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Alteration of the translational readthrough isoform AQP4ex induces redistribution and downregulation of AQP4 in human glioblastoma

Authors: Onofrio Valente, Raffaella Messina, Giuseppe Ingravallo, Emilio Bellitti, Domenico Sergio Zimatore, Luigi de Gennaro, Pasqua Abbrescia, Roberta Pati, Claudia Palazzo, Grazia Paola Nicchia, Maria Trojano, Francesco Signorelli, Antonio Frigeri

Journal: Cell Mol Life Sci

PubMed ID: 35187599

Doi: 10.1007/s00018-021-04123-y

Products & Services: Gene Synthesis

Overexpression of m6A-factors METTL3, ALKBH5, and YTHDC1 alters HPV16 mRNA splicing

Authors: Xiaoxu Cui, Kersti Nilsson, Naoko Kajitani, Stefan Schwartz

Journal: Virus Genes

PubMed ID: 35190939

Doi: 10.1007/s11262-022-01889-6

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Enzyme immunoassays (EIA) for serodiagnosis of human leptospirosis: specific IgG3/IgG1 isotyping may further inform diagnosis of acute disease

Authors: Elsa Fortes-Gabriel, Mariana Soares Guedes, Advait Shetty, Charles Klazer Gomes, Teresa Carreira, Maria Luísa Vieira, Lisa Esteves, Luísa Mota-Vieira, Maria Gomes-Solecki

Journal: PLoS Negl Trop Dis

PubMed ID: 35196321

Doi: 10.1371/journal.pntd.0010241

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Collection of Monoclonal Antibodies Targeting SARS-CoV-2 Proteins

Authors: Marina Pribanić Matešić, Paola Kučan Brlić, Tihana Lenac Roviš, Željka Mačak Šafranko, Abigael Eva Chaouat, Karmela Miklić, Suzana Malić, Nina Ivanković, Maren Schubert, Federico Bertoglio, Alemka Markotić, Ofer Mandelboim, Stipan Jonjić, Ilija Brizić

Journal: Viruses

PubMed ID: 35216036

Doi: 10.3390/v14020443

Products & Services: Bacterial Expression

Zinc finger protein 277 is an intestinal transit-amplifying cell marker and colon cancer oncogene

Authors: Guofeng Xie, Zhongsheng Peng, Jinqing Liang, Shannon M Larabee, Cinthia B Drachenberg, Harris Yfantis, Jean-Pierre Raufman

Journal: JCI Insight

PubMed ID: 35015732

Doi: 10.1172/jci.insight.150894

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The cell adhesion protein dystroglycan affects the structural remodeling of dendritic spines

Authors: Izabela Figiel, Ewa Bączyńska, Tomasz Wójtowicz, Marta Magnowska, Anna Buszka, Monika Bijata, Jakub Włodarczyk

Journal: Sci Rep

PubMed ID: 35169214

Doi: 10.1038/s41598-022-06462-7

Products & Services: PCR Cloning and Subcloning

ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation

Authors: Xiuyuan Zhang, Qijian Zheng, Xiuying Yue, Zhanna Yuan, Jiming Ling, Yanzhi Yuan, Yanying Liang, Aihua Sun, Yuchen Liu, Hui Li, Kaikun Xu, Fuchu He, Jian Wang, Jin Wu, Chunling Zhao, Chunyan Tian

Journal: J Exp Clin Cancer Res

PubMed ID: 35227287

Doi: 10.1186/s13046-022-02288-3

Products & Services: Mammalian Expression

Impaired Function of PLEKHG2, a Rho-Guanine Nucleotide-Exchange Factor, Disrupts Corticogenesis in Neurodevelopmental Phenotypes

Authors: Masashi Nishikawa, Hidenori Ito, Hidenori Tabata, Hiroshi Ueda, Koh-Ichi Nagata

Journal: Cells

PubMed ID: 35203342

Doi: 10.3390/cells11040696

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Characterization of adenine phosphoribosyltransferase (APRT) activity in Trypanosoma brucei brucei: Only one of the two isoforms is kinetically active

Authors: Kayla Glockzin, Thomas D Meek, Ardala Katzfuss

Journal: PLoS Negl Trop Dis

PubMed ID: 35104286

Doi: 10.1371/journal.pntd.0009926

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Immunogenicity and safety of an intradermal fractional third dose of ChAdOx1 nCoV-19/AZD1222 vaccine compared with those of a standard intramuscular third dose in volunteers who previously received two doses of CoronaVac: A randomized controlled trial

Authors: Kriangkrai Tawinprai, Taweegrit Siripongboonsitti, Thachanun Porntharukchareon, Kasiruck Wittayasak, Nawarat Thonwirak, Kamonwan Soonklang, Gaidganok Sornsamdang, Chirayu Auewarakul, Nithi Mahanonda

Journal: Vaccine

PubMed ID: 35210118

Doi: 10.1016/j.vaccine.2022.02.019

Leveraging the multivalent p53 peptide-MdmX interaction to guide the improvement of small molecule inhibitors

Authors: Xiyao Cheng, Rong Chen, Ting Zhou, Bailing Zhang, Zichun Li, Meng Gao, Yongqi Huang, Huili Liu, Zhengding Su

Journal: Nat Commun

PubMed ID: 35228542

Doi: 10.1038/s41467-022-28721-x

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Reduced α-galactosidase A activity in zebrafish ( mirrors distinct features of Fabry nephropathy phenotype

Authors: Hassan O A Elsaid, Jessica Furriol, Maria Blomqvist, Mette Diswall, Sabine Leh, Naouel Gharbi, Jan Haug Anonsen, Janka Babickova, Camilla Tøndel, Einar Svarstad, Hans-Peter Marti, Maximilian Krause

Journal: Mol Genet Metab Rep

PubMed ID: 35242583

Doi: 10.1016/j.ymgmr.2022.100851

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Characterization of a Group of UDP-Glycosyltransferases Involved in the Biosynthesis of Triterpenoid Saponins of

Authors: Yanting Li, Jianxiu Li, Mengxue Diao, Longyun Peng, Shihai Huang, Nengzhong Xie

Journal: ACS Synth Biol

PubMed ID: 35107265

Doi: 10.1021/acssynbio.1c00469

Products & Services: Gene Synthesis

miR-AB, a miRNA-based shRNA viral toolkit for multicolor-barcoded multiplex RNAi at a single-cell level

Authors: Dapeng Wang, Jianbo Xiu, Jiangyue Zhao, Junli Luo

Journal: EMBO Rep

PubMed ID: 35201651

Doi: 10.15252/embr.202153691

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Changes in Non-Deamidated versus Deamidated Epitope Targeting and Disease Prediction during the Antibody Response to Gliadin and Transglutaminase of Infants at Risk for Celiac Disease

Authors: Ádám Diós, Bharani Srinivasan, Judit Gyimesi, Katharina Werkstetter, Rudolf Valenta, Sibylle Koletzko, Ilma R Korponay-Szabó

Journal: Int J Mol Sci

PubMed ID: 35269639

Doi: 10.3390/ijms23052498

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Poly(ADP-ribose) drives condensation of FUS via a transient interaction

Authors: Kevin Rhine, Morgan Dasovich, Joseph Yoniles, Mohsen Badiee, Sophie Skanchy, Laura R Ganser, Yingda Ge, Charlotte M Fare, James Shorter, Anthony K L Leung, Sua Myong

Journal: Mol Cell

PubMed ID: 35182479

Doi: 10.1016/j.molcel.2022.01.018

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Affibody Modified G-quadruplex DNA Micelles Incorporating Polymeric 5-Fluorodeoxyuridine for Targeted Delivery of Curcumin to Enhance Synergetic Therapy of HER2 Positive Gastric Cancer

Authors: Chao Zhang, Shuangqing Fu, Fanghua Zhang, Mengnan Han, Xuming Wang, Jie Du, Honglei Zhang, Wei Li

Journal: Nanomaterials (Basel)

PubMed ID: 35215023

Doi: 10.3390/nano12040696

Products & Services: Custom DNA/RNA Oligos

KIF18B promotes breast cancer cell proliferation, migration and invasion by targeting TRIP13 and activating the Wnt/β-catenin signaling pathway

Authors: Lan Liu, Zhaofeng Zhang, Xiulin Xia, Jing Lei

Journal: Oncol Lett

PubMed ID: 35251343

Doi: 10.3892/ol.2022.13232

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A CRISPR-based nucleic acid detection method for severe fever with thrombocytopenia syndrome virus

Authors: Yansong Zhang, Xuanyang Bai, Jinhui Li, Jing Xie, Huan Li, Lang Yang, Peihan Li, Peng Li, Hao Dong, Qichao Chen, Xinyan Hu, Yun Wang, Tingting Jiang, Hongbin Song, Leili Jia, Lizhong Li

Journal: Virus Res

PubMed ID: 35143909

Doi: 10.1016/j.virusres.2022.198691

Products & Services: Proteins, Expression, Isolation and Analysis

A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

Authors: Ashleigh Shannon, Véronique Fattorini, Bhawna Sama, Barbara Selisko, Mikael Feracci, Camille Falcou, Pierre Gauffre, Priscila El Kazzi, Adrien Delpal, Etienne Decroly, Karine Alvarez, Cécilia Eydoux, Jean-Claude Guillemot, Adel Moussa, Steven S Good, Paolo La Colla, Kai Lin, Jean-Pierre Sommadossi, Yingxiao Zhu, Xiaodong Yan, Hui Shi, François Ferron, Bruno Canard

Journal: Nat Commun

PubMed ID: 35110538

Doi: 10.1038/s41467-022-28113-1

Products & Services: Custom DNA/RNA Oligos

Lack of Induction of RBD-Specific Neutralizing Antibodies despite Repeated Heterologous SARS-CoV-2 Vaccination Leading to Seroconversion and Establishment of T Cell-Specific Memory in a Patient in Remission of Multiple Myeloma

Authors: Bernhard Kratzer, Doris Trapin, Pia Gattinger, Teresa Oberhofer, Al Nasar Ahmed Sehgal, Petra Waidhofer-Söllner, Arno Rottal, Ulrike Körmöczi, Katharina Grabmeier-Pfistershammer, Gerhard H Kopetzky, Franz Tischer, Rudolf Valenta, Winfried F Pickl

Journal: Vaccines (Basel)

PubMed ID: 35335006

Doi: 10.3390/vaccines10030374

Products & Services: Proteins, Expression, Isolation and Analysis

Myricetin reverses epithelial-endothelial transition and inhibits vasculogenic mimicry and angiogenesis of hepatocellular carcinoma by directly targeting PAR1

Authors: Ming Wang, Shanfa Ren, Zhun Bi, Liang Zhang, Mengqi Cui, Ronghao Sun, Jiali Bao, Dandi Gao, Bo Yang, Xiaoping Li, Mingjiang Li, Ting Xiao, Hong-Gang Zhou, Cheng Yang

Journal: Phytother Res

PubMed ID: 35229382

Doi: 10.1002/ptr.7427

Products & Services: Stable Cell Lines

Extended β-Strands Contribute to Reversible Amyloid Formation

Authors: Kevin A Murray, Declan Evans, Michael P Hughes, Michael R Sawaya, Carolyn J Hu, Kendall N Houk, David Eisenberg

Journal: ACS Nano

PubMed ID: 35132852

Doi: 10.1021/acsnano.1c08043

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Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors

Authors: Nishanth Belugali Nataraj, Ashish Noronha, Joo Sang Lee, Soma Ghosh, Harsha Raj Mohan Raju, Arunachalam Sekar, Binyamin Zuckerman, Moshit Lindzen, Emilio Tarcitano, Swati Srivastava, Michael Selitrennik, Ido Livneh, Diana Drago-Garcia, Oscar Rueda, Carlos Caldas, Sima Lev, Tamar Geiger, Aaron Ciechanover, Igor Ulitsky, Rony Seger, Eytan Ruppin, Yosef Yarden

Journal: Cell Rep

PubMed ID: 35196484

Doi: 10.1016/j.celrep.2022.110418

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Blockage of NDUFB9‑SCD1 pathway inhibits adipogenesis

Authors: Shenglong Zhu, Jingwei Zhang, Wei Wang, Xuan Jiang, Yong Q Chen

Journal: J Physiol Biochem

PubMed ID: 35122619

Doi: 10.1007/s13105-022-00876-7

Products & Services: Recombinant Proteins Plasmid DNA Preparation

Omicron adopts a different strategy from Delta and other variants to adapt to host

Authors: Xiaohong Du , Haijun Tang , Long Gao , Zhao Wu , Fang Meng , Ruhong Yan , Shigang Qiao, Jianzhong An , Chen Wang , F Xiao-Feng Qin

Journal: Signal Transduct Target Ther

PubMed ID: 35145066

Doi: 10.1038/s41392-022-00903-5

Products & Services: Gene Synthesis

Modulation of Hippo signaling by Mnat9 N-acetyltransferase for normal growth and tumorigenesis in Drosophila

Authors: Jung-Wan Mok , Kwang-Wook Choi

Journal: Cell Death Dis

PubMed ID: 35110540

Doi: 10.1038/s41419-022-04532-2

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Targeting IFN-λ Signaling Promotes Recovery from Central Nervous System Autoimmunity

Authors: Sindhu Manivasagam, Jessica L Williams, Lauren L Vollmer, Bryan Bollman, Juliet M Bartleson, Shenjian Ai, Gregory F Wu, Robyn S Klein

Journal: J Immunol

PubMed ID: 35181638

Doi: 10.4049/jimmunol.2101041

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Dynamic Interplay between Cockayne Syndrome Protein B and Poly(ADP-Ribose) Polymerase 1 during Oxidative DNA Damage Repair

Authors: Robert J Lake, Rabeya Bilkis, Hua-Ying Fan

Journal: Biomedicines

PubMed ID: 35203571

Doi: 10.3390/biomedicines10020361

Products & Services: Proteins, Expression, Isolation and Analysis

Elicitation of potent SARS-CoV-2 neutralizing antibody responses through immunization with a versatile adenovirus-inspired multimerization platform

Authors: Christopher Chevillard, Axelle Amen, Solène Besson, Dalil Hannani, Isabelle Bally, Valentin Dettling, Evelyne Gout, Christophe J Moreau, Marlyse Buisson, Salomé Gallet, Daphna Fenel, Emilie Vassal-Stermann, Guy Schoehn, Pascal Poignard, Marie-Claire Dagher, Pascal Fender

Journal: Mol Ther

PubMed ID: 35151843

Doi: 10.1016/j.ymthe.2022.02.011

Products & Services: PCR Cloning and Subcloning

FRAGILE CULM 18 encodes a UDP-glucuronic acid decarboxylase required for xylan biosynthesis and plant growth in rice

Authors: Nan Ruan, Zhengjun Dang, Meihan Wang, Liyu Cao, Ye Wang, Sitong Liu, Yijun Tang, Yuwei Huang, Qun Zhang, Quan Xu, Wenfu Chen, Fengcheng Li

Journal: J Exp Bot

PubMed ID: 35104839

Doi: 10.1093/jxb/erac036

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Proteasome 26S subunit, non-ATPase 1 (PSMD1) facilitated the progression of lung adenocarcinoma by the de-ubiquitination and stability of PTEN-induced kinase 1 (PINK1)

Authors: Lihua Liu, Aihua Liu, Jun Dong, Zhongfu Zuo, Xuezheng Liu

Journal: Exp Cell Res

PubMed ID: 35192838

Doi: 10.1016/j.yexcr.2022.113075

Products & Services: Plasmid DNA Preparation

Differential escape of neutralizing antibodies by SARS-CoV-2 Omicron and pre-emergent sarbecoviruses

Authors: Lin-Fa Wang, Chee Wah Tan, Wan Ni Chia, Feng Zhu, Barnaby Young, Napaporn Chantasrisawad, Shi-Hsia Hwa, Aileen Ying-Yan Yeoh, Beng Lee Lim, Wee Chee Yap, Surinder Kaur Pada, Seow Yen Tan, Watsamon Jantarabenjakul, Shiwei Chen, Jinyan Zhang, Yun Yan Mah, Vivian Chen, Mark Chen, Supaporn Wacharapluesadee, Commit-Kzn Team, Opass Putcharoen, David Lye

Journal: Res Sq

PubMed ID: 35233568

Doi: 10.21203/rs.3.rs-1362541/v1

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Identification and Expression Analysis of WRKY Gene Family in Response to Abiotic Stress in

Authors: Tingting Zhang, Ying Xu, Yadan Ding, Wengang Yu, Jian Wang, Hanggui Lai, Yang Zhou

Journal: Front Genet

PubMed ID: 35186030

Doi: 10.3389/fgene.2022.800019

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Dissecting Molecular Phenotypes Through FACS-Based Pooled CRISPR Screens

Authors: Oriana Genolet, Liat Ravid Lustig, Edda G Schulz

Journal: Methods Mol Biol

PubMed ID: 35218528

Doi: 10.1007/7651_2021_457

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The suppressor of copper sensitivity protein C from Caulobacter crescentus is a trimeric disulfide isomerase that binds copper(I) with subpicomolar affinity

Authors: Guillaume A Petit, Yaoqin Hong, Karrera Y Djoko, Andrew E Whitten, Emily J Furlong, Airlie J McCoy, Jacqueline M Gulbis, Makrina Totsika, Jennifer L Martin, Maria A Halili

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35234148

Doi: 10.1107/S2059798322000729

Products & Services: Bacterial Expression

PAD-2-mediated citrullination of nucleophosmin provides an effective target for tumor immunotherapy

Authors: Ruhul H Choudhury, Peter Symonds, Samantha J Paston, Ian Daniels, Katherine W Cook, Mohamed Gijon, Rachael L Metheringham, Victoria A Brentville, Lindy G Durrant

Journal: J Immunother Cancer

PubMed ID: 35140112

Doi: 10.1136/jitc-2021-003526

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Engineering of an Avidity-Optimized CD19-Specific Parallel Chimeric Antigen Receptor That Delivers Dual CD28 and 4-1BB Co-Stimulation

Authors: Leena Halim, Kushal K Das, Daniel Larcombe-Young, Adam Ajina, Andrea Candelli, Reuben Benjamin, Richard Dillon, David M Davies, John Maher

Journal: Front Immunol

PubMed ID: 35222427

Doi: 10.3389/fimmu.2022.836549

Products & Services: Mutagenesis Services

Longitudinal analysis of antibody dynamics in COVID-19 convalescents reveals neutralizing responses up to 16 months after infection

Authors: Yang Yang, Minghui Yang, Yun Peng, Yanhua Liang, Jinli Wei, Li Xing, Liping Guo, Xiaohe Li, Jie Li, Jun Wang, Mianhuan Li, Zhixiang Xu, Mingxia Zhang, Fuxiang Wang, Yi Shi, Jing Yuan, Yingxia Liu

Journal: Nat Microbiol

PubMed ID: 35132197

Doi: 10.1038/s41564-021-01051-2

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Engineering laboratory/factory-specific phage-resistant strains of Escherichia coli by mutagenesis and screening

Authors: Qi Shen, Xiao-Ting Zhou, Qian Guo, Ya-Ping Xue, Yu-Guo Zheng

Journal: World J Microbiol Biotechnol

PubMed ID: 35128603

Doi: 10.1007/s11274-022-03239-y

Products & Services: Proteins, Expression, Isolation and Analysis

Engineering laboratory/factory-specific phage-resistant strains of Escherichia coli by mutagenesis and screening

Authors: Qi Shen, Xiao-Ting Zhou, Qian Guo, Ya-Ping Xue, Yu-Guo Zheng

Journal: World J Microbiol Biotechnol

PubMed ID: 35128603

Doi: 10.1007/s11274-022-03239-y

Products & Services: Proteins, Expression, Isolation and Analysis

FXYD domain containing ion transport regulator 5 (FXYD5) silencing promotes cell viability and alleviates inflammatory response in cerulein-induced AR42J cells by blocking JAK2/STAT3 signaling pathway

Authors: Licheng Ding, Jie Li

Journal: Bioengineered

PubMed ID: 35042436

Doi: 10.1080/21655979.2021.2023795

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Inhibition of Schistosoma mansoni carbonic anhydrase by the antiparasitic drug clorsulon: X-ray crystallographic and in vitro studies

Authors: Marta Ferraroni, Andrea Angeli, Simone Carradori, Claudiu T Supuran

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35234146

Doi: 10.1107/S2059798322000079

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Inhibition of Schistosoma mansoni carbonic anhydrase by the antiparasitic drug clorsulon: X-ray crystallographic and in vitro studies

Authors: Marta Ferraroni, Andrea Angeli, Simone Carradori, Claudiu T Supuran

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35234146

Doi: 10.1107/S2059798322000079

Products & Services: Codon Optimization

CoronaVac and ChAdOx1 Vaccination and Gamma Infection Elicited Neutralizing Antibodies against the SARS-CoV-2 Delta Variant

Authors: Marcilio Jorge Fumagalli, Luiza Antunes Castro-Jorge, William Marciel de Souza, Patrick Orestes de Azevedo, Alana Witt Hansen, Ricardo Tostes Gazzinelli, Benedito Antônio Lopes da Fonseca, Fernando Rosado Spilki, Luiz Tadeu Moraes Figueiredo

Journal: Viruses

PubMed ID: 35215895

Doi: 10.3390/v14020305

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Genome-wide identification and characterization of aquaporins in mangrove plant Kandelia obovata and its role in response to the intertidal environment

Authors: Zejun Guo, Dongna Ma, Jing Li, Mingyue Wei, Ludan Zhang, Lichun Zhou, Xiaoxuan Zhou, Shanshan He, Lin Wang, Yingjia Shen, Qingshun Quinn Li, Hai-Lei Zheng

Journal: Plant Cell Environ

PubMed ID: 35141923

Doi: 10.1111/pce.14286

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Silencing of IGF2BP1 restrains ox-LDL-induced lipid accumulation and inflammation by reducing RUNX1 expression and promoting autophagy in macrophages

Authors: Mingxin Liu, Guizhou Tao, Yiming Cao, Yu Hu, Zhe Zhang

Journal: J Biochem Mol Toxicol

PubMed ID: 35179253

Doi: 10.1002/jbt.22994

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Backbone NMR resonance assignment of the intrinsically disordered UBact protein from Nitrospira nitrosa

Authors: Steven M Bonn, David Fushman

Journal: Biomol NMR Assign

PubMed ID: 35107780

Doi: 10.1007/s12104-022-10070-x

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RNA modifications stabilize the tertiary structure of tRNAfMet by locally increasing conformational dynamics

Authors: Thomas Biedenbänder, Vanessa de Jesus, Martina Schmidt-Dengler, Mark Helm, Björn Corzilius, Boris Fürtig

Journal: Nucleic Acids Res

PubMed ID: 35137185

Doi: 10.1093/nar/gkac040

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PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation

Authors: Prasidda Khadka, Zachary J Reitman, Sophie Lu, Graham Buchan, Gabrielle Gionet, Frank Dubois, Diana M Carvalho, Juliann Shih, Shu Zhang, Noah F Greenwald, Travis Zack, Ofer Shapira, Kristine Pelton, Rachel Hartley, Heather Bear, Yohanna Georgis, Spandana Jarmale, Randy Melanson, Kevin Bonanno, Kathleen Schoolcraft, Peter G Miller, Alexandra L Condurat, Elizabeth M Gonzalez, Kenin Qian, Eric Morin, Jaldeep Langhnoja, Leslie E Lupien, Veronica Rendo, Jeromy Digiacomo, Dayle Wang, Kevin Zhou, Rushil Kumbhani, Maria E Guerra Garcia, Claire E Sinai, Sarah Becker, Rachel Schneider, Jayne Vogelzang, Karsten Krug, Amy Goodale, Tanaz Abid, Zohra Kalani, Federica Piccioni, Rameen Beroukhim, Nicole S Persky, David E Root, Angel M Carcaboso, Benjamin L Ebert, Christine Fuller, Ozgun Babur, Mark W Kieran, Chris Jones, Hasmik Keshishian, Keith L Ligon, Steven A Carr, Timothy N Phoenix, Pratiti Bandopadhayay

Journal: Nat Commun

PubMed ID: 35105861

Doi: 10.1038/s41467-022-28198-8

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