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Piwi4 Structural Features Are Necessary for RNA Binding and Nuclear Localization

Authors: Adeline E Williams, Gaurav Shrivastava, Apostolos G Gittis, Sundar Ganesan, Ines Martin-Martin, Paola Carolina Valenzuela Leon, Ken E Olson, Eric Calvo

Journal: Int J Mol Sci

PubMed ID: 34884537

Doi: 10.3390/ijms222312733

Products & Services: Proteins, Expression, Isolation and Analysis

Gain of Spontaneous Mutations Boosting Motility Adaption to Environments in

Authors: Bingyu Li, Chaofan Hou, Xian Ju, Yong Feng, Zhi-Qiang Ye, Yunzhu Xiao, Mingyao Gu, Chunxiang Fu, Chaoliang Wei, Conghui You

Journal: Front Bioeng Biotechnol

PubMed ID: 34900963

Doi: 10.3389/fbioe.2021.772397

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G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators

Authors: Malarvizhi Gurusamy, Denise Tischner, Jingchen Shao, Stephan Klatt, Sven Zukunft, Remy Bonnavion, Stefan Günther, Kai Siebenbrodt, Roxane-Isabelle Kestner, Tanja Kuhlmann, Ingrid Fleming, Stefan Offermanns, Nina Wettschureck

Journal: Nat Commun

PubMed ID: 34815397

Doi: 10.1038/s41467-021-26882-9

Products & Services: Custom DNA/RNA Oligos

TIFAB accelerates MLL-AF9-Induced acute myeloid leukemia through upregulation of HOXA9

Authors: Jinming Zhao, Yan Xiu, Lin Fu, Qianze Dong, Nicholas Borcherding, Yang Wang, Qingchang Li, Nilushi S De Silva, Ulf Klein, Brendan F Boyce, Chen Zhao

Journal: iScience

PubMed ID: 34877491

Doi: 10.1016/j.isci.2021.103425

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Curcumol inhibits malignant biological behaviors and TMZ-resistance in glioma cells by inhibiting long noncoding RNA FOXD2-As1-promoted EZH2 activation

Authors: Xuyang Lv, Jiangchuan Sun, Linfeng Hu, Ying Qian, Chunlei Fan, Nan Tian

Journal: Aging (Albany NY)

PubMed ID: 34739394

Doi: 10.18632/aging.203662

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Plant LHC-like proteins show robust folding and static non-photochemical quenching

Authors: Petra Skotnicová, Hristina Staleva-Musto, Valentyna Kuznetsova, David Bína, Minna M Konert, Shan Lu, Tomáš Polívka, Roman Sobotka

Journal: Nat Commun

PubMed ID: 34824207

Doi: 10.1038/s41467-021-27155-1

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A nanocompartment system contributes to defense against oxidative stress in

Authors: Katie A Lien, Kayla Dinshaw, Robert J Nichols, Caleb Cassidy-Amstutz, Matthew Knight, Rahul Singh, Lindsay D Eltis, David F Savage, Sarah A Stanley

Journal: Elife

PubMed ID: 34751132

Doi: 10.7554/eLife.74358

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Limited Impact of Delta Variant's Mutations on the Effectiveness of Neutralization Conferred by Natural Infection or COVID-19 Vaccines in a Latino Population

Authors: Carlos A Sariol, Crisanta Serrano-Collazo, Edwin J Ortiz, Petraleigh Pantoja, Lorna Cruz, Teresa Arana, Dianne Atehortua, Christina Pabon-Carrero, Ana M Espino

Journal: Viruses

PubMed ID: 34960674

Doi: 10.3390/v13122405

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Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages

Authors: Christian Kretzer, Paul M Jordan, Katharina P L Meyer, Daniel Hoff, Markus Werner, Robert Klaus Hofstetter, Andreas Koeberle, Antonio Cala Peralta, Guillaume Viault, Denis Seraphin, Pascal Richomme, Jean-Jacques Helesbeux, Hermann Stuppner, Veronika Temml, Daniela Schuster, Oliver Werz

Journal: Biochem Pharmacol

PubMed ID: 34762841

Doi: 10.1016/j.bcp.2021.114825

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Translational activators and mitoribosomal isoforms cooperate to mediate mRNA-specific translation in Schizosaccharomyces pombe mitochondria

Authors: Christopher J Herbert, Sylvie Labarre-Mariotte, David Cornu, Cyrielle Sophie, Cristina Panozzo, Thomas Michel, Geneviève Dujardin, Nathalie Bonnefoy

Journal: Nucleic Acids Res

PubMed ID: 34634819

Doi: 10.1093/nar/gkab789

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An acetylation-enhanced interaction between transcription factor Sox2 and the steroid receptor coactivators facilitates Sox2 transcriptional activity and function

Authors: Yuanyong Huang, Xiaoya Duan, Zhen Wang, Yimei Sun, Qingqing Guan, Li Kang, Qiao Zhang, Lan Fang, Jiwen Li, Jiemin Wong

Journal: J Biol Chem

PubMed ID: 34762910

Doi: 10.1016/j.jbc.2021.101389

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His domain protein tyrosine phosphatase and Rabaptin-5 couple endo-lysosomal sorting of EGFR with endosomal maturation

Authors: Gabrielle Parkinson, Peristera Roboti, Ling Zhang, Sandra Taylor, Philip Woodman

Journal: J Cell Sci

PubMed ID: 34657963

Doi: 10.1242/jcs.259192

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Comprehensive Comparative Analysis of the GATA Transcription Factors in Four Rosaceae Species and Phytohormonal Response in Chinese Pear () Fruit

Authors: Muhammad Aamir Manzoor, Irfan Ali Sabir, Iftikhar Hussain Shah, Han Wang, Zhao Yu, Faiz Rasool, Muhammad Zaid Mazhar, Shoaib Younas, Muhammad Abdullah, Yongping Cai

Journal: Int J Mol Sci

PubMed ID: 34830372

Doi: 10.3390/ijms222212492

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Novel immortalization approach defers senescence of cultured canine adipose-derived mesenchymal stromal cells

Authors: Ana Stojiljković, Véronique Gaschen, Franck Forterre, Ulrich Rytz, Michael H Stoffel, Jasmin Bluteau

Journal: Geroscience

PubMed ID: 34806133

Doi: 10.1007/s11357-021-00488-x

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Hsa_circRNA_103124 Upregulation in Crohn's Disease Promotes Cell Proliferation and Inhibits Autophagy by Regulating the Hsa-miR-650/AKT2 Signaling Pathway

Authors: Juan Yin, Fuyi Tong, Yulan Ye, Tong Hu, Lijuan Xu, Liping Zhang, Jianyun Zhu, Zhi Pang

Journal: Front Genet

PubMed ID: 34804121

Doi: 10.3389/fgene.2021.753161

Products & Services: Gene Synthesis

Insulin-like growth factor 2 mRNA binding protein 2 regulates proliferation, migration and angiogenesis of keratinocytes by modulating heparanase stability

Authors: Shaomin Zhi, Jun Li, Xiao Kong, Xuemei Xie, Qiangli Zhang, Guoxiang Fang

Journal: Bioengineered

PubMed ID: 34753397

Doi: 10.1080/21655979.2021.2002495

Products & Services: ORF cDNA Clones/MolecularCloud

Reconstitution and use of highly active human CDK1:Cyclin-B:CKS1 complexes

Authors: Pim J Huis In 't Veld, Sabine Wohlgemuth, Carolin Koerner, Franziska Müller, Petra Janning, Andrea Musacchio

Journal: Protein Sci

PubMed ID: 34791727

Doi: 10.1002/pro.4233

Products & Services: Proteins, Expression, Isolation and Analysis

SARS-CoV-2 nucleocapsid protein interacts with immunoregulators and stress granules and phase separates to form liquid droplets

Authors: Syam Prakash Somasekharan, Martin Gleave

Journal: FEBS Lett

PubMed ID: 34780058

Doi: 10.1002/1873-3468.14229

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Serine palmitoyltransferase assembles at ER-mitochondria contact sites

Authors: Mari J Aaltonen, Irina Alecu, Tim König, Steffany Al Bennett, Eric A Shoubridge

Journal: Life Sci Alliance

PubMed ID: 34785538

Doi: 10.26508/lsa.202101278

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SEC23A rescues SEC23B-deficient congenital dyserythropoietic anemia type II

Authors: Richard King, Zesen Lin, Ginette Balbin-Cuesta, Gregg Myers, Ann Friedman, Guojing Zhu, Beth McGee, Thomas L Saunders, Ryo Kurita, Yukio Nakamura, James Douglas Engel, Pavan Reddy, Rami Khoriaty

Journal: Sci Adv

PubMed ID: 34818036

Doi: 10.1126/sciadv.abj5293

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MLL1 is regulated by KSHV LANA and is important for virus latency

Authors: Min Tan, Shijun Li, Franceline Juillard, Rute Chitas, Tânia F Custódio, Han Xue, Agnieszka Szymula, Qiming Sun, Bing Liu, Ángel L Álvarez, She Chen, Jing Huang, J Pedro Simas, Colin E McVey, Kenneth M Kaye

Journal: Nucleic Acids Res

PubMed ID: 34850113

Doi: 10.1093/nar/gkab1094

Products & Services: Peptide Synthesis

A cell-based multiplex immunoassay platform using fluorescent protein-barcoded reporter cell lines

Authors: Shengli Song, Miriam Manook, Jean Kwun, Annette M Jackson, Stuart J Knechtle, Garnett Kelsoe

Journal: Commun Biol

PubMed ID: 34824350

Doi: 10.1038/s42003-021-02881-w

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Protoplast isolation and transcriptome analysis of developing xylem in Pinus massoniana (Pinaceae)

Authors: Tengfei Shen, Mengxuan Xu, Haoran Qi, Yuanheng Feng, Zhangqi Yang, Meng Xu

Journal: Mol Biol Rep

PubMed ID: 34826048

Doi: 10.1007/s11033-021-06995-6

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Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study

Authors: Hamid Reza Kouhpayeh, Farhad Tabasi, Mohammad Dehvari, Mohammad Naderi, Gholamreza Bahari, Tahereh Khalili, Courtney Clark, Saeid Ghavami, Mohsen Taheri

Journal: Transl Med Commun

PubMed ID: 34805533

Doi: 10.1186/s41231-021-00106-0

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Prevalence of SARS-CoV-2 Antibody in 2,935 Healthcare Workers at 6 Major Hospitals, Daegu, Korea

Authors: Yu Kyung Kim, Dohsik Minn, Do Young Song, Chae Hoon Lee, Nam Hee Ryoo, Chang-Ho Jeon, Kyung Eun Song, Jang Soo Suh, Soon Hee Chang

Journal: J Korean Med Sci

PubMed ID: 34751011

Doi: 10.3346/jkms.2021.36.e294

AZD3759 enhances radiation effects in non-small-cell lung cancer by a synergistic blockade of epidermal growth factor receptor and Janus kinase-1

Authors: Ruing Zhao, Wei Yin, Qingqing Yu, Yanjiao Mao, Qinghua Deng, Ke Zhang, Shenglin Ma

Journal: Bioengineered

PubMed ID: 34738874

Doi: 10.1080/21655979.2021.2001238

Products & Services: Gene Synthesis

Development of surface engineered antigenic exosomes as vaccines for respiratory syncytial virus

Authors: Suyeon Hong, Shaobo Ruan, Zachary Greenberg, Mei He, Jodi L McGill

Journal: Sci Rep

PubMed ID: 34725399

Doi: 10.1038/s41598-021-00765-x

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CaMKK2 facilitates Golgi-associated vesicle trafficking to sustain cancer cell proliferation

Authors: Lorna M Stewart, Lisa Gerner, Mandy Rettel, Frank Stein, James F Burrows, Ian G Mills, Emma Evergren

Journal: Cell Death Dis

PubMed ID: 34725334

Doi: 10.1038/s41419-021-04335-x

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Breadth of CD8 T-cell mediated inhibition of replication of diverse HIV-1 transmitted-founder isolates correlates with the breadth of recognition within a comprehensive HIV-1 Gag, Nef, Env and Pol potential T-cell epitope (PTE) peptide set

Authors: Peter Hayes, Natalia Fernandez, Christina Ochsenbauer, Jama Dalel, Jonathan Hare, Deborah King, Lucas Black, Claire Streatfield, Vanaja Kakarla, Gladys Macharia, Julia Makinde, Matt Price, Eric Hunter, Jill Gilmour

Journal: PLoS ONE

PubMed ID: 34788349

Doi: 10.1371/journal.pone.0260118

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Antiseptic 9-Meric Peptide with Potency against Carbapenem-Resistant Infection

Authors: Manigandan Krishnan, Joonhyeok Choi, Ahjin Jang, Young Kyung Yoon, Yangmee Kim

Journal: Int J Mol Sci

PubMed ID: 34830401

Doi: 10.3390/ijms222212520

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Long noncoding RNA SNHG25 promotes the malignancy of endometrial cancer by sponging microRNA-497-5p and increasing FASN expression

Authors: Yuhua He, Shuifang Xu, Yi Qi, Jinfang Tian, Fengying Xu

Journal: J Ovarian Res

PubMed ID: 34789312

Doi: 10.1186/s13048-021-00906-w

Products & Services: Plasmid DNA Preparation

Comparison of Antibody Response Elicited by ChAdOx1 and BNT162b2 COVID-19 Vaccine

Authors: Yu Min Kang, Dohsik Minn, Jaegyun Lim, Ki-Deok Lee, Dong Ho Jo, Kang-Won Choe, Moon Jung Kim, Jong Min Kim, Kwang Nam Kim

Journal: J Korean Med Sci

PubMed ID: 34845875

Doi: 10.3346/jkms.2021.36.e311

PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates

Authors: Nobuyuki Shimizu, Tomoko Asatsuma-Okumura, Junichi Yamamoto, Yuki Yamaguchi, Hiroshi Handa, Takumi Ito

Journal: Commun Biol

PubMed ID: 34764413

Doi: 10.1038/s42003-021-02801-y

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PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ

Authors: Fengxiang Wang, Emily T Graham, Nathchar Naowarojna, Zhennan Shi, Yuqi Wang, Guanglei Xie, Lili Zhou, Wendy Salmon, Jie-Min Jia, Xi Wang, Yuwei Huang, Stuart L Schreiber, Yilong Zou

Journal: Cell Chem Biol

PubMed ID: 34813762

Doi: 10.1016/j.chembiol.2021.11.001

Products & Services: Proteins, Expression, Isolation and Analysis

Photobiomodulation inhibits the activation of neurotoxic microglia and astrocytes by inhibiting Lcn2/JAK2-STAT3 crosstalk after spinal cord injury in male rats

Authors: Xuankang Wang, Xin Li, Xiaoshuang Zuo, Zhuowen Liang, Tan Ding, Kun Li, Yangguang Ma, Penghui Li, Zhijie Zhu, Cheng Ju, Zhihao Zhang, Zhiwen Song, Huilin Quan, Jiawei Zhang, Xueyu Hu, Zhe Wang

Journal: J Neuroinflammation

PubMed ID: 34740378

Doi: 10.1186/s12974-021-02312-x

Products & Services: Proteins, Expression, Isolation and Analysis

3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels

Authors: Niraimathi Govindasamy, Hongyan Long, Hyun-Woo Jeong, Ratish Raman, Burak Özcifci, Simone Probst, Sebastian J Arnold, Kristina Riehemann, Adrian Ranga, Ralf H Adams, Britta Trappmann, Ivan Bedzhov

Journal: Dev Cell

PubMed ID: 34741805

Doi: 10.1016/j.devcel.2021.10.014

Products & Services: Proteins, Expression, Isolation and Analysis

Capillary electrophoresis-based functional genomics screening to discover novel archaeal DNA modifying enzymes

Authors: Kelly M Zatopek, Samantha L Fossa, Katharina Bilotti, Paul J Caffrey, Léa Chuzel, Alexandra M Gehring, Gregory J S Lohman, Christopher H Taron, Andrew F Gardner

Journal: Appl Environ Microbiol

PubMed ID: 34788065

Doi: 10.1128/AEM.02137-21

Products & Services: Plasmid DNA Preparation

New highly antigenic linear B cell epitope peptides from PvAMA-1 as potential vaccine candidates

Authors: Raianna F Fantin, Vanessa G Fraga, Camila A Lopes, Isabella C de Azevedo, João L Reis-Cunha, Dhelio B Pereira, Francisco P Lobo, Marcela M de Oliveira, Anderson C Dos Santos, Daniela C Bartholomeu, Ricardo T Fujiwara, Lilian L Bueno

Journal: PLoS ONE

PubMed ID: 34727117

Doi: 10.1371/journal.pone.0258637

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The tumor suppressor activity of DLC1 requires the interaction of its START domain with Phosphatidylserine, PLCD1, and Caveolin-1

Authors: Beatriz Sanchez-Solana, Dunrui Wang, Xiaolan Qian, Parthibane Velayoudame, Dhirendra K Simanshu, Jairaj K Acharya, Douglas R Lowy

Journal: Mol Cancer

PubMed ID: 34727930

Doi: 10.1186/s12943-021-01439-y

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The phage defence island of a multidrug resistant plasmid uses both BREX and type IV restriction for complementary protection from viruses

Authors: David M Picton, Yvette A Luyten, Richard D Morgan, Andrew Nelson, Darren L Smith, David T F Dryden, Jay C D Hinton, Tim R Blower

Journal: Nucleic Acids Res

PubMed ID: 34657954

Doi: 10.1093/nar/gkab906

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Effector-mediated membrane disruption controls cell death in CBASS antiphage defense

Authors: Brianna Duncan-Lowey, Nora K McNamara-Bordewick, Nitzan Tal, Rotem Sorek, Philip J Kranzusch

Journal: Mol Cell

PubMed ID: 34784509

Doi: 10.1016/j.molcel.2021.10.020

Products & Services: Mutant Libraries

Stress Induced Transcription Factors Transactivate the Herpes Simplex Virus 1 Infected Cell Protein 27 (ICP27) Transcriptional Enhancer

Authors: Jeffery B Ostler, Clinton Jones

Journal: Viruses

PubMed ID: 34835102

Doi: 10.3390/v13112296

Products & Services: Mutant Libraries

A mosquito AgTRIO monoclonal antibody reduces early infection of mice

Authors: Yu-Min Chuang, Xu-Dong Tang, Erol Fikrig

Journal: Infect Immun

PubMed ID: 34724388

Doi: 10.1128/IAI.00359-21

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Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization

Authors: Nikolas Friedrich, Emanuel Stiegeler, Matthias Glögl, Thomas Lemmin, Simon Hansen, Claus Kadelka, Yufan Wu, Patrick Ernst, Liridona Maliqi, Caio Foulkes, Mylène Morin, Mustafa Eroglu, Thomas Liechti, Branislav Ivan, Thomas Reinberg, Jonas V Schaefer, Umut Karakus, Stephan Ursprung, Axel Mann, Peter Rusert, Roger D Kouyos, John A Robinson, Huldrych F Günthard, Andreas Plückthun, Alexandra Trkola

Journal: Nat Commun

PubMed ID: 34795280

Doi: 10.1038/s41467-021-27075-0

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Structures of prokaryotic ubiquitin-like protein Pup in complex with depupylase Dop reveal the mechanism of catalytic phosphate formation

Authors: Hengjun Cui, Andreas U Müller, Marc Leibundgut, Jiawen Tian, Nenad Ban, Eilika Weber-Ban

Journal: Nat Commun

PubMed ID: 34789727

Doi: 10.1038/s41467-021-26848-x

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Tryptophan Side-Chain Oxidase Enzyme Suppresses Hepatocellular Carcinoma Growth through Degradation of Tryptophan

Authors: Yang Ai, Ben Wang, Shuai Xiao, Sang Luo, Yefu Wang

Journal: Int J Mol Sci

PubMed ID: 34830310

Doi: 10.3390/ijms222212428

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Germinal centre-driven maturation of B cell response to SARS-CoV-2 vaccination

Authors: Wooseob Kim, Julian Q Zhou, Alexandria J Sturtz, Stephen C Horvath, Aaron J Schmitz, Tingting Lei, Elizaveta Kalaidina, Mahima Thapa, Wafaa B Alsoussi, Alem Haile, Michael K Klebert, Teresa Suessen, Luis Parra-Rodriguez, Philip A Mudd, William D Middleton, Sharlene A Teefey, Iskra Pusic, Jane A O'Halloran, Rachel M Presti, Jackson S Turner, Ali H Ellebedy

Journal: biorxiv

PubMed ID: 34751268

Doi: 10.1101/2021.10.31.466651

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MiR-702-3p inhibits the inflammatory injury in septic H9c2 cells by regulating NOD1

Authors: Chun Liu, Yang Yang, Guiwen Liang, Aixian Zhang, Feng Xu

Journal: Transpl Immunol

PubMed ID: 34774740

Doi: 10.1016/j.trim.2021.101493

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T cell receptor therapy targeting mutant capicua transcriptional repressor in experimental gliomas

Authors: Michael Kilian, Mirco Friedrich, Khwab Sanghvi, Edward Green, Stefan Pusch, Daisuke Kawauchi, Martin Löwer, Jana K Sonner, Christopher Krämer, Julia Zaman, Stefanie Jung, Michael O Breckwoldt, Gerald Willimksy, Stefan B Eichmüller, Andreas von Deimling, Wolfgang Wick, Felix Sahm, Michael Platten, Lukas Bunse

Journal: Clin Cancer Res

PubMed ID: 34782365

Doi: 10.1158/1078-0432.CCR-21-1881

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Structural insights into bifunctional thaumarchaeal crotonyl-CoA hydratase and 3-hydroxypropionyl-CoA dehydratase from Nitrosopumilus maritimus

Authors: Ebru Destan, Busra Yuksel, Bradley B Tolar, Esra Ayan, Sam Deutsch, Yasuo Yoshikuni, Soichi Wakatsuki, Christopher A Francis, Hasan DeMirci

Journal: Sci Rep

PubMed ID: 34819551

Doi: 10.1038/s41598-021-02180-8

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