Darin Boyes, David Bengford, Joy Ku, Renceh Flojo, Pengyang Zhang, Biao Lu

Journal: Pharmaceutics

PubMed ID: 38931944

Doi: 10.3390/pharmaceutics16060824

Products & Services: Molecular Biology Reagents

Integrated pathway mining and selection of an artificial CYP79-mediated bypass to improve benzylisoquinoline alkaloid biosynthesis

Authors: Musashi Takenaka, Kouhei Kamasaka, Kim Daryong, Keiko Tsuchikane, Seiha Miyazawa, Saeko Fujihana, Yoshimi Hori, Christopher J Vavricka, Akira Hosoyama, Hiroko Kawasaki, Tomokazu Shirai, Michihiro Araki, Akira Nakagawa, Hiromichi Minami, Akihiko Kondo, Tomohisa Hasunuma

Journal: Microb Cell Fact

PubMed ID: 38879464

Doi: 10.1186/s12934-024-02453-7

Products & Services: Gene Synthesis

Designing monomeric IFNγ: the significance of domain-swapped dimer structure in IFNγ immune responses

Authors: Yota Goto, Takamitsu Miyafusa, Shinya Honda

Journal: J Biol Chem

PubMed ID: 38879015

Doi: 10.1016/j.jbc.2024.107464

Products & Services: Molecular Biology Reagents

Identification of potential crucial cuproptosis-related genes in myocardial ischemia-reperfusion injury through the bioinformatic analysis

Authors: Rong Huang, Rongfeng Xu, Rui Zhang, Wenjie Zuo, Zhenjun Ji, Zaixiao Tao, Yongjun Li, Genshan Ma

Journal: Clinics (Sao Paulo)

PubMed ID: 38901133

Doi: 10.1016/j.clinsp.2024.100410

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SARS-CoV-2 Humoral and Cellular Immune Responses in People Living with HIV

Authors: Simona Ruta, Corneliu Petru Popescu, Lilia Matei, Camelia Grancea, Adrian Marius Paun, Cristiana Oprea, Camelia Sultana

Journal: Vaccines (Basel)

PubMed ID: 38932392

Doi: 10.3390/vaccines12060663

Products & Services: Molecular Biology Reagents

PDZ2-conjugated-PLGA nanoparticles are tiny heroes in the battle against SARS-CoV-2

Authors: Noah Giacon, Ettore Lo Cascio, Valeria Pennacchietti, Flavio De Maio, Giulia Santarelli, Diego Sibilia, Federica Tiberio, Maurizio Sanguinetti, Wanda Lattanzi, Angelo Toto, Alessandro Arcovito

Journal: Sci Rep

PubMed ID: 38844490

Doi: 10.1038/s41598-024-63239-w

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Inefficient recruitment of DDX39B impedes pre-spliceosome assembly on introns

Authors: Chloe K Nagasawa, Aaron O Bailey, William K Russell, Mariano A Garcia-Blanco

Journal: RNA

PubMed ID: 38575347

Doi: 10.1261/rna.079933.123

Products & Services: Proteins, Expression, Isolation and Analysis

Discovery of Monovalent Direct Degraders of BRD4 That Act Via the Recruitment of DCAF11

Authors: Gregory S Parker, Julia I Toth, Sarah Fish, Gabrielle A Blanco, Taylor Kampert, Xiaoming Li, Linette Yang, Craig R Stumpf, Kenneth Steadman, Aleksandar Jamborcic, Stephen Chien, Elizabeth Daniele, Alejandro Dearie, Geoffray Leriche, Simon Bailey, Peggy A Thompson

Journal: Mol Cancer Ther

PubMed ID: 38907538

Doi: 10.1158/1535-7163.MCT-24-0219

Products & Services: Proteins, Expression, Isolation and Analysis

Molecular Mechanism of WWOX Inhibiting the Development of Esophageal Cancer by Inhibiting Hippo Signaling Pathway

Authors: Zihan Chen, Jingyu Sun, Lili Zhang, Yanglin Sun, Qingqing Ni, Hongkun Zhu, Miao Hui, Longzhen Zhang, Qiang Wang

Journal: Biochem Genet

PubMed ID: 38902482

Doi: 10.1007/s10528-024-10856-9

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Patients taking benralizumab, dupilumab, or mepolizumab have lower postvaccination SARS-CoV-2 immunity

Authors: Martin C Runnstrom, Pedro A Lamothe, Caterina E Faliti, Narayanaiah Cheedarla, Alberto Moreno, Mehul S Suthar, Rishika Nahata, Mayuran Ravindran, Natalie S Haddad, Andrea Morrison-Porter, Hannah Quehl, Richard P Ramonell, Matthew Woodruff, Fabliha Anam, Rebeca Zhang, Colin Swenson, Carmen Polito, Wendy Neveu, Rahulkumar Patel, Natalia Smirnova, Doan C Nguyen, Caroline Kim, Ian Hentenaar, Shuya Kyu, Sabeena Usman, Thuy Ngo, Zhenxing Guo, Hao Wu, John L Daiss, Jiwon Park, Kelly E Manning, Bursha Wali, Madison L Ellis, Sunita Sharma, Fernando Holguin, Suneethamma Cheedarla, Andrew S Neish, John D Roback, Ignacio Sanz, F Eun-Hyung Lee

Journal: J Allergy Clin Immunol

PubMed ID: 38878020

Doi: 10.1016/j.jaci.2024.03.029

Products & Services: Proteins, Expression, Isolation and Analysis

Integration of Image Pattern Recognition and Photon Sensor for Analyzing Cytokine Gene Expression Using πCode MicroDisc

Authors: On-Anong Juntit, Kanokporn Sornsuwan, Umpa Yasamut, Chatchai Tayapiwatana

Journal: Biosensors (Basel)

PubMed ID: 38920610

Doi: 10.3390/bios14060306

Products & Services: Recombinant Proteins

High sugar diet-induced fatty acid oxidation potentiates cytokine-dependent cardiac ECM remodeling

Authors: Jayati Gera, Dheeraj Kumar, Gunjan Chauhan, Adarsh Choudhary, Lavi Rani, Lolitika Mandal, Sudip Mandal

Journal: J Cell Biol

PubMed ID: 38916917

Doi: 10.1083/jcb.202306087

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Injectable Self-Healing Antibacterial Hydrogels with Tailored Functions by Loading Peptide Nanofiber-Biomimetic Silver Nanoparticles

Authors: Mingze Zhang, Guanghui Gu, Youyin Xu, Xin Luan, Jianyu Liu, Peng He, Gang Wei

Journal: Macromol Rapid Commun

PubMed ID: 38923127

Doi: 10.1002/marc.202400173

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A peptide derived from sorting nexin 1 inhibits HPV16 entry, retrograde trafficking, and L2 membrane spanning

Authors: Shuaizhi Li, Zachary L Williamson, Matthew A Christofferson, Advait Jeevanandam, Samuel K Campos

Journal: Tumour Virus Res

PubMed ID: 38909779

Doi: 10.1016/j.tvr.2024.200287

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Genetically Programmed Temperature-Responsive Barnacle-Derived Protein with an Enhanced Adhesion Ability

Authors: Yuanxing Shi, Yun Xu, Longyu Zhang, Yunjun Yan, Jinyong Yan

Journal: ACS Appl Bio Mater

PubMed ID: 38926913

Doi: 10.1021/acsabm.4c00455

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Evaluating the antibody response elicited by diverse HIV envelope immunogens in the African green monkey (Vervet) model

Authors: Thandeka Moyo-Gwete, Frances Ayres, Nonkululeko B Mzindle, Zanele Makhado, Nelia P Manamela, Simone I Richardson, Dale Kitchin, Strauss van Graan, Joritha van Heerden, Nishal Parbhoo, Gerald K Chege, Penny L Moore

Journal: Sci Rep

PubMed ID: 38858452

Doi: 10.1038/s41598-024-63703-7

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CEPs suppress auxin signaling but promote cytokinin signaling to inhibit root growth in Arabidopsis

Authors: Yuwen Zhang, Xingliang Duan, Zhen Wang, Yuanda Lv, Weicong Qi, Lun Li, Le Luo, Wei Xuan

Journal: Biochem Biophys Res Commun .

PubMed ID: 38626621

Doi: 10.1016/j.bbrc.2024.149934

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A growth selection system for sucrose synthases (SuSy): design and test

Authors: Gonzalo N Bidart, Se Hyeuk, Tobias Benedikt Alter, Lei Yang, Ditte Hededam Welner

Journal: AMB Express

PubMed ID: 38865019

Doi: 10.1186/s13568-024-01727-y

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BRET-based biosensors for SARS-CoV-2 oligonucleotide detection

Authors: Asfia Sultana, Anupriya M Geethakumari, Zeyaul Islam, Prasanna R Kolatkar, Kabir H Biswas

Journal: Front Bioeng Biotechnol

PubMed ID: 38887615

Doi: 10.3389/fbioe.2024.1353479

Products & Services: Proteins, Expression, Isolation and Analysis

Repeat controlled human Plasmodium falciparum infections delay bloodstream patency and reduce symptoms

Authors: Patricia Ferrer, Andrea A Berry, Allison N Bucsan, Surendra K Prajapati, Karthik Krishnan, Michelle C Barbeau, David M Rickert, Sandra Mendoza Guerrero, Miho Usui, Yonas Abebe, Asha Patil, Sumana Chakravarty, Peter F Billingsley, Faith Pa'ahana-Brown, Kathy Strauss, Biraj Shrestha, Effie Nomicos, Gregory A Deye, B Kim Lee Sim, Stephen L Hoffman, Kim C Williamson, Kirsten E Lyke

Journal: Nat Commun

PubMed ID: 38890271

Doi: 10.1038/s41467-024-49041-2

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The role of shear forces in primary and secondary nucleation of amyloid fibrils

Authors: Emil Axell, Jing Hu, Max Lindberg, Alexander J Dear, Lei Ortigosa-Pascual, Ewa A Andrzejewska, Greta Šneiderienė, Dev Thacker, Tuomas P J Knowles, Emma Sparr, Sara Linse

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38875148

Doi: 10.1073/pnas.2322572121

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The generation of stable transgenic lines in the human-infective nematode Strongyloides stercoralis

Authors: Ruhi Patel, Astra S Bryant, Michelle L Castelletto, Breanna Walsh, Damia Akimori, Elissa A Hallem

Journal: G3 (Bethesda)

PubMed ID: 38839055

Doi: 10.1093/g3journal/jkae122

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The BICD2 dynein cargo adaptor binds to the HPV16 L2 capsid protein and promotes HPV infection

Authors: Kaitlyn Speckhart, Jeongjoon Choi, Daniel DiMaio, Billy Tsai

Journal: PLoS Pathog

PubMed ID: 38829892

Doi: 10.1371/journal.ppat.1012289

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The annotation of has been concealed by its protein-coding pseudogene

Authors: Emil K Gustavsson, Siddharth Sethi, Yujing Gao, Jonathan W Brenton, Sonia García-Ruiz, David Zhang, Raquel Garza, Regina H Reynolds, James R Evans, Zhongbo Chen, Melissa Grant-Peters, Hannah Macpherson, Kylie Montgomery, Rhys Dore, Anna I Wernick, Charles Arber, Selina Wray, Sonia Gandhi, Julian Esselborn, Cornelis Blauwendraat, Christopher H Douse, Anita Adami, Diahann A M Atacho, Antonina Kouli, Annelies Quaegebeur, Roger A Barker, Elisabet Englund, Frances Platt, Johan Jakobsson, Nicholas W Wood, Henry Houlden, Harpreet Saini, Carla F Bento, John Hardy, Mina Ryten

Journal: Sci Adv

PubMed ID: 38924406

Doi: 10.1126/sciadv.adk1296

Products & Services: Proteins, Expression, Isolation and Analysis

Divergent humoral responses between males and females against 24 kDa excretory-secretory protein of Haemonchus contortus and influence of ovine β-globin polymorphism

Authors: Cintia Hiromi Okino, Simone Cristina Méo Niciura, Alessandro Pelegrine Minho, Sérgio Novita Esteves, Gláucia Roberta Melito, Hélio José Montassier, Ana Carolina de Souza Chagas

Journal: Dev Comp Immunol

PubMed ID: 38901502

Doi: 10.1016/j.dci.2024.105216

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Arabidopsis pollen prolyl-hydroxylases P4H4/6 are relevant for correct hydroxylation and secretion of LRX11 in pollen tubes

Authors: Ana R Sede, Diego L Wengier, Cecilia Borassi, Martiniano Ricardi, Sofía C Somoza, Rafael Aguiló, José M Estevez, Jorge P Muschietti

Journal: J Exp Bot

PubMed ID: 38877792

Doi: 10.1093/jxb/erae269

Products & Services: Proteins, Expression, Isolation and Analysis

Ancient nitrogenases are ATP dependent

Authors: Derek F Harris, Holly R Rucker, Amanda K Garcia, Zhi-Yong Yang, Scott D Chang, Hannah Feinsilber, Betül Kaçar, Lance C Seefeldt

Journal: MBio

PubMed ID: 38869277

Doi: 10.1128/mbio.01271-24

Products & Services: Proteins, Expression, Isolation and Analysis

MiR-23b-3p alleviates Sjögren's syndrome by targeting SOX6 and inhibiting the NF-κB signaling

Authors: Yan Cai, Yi Zhang, Sihan Wang, E Changyong

Journal: Mol Immunol

PubMed ID: 38901181

Doi: 10.1016/j.molimm.2024.06.002

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