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Selection and characterization of bispecific aptamers against malachite green and leucomalachite green

Authors: Wenwei Wu, Qifeng Sun, Tiansong Li, Kexin Liu, Yan Jiang, Yi Wang, Yongjie Yang

Journal: Anal Biochem

PubMed ID: 36150472

Doi: 10.1016/j.ab.2022.114849

Products & Services: Gene Synthesis

Vaccine target and carrier molecule nontypeable Haemophilus influenzae protein D dimerizes like the close Escherichia coli GlpQ homolog but unlike other known homolog dimers

Authors: Seth P Jones, Kali H Cook, Melody L Holmquist, Liam J Almekinder, Annie M Delaney, Ryhl Charles, Natalie Labbe, Janai Perdue, Niaya Jackson, Michael E Pichichero, Ravinder Kaur, Lea V Michel, Michael L Gleghorn

Journal: Proteins

PubMed ID: 36065600

Doi: 10.1002/prot.26418

Products & Services: Proteins, Expression, Isolation and Analysis

Mapping monoclonal anti-SARS-CoV-2 antibody repertoires against diverse coronavirus antigens

Authors: Matheus Oliveira de Souza, Bharat Madan, I-Ting Teng, Aric Huang, Lihong Liu, Ahmed S Fahad, Sheila N Lopez Acevedo, Xiaoli Pan, Mallika Sastry, Matias Gutierrez-Gonzalez, Michael T Yin, Tongqing Zhou, David D Ho, Peter D Kwong, Brandon J DeKosky

Journal: Front Immunol

PubMed ID: 36119018

Doi: 10.3389/fimmu.2022.977064

Products & Services: Proteins, Expression, Isolation and Analysis

A recombinant subunit vaccine candidate produced in plants elicits neutralizing antibodies against SARS-CoV-2 variants in macaques

Authors: Narach Khorattanakulchai, Kanjana Srisutthisamphan, Balamurugan Shanmugaraj, Suwimon Manopwisedjaroen, Kaewta Rattanapisit, Chalisa Panapitakkul, Taratorn Kemthong, Nutchanat Suttisan, Suchinda Malaivijitnond, Arunee Thitithanyanont, Anan Jongkaewwattana, Waranyoo Phoolcharoen

Journal: Front Plant Sci

PubMed ID: 36247553

Doi: 10.3389/fpls.2022.901978

Products & Services: Proteins, Expression, Isolation and Analysis

Lymphocyte Subpopulations Associated with Neutralizing Antibody Levels of SARS-CoV-2 for COVID-19 Vaccination

Authors: Wan-Ting Huang, Shao-Wen Weng, Hong-Tai Tzeng, Feng-Chun Yen, Yu-Shao Chiang, Huey-Ling You

Journal: Vaccines (Basel)

PubMed ID: 36146627

Doi: 10.3390/vaccines10091550

Products & Services: Recombinant Proteins

Function identification and characterization of ZRT and IRT-like proteins computationally for nutrition and biofortification in rice

Authors: Khaled Fathy Abdelmotelb Mohammed, Tanushri Kaul, Pawan Kumar Agrawal, Arulprakash Thangaraj, Rashmi Kaul, Sudhir K Sopory

Journal: J Biomol Struct Dyn

PubMed ID: 36111599

Doi: 10.1080/07391102.2022.2118169

Products & Services: Protein Tools

Single-chain insulin analogs threaded by the insulin receptor αCT domain

Authors: Nicholas A Smith, John G Menting, Michael A Weiss, Michael C Lawrence, Brian J Smith

Journal: Biophys J

PubMed ID: 36181268

Doi: 10.1016/j.bpj.2022.09.038

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Comparative transcriptome analysis of longissimus dorsi tissues with different intramuscular fat contents from Guangling donkeys

Authors: Wufeng Li, Lixia Qiu, Jiawei Guan, Yutong Sun, Jingwei Zhao, Min Du

Journal: BMC Genomics

PubMed ID: 36085018

Doi: 10.1186/s12864-022-08857-2

Products & Services: Molecular Biology Tools

Immunogenicity after a Third COVID-19 mRNA Booster in Solid Cancer Patients Who Previously Received the Primary Heterologous CoronaVac/ChAdOx1 Vaccine

Authors: Sutima Luangdilok, Passakorn Wanchaijiraboon, Nussara Pakvisal, Thiti Susiriwatananont, Nicha Zungsontiporn, Virote Sriuranpong, Panot Sainamthip, Nungruthai Suntronwong, Preeyaporn Vichaiwattana, Nasamon Wanlapakorn, Yong Poovorawan, Nattaya Teeyapun, Suebpong Tanasanvimon

Journal: Vaccines (Basel)

PubMed ID: 36298478

Doi: 10.3390/vaccines10101613

Treatment of Sindbis Virus-Infected Neurons with Antibody to E2 Alters Synthesis of Complete and nsP1-Expressing Defective Viral RNAs

Authors: Jane X Yeh, Yunfan Fan, Maggie L Bartlett, Xiaoyan Zhang, Norah Sadowski, Debra A Hauer, Winston Timp, Diane E Griffin

Journal: MBio

PubMed ID: 36069441

Doi: 10.1128/mbio.02221-22

Products & Services: Plasmid DNA Preparation

mRNA Vaccine Designing Using Chikungunya Virus E Glycoprotein through Immunoinformatics-Guided Approaches

Authors: Samavia Jaan, Aqal Zaman, Sarfraz Ahmed, Mohibullah Shah, Suvash Chandra Ojha

Journal: Vaccines (Basel)

PubMed ID: 36146554

Doi: 10.3390/vaccines10091476

Products & Services: Molecular Biology Tools

The gene regulates dimorphic sexual and aggressive behaviors in

Authors: Caihong Han, Qionglin Peng, Mengshi Sun, Xinyu Jiang, Xiangbin Su, Jiangtao Chen, Mingze Ma, Huan Zhu, Xiaoxiao Ji, Yufeng Pan

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36067320

Doi: 10.1073/pnas.2201513119

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A megadiverse naïve library derived from numerous camelids for efficient and rapid development of VHH antibodies

Authors: Meiniang Wang, Likun Wei, Haitao Xiang, Bingzhao Ren, Xiaopan Liu, Lin Jiang, Naibo Yang, Jiahai Shi

Journal: Anal Biochem

PubMed ID: 36108795

Doi: 10.1016/j.ab.2022.114871

Products & Services: Proteins, Expression, Isolation and Analysis

A gain-of-function filamin A mutation in mouse platelets induces thrombus instability

Authors: Frédéric Adam, Alexandre Kauskot, Lamia Lamrani, Jean Solarz, Christelle Soukaseum, Christelle Repérant, Cécile V Denis, Hana Raslova, Jean-Philippe Rosa, Marijke Bryckaert

Journal: J Thromb Haemost

PubMed ID: 36006037

Doi: 10.1111/jth.15864

Products & Services: Polyclonal Antibody Services

The plant nucleoplasmin AtFKBP43 needs its extended arms for histone interaction

Authors: Ajit Kumar Singh, Ketul Saharan, Somanath Baral, Dileep Vasudevan

Journal: Biochim Biophys Acta Gene Regul Mech

PubMed ID: 36058470

Doi: 10.1016/j.bbagrm.2022.194872

Products & Services: Bacterial Expression

Computer vision enabled funnel adapted sensing tube (FAST) for power-free and pipette-free nucleic acid detection

Authors: Mengdi Bao, Shuhuan Zhang, Chad Ten Pas, Stephen J Dollery, Ruth V Bushnell, F N U Yuqing, Rui Liu, Guoyu Lu, Gregory J Tobin, Ke Du

Journal: Lab Chip

PubMed ID: 36111877

Doi: 10.1039/d2lc00586g

Products & Services: PCR and Cloning

Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE

Authors: Brendan Miller, Su-Jeong Kim, Hemal H Mehta, Kevin Cao, Hiroshi Kumagai, Neehar Thumaty, Naphada Leelaprachakul, Henry Jiao, Joan Vaughan, Jolene Diedrich, Alan Saghatelian, Thalida E Arpawong, Eileen M Crimmins, Nilüfer Ertekin-Taner, Meral A Tubi, Evan T Hare, Meredith N Braskie, Léa Décarie-Spain, Scott E Kanoski, Francine Grodstein, David A Bennett, Lu Zhao, Arthur W Toga, Junxiang Wan, Kelvin Yen, Pinchas Cohen

Journal: Mol Psychiatry

PubMed ID: 36127429

Doi: 10.1038/s41380-022-01769-3

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Acetylation of Atp5f1c Mediates Cardiomyocyte Senescence via Metabolic Dysfunction in Radiation-Induced Heart Damage

Authors: Zhimin Zeng, Peng Xu, Yanqing He, Yali Yi, Zhicheng Liu, Jing Cai, Long Huang, Anwen Liu

Journal: Oxid Med Cell Longev

PubMed ID: 36160705

Doi: 10.1155/2022/4155565

Products & Services: Protein Tools

Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions

Authors: Eric S Pringle, Brett A Duguay, Maxwell P Bui-Marinos, Rory P Mulloy, Shelby L Landreth, Krishna Swaroop Desireddy, Stacia M Dolliver, Shan Ying, Taylor Caddell, Trinity H Tooley, Patrick D Slaine, Stephen L Bearne, Darryl Falzarano, Jennifer A Corcoran, Denys A Khaperskyy, Craig McCormick

Journal: PLoS Pathog

PubMed ID: 36121863

Doi: 10.1371/journal.ppat.1010832

Products & Services: PCR Cloning and Subcloning

D121 Located within the DRY Motif of P2Y12 Is Essential for P2Y12-Mediated Platelet Function

Authors: Carol Dangelmaier, Benjamin Mauri, Akruti Patel, Satya P Kunapuli, John C Kostyak

Journal: Int J Mol Sci

PubMed ID: 36232816

Doi: 10.3390/ijms231911519

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Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein

Authors: Kailu Yang, Chuchu Wang, Alex J B Kreutzberger, Ravi Ojha, Suvi Kuivanen, Sergio Couoh-Cardel, Serena Muratcioglu, Timothy J Eisen, K Ian White, Richard G Held, Subu Subramanian, Kendra Marcus, Richard A Pfuetzner, Luis Esquivies, Catherine A Doyle, John Kuriyan, Olli Vapalahti, Giuseppe Balistreri, Tom Kirchhausen, Axel T Brunger

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36122200

Doi: 10.1073/pnas.2210990119

Products & Services: Peptide Synthesis

Fatty acid binding protein is required for chitin biosynthesis in the wing of Drosophila melanogaster

Authors: Jiqiang Chen, Xu Zou, Weixing Zhu, Yanwei Duan, Hans Merzendorfer, Zhangwu Zhao, Qing Yang

Journal: Insect Biochem Mol Biol

PubMed ID: 36165873

Doi: 10.1016/j.ibmb.2022.103845

Products & Services: Plasmid DNA Preparation

Seed-Based System for Cost-Effective Production of Vaccine Against Chronic Respiratory Disease in Chickens

Authors: Yao Shi, Peyman Habibi, Ayesha Naveed Ul Haq, Madiha Saeed, Namra Gulghutay Amjad, Imran Khan

Journal: Mol Biotechnol

PubMed ID: 36087216

Doi: 10.1007/s12033-022-00554-5

Products & Services: PCR Cloning and Subcloning

Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening

Authors: Peter C DeWeirdt, Abby V McGee, Fengyi Zheng, Ifunanya Nwolah, Mudra Hegde, John G Doench

Journal: Nat Commun

PubMed ID: 36068235

Doi: 10.1038/s41467-022-33024-2

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Oral or intranasal immunization with recombinant Lactobacillus plantarum displaying head domain of Swine Influenza A virus hemagglutinin protects mice from H1N1 virus

Authors: Yufei Zhang, Li Yang, Jiali Zhang, Kun Huang, Xiaomei Sun, Ying Yang, Ting Wang, Qiang Zhang, Zhong Zou, Meilin Jin

Journal: Microb Cell Fact

PubMed ID: 36085207

Doi: 10.1186/s12934-022-01911-4

Products & Services: Plasmid DNA Preparation

Identification of a UDP-glucosyltransferase conferring deoxynivalenol resistance in Aegilops tauschii and wheat

Authors: Rizky Pasthika Kirana, Kumar Gaurav, Sanu Arora, Gerlinde Wiesenberger, Maria Doppler, Sebastian Michel, Simone Zimmerl, Magdalena Matic, Chinedu E Eze, Mukesh Kumar, Ajla Topuz, Marc Lemmens, Rainer Schuhmacher, Gerhard Adam, Brande B H Wulff, Hermann Buerstmayr, Barbara Steiner

Journal: Plant Biotechnol J

PubMed ID: 36121345

Doi: 10.1111/pbi.13928

Products & Services: Recombinant Antibody Expression

A Cephalosporin-Tripodalamine Conjugate Inhibits Metallo-β-Lactamase with High Efficacy and Low Toxicity

Authors: Hongyan Tian, Yiwan Wang, Yang Dai, Anwen Mao, Wanqing Zhou, Xiaoli Cao, Hui Deng, Hao Lu, Lin Ding, Han Shen, Xiaojian Wang

Journal: Antimicrob Agents Chemother

PubMed ID: 36094199

Doi: 10.1128/aac.00352-22

Products & Services: Plasmid DNA Preparation

Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors

Authors: Hadar Cohen, Noam Baram, Chaya Mushka Fridman, Liat Edry-Botzer, Dor Salomon, Motti Gerlic

Journal: Elife

PubMed ID: 36155655

Doi: 10.7554/eLife.82766

Products & Services: Proteins, Expression, Isolation and Analysis

Sensing of individual stalled 80S ribosomes by Fap1 for nonfunctional rRNA turnover

Authors: Sihan Li, Ken Ikeuchi, Misaki Kato, Robert Buschauer, Takato Sugiyama, Shungo Adachi, Hideo Kusano, Tohru Natsume, Otto Berninghausen, Yoshitaka Matsuo, Thomas Becker, Roland Beckmann, Toshifumi Inada

Journal: Mol Cell

PubMed ID: 36113412

Doi: 10.1016/j.molcel.2022.08.018

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Evasion of neutralizing antibody responses by the SARS-CoV-2 BA275 variant

Authors: Panke Qu, John P Evans, Yi-Min Zheng, Claire Carlin, Linda J Saif, Eugene M Oltz, Kai Xu, Richard J Gumina, Shan-Lu Liu

Journal: Cell Host Microbe

PubMed ID: 36240764

Doi: 10.1016/j.chom.2022.09.015

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Recombinase polymerase amplification-lateral flow dipstick assay for rapid detection of Fusarium circinatum based on a newly identified unique target gene

Authors: Jieying Xu , Xiao Yang , Cuiping Wu , Zhenpeng Chen , Tingting Dai

Journal: Plant Dis

PubMed ID: 36089688

Doi: 10.1094/PDIS-04-22-0864-RE

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GAGE is a method for identification of plant species based on whole genome analysis and genome editing

Authors: Lijun Hao , Wenjie Xu , Guihong Qi , Tianyi Xin , Zhichao Xu , Hetian Lei , Jingyuan Song

Journal: Commun Biol

PubMed ID: 36088518

Doi: 10.1038/s42003-022-03894-9

Products & Services: Gene Synthesis

Structural and large-scale analysis unveil the intertwined paths promoting NMT-catalyzed lysine and glycine myristoylation

Authors: Frédéric Rivière , Cyril Dian , Rémi F Dutheil , Paul Monassa , Carmela Giglione , Thierry Meinnel

Journal: J Mol Biol

PubMed ID: 36181773

Doi: 10.1016/j.jmb.2022.167843

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Phosphorylation of Jhd2 by the Ras-cAMP-PKA(Tpk2) pathway regulates histone modifications and autophagy

Authors: Qi Yu , Xuanyunjing Gong , Yue Tong , Min Wang , Kai Duan , Xinyu Zhang , Feng Ge , Xilan Yu , Shanshan Li

Journal: NaCommunt

PubMed ID: 36167807

Doi: 10.1038/s41467-022-33423-5

Products & Services: Proteins, Expression, Isolation and Analysis

Hydrophobic cell surface display system of PETase as a sustainable biocatalyst for PET degradation

Authors: Yunpu Jia , Nadia A Samak , Xuemi Hao , Zheng Chen , Qifeng Wen , Jianmin Xing

Journal: Front Microbiol

PubMed ID: 36246227

Doi: 10.3389/fmicb.2022.1005480

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The sequestration mechanism as a generalizable approach to improve the sensitivity of biosensors and bioassays

Authors: Alejandro Chamorro-Garcia , Claudio Parolo , Gabriel Ortega , Andrea Idili , Joshua Green , Francesco Ricci , Kevin W Plaxco

Journal: Chem Sci

PubMed ID: 36349092

Doi: 10.1039/d2sc03901j

Products & Services: Monoclonal Antibody Services

Lentiviral vector mediated gene therapy for type I Dent disease ameliorates Dent disease-like phenotypes for three months in ClC-5 null mice

Authors: Manish Kumar Yadav , Kyung Whan Yoo , Anthony Atala , Baisong Lu

Journal: Mol Ther Methods Clin Dev

PubMed ID: 36284768

Doi: 10.1016/j.omtm.2022.09.009

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Cross-reactivity between vaccine antigens from the chitin deacetylase protein family improves survival in a mouse model of cryptococcosis

Authors: Maureen M Hester, Lorena V N Oliveira, Ruiying Wang, Zhongming Mou, Diana Lourenco, Gary R Ostroff, Charles A Specht, Stuart M Levitz

Journal: Front Immunol

PubMed ID: 36248898

Doi: 10.3389/fimmu.2022.1015586

Products & Services: Bacterial Expression

Spike mutation resilient scFv76 antibody counteracts SARS-CoV-2 lung damage upon aerosol delivery

Authors: Ferdinando M Milazzo, Antonio Chaves-Sanjuan, Olga Minenkova, Daniela Santapaola, Anna M Anastasi, Gianfranco Battistuzzi, Caterina Chiapparino, Antonio Rosi, Emilio Merlo Pich, Claudio Albertoni, Emanuele Marra, Laura Luberto, Cécile Viollet, Luigi G Spagnoli, Anna Riccio, Antonio Rossi, M Gabriella Santoro, Federico Ballabio, Cristina Paissoni, Carlo Camilloni, Martino Bolognesi, Rita De Santis

Journal: Mol Ther

PubMed ID: 36114671

Doi: 10.1016/j.ymthe.2022.09.010

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Structural characterization of SARS-CoV-2 dimeric ORF9b reveals potential fold-switching trigger mechanism

Authors: Xiyue Jin, Xue Sun, Yan Chai, Yu Bai, Ying Li, Tianjiao Hao, Jianxun Qi, Hao Song, Catherine C L Wong, George F Gao

Journal: Sci China Life Sci

PubMed ID: 36184694

Doi: 10.1007/s11427-022-2168-8

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SPTLC1 variants associated with ALS produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins

Authors: Museer A Lone, Mari J Aaltonen, Aliza Zidell, Helio F Pedro, Jonas A Morales Saute, Shalett Mathew, Payam Mohassel, Carsten G Bönnemann, Eric A Shoubridge, Thorsten Hornemann

Journal: J Clin Invest

PubMed ID: 35900868

Doi: 10.1172/JCI161908

Products & Services: Proteins, Expression, Isolation and Analysis

Chemoenzymatic Synthesis of SARS-CoV-2 Homogeneous O-Linked Glycopeptides for Exploring Their Inhibition Functions

Authors: Yongheng Rong, Xingyun Wang, Weian Mao, Fang Yuan, Min Chen, Shengjun Wang, Peng George Wang, Zhigang Wu, Yunjiao He, Yun Kong

Journal: ACS Infect Dis

PubMed ID: 36095241

Doi: 10.1021/acsinfecdis.2c00383

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Herpes Simplex Virus 1 Glycoproteins Differentially Regulate the Activity of Costimulatory Molecules and T Cells

Authors: Harry H Matundan, Ujjaldeep Jaggi, Homayon Ghiasi

Journal: mSphere

PubMed ID: 36094100

Doi: 10.1128/msphere.00382-22

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A 1-aminocyclopropane-1-carboxylic-acid (ACC) dipeptide elicits ethylene responses through ACC-oxidase mediated substrate promiscuity

Authors: John Vaughan-Hirsch, Dongdong Li, Albert Roig Martinez, Stijn Roden, Jolien Pattyn, Shu Taira, Hitomi Shikano, Yoko Miyama, Yukari Okano, Arnout Voet, Bram Van de Poel

Journal: Front Plant Sci

PubMed ID: 36172554

Doi: 10.3389/fpls.2022.995073

Products & Services: Proteins, Expression, Isolation and Analysis

Peptide-Based HDL as an Effective Delivery System for Lipophilic Drugs to Restrain Atherosclerosis Development

Authors: Junwei Gao, Ziyun Li, Jing Li, Ping Song, Jinsheng Yang, Wei Xiao, Ning Li, Ruodan Xu

Journal: Int J Nanomedicine

PubMed ID: 36097444

Doi: 10.2147/IJN.S374736

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Engineered CRISPR prime editors with compact, untethered reverse transcriptases

Authors: Julian Grünewald, Bret R Miller, Regan N Szalay, Peter K Cabeceiras, Christopher J Woodilla, Eliza Jane B Holtz, Karl Petri, J Keith Joung

Journal: Nat Biotechnol

PubMed ID: 36163548

Doi: 10.1038/s41587-022-01473-1

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Small secreted peptides encoded on the wheat ( L) genome and their potential roles in stress responses

Authors: Dongdong Tian, Qi Xie, Zhichao Deng, Jin Xue, Wei Li, Zenglin Zhang, Yifei Dai, Bo Zheng, Tiegang Lu, Ive De Smet, Yongfeng Guo

Journal: Front Plant Sci

PubMed ID: 36212358

Doi: 10.3389/fpls.2022.1000297

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Fibrotic immune microenvironment remodeling mediates superior anti-tumor efficacy of a nano-PD-L1 trap in hepatocellular carcinoma

Authors: Xiaoyu Liu, Jingying Zhou, Haoran Wu, Shufen Chen, Lingyun Zhang, Wenshu Tang, Liang Duan, Ying Wang, Eleanor McCabe, Mengying Hu, Zhuo Yu, Hanzhuang Liu, Chung Hang Jonathan Choi, Joseph Jao-Yiu Sung, Leaf Huang, Rihe Liu, Alfred Sze-Lok Cheng

Journal: Mol Ther

PubMed ID: 36146933

Doi: 10.1016/j.ymthe.2022.09.012

Products & Services: Proteins, Expression, Isolation and Analysis

Delivery of ceramide phosphoethanolamine lipids to the cleavage furrow through the endocytic pathway is essential for male meiotic cytokinesis

Authors: Govind Kunduri, Si-Hung Le, Valentina Baena, Nagampalli Vijaykrishna, Adam Harned, Kunio Nagashima, Daniel Blankenberg, Izumi Yoshihiro, Kedar Narayan, Takeshi Bamba, Usha Acharya, Jairaj K Acharya

Journal: PLoS Biol

PubMed ID: 36170207

Doi: 10.1371/journal.pbio.3001599

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Lipidomic Analysis of Arabidopsis T-DNA Insertion Lines Leads to Identification and Characterization of C-Terminal Alterations in FATTY ACID DESATURASE 6

Authors: Hannah J Lusk, Nicholas Neumann, Madeline Colter, Mary R Roth, Pamela Tamura, Libin Yao, Sunitha Shiva, Jyoti Shah, Kathrin Schrick, Timothy P Durrett, Ruth Welti

Journal: Plant Cell Physiol

PubMed ID: 35726963

Doi: 10.1093/pcp/pcac088

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