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Smp76, a Scorpine-Like Peptide Isolated from the Venom of the Scorpion Scorpio maurus palmatus, with a Potent Antiviral Activity Against Hepatitis C Virus and Dengue Virus

International Journal of Peptide Research and Therapeutics. 2019-07; 
Alaa M. H. El-BitarMoustafa SarhanEmail authorMohamed A. Abdel-RahmanEmail authorVeronica Quintero-HernandezChie Aoki-UtsuboMohsen A. MoustafaLourival D. PossaniHak Hotta
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Custom DNA/RNA Oligos … Biotech, Maryland, United States). Synthetic N, C-terminal and full- length Smp76 peptides were manufactured by GenScript Japan Inc. Construction of Recombinant Smp76C Terminal Peptide (44 aa) Six oligonucleotides were … Get A Quote

摘要

Growing global viral infections have been a serious public health problem in recent years. This current situation emphasizes the importance of developing more therapeutic antiviral compounds. Hepatitis C virus (HCV) and dengue virus (DENV) belong to the Flaviviridae family and are an increasing global health threat. Our previous study reported that the crude venom of Scorpio maurus palmatus possessed anti-HCV and anti-DENV activities in vitro. We report here the characterization of a natural antiviral peptide (scorpion-like peptide Smp76) that prevents HCV and DENV infection. Smp76 was purified from S. m. palmatus venom and contains 76 amino acids with six residues of cysteine. Smp76 antiviral activity was eval... More

关键词

Animal venom Antiviral peptide DENV HCV Scorpio maurus palmatus Smp76