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An insect antifreeze protein from Anatolica polita enhances the cryoprotection of Xenopus laevis eggs and embryos

Authors: Predrag Jevtić, K Wade Elliott, Shelby E Watkins, Jonathan A Sreter, Katarina Jovic, Ian B Lehner, Paul W Baures, John G Tsavalas, Daniel L Levy, Krisztina Varga

Journal: J Exp Biol

PubMed ID: 35014670

Doi: 10.1242/jeb.243662

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Enhanced transglycosylation activity of an Endo-F3 mutant by ligand-directed localization

Authors: Xiangman Zou, Zhi Liu, Liya Liu, Wei Shi, Wanzhen Li, Zifen Guo, Feng Tang, Wei Huang

Journal: Org Biomol Chem

PubMed ID: 35166761

Doi: 10.1039/d2ob00030j

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Backbone NMR resonance assignment of the intrinsically disordered UBact protein from Nitrospira nitrosa

Authors: Steven M Bonn, David Fushman

Journal: Biomol NMR Assign

PubMed ID: 35107780

Doi: 10.1007/s12104-022-10070-x

Products & Services: Custom Vector Construction

Development and validation of an LC-MS/MS based quantitative assay for marmoset insulin in serum

Authors: Robinson W Goy, Hemanta K Shrestha, Ricki J Colman, Natalie J Dukes, Toni E Ziegler, Amita Kapoor

Journal: J Chromatogr B Analyt Technol Biomed Life Sci

PubMed ID: 35247678

Doi: 10.1016/j.jchromb.2022.123150

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Development and validation of an LC-MS/MS based quantitative assay for marmoset insulin in serum

Authors: Robinson W Goy, Hemanta K Shrestha, Ricki J Colman, Natalie J Dukes, Toni E Ziegler, Amita Kapoor

Journal: J Chromatogr B Analyt Technol Biomed Life Sci

PubMed ID: 35247678

Doi: 10.1016/j.jchromb.2022.123150

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Physiological ROS controls Upd3-dependent modeling of ECM to support cardiac function in

Authors: Jayati Gera, Prerna Budakoti, Meghna Suhag, Lolitika Mandal, Sudip Mandal

Journal: Sci Adv

PubMed ID: 35179958

Doi: 10.1126/sciadv.abj4991

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Distinct impact of DMARD combination and monotherapy in immunogenicity of an inactivated SARS-CoV-2 vaccine in rheumatoid arthritis

Authors: Ana Cristina Medeiros-Ribeiro, Karina Rossi Bonfiglioli, Diogo Souza Domiciano, Andrea Yukie Shimabuco, Henrique Carriço da Silva, Carla G S Saad, Emily Figueiredo Neves Yuki, Sandra Gofinet Pasoto, Carlo Scognamiglio Renner Araujo, Tatiane Lie Nakai, Clóvis Artur Silva, Tatiana Pedrosa, Léonard de Vinci Kanda Kupa, Matheus Santos Rodrigues Silva, Guilherme Guimarães Moreira Balbi, Esper Georges Kallas, Nádia Emi Aikawa, Eloisa Bonfa

Journal: Ann Rheum Dis

PubMed ID: 35135832

Doi: 10.1136/annrheumdis-2021-221735

Products & Services: Recombinant Proteins

CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

Authors: Yiru Long , Jianhua Sun , Tian-Zhang Song , Tingting Liu , Feng Tang , Xinxin Zhang, Longfei Ding , Yunqiu Miao , Weiliang Zhu , Xiaoyan Pan , Qi An, Mian Qin , Xiankun Tong , Xionghua Peng , Pan Yu, Peng Zhu , Jianqing Xu , Xiaoyan Zhang , Yachun Zhang , Datao Liu, Ben Chen , Huilin Chen , Leike Zhang , Gengfu Xiao, Jianping Zuo , Wei Tang , Ji Zhou, Heng Li , Zhijian Xu, Hong-Yi Zheng , Xin-Yan Long , Qiuping Qin , Yong Gan , Jin Ren , Wei Huang , Yong-Tang Zheng , Guangyi Jin , Likun Gong

Journal: Cell Discov .

PubMed ID: 35102138

Doi: 10.1038/s41421-021-00370-2

Products & Services: Recombinant Proteins

Vaccination Strategies at a COVID-19 Mass Vaccination Site

Authors: Sheng-Huang Hsiao, Sheng-Jean Huang, Chiao-Yu Huang

Journal: Int J Health Policy Manag

PubMed ID: 35247942

Doi: 10.34172/ijhpm.2022.6881

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CoronaVac and ChAdOx1 Vaccination and Gamma Infection Elicited Neutralizing Antibodies against the SARS-CoV-2 Delta Variant

Authors: Marcilio Jorge Fumagalli, Luiza Antunes Castro-Jorge, William Marciel de Souza, Patrick Orestes de Azevedo, Alana Witt Hansen, Ricardo Tostes Gazzinelli, Benedito Antônio Lopes da Fonseca, Fernando Rosado Spilki, Luiz Tadeu Moraes Figueiredo

Journal: Viruses

PubMed ID: 35215895

Doi: 10.3390/v14020305

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Engineering of an Avidity-Optimized CD19-Specific Parallel Chimeric Antigen Receptor That Delivers Dual CD28 and 4-1BB Co-Stimulation

Authors: Leena Halim, Kushal K Das, Daniel Larcombe-Young, Adam Ajina, Andrea Candelli, Reuben Benjamin, Richard Dillon, David M Davies, John Maher

Journal: Front Immunol

PubMed ID: 35222427

Doi: 10.3389/fimmu.2022.836549

Products & Services: Mutagenesis Services

Base excision repair system targeting DNA adducts of trioxacarcin/LL-D49194 antibiotics for self-resistance

Authors: Xiaorong Chen, Noah P Bradley, Wei Lu, Katherine L Wahl, Mei Zhang, Hua Yuan, Xian-Feng Hou, Brandt F Eichman, Gong-Li Tang

Journal: Nucleic Acids Res

PubMed ID: 35191495

Doi: 10.1093/nar/gkac085

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The suppressor of copper sensitivity protein C from Caulobacter crescentus is a trimeric disulfide isomerase that binds copper(I) with subpicomolar affinity

Authors: Guillaume A Petit, Yaoqin Hong, Karrera Y Djoko, Andrew E Whitten, Emily J Furlong, Airlie J McCoy, Jacqueline M Gulbis, Makrina Totsika, Jennifer L Martin, Maria A Halili

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 35234148

Doi: 10.1107/S2059798322000729

Products & Services: Bacterial Expression

Bioinformatic characterization of a triacylglycerol lipase produced by isolated from the decaying seed of

Authors: Benjamin O Ezema, Kingsley O Omeje, Roslyn M Bill, Alan D Goddard, Sabinus Oscar O Eze, Alfred Fernandez-Castane

Journal: J Biomol Struct Dyn

PubMed ID: 35147487

Doi: 10.1080/07391102.2022.2035821

Products & Services: Codon Optimization

OmpA may be used as a novel target to enrich and detect Escherichia coli in milk samples

Authors: Yichen Tian, Kaiqing Yang, Yaoqiang Shi, Jinyang Zhang, Qinqin Han, Xueshan Xia, Yuzhu Song

Journal: J Dairy Sci

PubMed ID: 35151480

Doi: 10.3168/jds.2021-20974

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Crystal packing reveals rapamycin-mediated homodimerization of an FK506-binding domain

Authors: Ajit Kumar Singh, Ketul Saharan, Somanath Baral, Sheng Luan, Dileep Vasudevan

Journal: Int J Biol Macromol

PubMed ID: 35218805

Doi: 10.1016/j.ijbiomac.2022.02.107

Products & Services: Plasmid DNA Preparation

The Anticancer Effect of a Conjugated Antimicrobial Peptide Against Colorectal Cancer (CRC) Cells

Authors: Raed Obaid Saleh, Ihsan Naji Atiyah Essia, Saade Abdalkareem Jasim

Journal: J Gastrointest Cancer

PubMed ID: 35217999

Doi: 10.1007/s12029-021-00799-4

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A self-assembling nanoparticle vaccine targeting the conserved epitope of influenza virus hemagglutinin stem elicits a cross-protective immune response

Authors: Yongbo Qiao, Shuang Li, Shenghui Jin, Yi Pan, Yuhua Shi, Wei Kong, Yaming Shan

Journal: Nanoscale

PubMed ID: 35157751

Doi: 10.1039/d1nr08460g

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Microparticles from Hyperphosphatemia-Stimulated Endothelial Cells Promote Vascular Calcification Through Astrocyte-Elevated Gene-1

Authors: Yazhou Xiang, Yingjie Duan, Zhong Peng, Hong Huang, Wenjun Ding, En Chen, Zilong Liu, Chengyun Dou, Jianlong Li, Jihong Ou, Qingsong Wan, Bo Yang, Zhangxiu He

Journal: Calcif Tissue Int

PubMed ID: 35195734

Doi: 10.1007/s00223-022-00960-6

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Synthesis and identification of lithocholic acid 3-sulfate as RORγt ligand to inhibit Th17 cell differentiation

Authors: Riping Xiao, Kawai Lei, Hioha Kuok, Wende Deng, Yuxin Zhuang, Yanqing Tang, Zhengyang Guo, Hongyan Qin, Li-Ping Bai, Ting Li

Journal: J Leukoc Biol

PubMed ID: 35188700

Doi: 10.1002/JLB.1MA0122-513R

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Aqueous Extract of Reprogramming Macrophage Polarization by Activating TLR4-NF-κB Signaling Pathway

Authors: Shushu Qian, Xuan Han, Xiaocao Sha, Fang Tian, Hong Huang, Pengjun Jiang, Guoshun Huang, Bangyun Ma, Hong Zhang, Yiye Zhu, Xuemei Sun

Journal: J Inflamm Res

PubMed ID: 35210810

Doi: 10.2147/JIR.S345497

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orter: A Novel Inducible Human CASP1/NALP3/ASC Inflammasome Biosensor

Authors: Chan Zou, Jordan A Beard, Guoping Yang, William E Evans, Erik J Bonten

Journal: J Inflamm Res

PubMed ID: 35221708

Doi: 10.2147/JIR.S333725

Products & Services: Plasmid DNA Preparation

High density lipoprotein nanoparticle as delivery system for radio-sensitising miRNA: An investigation in 2D/3D head and neck cancer models

Authors: Pouya Dehghankelishadi, Michelle F Maritz, Parisa Badiee, Benjamin Thierry

Journal: Int J Pharm

PubMed ID: 35176332

Doi: 10.1016/j.ijpharm.2022.121585

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A machine learning approach-based array sensor for rapidly predicting the mechanisms of action of antibacterial compounds

Authors: Zhijun Li, Kun Jin, Hong Chen, Liyuan Zhang, Guitao Zhang, Yizhou Jiang, Haixia Zou, Wentao Wang, Guangpei Qi, Xiangmeng Qu

Journal: Nanoscale

PubMed ID: 35167631

Doi: 10.1039/d1nr07452k

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Development of SARS-CoV-2 variant protein microarray for profiling humoral immunity in vaccinated subjects

Authors: Tzong-Shiann Ho, Pin-Xian Du, Wen-Yu Su, Harvey M Santos, Ya-Lan Lin, Yi-Yu Chou, Batuhan Birol Keskin, Chi Ho Pau, Guan-Da Syu

Journal: Biosens Bioelectron

PubMed ID: 35168024

Doi: 10.1016/j.bios.2022.114067

The small DdrR protein directly interacts with the UmuDAb regulator of the mutagenic DNA damage response in

Authors: Anja Pavlin, Gregor Bajc, Nadine Fornelos, Douglas F Browning, Matej Butala

Journal: J Bacteriol

PubMed ID: 35191762

Doi: 10.1128/jb.00601-21

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Occludin Promotes Adhesion of CD8 T Cells and Melanocytes in Vitiligo via the HIF-1 Signaling Pathway

Authors: Puyu Zou, Yangfan Xiao, Qiancheng Deng, Yaqian Shi, Ruixuan You, Zixin Pi, Jiani Liu, Yi Zhan, Qinghai Zeng, Zhuotong Zeng, Rong Xiao

Journal: Oxid Med Cell Longev

PubMed ID: 35222802

Doi: 10.1155/2022/6732972

Products & Services: Gene Synthesis

Occludin Promotes Adhesion of CD8 T Cells and Melanocytes in Vitiligo via the HIF-1 Signaling Pathway

Authors: Puyu Zou, Yangfan Xiao, Qiancheng Deng, Yaqian Shi, Ruixuan You, Zixin Pi, Jiani Liu, Yi Zhan, Qinghai Zeng, Zhuotong Zeng, Rong Xiao

Journal: Oxid Med Cell Longev

PubMed ID: 35222802

Doi: 10.1155/2022/6732972

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FXYD domain containing ion transport regulator 5 (FXYD5) silencing promotes cell viability and alleviates inflammatory response in cerulein-induced AR42J cells by blocking JAK2/STAT3 signaling pathway

Authors: Licheng Ding, Jie Li

Journal: Bioengineered

PubMed ID: 35042436

Doi: 10.1080/21655979.2021.2023795

Products & Services: Gene Synthesis

Identification and mapping of post-transcriptional modifications on the HIV-1 antisense transcript Ast in human cells

Authors: Mariana Estevez, Rui Li, Biplab Paul, Kaveh Daneshvar, Alan C Mullen, Fabio Romerio, Balasubrahmanyam Addepalli

Journal: RNA

PubMed ID: 35168996

Doi: 10.1261/rna.079043.121

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The small DdrR protein directly interacts with the UmuDAb regulator of the mutagenic DNA damage response in

Authors: Anja Pavlin, Gregor Bajc, Nadine Fornelos, Douglas F Browning, Matej Butala

Journal: J Bacteriol

PubMed ID: 35191762

Doi: 10.1128/jb.00601-21

Products & Services: ORF cDNA Clones/MolecularCloud

Identification and Characterization of a Set of Monocot BAHD Monolignol Transferases

Authors: Rebecca A Smith, Emily T Beebe, Craig A Bingman, Kirk Vander Meulen, Alexis Eugene, Alexander J Steiner, Steven D Karlen, John Ralph, Brian G Fox

Journal: Plant Physiol

PubMed ID: 35134228

Doi: 10.1093/plphys/kiac035

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Identification and Characterization of a Set of Monocot BAHD Monolignol Transferases

Authors: Rebecca A Smith, Emily T Beebe, Craig A Bingman, Kirk Vander Meulen, Alexis Eugene, Alexander J Steiner, Steven D Karlen, John Ralph, Brian G Fox

Journal: Plant Physiol

PubMed ID: 35134228

Doi: 10.1093/plphys/kiac035

Products & Services: Plasmid DNA Preparation

Lanthanide-based β-Tricalcium Phosphate Upconversion Nanoparticles as an Effective Theranostic Nonviral Vectors for Image-Guided Gene Therapy

Authors: Flavia Rodrigues Oliveira Silva, Nelson Batista Lima, Maria Helena Bellini, Luiz Felipe Silva Teixeira, Eric Yiwei Du, Niloufar Jamshidi, Justin Gooding, Adam David Martin, Alexander Macmillan, Christopher Peter Marquis, Pall Thordarson

Journal: Nanotheranostics

PubMed ID: 35223382

Doi: 10.7150/ntno.68789

Products & Services: Mammalian Expression

Rapid screening of aptamers for fluorescent targets by integrated digital PCR and flow cytometry

Authors: Xiaona Fang, Wenjing Li, Tian Gao, Qurat Ul Ain Zahra, Zhaofeng Luo, Renjun Pei

Journal: Talanta

PubMed ID: 35180537

Doi: 10.1016/j.talanta.2022.123302

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Transformation of by for the Expression of the Hemagglutinin of Avian Influenza Virus H5

Authors: Inkar Castellanos-Huerta, Gabriela Gómez-Verduzco, Guillermo Tellez-Isaias, Guadalupe Ayora-Talavera, Bernardo Bañuelos-Hernández, Víctor Manuel Petrone-García, Gilberto Velázquez-Juárez, Isidro Fernández-Siurob

Journal: Microorganisms

PubMed ID: 35208815

Doi: 10.3390/microorganisms10020361

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Aluminum nanoparticles deliver a dual-epitope peptide for enhanced anti-tumor immunotherapy

Authors: Shuting Bai, Hao Jiang, Yuanshuai Song, Yining Zhu, Ming Qin, Chunting He, Guangsheng Du, Xun Sun

Journal: J Control Release

PubMed ID: 35217098

Doi: 10.1016/j.jconrel.2022.02.027

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IL-9/STAT3/fatty acid oxidation-mediated lipid peroxidation contributes to Tc9 cell longevity and enhanced antitumor activity

Authors: Liuling Xiao, Xingzhe Ma, Lingqun Ye, Pan Su, Wei Xiong, Enguang Bi, Qiang Wang, Miao Xian, Maojie Yang, Jianfei Qian, Qing Yi

Journal: J Clin Invest

PubMed ID: 35192544

Doi: 10.1172/JCI153247

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IL-4 plays an essential role in DnaJ-ΔA146Ply-mediated immunoprotection against Streptococcus pneumoniae in mice

Authors: Yi Hu, Lian Li, Wenchun Xu, Kaifeng Wu, Jiangming Xiao, Yang Peng, Yusi Liu, Yibing Yin, Xuemei Zhang

Journal: Mol Immunol

PubMed ID: 35114487

Doi: 10.1016/j.molimm.2022.01.010

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A Novel CD3/BCMA Bispecific T-cell Redirecting Antibody for the Treatment of Multiple Myeloma

Authors: Mengshang Xiong, Ruoqi Liu, Xiaomin Lei, Dongmei Fan, Fangzhen Lin, Wei Hao, Xiangfei Yuan, Yuanyuan Yang, Xiaolong Zhang, Zhou Ye, Yang Lu, Yanjun Zhang, Jianxiang Wang, Dongsheng Xiong

Journal: J Immunother

PubMed ID: 34711791

Doi: 10.1097/CJI.0000000000000401

Products & Services: Proteins, Expression, Isolation and Analysis

RNA interference targeting UL25 gene as a gene therapy approach against BHV-1

Authors: Elaheh Amjadimanesh, Azam Mokhtari, Behnaz Saffar

Journal: Res Vet Sci

PubMed ID: 35182967

Doi: 10.1016/j.rvsc.2022.02.007

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Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state

Authors: Chi-Chuan Lin, Kin Man Suen, Polly-Anne Jeffrey, Lukasz Wieteska, Jessica A Lidster, Peng Bao, Alistair P Curd, Amy Stainthorp, Caroline Seiler, Hans Koss, Eric Miska, Zamal Ahmed, Stephen D Evans, Carmen Molina-París, John E Ladbury

Journal: Mol Cell

PubMed ID: 35231400

Doi: 10.1016/j.molcel.2022.02.005

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Ligand-directed bias of G protein signaling at the dopamine D2 receptor

Authors: Ee Von Moo , Kasper Harpsøe , Alexander S Hauser , Ikuo Masuho , Hans Bräuner-Osborne , David E Gloriam , Kirill A Martemyanov

Journal: Cell Chem Biol .

PubMed ID: 34302750

Doi: 10.1016/j.chembiol.2021.07.004

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SARS-CoV-2 Variants Increase Kinetic Stability of Open Spike Conformations as an Evolutionary Strategy

Authors: Ziwei Yang, Yang Han, Shilei Ding, Wei Shi, Tongqing Zhou, Andrés Finzi, Peter D Kwong, Walther Mothes, Maolin Lu

Journal: MBio

PubMed ID: 35164561

Doi: 10.1128/mbio.03227-21

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Germinal centre-driven maturation of B cell response to mRNA vaccination

Authors: Wooseob Kim, Julian Q Zhou, Stephen C Horvath, Aaron J Schmitz, Alexandria J Sturtz, Tingting Lei, Zhuoming Liu, Elizaveta Kalaidina, Mahima Thapa, Wafaa B Alsoussi, Alem Haile, Michael K Klebert, Teresa Suessen, Luis Parra-Rodriguez, Philip A Mudd, Sean P J Whelan, William D Middleton, Sharlene A Teefey, Iskra Pusic, Jane A O'Halloran, Rachel M Presti, Jackson S Turner, Ali H Ellebedy

Journal: Nature

PubMed ID: 35168246

Doi: 10.1038/s41586-022-04527-1

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Disentangling the recognition complexity of a protein hub using a nanopore

Authors: Lauren Ashley Mayse, Ali Imran, Motahareh Ghahari Larimi, Michael S Cosgrove, Aaron James Wolfe, Liviu Movileanu

Journal: Nat Commun

PubMed ID: 35190547

Doi: 10.1038/s41467-022-28465-8

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Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy

Authors: Sheng-Han Kuo, Inmaculada Tasset, Melody M Cheng, Antonio Diaz, Ming-Kai Pan, Ori J Lieberman, Samantha J Hutten, Roy N Alcalay, Sangjun Kim, Pilar Ximénez-Embún, Li Fan, Donghoon Kim, Han Seok Ko, Talene Yacoubian, Ellen Kanter, Ling Liu, Guomei Tang, Javier Muñoz, Sergio Pablo Sardi, Aiqun Li, Li Gan, Ana Maria Cuervo, David Sulzer

Journal: Sci Adv

PubMed ID: 35138901

Doi: 10.1126/sciadv.abm6393

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CNOT6: A Novel Regulator of DNA Mismatch Repair

Authors: Peng Song, Shaojun Liu, Dekang Liu, Guido Keijzers, Daniela Bakula, Shunlei Duan, Niels de Wind, Zilu Ye, Sergey Y Vakhrushev, Morten Scheibye-Knudsen, Lene Juel Rasmussen

Journal: Cells

PubMed ID: 35159331

Doi: 10.3390/cells11030521

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mRNA COVID-19 vaccine booster fosters B- and T-cell responses in immunocompromised patients

Authors: Elena Azzolini, Chiara Pozzi, Luca Germagnoli, Bianca Oresta, Nicola Carriglio, Mariella Calleri, Carlo Selmi, Maria De Santis, Silvia Finazzi, Carmelo Carlo-Stella, Alexia Bertuzzi, Francesca Motta, Angela Ceribelli, Alberto Mantovani, Fabrizio Bonelli, Maria Rescigno

Journal: Life Sci Alliance

PubMed ID: 35169017

Doi: 10.26508/lsa.202201381

Humoral Immunity to Allogeneic Immunoproteasome-Expressing Mesenchymal Stromal Cells Requires Efferocytosis by Endogenous Phagocytes

Authors: Jean-Pierre Bikorimana, Jamilah Abusarah, Natasha Salame, Nehme El-Hachem, Riam Shammaa, Moutih Rafei

Journal: Cells

PubMed ID: 35203247

Doi: 10.3390/cells11040596

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