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De Novo design of a humanized antiCD33 antibody-oridonin conjugate for acute myeloid leukemia therapy

Authors: Hui Feng, Yi Liu, Mengyao Zhang, Ruimin Liu, Jincheng Wang, Wenjuan Wang, Pengcheng He, Penghui Zhang, Fan Niu

Journal: Biochem Biophys Res Commun

PubMed ID: 36122452

Doi: 10.1016/j.bbrc.2022.09.032

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Cutaneous kinase activity correlates with treatment outcomes following PI3K delta inhibition in mice with experimental pemphigoid diseases

Authors: Saeedeh Ghorbanalipoor, Shirin Emtenani, Melissa Parker, Mayumi Kamaguchi, Colin Osterloh, Manuela Pigors, Natalie Gross, Stanislav Khil'chenko, Anika Kasprick, Sabrina Patzelt, Diana Wortmann, Ibrahim O Ibrahim, Kentaro Izumi, Stephanie Goletz, Katharina Boch, Kathrin Kalies, Katja Bieber, Paul Smith, Enno Schmidt, Ralf J Ludwig

Journal: Front Immunol

PubMed ID: 36248903

Doi: 10.3389/fimmu.2022.865241

Products & Services: Proteins, Expression, Isolation and Analysis

A bead-based method for high-throughput mapping of the sequence- and force-dependence of T cell activation

Authors: Yinnian Feng, Xiang Zhao, Adam K White, K Christopher Garcia, Polly M Fordyce

Journal: Nat Methods

PubMed ID: 36064771

Doi: 10.1038/s41592-022-01592-2

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Characterization of prefusion-F-specific antibodies elicited by natural infection with human metapneumovirus

Authors: Scott A Rush, Gurpreet Brar, Ching-Lin Hsieh, Emilie Chautard, Jennifer N Rainho-Tomko, Chris D Slade, Christine A Bricault, Ana Kume, James Kearns, Rachel Groppo, Sophia T Mundle, Linong Zhang, Danilo Casimiro, Tong-Ming Fu, Joshua M DiNapoli, Jason S McLellan

Journal: Cell Rep

PubMed ID: 36130517

Doi: 10.1016/j.celrep.2022.111399

Products & Services: Proteins, Expression, Isolation and Analysis

Evidence of Orientation-Dependent Early States of Prion Protein Misfolded Structures from Single Molecule Force Spectroscopy

Authors: Andrea Raspadori, Valentina Vignali, Anna Murello, Gabriele Giachin, Bruno Samorì, Motomasa Tanaka, Carlos Bustamante, Giampaolo Zuccheri, Giuseppe Legname

Journal: Biology (Basel)

PubMed ID: 36138837

Doi: 10.3390/biology11091358

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Metabolic remodeling of pyrimidine synthesis pathway and serine synthesis pathway in human glioblastoma

Authors: Akira Nakamizo, Yuichiro Miyamatsu, Haruka Hirose, Toshiyuki Amano, Satoshi Matsuo, Minako Fujiwara, Teppei Shimamura, Koji Yoshimoto

Journal: Sci Rep

PubMed ID: 36175487

Doi: 10.1038/s41598-022-20613-w

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The Musashi proteins direct post-transcriptional control of protein expression and alternate exon splicing in vertebrate photoreceptors

Authors: Fatimah Matalkah, Bohye Jeong, Macie Sheridan, Eric Horstick, Visvanathan Ramamurthy, Peter Stoilov

Journal: Commun Biol

PubMed ID: 36153373

Doi: 10.1038/s42003-022-03990-w

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mRNA-1273 but not BNT162b2 induces antibodies against polyethylene glycol (PEG) contained in mRNA-based vaccine formulations

Authors: Juan Manuel Carreño, Gagandeep Singh, Johnstone Tcheou, Komal Srivastava, Charles Gleason, Hiromi Muramatsu, Parnavi Desai, Judith A Aberg, Rachel L Miller, Paris Study Group, Norbert Pardi, Viviana Simon, Florian Krammer

Journal: Vaccine

PubMed ID: 36115801

Doi: 10.1016/j.vaccine.2022.08.024

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Disease-associated inosine misincorporation into RNA hinders translation

Authors: Jacob H Schroader, Lindsey A Jones, Ryan Meng, Hannah K Shorrock, Jared I Richardson, Sharon M Shaughnessy, Qishan Lin, Thomas J Begley, J Andrew Berglund, Gabriele Fuchs, Mark T Handley, Kaalak Reddy

Journal: Nucleic Acids Res

PubMed ID: 35979951

Doi: 10.1093/nar/gkac709

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Investigation of the Neutralizing Antibody Response of Healthcare Workers at a Korean University Hospital Six Months After the Introduction of the COVID-19 Vaccine

Authors: Seong-Ho Choi, Ji Young Park, Joung Ha Park, Min-Chul Kim, Oh Joo Kweon, Jin-Won Chung

Journal: Ann Lab Med

PubMed ID: 35470282

Doi: 10.3343/alm.2022.42.5.612

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OsAMT1;1 and OsAMT1;2 Coordinate Root Morphological and Physiological Responses to Ammonium for Efficient Nitrogen Foraging in Rice

Authors: Xiangyu Wu, Xiaoxiao Xie, Shan Yang, Qianyu Yin, Huairong Cao, Xiaonan Dong, Jing Hui, Zhi Liu, Zhongtao Jia, Chuanzao Mao, Lixing Yuan

Journal: Plant&cell physiology

PubMed ID: 35861152

Doi: 10.1093/pcp/pcac104

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Splice-switch oligonucleotide-based combinatorial platform prioritizes synthetic lethal targets CHK1 and BRD4 against MYC-driven hepatocellular carcinoma

Authors: Dexter Kai Hao Thng, Tan Boon Toh, Paolo Pigini, Lissa Hooi, Yock Young Dan, Pierce Kah-Hoe Chow, Glenn Kunnath Bonney, Masturah Bte Mohd Abdul Rashid, Ernesto Guccione, Dave Keng Boon Wee, Edward Kai-Hua Chow

Journal: Bioeng Transl Med

PubMed ID: 36684069

Doi: 10.1002/btm2.10363

Products & Services: Proteins, Expression, Isolation and Analysis

A new blocking ELISA for detection of foot-and-mouth disease non-structural protein (NSP) antibodies in a broad host range

Authors: Madhusudan Hosamani, Shreya Gopinath, B P Sreenivasa, Subhasmita Behera, Suresh H Basagoudanavar, Ashok Boora, Durlav P Bora, Pankaj Deka, Veerakyathappa Bhanuprakash, Raj Kumar Singh, Aniket Sanyal, Klaas Weerdmeester, Aldo Dekker

Journal: Appl Microbiol Biotechnol

PubMed ID: 36089639

Doi: 10.1007/s00253-022-12151-2

Products & Services: Proteins, Expression, Isolation and Analysis

Synthetic evolution of herbicide resistance using a T7 RNAP-based random DNA base editor

Authors: Haroon Butt, Jose Luis Moreno Ramirez, Magdy Mahfouz

Journal: Life Sci Alliance

PubMed ID: 36171140

Doi: 10.26508/lsa.202201538

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Body Weight is Inversely Associated with Anti-SARS-CoV-2 Antibody Levels after BNT162b2 mRNA Vaccination in Young and Middle Aged Adults

Authors: Su Youn Nam, Seong Woo Jeon, Deuk Kju Jung, Sung-Jae Heo

Journal: Infect Chemother

PubMed ID: 36196609

Doi: 10.3947/ic.2022.0089

Products & Services: Recombinant Proteins

Co-expression and Interaction of Pax6 with Genes and Proteins of Immunological Surveillance in the Brain of Mice

Authors: Shashank Kumar Maurya, Rajnikant Mishra

Journal: Neurotox Res

PubMed ID: 36069979

Doi: 10.1007/s12640-022-00562-y

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Bombyx mori transcription factor, E74A, beneficially affects BmNPV infection through direct interaction

Authors: Xin Wang, Jun-Li Lv, Shuang Cheng, Zhi-Hao Su, Sheng Qin, Xia Sun, Xu-Dong Tang, Qiu-Ning Liu, Mu-Wang Li, Xue-Yang Wang

Journal: Pest Manag Sci

PubMed ID: 36054174

Doi: 10.1002/ps.7152

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Nanobody-based RFP-dependent Cre recombinase for selective anterograde tracing in RFP-expressing transgenic animals

Authors: Ayumu Inutsuka, Sho Maejima, Hiroyuki Mizoguchi, Ryosuke Kaneko, Rei Nomura, Keiko Takanami, Hirotaka Sakamoto, Tatsushi Onaka

Journal: Commun Biol

PubMed ID: 36114373

Doi: 10.1038/s42003-022-03944-2

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Heterologous Expression and Catalytic Properties of Codon-Optimized Small-Sized Bromelain from MD2 Pineapple

Authors: Rafida Razali, Fikran Aranda Fahrudin, Vijay Kumar Subbiah, Kazufumi Takano, Cahyo Budiman

Journal: Molecules

PubMed ID: 36144767

Doi: 10.3390/molecules27186031

Products & Services: Bacterial Expression

Antigenic characterization of the SARS-CoV-2 Omicron subvariant BA275

Authors: Qian Wang, Sho Iketani, Zhiteng Li, Yicheng Guo, Andre Yanchen Yeh, Michael Liu, Jian Yu, Zizhang Sheng, Yaoxing Huang, Lihong Liu, David D Ho

Journal: Cell Host Microbe

PubMed ID: 36108630

Doi: 10.1016/j.chom.2022.09.002

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Dynamic Actin Filament Traps Mediate Active Diffusion of Vesicular Stomatitis Virus Ribonucleoproteins

Authors: Steven J Moran, Shelby Puckett, David A Ornelles, Jed C Macosko, George Holzwarth, Douglas S Lyles

Journal: J Virol

PubMed ID: 36135365

Doi: 10.1128/jvi.00934-22

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Boosting the Cannabidiol Production in Engineered by Harnessing the Vacuolar Transporter BPT1

Authors: Jie Qiu, Kangxin Hou, Qiang Li, Jialin Chen, Xiwen Li, Hongping Hou, Liqiang Wang, Jia Liu, Qiang Xue, Caixia Wang

Journal: J Agric Food Chem

PubMed ID: 36122349

Doi: 10.1021/acs.jafc.2c05468

Products & Services: Proteins, Expression, Isolation and Analysis

Vaspin Ameliorates Cardiac Remodeling by Suppressing Phosphoinositide 3-Kinase/Protein Kinase B Pathway to Improve Oxidative Stress in Heart Failure Rats

Authors: Mingyue Ji, Yong Li, Yun Liu, Genshan Ma

Journal: J Cardiovasc Pharmacol

PubMed ID: 36067399

Doi: 10.1097/FJC.0000000000001291

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Disruption of grin2B, an ASD-associated gene, produces social deficits in zebrafish

Authors: Josiah D Zoodsma, Emma J Keegan, Gabrielle R Moody, Ashwin A Bhandiwad, Amalia J Napoli, Harold A Burgess, Lonnie P Wollmuth, Howard I Sirotkin

Journal: Mol Autism

PubMed ID: 36138431

Doi: 10.1186/s13229-022-00516-3

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Development and optimization of biologically contained Marburg virus for high-throughput antiviral screening

Authors: Bert Vanmechelen, Joren Stroobants, Winston Chiu, Lieve Naesens, Joost Schepers, Kurt Vermeire, Piet Maes

Journal: Antiviral Res

PubMed ID: 36183903

Doi: 10.1016/j.antiviral.2022.105426

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Utilization of the Abbott SARS-CoV-2 IgG II Quant Assay To Identify High-Titer Anti-SARS-CoV-2 Neutralizing Plasma against Wild-Type and Variant SARS-CoV-2 Viruses

Authors: Yi-Chan J Lin, David H Evans, Ninette F Robbins, Guillermo Orjuela, Queenie Hu, Reuben Samson, Kento T Abe, Bhavisha Rathod, Karen Colwill, Anne-Claude Gingras, Ashleigh Tuite, Qi-Long Yi, Sheila F O'Brien, Steven J Drews

Journal: Microbiol Spectr

PubMed ID: 36125288

Doi: 10.1128/spectrum.02811-22

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Role of lipopolysaccharide in antimicrobial and cell penetrating peptide membrane interactions probed by deuterium NMR of whole cells

Authors: Sarika Kumari, Michael R Morrow, Valerie Booth

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 36155053

Doi: 10.1016/j.bbamem.2022.184053

Products & Services: Bacterial Expression

Activated AMP-activated protein kinase prevents hepatic steatosis, oxidative stress and inflammation in primary chicken hepatocytes

Authors: Yao Yao, Longlong Li, Huihui Wang, Ying Yang, Haitian Ma

Journal: Front Physiol

PubMed ID: 36160867

Doi: 10.3389/fphys.2022.974825

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A nuclear import pathway exploited by pathogenic noncoding RNAs

Authors: Junfei Ma, Shachinthaka D Dissanayaka Mudiyanselage, Woong June Park, Mo Wang, Ryuta Takeda, Bin Liu, Ying Wang

Journal: Plant Cell

PubMed ID: 35877068

Doi: 10.1093/plcell/koac210

Products & Services: Proteins, Expression, Isolation and Analysis

ATP levels influence cell movement during the mound phase in Dictyostelium discoideum as revealed by ATP visualization and simulation

Authors: Haruka Hiraoka, Jiewen Wang, Tadashi Nakano, Yasuhiro Hirano, Shinichi Yamazaki, Yasushi Hiraoka, Tokuko Haraguchi

Journal: FEBS Open Bio

PubMed ID: 36054629

Doi: 10.1002/2211-5463.13480

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The CD4 T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn's disease

Authors: Thomas K Pedersen, Eric M Brown, Damian R Plichta, Joachim Johansen, Shaina W Twardus, Toni M Delorey, Helena Lau, Hera Vlamakis, James J Moon, Ramnik J Xavier, Daniel B Graham

Journal: Immunity

PubMed ID: 36115338

Doi: 10.1016/j.immuni.2022.08.016

Products & Services: Proteins, Expression, Isolation and Analysis

Comprehensive analysis of mitogenome of native Henan pig breeds with 58 worldwide pig breeds

Authors: Menghao Zhang, Chen Zhang, Panyang Hu, Lidan Shi, Mingming Ju, Ben Zhang, Xinjian Li, Xuelei Han, Kejun Wang, Xiuling Li, Ruimin Qiao

Journal: Anim Genet

PubMed ID: 36071602

Doi: 10.1111/age.13261

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PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design

Authors: Jeetendra Kumar Nag, Hodaya Malka, Shoshana Sedley, Priyanga Appasamy, Tatyana Rudina, Tgst Levi, Amnon Hoffman, Chaim Gilon, Beatrice Uziely, Rachel Bar-Shavit

Journal: Mol Cancer Ther

PubMed ID: 36066448

Doi: 10.1158/1535-7163.MCT-21-0946

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Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to variants of concern

Authors: Peifang Sun, Irene Ramos, Camila H Coelho, Alba Grifoni, Corey A Balinsky, Sindhu Vangeti, Alison Tarke, Nathaniel I Bloom, Vihasi Jani, Silvia J Jakubski, David A Boulifard, Elizabeth Cooper, Carl W Goforth, Jan Marayag, Amethyst Marrone, Edgar Nunez, Lindsey White, Chad K Porter, Victor A Sugiharto, Megan Schilling, Avinash S Mahajan, Charmagne Beckett, Alessandro Sette, Stuart C Sealfon, Shane Crotty, Andrew G Letizia

Journal: iScience

PubMed ID: 36168391

Doi: 10.1016/j.isci.2022.105202

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Overexpression of NDST1 Attenuates Fibrotic Response in Murine Adipose-Derived Stem Cells

Authors: Takayoshi Otsuka, Ho-Man Kan, Timothy D Mason, Lakshmi S Nair, Cato T Laurencin

Journal: Stem Cells Dev

PubMed ID: 35920108

Doi: 10.1089/scd.2022.0053

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Immunoglobulin yolk targeting spike 1, receptor binding domain of spike glycoprotein and nucleocapsid of SARS-CoV-2 blocking RBD-ACE2 binding interaction

Authors: Meliana Eka Saputri, Siti Aisyah Rahmalia Effendi, Rifa Nadila, Syauqi Azzam Fajar, Retno Damajanti Soejoedono, Ekowati Handharyani, Okti Nadia Poetri

Journal: Int Immunopharmacol

PubMed ID: 36183680

Doi: 10.1016/j.intimp.2022.109280

Personalized neoantigen vaccine combined with PD-1 blockade increases CD8+ tissue-resident memory T-cell infiltration in preclinical hepatocellular carcinoma models

Authors: Hengkai Chen, Zhenli Li, Liman Qiu, Xiuqing Dong, Geng Chen, Yingjun Shi, Linsheng Cai, Wenhan Liu,Honghao Ye,Yang Zhou,Jiahe Ouyang, Zhixiong Cai and Xiaolong Liu

Journal: J Immunother Cancer

PubMed ID: 36113894

Doi: 10.1136/jitc-2021-004389

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Dual-targeted magnetic mesoporous silica nanoparticles reduce brain amyloid-β burden via depolymerization and intestinal metabolism

Authors: Ni Liu, Xiaohan Liang, Changwen Yang, Shun Hu, Qingming Luo, Haiming Luo

Journal: Theranostics

PubMed ID: 36185606

Doi: 10.7150/thno.76574

Products & Services: Proteins, Expression, Isolation and Analysis

Evaluation of Immunogenicity to Three Doses of the SARS-CoV-2 BNT162b2 mRNA Vaccine in Lung Transplant Patients

Authors: Mariasilvia Guardiani, Maria Antonella Zingaropoli, Francesco Cogliati Dezza, Anastasia Centofanti, Carolina Carillo, Eeva Tortellini, Federica Dominelli, Anna Napoli, Cosmo Del Borgo, Aurelia Gaeta, Federico Venuta, Vincenzo Vullo, Miriam Lichtner, Maria Rosa Ciardi, Claudio Maria Mastroianni, Gianluca Russo

Journal: Vaccines (Basel)

PubMed ID: 36298507

Doi: 10.3390/vaccines10101642

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Gas Chromatography-Mass Spectrometry Metabolite Analysis Combined with Transcriptomic and Proteomic Provide New Insights into Revealing Cuticle Formation during Pepper Development

Authors: Shuai Ge, Keying Qin, Shenghua Ding, Jianfeng Yang, Liwen Jiang, Yeyou Qin, Rongrong Wang

Journal: J Agric Food Chem

PubMed ID: 36148491

Doi: 10.1021/acs.jafc.2c04522

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BT8009; a Nectin-4 targeting Bicycle® Toxin Conjugate for treatment of solid tumors

Authors: Michael Rigby, Gavin Bennett, Liuhong Chen, Gemma E Mudd, Helen Harrison, Paul J Beswick, Katerine van Rietschoten, Sophie M Watcham, Heather S Scott, Amy N Brown, Peter U Park, Carly Campbell, Eric Haines, Johanna Lahdenranta, Michael J Skynner, Phil Jeffrey, Nicholas Keen, Kevin Lee

Journal: Mol Cancer Ther

PubMed ID: 36112771

Doi: 10.1158/1535-7163.MCT-21-0875

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Toll-like receptor 4 signaling pathway mediates both liver and kidney injuries in mice with hepatorenal syndrome

Authors: Mingliang Wang, Tingting Qin, Yunyun Zhang, Ting Zhang, Zirui Zhuang, Yingyu Wang, Yongfang Ding, Yunru Peng

Journal: Am J Physiol Gastrointest Liver Physiol

PubMed ID: 36165507

Doi: 10.1152/ajpgi.00048.2022

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Förster resonance energy transfer-based kinase mutation phenotyping reveals an aberrant facilitation of Ca/calmodulin-dependent CaMKIIα activity in mutations related to intellectual disability

Authors: Hajime Fujii, Hiroyuki Kidokoro, Yayoi Kondo, Masahiro Kawaguchi, Shin-Ichiro Horigane, Jun Natsume, Sayaka Takemoto-Kimura, Haruhiko Bito

Journal: Front Mol Neurosci

PubMed ID: 36117912

Doi: 10.3389/fnmol.2022.970031

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Stacking herbicide detoxification and resistant genes improves glyphosate tolerance and reduces phytotoxicity in tobacco (Nicotiana tabacum L) and rice (Oryza sativa L)

Authors: Amaranatha Reddy Vennapusa, Subham Agarwal, Hanumanth Rao Hm, Thiagarayaselvam Aarthy, K C Babitha, Hirekodathakallu V Thulasiram, Mahesh J Kulkarni, Kalpalatha Melmaiee, Chinta Sudhakar, M Udayakumar, Ramu S Vemanna

Journal: Plant Physiol Biochem

PubMed ID: 36084528

Doi: 10.1016/j.plaphy.2022.08.025

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Rational design of photosynthetic reaction center protein maquettes

Authors: Nathan M Ennist, Steven E Stayrook, P Leslie Dutton, Christopher C Moser

Journal: Front Mol Biosci

PubMed ID: 36213121

Doi: 10.3389/fmolb.2022.997295

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Small molecule quercetin binds triplex and modulates its cellular function

Authors: Isha Rakheja, Asgar Hussain Ansari, Arjun Ray, Dheeraj Chandra Joshi, Souvik Maiti