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Double promoter and tandem gene strategy for efficiently expressing recombinant FGF21

Authors: Longying Liu, Nuoyi Ning, Simeng Xu, Dongqing Chen, Luping Zhou, Zhimou Guo, Xinmiao Liang, Xianlong Ye

Journal: Microb Cell Fact

PubMed ID: 38867280

Doi: 10.1186/s12934-024-02447-5

Products & Services: Gene Synthesis

Discovery, characterization, and comparative analysis of new UGT72 and UGT84 family glycosyltransferases

Authors: Tuo Li, Annika J E Borg, Leo Krammer, Hansjörg Weber, Rolf Breinbauer, Bernd Nidetzky

Journal: Commun Chem

PubMed ID: 38942997

Doi: 10.1038/s42004-024-01231-1

Products & Services: Molecular Biology Reagents

DNA mismatch and damage patterns revealed by single-molecule sequencing

Authors: Mei Hong Liu, Benjamin M Costa, Emilia C Bianchini, Una Choi, Rachel C Bandler, Emilie Lassen, Marta Grońska-Pęski, Adam Schwing, Zachary R Murphy, Daniel Rosenkjær, Shany Picciotto, Vanessa Bianchi, Lucie Stengs, Melissa Edwards, Nuno Miguel Nunes, Caitlin A Loh, Tina K Truong, Randall E Brand, Tomi Pastinen, J Richard Wagner, Anne-Bine Skytte, Uri Tabori, Jonathan E Shoag, Gilad D Evrony

Journal: Nature

PubMed ID: 38867045

Doi: 10.1038/s41586-024-07532-8

Products & Services: Molecular Biology Reagents

IgE-Mediated Sensitization to Blo t 21 and Blo t 5 Is Associated With Asthma in the Tropics: A Case-Control Study

Authors: J Zakzuk, K Donado, E Mondol, V Marrugo, R Regino, J F López, K Hernandez, D Mercado, R Dennis, L Puerta, L Caraballo

Journal: J Investig Allergol Clin Immunol

PubMed ID: 38888580

Doi: 10.18176/jiaci.0892

Products & Services: Molecular Biology Reagents

A soybean cyst nematode suppresses microbial plant symbionts using a lipochitooligosaccharide-hydrolysing enzyme

Authors: Wei Chen, Di Wang, Shaoyong Ke, Yangrong Cao, Wensheng Xiang, Xiaoli Guo, Qing Yang

Journal: Nat Microbiol

PubMed ID: 38886584

Doi: 10.1038/s41564-024-01727-5

Products & Services: Codon Optimization

Structural Basis for Recognition of the FLAG-tag by Anti-FLAG M2

Authors: J Wouter Beugelink, Els Sweep, Bert J C Janssen, Joost Snijder, Matti F Pronker

Journal: J Mol Biol

PubMed ID: 38852931

Doi: 10.1016/j.jmb.2024.168649

Products & Services: Catalog Peptides

Cost-Efficient Expression of Human Cardiac Myosin Heavy Chain in C2C12 Cells with a Non-Viral Transfection Reagent

Authors: Albin E Berg, Lok Priya Velayuthan, Alf Månsson, Marko Ušaj

Journal: Int J Mol Sci

PubMed ID: 38928453

Doi: 10.3390/ijms25126747

Products & Services: Molecular Biology Reagents

CircVIRMA enhances cell malignant behavior by governing the miR-452-5p/CREBRF pathway in cervical cancer

Authors: Chengluo Hao, Jianjun Han, Kechao Xiang, Yun Wang, Xiangrui Chen, Chen Yang, Ailin Liang, Li Jia

Journal: Naunyn Schmiedebergs Arch Pharmacol

PubMed ID: 38850300

Doi: 10.1007/s00210-024-03159-8

Products & Services: Molecular Biology Reagents

Circ_002033 Regulates Proliferation, Apoptosis, and Oxidative Damage of Bovine Mammary Epithelial Cells via the miR-199a-5p-MAP3K11 Axis in Heat Stress

Authors: Hanfang Zeng, Shujie Li, Haomiao Chang, Yunfei Zhai, Haihui Wang, Hantong Weng, Zhaoyu Han

Journal: J Agric Food Chem

PubMed ID: 38869955

Doi: 10.1021/acs.jafc.3c09835

Products & Services: Proteins, Expression, Isolation and Analysis

Immune responses and reinfection of SARS-CoV-2 Omicron variant in patients with lung cancer

Authors: Chen Chen, Xiaoyun Zhou, Xiaoxing Gao, Ruili Pan, Qi He, Xiaobei Guo, Siyuan Yu, Na Wang, Qian Zhao, Mengzhao Wang, Yan Xu, Xiaohong Han

Journal: Int J Cancer

PubMed ID: 38837354

Doi: 10.1002/ijc.35038

Products & Services: Catalog Peptides

Structure of the E. coli nucleoid-associated protein YejK reveals a novel DNA binding clamp

Authors: Maria A Schumacher, Rajiv R Singh, Raul Salinas

Journal: Nucleic Acids Res

PubMed ID: 38832628

Doi: 10.1093/nar/gkae459

Products & Services: Proteins, Expression, Isolation and Analysis

Auxin resistant 2 and short hypocotyl 2 regulate cotton fiber initiation and elongation

Authors: Fei Jin, Liping Zhu, Liyong Hou, Hongbin Li, Ling Li, Guanghui Xiao

Journal: Plant Physiol

PubMed ID: 38527791

Doi: 10.1093/plphys/kiae183

Products & Services: Proteins, Expression, Isolation and Analysis

Interleukin-1 beta (IL-1β) as adjuvant enhances the immune effects of Aeromonas veronii inactivated vaccine in largemouth bass (Micropterus salmoides)

Authors: Ze-Sheng Zhang, Heng-Chu Ren, Xie Gu, Qian-Rong Liang, Hui Fei, Yu-Hong Yang, Shun Yang, Liang-Yin He, Li-Li Liu

Journal: Int J Biol Macromol

PubMed ID: 38876231

Doi: 10.1016/j.ijbiomac.2024.133135

Products & Services: Molecular Biology Reagents

Development of Broad-Spectrum Nanobodies for the Therapy and Diagnosis of SARS-CoV-2 and Its Multiple Variants

Authors: Lei He, Qian Wu, Zhaoyong Zhang, Lingling Chen, Kuai Yu, Leibin Li, Qiong Jia, Yanqun Wang, Jianqiang Ni, Chuanbin Wang, Qi Li, Xinyan Zhai, Jincun Zhao, Yuliang Liu, Ruiwen Fan, Yi-Ping Li

Journal: Mol Pharm

PubMed ID: 38920116

Doi: 10.1021/acs.molpharmaceut.4c00165

Products & Services: Proteins, Expression, Isolation and Analysis

Synthetic Peptides Elicit Humoral Response against Porcine Reproductive and Respiratory Syndrome Virus in Swine

Authors: Francisco Perez-Duran, Fernando Calderon-Rico, Luis Enrique Franco-Correa, Alicia Gabriela Zamora-Aviles, Roberto Ortega-Flores, Daniel Durand-Herrera, Alejandro Bravo-Patiño, Ricarda Cortes-Vieyra, Ilane Hernandez-Morales, Rosa Elvira Nuñez-Anita

Journal: Vaccines (Basel)

PubMed ID: 38932381

Doi: 10.3390/vaccines12060652

Products & Services: Catalog Peptides

Exploring a novel GH13_5 α-amylase from Jeotgalibacillus malaysiensis D5 for raw starch hydrolysis

Authors: Nurfatini Radzlin, Mohd Shukuri Mohamad Ali, Kian Mau Goh, Amira Suriaty Yaakop, Iffah Izzati Zakaria, Ummirul Mukminin Kahar

Journal: AMB Express

PubMed ID: 38874807

Doi: 10.1186/s13568-024-01722-3

Products & Services: Gene Synthesis

Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome

Authors: Boyang Zhao, Zhongzheng Cao, Yi Zheng, Phuong Nguyen, Alisa Bowen, Robert H Edwards, Robert M Stroud, Yi Zhou, Menno Van Lookeren Campagne, Fei Li

Journal: Nat Commun

PubMed ID: 38918376

Doi: 10.1038/s41467-024-49614-1

Products & Services: PCR Cloning and Subcloning

Development of a Ferritin Protein Nanoparticle Vaccine with PRRSV GP5 Protein

Authors: Xinjian Chang, Jun Ma, Yanrong Zhou, Shaobo Xiao, Xun Xiao, Liurong Fang

Journal: Viruses

PubMed ID: 38932282

Doi: 10.3390/v16060991

Products & Services: Molecular Biology Reagents

Assessing Predictive Value of SARS-CoV-2 Epitope-Specific CD8 T-Cell Response in Patients with Severe Symptoms

Authors: Cristina Martín-Martín, Estefanía Salgado Del Riego, Jose R Vidal Castiñeira, Maria Soledad Zapico-Gonzalez, Mercedes Rodríguez-Pérez, Viviana Corte-Iglesias, Maria Laura Saiz, Paula Diaz-Bulnes, Dolores Escudero, Beatriz Suárez-Alvarez, Carlos López-Larrea

Journal: Vaccines (Basel)

PubMed ID: 38932408

Doi: 10.3390/vaccines12060679

Products & Services: Catalog Peptides

Functional characterization of a cystatin A from the bat Myotis davidii

Authors: Gabriel Cerqueira Alves Costa, Ricardo Jose Soares Torquato, Vinícius de Morais Gomes, Lívia Rosa-Fernandes, Giuseppe Palmisano, Aparecida Sadae Tanaka

Journal: Comp Biochem Physiol B Biochem Mol Biol

PubMed ID: 38936799

Doi: 10.1016/j.cbpb.2024.111003

Products & Services: Custom Vector Construction

C-terminal Poly-histidine Tags Alter Escherichia coli Polyphosphate Kinase Activity and Susceptibility to Inhibition

Authors: Marvin Q Bowlin, Avery D Lieber, Abagail R Long, Michael J Gray

Journal: J Mol Biol

PubMed ID: 38866092

Doi: 10.1016/j.jmb.2024.168651

Products & Services: Molecular Biology Reagents

Production of norovirus-, rotavirus-, and enterovirus-like particles in insect cells is simplified by plasmid-based expression

Authors: Vili Lampinen, Stina Gröhn, Nina Lehmler, Minne Jartti, Vesa P Hytönen, Maren Schubert, Minna M Hankaniemi

Journal: Sci Rep

PubMed ID: 38937523

Doi: 10.1038/s41598-024-65316-6

Products & Services: Molecular Biology Reagents

Red2Flpe-SCON: a versatile, multicolor strategy for generating mosaic conditional knockout mice

Authors: Szu-Hsien Sam Wu, Somi Kim, Heetak Lee, Ji-Hyun Lee, So-Yeon Park, Réka Bakonyi, Isaree Teriyapirom, Natalia Hallay, Sandra Pilat-Carotta, Hans-Christian Theussl, Jihoon Kim, Joo-Hyeon Lee, Benjamin D Simons, Jong Kyoung Kim, Gabriele Colozza, Bon-Kyoung Koo

Journal: Nat Commun

PubMed ID: 38862535

Doi: 10.1038/s41467-024-49382-y

Products & Services: Molecular Biology Reagents

New wheat straw fermentation feed: recombinant efficient degradation of lignocellulose and increase feed protein

Authors: Xihua Chen, Xiaoyu Liang, Na Shi, Lu He, Yi Ma, Daochen Zhu, Zhong Ni, Huayou Chen

Journal: Prep Biochem Biotechnol

PubMed ID: 38824495

Doi: 10.1080/10826068.2024.2353637

Products & Services: Gene Synthesis

Mechanism of human PINK1 activation at the TOM complex in a reconstituted system

Authors: Olawale G Raimi, Hina Ojha, Kenneth Ehses, Verena Dederer, Sven M Lange, Cristian Polo Rivera, Tom D Deegan, Yinchen Chen, Melanie Wightman, Rachel Toth, Karim P M Labib, Sebastian Mathea, Neil Ranson, Rubén Fernández-Busnadiego, Miratul M K Muqit

Journal: SCIENCE ADVANCES

PubMed ID: 38848361

Doi: 10.1126/sciadv.adn7191

Products & Services: Proteins, Expression, Isolation and Analysis

Understanding the Phase Behavior of a Multistimuli-Responsive Elastin-like Polymer: Insights from Dynamic Light Scattering Analysis

Authors: Peter C Swanson, Galen P Arnold, Carolyn E Curley, Savannah C Wakita, Jeffery D V Waters, Eva Rose M Balog

Journal: J Phys Chem B

PubMed ID: 38830627

Doi: 10.1021/acs.jpcb.4c00070

Products & Services: Molecular Biology Reagents

TnpB homologues exapted from transposons are RNA-guided transcription factors

Authors: Tanner Wiegand, Florian T Hoffmann, Matt W G Walker, Stephen Tang, Egill Richard, Hoang C Le, Chance Meers, Samuel H Sternberg

Journal: Nature

PubMed ID: 38926585

Doi: 10.1038/s41586-024-07598-4

Cholesterol neutralized vemurafenib treatment by promoting melanoma stem‑like cells via its metabolite 27‑hydroxycholesterol

Authors: Xiaohong Wang, Feiliang Zhong, Tingting Chen, Hongbo Wang, Weifang Wang, Hongkai Jin, Chouyang Li, Xuan Guo, Ying Liu, Yu Zhang, Bo Li

Journal: Cell Mol Life Sci

PubMed ID: 38775844

Doi: 10.1007/s00018-024-05267-3

Products & Services: Proteins, Expression, Isolation and Analysis

Engineered probiotics with sustained release of interleukin-2 for the treatment of inflammatory bowel disease after oral delivery

Authors: Maoyi Li, Nanhui Liu, Jiafei Zhu, Yumin Wu, Le Niu, Yi Liu, Linfu Chen, Boxiong Bai, Yu Miao, Yang Yang, Qian Chen

Journal: Biomaterials

PubMed ID: 38735180

Doi: doi.org/10.1016/j.biomaterials.2024.122584

Products & Services: Catalog Antibody

Identification of an FMNL2 Interactome by Quantitative Mass Spectrometry

Authors: Sarah Fox, Antoine Gaudreau-LaPierre, Ryan Reshke, Irina Podinic, Derrick J Gibbings, Laura Trinkle-Mulcahy, John W Copeland

Journal: Int J Mol Sci

PubMed ID: 38891874

Doi: 10.3390/ijms25115686

Products & Services: Proteins, Expression, Isolation and Analysis

Blue light-mediated gene expression as a promising strategy to reduce antibiotic resistance in Escherichia coli

Authors: Qingwei Jiang, Feng Geng, Juan Shen, Ping Zhu, Zhaoxin Lu, Fengxia Lu, Libang Zhou

Journal: Biotechnol J

PubMed ID: 38719589

Doi: 10.1002/biot.202400023

Products & Services: Proteins, Expression, Isolation and Analysis

Effect of Free Cysteine Residues to Serine Mutation on Cellodextrin Phosphorylase

Authors: Tomohiro Kuga, Naoki Sunagawa, Kiyohiko Igarashi

Journal: J Appl Glycosci (1999)

PubMed ID: 38863949

Doi: 10.5458/jag.jag.JAG-2023_0011

Products & Services: Molecular Biology Reagents

Micro-and nano-plastics induce kidney damage and suppression of innate immune function in zebrafish (Danio rerio) larvae

Authors: Hui Yang, Jian Ju, Yuting Wang, Zhu Zhu, Wenyan Lu, Yingying Zhang

Journal: Sci Total Environ

PubMed ID: 38703841

Doi: 10.1016/j.scitotenv.2024.172952

Products & Services: Catalog Antibody

Tetrahydroxy stilbene glucoside rejuvenates aging hematopoietic stem cells with predilection for lymphoid differentiation via AMPK and Tet2

Authors: Dan Gao, Wei-Wei Yi, Bo Liu, Cong-En Zhang, Cui-Cui Yang, Li Zeng, Lin Li, Guangbin Luo, Lan Zhang, Zhen-Yu Ju, Jia-Bo Wang

Journal: J Adv Res

PubMed ID: 38704089

Doi: 10.1016/j.jare.2024.04.027

Products & Services: Proteins, Expression, Isolation and Analysis

CRTAC1 identified as a promising diagnosis and prognostic biomarker in lung adenocarcinoma

Authors: Lin Tan, Han Zhang, Yun Ding, Yangyun Huang, Daqiang Sun

Journal: Sci Rep

PubMed ID: 38755183

Doi: 10.1038/s41598-024-61804-x

Products & Services: Proteins, Expression, Isolation and Analysis

A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy

Authors: Dan A Tudorica, Bishal Basak, Alexia S Puerta Cordova, Grace Khuu, Kevin Rose, Michael Lazarou, Erika L F Holzbaur, James H Hurley

Journal: J Cell Biol

PubMed ID: 38728007

Doi: 10.1083/jcb.202309015

Products & Services: Molecular Biology Reagents

Antitumor activity of Z15-0-2, a bispecific nanobody targeting PD-1 and CTLA-4

Authors: Jianyao Zeng, Yuan Fang, Zixuan Zhang, Zhenzhen Lv, Xiaodie Wang, Qian Huang, Zhidan Tian, Jiaguo Li, Wenfeng Xu, Weimin Zhu, Jing Yu, Tao Liu, Qijun Qian

Journal: Oncogene

PubMed ID: 38806619

Doi: 10.1038/s41388-024-03066-5

Products & Services: Proteins, Expression, Isolation and Analysis

Post-transcriptional regulation of the T-box gene midline via the 3'UTR in Drosophila is complex and cell and tissue-dependent

Authors: Kalpana Makhijani, Jordan Mar, Ivana Gaziova, Krishna Moorthi Bhat

Journal: Genetics

PubMed ID: 38805187

Doi: 10.1093/genetics/iyae087

Products & Services: Molecular Biology Reagents

Identification and characterization of calcium binding protein, spermatid-associated 1 (CABS1)# in selected human tissues and fluids

Authors: Eduardo Reyes-Serratos, Joy Ramielle L Santos, Lakshmi Puttagunta, Stephen J Lewis, Mechiko Watanabe, Aron Gonshor, Robert Buck, A Dean Befus, Marcelo Marcet-Palacios

Journal: PLoS ONE

PubMed ID: 38753592

Doi: 10.1371/journal.pone.0301855

EDA2R knockdown alleviates myocardial ischemia/reperfusion injury through inhibiting the activation of the NF-κB signaling pathway

Authors: Zhi-Hui Guan, Di Yang, Yi Wang, Jia-Bin Ma, Guo-Nian Wang

Journal: Exp Anim

PubMed ID: 38797667

Doi: 10.1538/expanim.24-0020

Products & Services: Molecular Biology Reagents

Filtered Saliva for Rapid and Accurate Analyte Detection for POC Diagnostics

Authors: Nadia Farsaeivahid, Christian Grenier, Ming L Wang

Journal: Diagnostics (Basel)

PubMed ID: 38893615

Doi: 10.3390/diagnostics14111088

Products & Services: Proteins, Expression, Isolation and Analysis

BRD9 regulates normal human hematopoietic stem cell function and lineage differentiation

Authors: Swati Garg, Wei Ni, Basudev Chowdhury, Ellen L Weisberg, Martin Sattler, James D Griffin

Journal: Cell Death Differ

PubMed ID: 38816579

Doi: 10.1038/s41418-024-01306-5

Products & Services: Molecular Biology Reagents

L-serine deficiency: on the properties of the Asn133Ser variant of human phosphoserine phosphatase

Authors: Loredano Pollegioni, Barbara Campanini, Jean-Marc Good, Zoraide Motta, Giulia Murtas, Valeria Buoli Comani, Despina-Christina Pavlidou, Noëlle Mercier, Laureane Mittaz-Crettol, Silvia Sacchi, Francesco Marchesani

Journal: Sci Rep

PubMed ID: 38816452

Doi: 10.1038/s41598-024-63164-y

Products & Services: Proteins, Expression, Isolation and Analysis

Insights into PCSK9-LDLR Regulation and Trafficking via the Differential Functions of MHC-I Proteins HFE and HLA-C

Authors: Sepideh Mikaeeli, Ali Ben Djoudi Ouadda, Alexandra Evagelidis, Rachid Essalmani, Oscar Henrique Pereira Ramos, Carole Fruchart-Gaillard, Nabil G Seidah

Journal: Cells

PubMed ID: 38786080

Doi: 10.3390/cells13100857

Products & Services: Mutant Libraries

Gene network-based and ensemble modeling-based selection of tumor-associated antigens with a predicted low risk of tissue damage for targeted immunotherapy

Authors: Christopher Lischer, Martin Eberhardt, Cindy Flamann, Johannes Berges, Esther Güse, Anja Wessely, Adrian Weich, Jimmy Retzlaff, Jan Dörrie, Niels Schaft, Manuel Wiesinger, Johannes März, Beatrice Schuler-Thurner, Harald Knorr, Shailendra Gupta, Krishna Pal Singh, Gerold Schuler, Markus Vincent Heppt, Elias Andreas Thomas Koch, Nadine D van Kleef, Julian J Freen-van Heeren, Annelies W Turksma, Olaf Wolkenhauer, Bettina Hohberger, Carola Berking, Heiko Bruns, Julio Vera

Journal: J Immunother Cancer

PubMed ID: 38724462

Doi: 10.1136/jitc-2023-008104

Products & Services: Gene Synthesis

CircZFR promotes colorectal cancer progression via stabilizing BCLAF1 and regulating the miR-3127-5p/RTKN2 axis

Authors: Jiaxin Chen, Huijuan Wang, Jianbin Xu, Engeng Chen, Qing Meng, Jiawei Wang, Haoyi Xiang, Wei Zhou, Ge Shan, Zhenyu Ju, Zhangfa Song

Journal: Sci China Life Sci

PubMed ID: 38805063

Doi: 10.1007/s11427-023-2514-y

Products & Services: Proteins, Expression, Isolation and Analysis

Construction of a grpE-based plasmid addiction system in Escherichia coli and its application in phloroglucinol biosynthesis

Authors: Ji-Ming Wang, Yu-Jin Cao, Xiao Men, Hai-Bo Zhang

Journal: J Appl Microbiol

PubMed ID: 38724452

Doi: 10.1093/jambio/lxae116

Products & Services: Proteins, Expression, Isolation and Analysis

Detection of calcitonin gene-related peptide based on increased antigen-driven interaction with antibody variable regions

Authors: Yueqing Cheng, Yujie Gao, Shengshuo Zhang, Yujie Zou, Guangwei Zhao, Liyuan Zheng, Binghui Hou, Mei Li, Jinhua Dong

Journal: Front Bioeng Biotechnol

PubMed ID: 38882635

Doi: 10.3389/fbioe.2024.1395330

Products & Services: Molecular Biology Reagents

Glycan Profile and Sequence Variants of Certified Ricin Reference Material and Other Ricin Samples Yield Unique Molecular Signature Features

Authors: Roland Josuran, Andreas Wenger, Christian Müller, Bettina Kampa, Sylvia Worbs, Brigitte G Dorner, Sabina Gerber

Journal: Toxins (Basel)

PubMed ID: 38922138

Doi: 10.3390/toxins16060243

Products & Services: Proteins, Expression, Isolation and Analysis

TOP CAR with TMIGD2 as a safe and effective costimulatory domain in CAR cells treating human solid tumors

Authors: Christopher D Nishimura, Devin Corrigan, Xiang Yu Zheng, Phillip M Galbo, Shan Wang, Yao Liu, Yao Wei, Linna Suo, Wei Cui, Nadia Mercado, Deyou Zheng, Cheng Cheng Zhang, Xingxing Zang

Journal: Sci Adv

PubMed ID: 38718110

Doi: 10.1126/sciadv.adk1857

Products & Services: Proteins, Expression, Isolation and Analysis

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