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Association between Bacteroides fragilis and Fusobacterium nucleatum infection and colorectal cancer in Vietnamese patients

Authors: Truong Nguyen Duy, Hoang Le Huy, Quyen Đao Thanh, Hoai Ngo Thi, Hanh Ngo Thi Minh, Manh Nguyen Dang, Song Le Huu, Trung Ngo Tat

Journal: Anaerobe

PubMed ID: 38942229

Doi: 10.1016/j.anaerobe.2024.102880

Products & Services: Molecular Biology Reagents

Ordered and disordered regions of the Origin Recognition Complex direct differential in vivo binding at distinct motif sequences

Authors: Michal Chappleboim, Segev Naveh-Tassa, Miri Carmi, Yaakov Levy, Naama Barkai

Journal: Nucleic Acids Res

PubMed ID: 38597680

Doi: 10.1093/nar/gkae249

Products & Services: Recombinant Proteins

A novel selenium analog of HDACi-based twin drug induces apoptosis and cell cycle arrest via CDC25A to improve prostate cancer therapy

Authors: Zhiyong Shi , Miaomiao Liu , Xiaowen Zhang , Jingyang Wang , Junwei Zhang , Zeyan Peng , Li Meng , Ruijing Wang ,Yang Xu , Jie Yan , Jianlin Cui , Shan Ren , Yang Gao , Yanming Wang , Zhi Qi

Journal: Theranostics

PubMed ID: 38948069

Doi: 10.7150/thno.92119

Products & Services: Nucleic Acid Purification & Analysis

An emerging antibacterial nanovaccine for enhanced chemotherapy by selectively eliminating tumor-colonizing bacteria

Authors: Linfu Chen a, Zheyu Kang a, Jingjing Shen a, Rui Zhao a, Yu Miao a, Lin Zhang b, Zixuan Zheng c, Zhemin Zhang c, Nanhui Liu a, Cheng Wang a, Huapan Fang a, Jun Zhou a, Yudong Wang b, Zhuang Liu a, Yang Yang c, Qian Chen

Journal: Science Bulletin

Doi: doi.org/10.1016/j.scib.2024.06.016

Products & Services: Molecular Biology Reagents

Highly biased agonism for GPCR ligands via nanobody tethering

Authors: Shivani Sachdev, Brendan A Creemer, Thomas J Gardella, Ross W Cheloha

Journal: Nat Commun

PubMed ID: 38824166

Doi: 10.1038/s41467-024-49068-5.

Products & Services: Proteins, Expression, Isolation and Analysis PCR Cloning and Subcloning

BRET-based biosensors for SARS-CoV-2 oligonucleotide detection

Authors: Asfia Sultana, Anupriya M Geethakumari, Zeyaul Islam, Prasanna R Kolatkar, Kabir H Biswas

Journal: Front Bioeng Biotechnol

PubMed ID: 38887615

Doi: 10.3389/fbioe.2024.1353479

Products & Services: Proteins, Expression, Isolation and Analysis

A growth selection system for sucrose synthases (SuSy): design and test

Authors: Gonzalo N Bidart, Se Hyeuk, Tobias Benedikt Alter, Lei Yang, Ditte Hededam Welner

Journal: AMB Express

PubMed ID: 38865019

Doi: 10.1186/s13568-024-01727-y

Products & Services: Molecular Biology Reagents

Repeat controlled human Plasmodium falciparum infections delay bloodstream patency and reduce symptoms

Authors: Patricia Ferrer, Andrea A Berry, Allison N Bucsan, Surendra K Prajapati, Karthik Krishnan, Michelle C Barbeau, David M Rickert, Sandra Mendoza Guerrero, Miho Usui, Yonas Abebe, Asha Patil, Sumana Chakravarty, Peter F Billingsley, Faith Pa'ahana-Brown, Kathy Strauss, Biraj Shrestha, Effie Nomicos, Gregory A Deye, B Kim Lee Sim, Stephen L Hoffman, Kim C Williamson, Kirsten E Lyke

Journal: Nat Commun

PubMed ID: 38890271

Doi: 10.1038/s41467-024-49041-2

Products & Services: Catalog Peptides

Integrated pathway mining and selection of an artificial CYP79-mediated bypass to improve benzylisoquinoline alkaloid biosynthesis

Authors: Musashi Takenaka, Kouhei Kamasaka, Kim Daryong, Keiko Tsuchikane, Seiha Miyazawa, Saeko Fujihana, Yoshimi Hori, Christopher J Vavricka, Akira Hosoyama, Hiroko Kawasaki, Tomokazu Shirai, Michihiro Araki, Akira Nakagawa, Hiromichi Minami, Akihiko Kondo, Tomohisa Hasunuma

Journal: Microb Cell Fact

PubMed ID: 38879464

Doi: 10.1186/s12934-024-02453-7

Products & Services: Gene Synthesis

Designing monomeric IFNγ: the significance of domain-swapped dimer structure in IFNγ immune responses

Authors: Yota Goto, Takamitsu Miyafusa, Shinya Honda

Journal: J Biol Chem

PubMed ID: 38879015

Doi: 10.1016/j.jbc.2024.107464

Products & Services: Molecular Biology Reagents

Divergent humoral responses between males and females against 24 kDa excretory-secretory protein of Haemonchus contortus and influence of ovine β-globin polymorphism

Authors: Cintia Hiromi Okino, Simone Cristina Méo Niciura, Alessandro Pelegrine Minho, Sérgio Novita Esteves, Gláucia Roberta Melito, Hélio José Montassier, Ana Carolina de Souza Chagas

Journal: Dev Comp Immunol

PubMed ID: 38901502

Doi: 10.1016/j.dci.2024.105216

Products & Services: Recombinant Proteins

SARS-CoV-2 Humoral and Cellular Immune Responses in People Living with HIV

Authors: Simona Ruta, Corneliu Petru Popescu, Lilia Matei, Camelia Grancea, Adrian Marius Paun, Cristiana Oprea, Camelia Sultana

Journal: Vaccines (Basel)

PubMed ID: 38932392

Doi: 10.3390/vaccines12060663

Products & Services: Molecular Biology Reagents

Characteristics of Retinal Vascular Degeneration and the Expression of Vessel-Related Claudin Proteins in Retinal Degeneration Mouse

Authors: Aoxiang Wang, Jinxi Zhou, Yiwen Hong, Yamei Cui, Yishen Wang, Jianying Pan, Yue Wu, Yan Luo

Journal: Ophthalmic Res

PubMed ID: 38857592

Doi: 10.1159/000539605

Products & Services: Proteins, Expression, Isolation and Analysis

Celastrol reduces lung inflammation induced by multiwalled carbon nanotubes in mice NF-κb-signaling pathway

Authors: Tao-Lin Qing, Xuan-Yao Jiang, Jin-Feng Li, Qi Shen, Xin-Yi Zhao, Li-Jun Ren, Xiao-Yu Dai, Ji-Qian-Zhu Zhang, Wen-Jing Shi, Xiao-Fang Zhang, Bin Zhang, Lang Yan, Ji-Kuai Chen, Jiang-Bo Zhu

Journal: Inhal Toxicol

PubMed ID: 38836332

Doi: 10.1080/08958378.2024.2351098

Products & Services: Catalog Antibody

Yeast Expressing a Phage Endolysin Reduces Endogenous in 21-Day-Old Broiler Chicken Intestinal Fluids

Authors: Michael R Barnas, Wendy D Attuquayefio, David M Donovan, Christopher D Skory, Rosemarie W Hammond, Gregory R Siragusa, Jennifer R Timmons

Journal: Avian Dis

PubMed ID: 38885054

Doi: 10.1637/aviandiseases-D-23-00088

Products & Services: Molecular Biology Reagents

Patients taking benralizumab, dupilumab, or mepolizumab have lower postvaccination SARS-CoV-2 immunity

Authors: Martin C Runnstrom, Pedro A Lamothe, Caterina E Faliti, Narayanaiah Cheedarla, Alberto Moreno, Mehul S Suthar, Rishika Nahata, Mayuran Ravindran, Natalie S Haddad, Andrea Morrison-Porter, Hannah Quehl, Richard P Ramonell, Matthew Woodruff, Fabliha Anam, Rebeca Zhang, Colin Swenson, Carmen Polito, Wendy Neveu, Rahulkumar Patel, Natalia Smirnova, Doan C Nguyen, Caroline Kim, Ian Hentenaar, Shuya Kyu, Sabeena Usman, Thuy Ngo, Zhenxing Guo, Hao Wu, John L Daiss, Jiwon Park, Kelly E Manning, Bursha Wali, Madison L Ellis, Sunita Sharma, Fernando Holguin, Suneethamma Cheedarla, Andrew S Neish, John D Roback, Ignacio Sanz, F Eun-Hyung Lee

Journal: J Allergy Clin Immunol

PubMed ID: 38878020

Doi: 10.1016/j.jaci.2024.03.029

Products & Services: Proteins, Expression, Isolation and Analysis

Dietary intake of a MFGM/EV-rich concentrate promotes accretion of very long odd-chain sphingolipids and increases lipid metabolic turnover at the whole-body level

Authors: Richard R Sprenger, Mesut Bilgin, Marie S Ostenfeld, Ann Bjørnshave, Jan T Rasmussen, Christer S Ejsing

Journal: Food Res Int

PubMed ID: 38945615

Doi: 10.1016/j.foodres.2024.114601

Products & Services: Proteins, Expression, Isolation and Analysis

Injectable Self-Healing Antibacterial Hydrogels with Tailored Functions by Loading Peptide Nanofiber-Biomimetic Silver Nanoparticles

Authors: Mingze Zhang, Guanghui Gu, Youyin Xu, Xin Luan, Jianyu Liu, Peng He, Gang Wei

Journal: Macromol Rapid Commun

PubMed ID: 38923127

Doi: 10.1002/marc.202400173

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A peptide derived from sorting nexin 1 inhibits HPV16 entry, retrograde trafficking, and L2 membrane spanning

Authors: Shuaizhi Li, Zachary L Williamson, Matthew A Christofferson, Advait Jeevanandam, Samuel K Campos

Journal: Tumour Virus Res

PubMed ID: 38909779

Doi: 10.1016/j.tvr.2024.200287

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Evaluating the antibody response elicited by diverse HIV envelope immunogens in the African green monkey (Vervet) model

Authors: Thandeka Moyo-Gwete, Frances Ayres, Nonkululeko B Mzindle, Zanele Makhado, Nelia P Manamela, Simone I Richardson, Dale Kitchin, Strauss van Graan, Joritha van Heerden, Nishal Parbhoo, Gerald K Chege, Penny L Moore

Journal: Sci Rep

PubMed ID: 38858452

Doi: 10.1038/s41598-024-63703-7

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A full-length glycoprotein mRNA vaccine confers complete protection against severe fever with thrombocytopenia syndrome virus, with broad-spectrum protective effects against bandaviruses

Authors: Jia Lu, Jun Liu, Yan Wu, Xiaoxue He, Xiao Gao, Xinlan Chen, Shaoyi Chen, Xuerui Zhu, Yucai Peng, Gengfu Xiao, Xiaoyan Pan

Journal: J Virol

PubMed ID: 38829138

Doi: 10.1128/jvi.00769-24

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Mapping the structural landscape of the yeast Ty3 retrotransposon RNA genome

Authors: Angelika Andrzejewska-Romanowska, Julita Gumna, Ewa Tykwińska, Katarzyna Pachulska-Wieczorek

Journal: Nucleic Acids Res

PubMed ID: 38864374

Doi: 10.1093/nar/gkae494

Products & Services: Proteins, Expression, Isolation and Analysis

Functional characterization of polyphenol oxidase OfPPO2 supports its involvement in parallel biosynthetic pathways of acteoside

Authors: Yating Liu, Xiaoyang Han, Mengya Zhao, Lan Liu, Zixin Deng, Qiu Zhao, Yi Yu

Journal: PLANT JOURNAL

PubMed ID: 38872484

Doi: 10.1111/tpj.16807

Products & Services: Gene Synthesis

Unraveling the Roles of Neuropeptides in the Chemosensation of the Root-Knot Nematode

Authors: Chenmi Mo, Lei Zhang

Journal: Int J Mol Sci

PubMed ID: 38928010

Doi: 10.3390/ijms25126300

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Geospatial joint modeling of vector and parasite serology to microstratify malaria transmission

Authors: Ellen A Kearney, Punam Amratia, Su Yun Kang, Paul A Agius, Kefyalew Addis Alene, Katherine O'Flaherty, Win Han Oo, Julia C Cutts, Win Htike, Daniela Da Silva Goncalves, Zahra Razook, Alyssa E Barry, Damien Drew, Aung Thi, Kyaw Zayar Aung, Htin Kyaw Thu, Myat Mon Thein, Nyi Nyi Zaw, Wai Yan Min Htay, Aung Paing Soe, James G Beeson, Julie A Simpson, Peter W Gething, Ewan Cameron, Freya J I Fowkes

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38833464

Doi: 10.1073/pnas.2320898121

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Increased efficacy of influenza virus vaccine candidate through display of recombinant neuraminidase on virus like particles

Authors: Leticia Guzman Ruiz, Alexander M Zollner, Irene Hoxie, Elsa Arcalis, Florian Krammer, Miriam Klausberger, Alois Jungbauer, Reingard Grabherr

Journal: Front Immunol

PubMed ID: 38915410

Doi: 10.3389/fimmu.2024.1425842

Products & Services: Molecular Biology Reagents

Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus

Authors: Ignacio Fernández, Nell Saunders, Stéphane Duquerroy, William H Bolland, Atousa Arbabian, Eduard Baquero, Catherine Blanc, Pierre Lafaye, Ahmed Haouz, Julian Buchrieser, Olivier Schwartz, Félix A Rey

Journal: Cell

PubMed ID: 38964326

Doi: 10.1016/j.cell.2024.06.007

Products & Services: Mutagenesis Services

Trichostatin A Promotes Cytotoxicity of Cisplatin, as Evidenced by Enhanced Apoptosis/Cell Death Markers

Authors: Yang Zhou, Qun Luo, Fangang Zeng, Xingkai Liu, Juanjuan Han, Liangzhen Gu, Xiao Tian, Yanyan Zhang, Yao Zhao, Fuyi Wang

Journal: Molecules

PubMed ID: 38893499

Doi: 10.3390/molecules29112623

Products & Services: Proteins, Expression, Isolation and Analysis

The porcine circovirus 3 humoral response: characterization of maternally derived antibodies and dynamic following experimental infection

Authors: Molly Kroeger, Gun Temeeyasen, Steven Dilberger-Lawson, Eric Nelson, Ronaldo Magtoto, Luis Gimenez-Lirola, Pablo Piñeyro

Journal: Microbiol Spectr

PubMed ID: 38916319

Doi: 10.1128/spectrum.00870-24

Products & Services: Molecular Biology Reagents

High-yield porphyrin production through metabolic engineering and biocatalysis

Authors: Haihong Chen, Yaohong Wang, Weishan Wang, Ting Cao, Lu Zhang, Zhengduo Wang, Xuran Chi, Tong Shi, Huangwei Wang, Xinwei He, Mindong Liang, Mengxue Yang, Wenyi Jiang, Dongyuan Lv, Jiaming Yu, Guoliang Zhu, Yongtao Xie, Bei Gao, Xinye Wang, Xueting Liu, Youyuan Li, Liming Ouyang, Jingyu Zhang, Huimin Liu, Zilong Li, Yaojun Tong, Xuekui Xia, Gao-Yi Tan, Lixin Zhang

Journal: Nat Biotechnol

PubMed ID: 38839873

Doi: 10.1038/s41587-024-02267-3

Products & Services: Proteins, Expression, Isolation and Analysis

Drosophila immune cells transport oxygen through PPO2 protein phase transition

Authors: Mingyu Shin, Eunji Chang, Daewon Lee, Nayun Kim, Bumsik Cho, Nuri Cha, Ferdinand Koranteng, Ji-Joon Song, Jiwon Shim

Journal: Nature

PubMed ID: 38926577

Doi: 10.1038/s41586-024-07583-x

Products & Services: Proteins, Expression, Isolation and Analysis

Absolute quantification of viral proteins from pseudotyped VSV-GP using UPLC-MRM

Authors: Rajeswari Basu, Richard Dambra, Di Jiang, Sophia A Schätzlein, Shu Njiyang, Joseph Ashour, Abhilash I Chiramel, Adam Vigil, Vladimir V Papov

Journal: Microbiol Spectr

PubMed ID: 38916347

Doi: 10.1128/spectrum.03651-23

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Functional surface expression of immunoglobulin cleavage systems in a candidate Mycoplasma vaccine chassis

Authors: Sergi Torres-Puig, Silvia Crespo-Pomar, Hatice Akarsu, Thatcha Yimthin, Valentina Cippà, Thomas Démoulins, Horst Posthaus, Nicolas Ruggli, Peter Kuhnert, Fabien Labroussaa, Jörg Jores

Journal: Commun Biol

PubMed ID: 38942984

Doi: 10.1038/s42003-024-06497-8

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Cathepsins L and B target HIF1α for oxygen-independent proteolytic cleavage

Authors: Sarah Stuart, Daniel Tarade, Michael Ohh

Journal: Sci Rep

PubMed ID: 38926538

Doi: 10.1038/s41598-024-65537-9

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Mechanism and spectrum of inhibition of a 4´-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA viruses

Authors: Calvin J Gordon, Simon M Walker, Egor P Tchesnokov, Dana Kocincova, Jared Pitts, Dustin S Siegel, Jason K Perry, Joy Y Feng, John P Bilello, Matthias Götte

Journal: J Biol Chem

PubMed ID: 38945449

Doi: 10.1016/j.jbc.2024.107514

Products & Services: Molecular Biology Reagents

Broadly Applicable Bispecific Linker Approach to Noncovalently Target Therapeutic Nanoparticles to Tumor Cells Expressing Carcinoembryonic Antigen

Authors: Ann Fernando, Amanda Sparkes, Esther I Matus, Ayushi Patel, F Stuart Foster, David Goertz, Peter Lee, Jean Gariépy

Journal: ACS Pharmacol Transl Sci

PubMed ID: 38898951

Doi: 10.1021/acsptsci.4c00140

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Evaluation in mice of cell-free produced CT584 as a Chlamydia vaccine antigen

Authors: Steven Hoang-Phou, Sukumar Pal, Anatoli Slepenkin, Abisola Abisoye-Ogunniyun, Yuliang Zhang, Sean F Gilmore, Megan Shelby, Feliza Bourguet, Mariam Mohagheghi, Aleksandr Noy, Amy Rasley, Luis M de la Maza, Matthew A Coleman

Journal: biorxiv

PubMed ID: 38895407

Doi: 10.1101/2024.06.04.597210

Products & Services: Gene Synthesis

Deciphering Structural Traits for Thermal and Kinetic Stability Across Protein Family Evolution through Ancestral Sequence Reconstruction

Authors: Pablo A Cea, Myriam Pérez, Sixto M Herrera, Sebastián M Muñoz, Nicolás Fuentes-Ugarte, José Coche-Miranda, Pablo Maturana, Victoria Guixé, Victor Castro-Fernandez

Journal: Mol Biol Evol

PubMed ID: 38913681

Doi: 10.1093/molbev/msae127

Products & Services: DNA Sequencing

Prostaglandin F2 Receptor Negative Regulator (PTGFRN) Expression Correlates With a Metastatic-like Phenotype in Epidermoid Carcinoma, Pediatric Medulloblastoma, and Mesothelioma

Authors: Jorge Marquez, Jianping Dong, Jun Hayashi, Ginette Serrero

Journal: J Cell Biochem

PubMed ID: 38924562

Doi: 10.1002/jcb.30616

Products & Services: Proteins, Expression, Isolation and Analysis

Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-κB signaling pathway

Authors: Yuru Shi, Xiaoqian Zhang, Shengji Pei, Yuhua Wang

Journal: Nat Prod Bioprospect

PubMed ID: 38833115

Doi: 10.1007/s13659-024-00458-8

Products & Services: Proteins, Expression, Isolation and Analysis

A Plasmodium apicoplast-targeted unique exonuclease/FEN exhibits interspecies functional differences attributable to an insertion that alters DNA-binding

Authors: Tribeni Chatterjee, Anupama Tiwari, Ritika Gupta, Himadri Shukla, Aastha Varshney, Satish Mishra, Saman Habib

Journal: Nucleic Acids Res

PubMed ID: 38888125

Doi: 10.1093/nar/gkae512

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A chimeric membrane enzyme and an engineered whole-cell biocatalyst for efficient 1-alkene production

Authors: Tabish Iqbal, Subhashini Murugan, Debasis Das

Journal: Sci Adv

PubMed ID: 38924395

Doi: 10.1126/sciadv.adl2492

Products & Services: Proteins, Expression, Isolation and Analysis

Optimization of dilution rate and mixed carbon feed for continuous production of recombinant plant sucrose:sucrose 1-fructosyltransferase in Komagataella phaffii

Authors: Avijeet S Jaswal, Ravikrishnan Elangovan, Saroj Mishra

Journal: Bioprocess Biosyst Eng

PubMed ID: 38904715

Doi: 10.1007/s00449-024-03045-w

Products & Services: PCR Cloning and Subcloning

CoHIT: a one-pot ultrasensitive ERA-CRISPR system for detecting multiple same-site indels

Authors: Yin Liu, Xinyi Liu, Dongyi Wei, Lu Dang, Xiaoran Xu, Shisheng Huang, Liwen Li, Sanyun Wu, Jinxian Wu, Xiaoyan Liu, Wenjun Sun, Wanyu Tao, Yongchang Wei, Xingxu Huang, Kui Li, Xinjie Wang, Fuling Zhou

Journal: Nat Commun

PubMed ID: 38866774

Doi: 10.1038/s41467-024-49414-7

Products & Services: Gene Synthesis

SepM mutation in Streptococcus mutans clinical isolates and related function analysis

Authors: Shanshan Liu, Yidan Shao, Zhenzhen Zhang, Wen Xu, Yudong Liu, Kai Zhang, Li Xu, Qingwei Zheng, Yu Sun

Journal: BMC Oral Health

PubMed ID: 38918777

Doi: 10.1186/s12903-024-04436-x

Products & Services: Gene Synthesis

Distant relatives of a eukaryotic cell-specific toxin family evolved a complement-like mechanism to kill bacteria

Authors: Hunter L Abrahamsen, Tristan C Sanford, Casie E Collamore, Bronte A Johnstone, Michael J Coyne, Leonor García-Bayona, Michelle P Christie, Jordan C Evans, Allison J Farrand, Katia Flores, Craig J Morton, Michael W Parker, Laurie E Comstock, Rodney K Tweten

Journal: Nat Commun

PubMed ID: 38866748

Doi: 10.1038/s41467-024-49103-5

Products & Services: Recombinant Proteins

GPRC5A promotes gallbladder cancer metastasis by upregulating TNS4 via the JAK2-STAT3 pathway

Authors: Jiahua Yang, Xuechuan Li, Shili Chen, Guoqiang Li, Peng Pu, Yang Yang, Wenguang Wu, Yajun Geng, Yingbin Liu

Journal: Cancer Lett

PubMed ID: 38942137

Doi: 10.1016/j.canlet.2024.217067

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OsNLP3 enhances grain weight and reduces grain chalkiness in rice

Authors: Liang-Qi Sun, Yu Bai, Jie Wu, Shi-Jun Fan, Si-Yan Chen, Zheng-Yi Zhang, Jin-Qiu Xia, Shi-Mei Wang, Yu-Ping Wang, Peng Qin, Shi-Gui Li, Ping Xu, Zhong Zhao, Cheng-Bin Xiang, Zi-Sheng Zhang

Journal: Plant Commun

PubMed ID: 38853433

Doi: 10.1016/j.xplc.2024.100999

Products & Services: Recombinant Proteins

M tuberculosis PrrA binds the dosR promoter and regulates mycobacterial adaptation to hypoxia

Authors: Yannik A Haller, Jiapei Jiang, Zijian Wan, Alexia Childress, Shaopeng Wang, Shelley E Haydel

Journal: Tuberculosis (Edinb)

PubMed ID: 38885567

Doi: 10.1016/j.tube.2024.102531

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Immuno-Microbial Signature of Vaccine-Induced Immunity against SARS-CoV-2

Authors: Lesley Umeda, Amada Torres, Braden P Kunihiro, Noelle C Rubas, Riley K Wells, Krit Phankitnirundorn, Rafael Peres, Ruben Juarez, Alika K Maunakea

Journal: Vaccines (Basel)

PubMed ID: 38932366

Doi: 10.3390/vaccines12060637

Products & Services: Gene Synthesis

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