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Structural and functional insights into the spike protein mutations of emerging SARS-CoV-2 variants

Authors: Deepali Gupta, Priyanka Sharma, Mandeep Singh, Mukesh Kumar, A S Ethayathulla, Punit Kaur

Journal: Cell Mol Life Sci

PubMed ID: 34731254

Doi: 10.1007/s00018-021-04008-0

Products & Services: DNA Sequencing

Prokaryotic expression, evaluation, and prediction of the structure and function of the ecarin metalloproteinase domain

Authors: Nasrin Mohammadi, Mojgan Bandehpour, Fattah Sotoodehnejadnematalahi, Bahram Kazemi

Journal: Proteins

PubMed ID: 34739152

Doi: 10.1002/prot.26275

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African Swine Fever Virus pE199L Induces Mitochondrial-Dependent Apoptosis

Authors: Tingting Li, Gaihong Zhao, Taoqing Zhang, Zhaoxia Zhang, Xin Chen, Jie Song, Xiao Wang, Jiangnan Li, Li Huang, Lili Wen, Changyao Li, Dongming Zhao, Xijun He, Zhigao Bu, Jun Zheng, Changjiang Weng

Journal: Viruses

PubMed ID: 34835046

Doi: 10.3390/v13112240

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5' Half of specific tRNAs feeds back to promote corresponding tRNA gene transcription in vertebrate embryos

Authors: Luxi Chen, Wei Xu, Kunpeng Liu, Zheng Jiang, Yang Han, Hongbin Jin, Lin Zhang, Weimin Shen, Shunji Jia, Qianwen Sun, Anming Meng

Journal: Sci Adv

PubMed ID: 34797706

Doi: 10.1126/sciadv.abh0494

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Cyclophilin A is a key positive and negative feedback regulator within interleukin-6 trans-signaling pathway

Authors: Xiaohan Luan, Wenxian Yang, Xiaoyuan Bai, Heqiao Li, Huizi Li, Wenhui Fan, He Zhang, Wenjun Liu, Lei Sun

Journal: FASEB J

PubMed ID: 34606626

Doi: 10.1096/fj.202101044RRR

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A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA

Authors: Alicia K Byrd, Emory G Malone, Lindsey Hazeslip, Maroof Khan Zafar, David K Harrison, Matthew D Thompson, Jun Gao, Senthil K Perumal, John C Marecki, Kevin D Raney

Journal: Protein Sci

PubMed ID: 34761452

Doi: 10.1002/pro.4232

Products & Services: Codon Optimization

Identification and Characterization of Antigen-Specific CD8 T Cells Using Surface-Trapped TNF-α and Single-Cell Sequencing

Authors: Shaheed Abdulhaqq, Abigail B Ventura, Jason S Reed, Arman A Bashirova, Katherine B Bateman, Eric McDonald, Helen L Wu, Justin M Greene, John B Schell, David Morrow, Karin Wisskirchen, Jeffrey N Martin, Steven G Deeks, Mary Carrington, Ulrike Protzer, Klaus Früh, Scott G Hansen, Louis J Picker, Jonah B Sacha, Benjamin N Bimber

Journal: J Immunol

PubMed ID: 34810222

Doi: 10.4049/jimmunol.2100535

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The Ionic Selectivity of Lysenin Channels in Open and Sub-Conducting States

Authors: Andrew Bogard, Pangaea W Finn, Fulton McKinney, Ilinca M Flacau, Aviana R Smith, Rosey Whiting, Daniel Fologea

Journal: Membranes (Basel)

PubMed ID: 34832126

Doi: 10.3390/membranes11110897

Products & Services: Catalog Antibody

SARS-CoV-2 Infection of Rhesus Macaques Treated Early with Human COVID-19 Convalescent Plasma

Authors: Jesse D Deere, Timothy D Carroll, Joseph Dutra, Linda Fritts, Rebecca Lee Sammak, JoAnn L Yee, Katherine J Olstad, J Rachel Reader, Amy Kistler, Jack Kamm, Clara Di Germanio, Yashavanth Shaan Lakshmanappa, Sonny R Elizaldi, Jamin W Roh, Graham Simmons, Jennifer Watanabe, Rachel E Pollard, Jodie Usachenko, Ramya Immareddy, Brian A Schmidt, Shelby L O'Connor, Joseph DeRisi, Michael P Busch, Smita S Iyer, Koen K A Van Rompay, Dennis J Hartigan-O'Connor, Christopher J Miller

Journal: Microbiol Spectr

PubMed ID: 34817208

Doi: 10.1128/Spectrum.01397-21

Products & Services: Recombinant Proteins

Retinol-Binding Protein 4 Promotes Cardiac Injury After Myocardial Infarction Via Inducing Cardiomyocyte Pyroptosis Through an Interaction With NLRP3

Authors: Kang-Zhen Zhang, Xi-Yu Shen, Man Wang, Li Wang, Hui-Xian Sun, Xiu-Zhen Li, Jing-Jing Huang, Xiao-Qing Li, Cheng Wu, Can Zhao, Jia-Li Liu, Xiang Lu, Wei Gao

Journal: J Am Heart Assoc

PubMed ID: 34726071

Doi: 10.1161/JAHA.121.022011

Products & Services: Recombinant Proteins Protein Tools

Management of COVID patients with convalescent plasma: Do we have the final word?

Authors: Francesco Menichetti, Marco Falcone, Giusy Tiseo

Journal: Eur J Intern Med

PubMed ID: 34895816

Doi: 10.1016/j.ejim.2021.10.029

Products & Services: Recombinant Proteins

A study of cobalt (II) complexes involved in marine biogeochemical processes: Co(II)-1,10-Phenanthroline and Co(II)-1,10-Phenanthroline-L-α-Phosphatidylcholine

Authors: Anđela Bačinić, Sanja Frka, Marina Mlakar

Journal: Bioelectrochemistry

PubMed ID: 34902665

Doi: 10.1016/j.bioelechem.2021.108009

Products & Services: Peptide Synthesis

Immunotherapeutic Targeting of Mesothelin Positive Pediatric AML Using Bispecific T Cell Engaging Antibodies

Authors: Anilkumar Gopalakrishnapillai, Colin E Correnti, Kristina Pilat, Ida Lin, Man Kid Chan, Ashok D Bandaranayake, Christopher Mehlin, Anne Kisielewski, Darcy Hamill, Allison J Kaeding, Soheil Meshinchi, James M Olson, Edward Anders Kolb, Sonali P Barwe

Journal: Cancers (Basel)

PubMed ID: 34885074

Doi: 10.3390/cancers13235964

Products & Services: Gene Synthesis

Overexpression of N-acetylglucosaminyltransferase V promotes human parotid gland acinar cell immortalization via the epidermal receptor activation

Authors: Ching-Chia Cheng, Chih-Feng Lin, Yong-Chong Lin, Tai-Horng Young, Pei-Jen Lou

Journal: J Cell Physiol

PubMed ID: 34806177

Doi: 10.1002/jcp.30641

Products & Services: Proteins, Expression, Isolation and Analysis

Nucleic Acid Delivery from Granular Hydrogels

Authors: Evan Kurt, Tatiana Segura

Journal: Adv Healthc Mater

PubMed ID: 34742164

Doi: 10.1002/adhm.202101867

Products & Services: Proteins, Expression, Isolation and Analysis

Assembly of pH-Responsive Antibody-Drug-Inspired Conjugates

Authors: Marco Raabe, Astrid Johanna Heck, Siska Führer, Dominik Schauenburg, Michaela Pieszka, Tao Wang, Maksymilian Marek Zegota, Lutz Nuhn, David Y W Ng, Seah Ling Kuan, Tanja Weil

Journal: Macromol Biosci

PubMed ID: 34791790

Doi: 10.1002/mabi.202100299

Products & Services: Proteins, Expression, Isolation and Analysis

A single evolutionarily divergent mutation determines the different FAD-binding affinities of human and rat NQO1 due to site-specific phosphorylation

Authors: Juan Luis Pacheco-Garcia, Dmitry Loginov, Bruno Rizzuti, Pavla Vankova, Jose L Neira, Daniel Kavan, Noel Mesa-Torres, Rita Guzzi, Petr Man, Angel L Pey

Journal: FEBS Lett

PubMed ID: 34817874

Doi: 10.1002/1873-3468.14238

Products & Services: Gene Synthesis

Genomic structure, expression, and functional characterization of the Fem-1 gene family in the redclaw crayfish, Cherax quadricarinatus

Authors: Jianbo Zheng, Leran Chen, Yongyi Jia, Meili Chi, Fei Li, Shun Cheng, Shili Liu, Yinuo Liu, Zhimin Gu

Journal: Gen Comp Endocrinol

PubMed ID: 34861280

Doi: 10.1016/j.ygcen.2021.113961

Products & Services: Gene Synthesis

Commensal Strains Enhance the Efficacy of Neo-Epitope Based Cancer Vaccines

Authors: Michele Tomasi, Mattia Dalsass, Francesco Beghini, Ilaria Zanella, Elena Caproni, Laura Fantappiè, Assunta Gagliardi, Carmela Irene, Enrico König, Luca Frattini, Giulia Masetti, Samine Jessica Isaac, Federica Armanini, Fabio Cumbo, Aitor Blanco-Míguez, Alberto Grandi, Nicola Segata, Guido Grandi

Journal: Vaccines (Basel)

PubMed ID: 34835287

Doi: 10.3390/vaccines9111356

Products & Services: Peptide Synthesis

Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease

Authors: Marcel V Alavi

Journal: Biochim Biophys Acta Mol Cell Res.

PubMed ID: 34400172

Doi: 10.1016/j.bbamcr.2021.119116

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Cyclic peptides with a distinct arginine-fork motif recognize the HIV trans-activation response RNA in vitro and in cells

Authors: Sai Shashank Chavali, Sachitanand M Mali, Rachel Bonn, Abhijith Saseendran Anitha, Ryan P Bennett, Harold C Smith, Rudi Fasan, Joseph E Wedekind

Journal: J Biol Chem.

PubMed ID: 34767799

Doi: 10.1016/j.jbc.2021.101390

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Quantifying charge state heterogeneity for proteins with multiple ionizable residues

Authors: Martin J Fossat, Ammon E Posey, Rohit V Pappu

Journal: Biophys J

PubMed ID: 34826385

Doi: 10.1016/j.bpj.2021.11.2886

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Silencing of SBF2-AS1 inhibits cell growth and invasion by sponging microRNA-338-3p in serous ovarian carcinoma

Authors: Ai-Ai Luan, Ling-Ling Hou, Fang-Yuan Zhang

Journal: Kaohsiung J Med Sci

PubMed ID: 34850542

Doi: 10.1002/kjm2.12479

Products & Services: Gene Synthesis

Dl-3-N-Butylphthalide Attenuates Hypoxic Injury of Neural Stem Cells by Increasing Hypoxia-Inducible Factor-1alpha

Authors: Chaoqun Lin, Shiying Huang, Jianfeng Zhang, Huaitao Yuan, Tuchao Yao, Lukui Chen

Journal: J Stroke Cerebrovasc Dis

PubMed ID: 34837757

Doi: 10.1016/j.jstrokecerebrovasdis.2021.106221

Products & Services: Gene Synthesis

The Hydrogen-Coupled Oligopeptide Membrane Cotransporter Pept2 is SUMOylated in Kidney Distal Convoluted Tubule Cells

Authors: Takwa S Aroankins, Sathish K Murali, Robert A Fenton, Qi Wu

Journal: Front Mol Biosci

PubMed ID: 34881291

Doi: 10.3389/fmolb.2021.790606

Products & Services: Gene Synthesis

Characterization of the interaction domains between the phosphoprotein and the nucleoprotein of human Metapneumovirus

Authors: Hortense Decool, Benjamin Bardiaux, Luis Checa Ruano, Olivier Sperandio, Jenna Fix, Irina Gutsche, Charles-Adrien Richard, Monika Bajorek, Jean-François Eléouët, Marie Galloux

Journal: J Virol

PubMed ID: 34730389

Doi: 10.1128/JVI.00909-21

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Neural-Cadherin Influences the Homing of Terminally Differentiated Memory CD8 T Cells to the Lymph Nodes and Bone Marrow

Authors: Kyong Hoon Kim, Aryeong Choi, Sang Hoon Kim, Heonju Song, Seohoon Jin, Kyungim Kim, Jaebong Jang, Hanbyeul Choi, Yong Woo Jung

Journal: Mol Cells

PubMed ID: 34819396

Doi: 10.14348/molcells.2021.0137

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Autophagy Regulates VDAC3 Ubiquitination by FBXW7 to Promote Erastin-Induced Ferroptosis in Acute Lymphoblastic Leukemia

Authors: Ting Zhu, Bo Liu, Di Wu, Gang Xu, Yang Fan

Journal: Front Cell Dev Biol

PubMed ID: 34869326

Doi: 10.3389/fcell.2021.740884

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A poly(ethylene glycol) three-dimensional bone marrow hydrogel

Authors: Lauren E Jansen, Hyuna Kim, Christopher L Hall, Thomas P McCarthy, Michael J Lee, Shelly R Peyton

Journal: Biomaterials

PubMed ID: 34890973

Doi: 10.1016/j.biomaterials.2021.121270

Products & Services: Gene Synthesis

Oral Hsp90 inhibitor SNX-5422 attenuates SARS-CoV-2 replication and dampens inflammation in airway cells

Authors: Ria Goswami, Veronica S Russell, Joshua J Tu, Charlene Thomas, Philip Hughes, Francine Kelly, Stephanie N Langel, Justin Steppe, Scott M Palmer, Timothy Haystead, Maria Blasi, Sallie R Permar

Journal: iScience

PubMed ID: 34786537

Doi: 10.1016/j.isci.2021.103412

Products & Services: Plasmid DNA Preparation

Fabrication of MERS-nanovesicle biosensor composed of multi-functional DNA aptamer/graphene-MoS nanocomposite based on electrochemical and surface-enhanced Raman spectroscopy

Authors: Gahyeon Kim, Jinmyeong Kim, Soo Min Kim, Tatsuya Kato, Jinho Yoon, Seungwoo Noh, Enoch Y Park, Chulhwan Park, Taek Lee, Jeong-Woo Choi

Journal: Sens Actuators B Chem

PubMed ID: 34785863

Doi: 10.1016/j.snb.2021.131060

Products & Services: Recombinant Proteins

Genome-wide identification and characteristic analysis of the downstream melatonin metabolism gene GhM2H in Gossypium hirsutum L

Authors: Yuexin Zhang, Jing Wang, Xiugui Chen, Xuke Lu, Delong Wang, Junjuan Wang, Shuai Wang, Chao Chen, Lixue Guo, Waqar Afzal Malik, Yapeng Fan, Cun Rui, Ruifeng Cui, Qinqin Wang, Yuqian Lei, Wuwei Ye

Journal: Biol Res

PubMed ID: 34736526

Doi: 10.1186/s40659-021-00358-y

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LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy

Authors: Pin Li, Qin Li, Nilima Biswas, Hong Xin, Tanja Diemer, Lixian Liu, Lorena Perez Gutierrez, Giovanni Paternostro, Carlo Piermarocchi, Sergii Domanskyi, Ruikang K Wang, Napoleone Ferrara

Journal: EMBO Mol Med

PubMed ID: 34779136

Doi: 10.15252/emmm.202114511

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Tau-tubulin kinase 1 phosphorylates TDP-43 at disease-relevant sites and exacerbates TDP-43 pathology

Authors: Yuan Tian, Yi Wang, Angela M Jablonski, Yinghui Hu, Jonathan A Sugam, Markus Koglin, Shawn J Stachel, Heather Zhou, Jason M Uslaner, Sophie Parmentier-Batteur

Journal: Neurobiol Dis

PubMed ID: 34752923

Doi: 10.1016/j.nbd.2021.105548

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Bend family proteins mark chromatin boundaries and synergistically promote early germ cell differentiation

Authors: Guang Shi, Yaofu Bai, Xiya Zhang, Junfeng Su, Junjie Pang, Quanyuan He, Pengguihang Zeng, Junjun Ding, Yuanyan Xiong, Jingran Zhang, Jingwen Wang, Dan Liu, Wenbin Ma, Junjiu Huang, Zhou Songyang

Journal: Protein Cell

PubMed ID: 34731408

Doi: 10.1007/s13238-021-00884-1

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Sulforaphane suppresses autophagy during the malignant progression of gastric carcinoma via activating miR-4521/PIK3R3 pathway

Authors: Zi-Tan Peng, Pei Gu

Journal: Hum Exp Toxicol

PubMed ID: 34749521

Doi: 10.1177/09603271211054437

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Biosynthesis of Poly(3HB--3HP) with Variable Monomer Composition in Recombinant H16

Authors: Callum McGregor, Nigel P Minton, Katalin Kovács

Journal: ACS Synth Biol

PubMed ID: 34762808

Doi: 10.1021/acssynbio.1c00283

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A Genome-Phenome Association study in native microbiomes identifies a mechanism for cytosine modification in DNA and RNA

Authors: Weiwei Yang, Yu-Cheng Lin, William Johnson, Nan Dai, Romualdas Vaisvila, Peter Weigele, Yan-Jiun Lee, Ivan R Corrêa, Ira Schildkraut, Laurence Ettwiller

Journal: Elife

PubMed ID: 34747693

Doi: 10.7554/eLife.70021

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Poor neutralizing antibody responses in 106 patients with WM after vaccination against SARS-CoV-2: a prospective study

Authors: Maria Gavriatopoulou, Evangelos Terpos, Ioannis Ntanasis-Stathopoulos, Alexandros Briasoulis, Sentiljana Gumeni, Panagiotis Malandrakis, Despina Fotiou, Magdalini Migkou, Foteini Theodorakakou, Evangelos Eleutherakis-Papaiakovou, Nikolaos Kanellias, Efstathios Kastritis, Ioannis P Trougakos, Meletios A Dimopoulos

Journal: Blood Adv

PubMed ID: 34529762

Doi: 10.1182/bloodadvances.2021005444

The effect of Borago officinalis on the signaling pathway of the NLRP3 inflammasome complex, TLR4 and some inflammatory cytokines in type II diabetic patients with acute respiratory distress syndrome

Authors: Yanqiu Yue, Fengbin Jin, Xiaohui Yue

Journal: Cell Mol Biol (Noisy-le-grand)

PubMed ID: 34933712

Doi: 10.14715/cmb/2021.67.3.28

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SNHG17, as an EMT-related lncRNA, promotes the expression of c-Myc by binding to c-Jun in esophageal squamous cell carcinoma

Authors: Supeng Shen, Jia Liang, Xiaoliang Liang, Gaoyan Wang, Bo Feng, Wei Guo, Yanli Guo, Zhiming Dong

Journal: Cancer Sci

PubMed ID: 34714590

Doi: 10.1111/cas.15184

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Fasudil prevents neomycin-induced hair cell damage by inhibiting autophagy through the miR-489/NDP52 signaling pathway in HEI-OC1 cells

Authors: Wei Li, Yanqiu Zhang, Jifeng Xu, Jincan Chen, Xia Gao

Journal: Exp Ther Med

PubMed ID: 34849158

Doi: 10.3892/etm.2021.10965

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Vectored antibody gene delivery restores host B and T cell control of persistent viral infection

Authors: Yusuf I Ertuna, Benedict Fallet, Anna-Friederike Marx, Mirela Dimitrova, Anna Lena Kastner, Ingrid Wagner, Doron Merkler, Daniel D Pinschewer

Journal: Cell Rep

PubMed ID: 34852228

Doi: 10.1016/j.celrep.2021.110061

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Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells

Authors: Opeyemi S Adeniji, Leticia Kuri-Cervantes, Chenfei Yu, Ziyang Xu, Michelle Ho, Glen M Chew, Cecilia Shikuma, Costin Tomescu, Ashley F George, Nadia R Roan, Lishomwa C Ndhlovu, Qin Liu, Kar Muthumani, David B Weiner, Michael R Betts, Han Xiao, Mohamed Abdel-Mohsen

Journal: PLoS Pathog

PubMed ID: 34762717

Doi: 10.1371/journal.ppat.1010034

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Dual regulatory actions of LncBMP4 on BMP4 promote chicken primordial germ cell formation

Authors: Qisheng Zuo, Jin Jing, Jing Zhou, Yani Zhang, Wanhong Wei, Guohong Chen, Bichun Li

Journal: EMBO Rep

PubMed ID: 34747116

Doi: 10.15252/embr.202152491

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Genome-Wide Identification, Characterization and Expression Analysis of Soybean Gene Family

Authors: Bowei Jia, Yan Wang, Dajian Zhang, Wanhong Li, Hongli Cui, Jun Jin, Xiaoxi Cai, Yang Shen, Shengyang Wu, Yongxia Guo, Mingzhe Sun, Xiaoli Sun

Journal: Int J Mol Sci

PubMed ID: 34830077

Doi: 10.3390/ijms222212192

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Multicellular Ovarian Cancer Model for Evaluation of Nanovector Delivery in Ascites and Metastatic Environments

Authors: Stephen J Winter, Hunter A Miller, Jill M Steinbach-Rankins

Journal: Pharmaceutics

PubMed ID: 34834307

Doi: 10.3390/pharmaceutics13111891

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Understanding the Role of Genus in the Digestion of Lignocellulose and Other Substrates in Vietnamese Native Goats' Rumen by Metagenomic Deep Sequencing

Authors: Trong-Khoa Dao, Thi-Huyen Do, Ngoc-Giang Le, Hong-Duong Nguyen, Thi-Quy Nguyen, Thi-Thu-Hong Le, Nam-Hai Truong

Journal: Animals (Basel)

PubMed ID: 34827987

Doi: 10.3390/ani11113257

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Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells

Authors: Daniel Franjic, Mario Skarica, Shaojie Ma, Jon I Arellano, Andrew T N Tebbenkamp, Jinmyung Choi, Chuan Xu, Qian Li, Yury M Morozov, David Andrijevic, Zvonimir Vrselja, Ana Spajic, Gabriel Santpere, Mingfeng Li, Shupei Zhang, Yang Liu, Joshua Spurrier, Le Zhang, Ivan Gudelj, Lucija Rapan, Hideyuki Takahashi, Anita Huttner, Rong Fan, Stephen M Strittmatter, Andre M M Sousa, Pasko Rakic, Nenad Sestan

Journal: Neuron

PubMed ID: 34798047

Doi: 10.1016/j.neuron.2021.10.036

Products & Services: Recombinant Antibody Expression

Development and characterization of SARS-CoV-2 variant-neutralizing monoclonal antibodies

Authors: Hongyu Qiu, Xin-Yong Yuan, Teresa Cabral, Kathy Manguiat, Alyssia Robinson, Heidi Wood, Chris Grant, Peter McQueen, Garrett Westmacott, Daniel R Beniac, Lisa Lin, Michael Carpenter, Darwyn Kobasa, Tom Gräfenhan

Journal: Antiviral Res

PubMed ID: 34762975

Doi: 10.1016/j.antiviral.2021.105206

Products & Services: Proteins, Expression, Isolation and Analysis

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