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Proteolytic processing of plant proteins by potyvirus NIa proteases

Authors: Huogen Xiao, Etienne Lord, Hélène Sanfaçon

Journal: J Virol

PubMed ID: 34757836

Doi: 10.1128/JVI.01444-21

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Structure of native HIV-1 cores and their interactions with IP6 and CypA

Authors: Tao Ni, Yanan Zhu, Zhengyi Yang, Chaoyi Xu, Yuriy Chaban, Tanya Nesterova, Jiying Ning, Till Böcking, Michael W Parker, Christina Monnie, Jinwoo Ahn, Juan R Perilla, Peijun Zhang

Journal: Sci Adv

PubMed ID: 34797722

Doi: 10.1126/sciadv.abj5715

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Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity

Authors: Jonathan P Renn, Justin Y A Doritchamou, Bergeline C Nguemwo Tentokam, Robert D Morrison, Matthew V Cowles, Martin Burkhardt, Rui Ma, Niraj H Tolia, Michal Fried, Patrick E Duffy

Journal: Commun Biol

PubMed ID: 34799664

Doi: 10.1038/s42003-021-02787-7

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Multi-Antigen Outer Membrane Vesicle Engineering to Develop Polyvalent Vaccines: The Case

Authors: Enrico König, Assunta Gagliardi, Ilary Riedmiller, Chiara Andretta, Michele Tomasi, Carmela Irene, Luca Frattini, Ilaria Zanella, Francesco Berti, Alberto Grandi, Elena Caproni, Laura Fantappiè, Guido Grandi

Journal: Front Immunol

PubMed ID: 34819933

Doi: 10.3389/fimmu.2021.752168

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Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy

Authors: Jun Zheng, Xi Chen, Qiang Liu, Guisheng Zhong, Min Zhuang

Journal: J Cell Biol

PubMed ID: 34747980

Doi: 10.1083/jcb.202103156

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Identification of a gut microbiota member that ameliorates DSS-induced colitis in intestinal barrier enhanced Dusp6-deficient mice

Authors: Cherng-Shyang Chang, Yi-Chu Liao, Chih-Ting Huang, Chiao-Mei Lin, Chantal Hoi Yin Cheung, Jhen-Wei Ruan, Wen-Hsuan Yu, Yi-Ting Tsai, I-Jung Lin, Chien-Hsun Huang, Jong-Shian Liou, Ya-Hsien Chou, Hung-Jen Chien, Hsiao-Li Chuang, Hsueh-Fen Juan, Hsuan-Cheng Huang, Hong-Lin Chan, Yu-Chieh Liao, Shiue-Cheng Tang, Yu-Wen Su, Tse-Hua Tan, Andreas J Bäumler, Cheng-Yuan Kao

Journal: Cell Rep

PubMed ID: 34818535

Doi: 10.1016/j.celrep.2021.110016

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Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains*

Authors: Karen T Elvers, Magdalena Lipka-Lloyd, Rebecca C Trueman, Benjamin D Bax, Youcef Mehellou

Journal: Chembiochem

PubMed ID: 34726826

Doi: 10.1002/cbic.202100441

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Pharmacological modulation of the cAMP signaling of two isoforms of melanocortin-3 receptor by melanocortin receptor accessory proteins in the tetrapod Xenopus laevis

Authors: Ying Xu, Lei Li, Jihong Zheng, Meng Wang, Bopei Jiang, Yue Zhai, Liumei Lu, Cong Zhang, Zhe Kuang, Xiaomei Yang, Li-Na Jin, Gufa Lin, Chao Zhang

Journal: Endocr Connect

PubMed ID: 34678757

Doi: 10.1530/EC-21-0179

Products & Services: Recombinant Proteins

Structure of Rift Valley fever virus RNA-dependent RNA polymerase

Authors: Xue Wang, Cuixia Hu, Wei Ye, Jia Wang, Xiaofei Dong, Jie Xu, Xiaorong Li, Manfeng Zhang, Hongyun Lu, Fanglin Zhang, Wei Wu, Shaodong Dai, Hong-Wei Wang, Zhongzhou Chen

Journal: J Virol

PubMed ID: 34787453

Doi: 10.1128/JVI.01713-21

Products & Services: Proteins, Expression, Isolation and Analysis

Alpha adaptins show isoform-specific association with neurofibrillary tangles in Alzheimer's disease

Authors: Sukanya Srinivasan, Jozsef Gal, Adam Bachstetter, Peter T Nelson

Journal: Neuropathol Appl Neurobiol

PubMed ID: 34820873

Doi: 10.1111/nan.12776

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ABCC2 is a functional receptor of Bacillus thuringiensis Cry1Ca in Spodoptera litura

Authors: Xue Yao, Chen Liu, Yunpeng Duan, Shiheng An, Jizhen Wei, Gemei Liang

Journal: Int J Biol Macromol

PubMed ID: 34861271

Doi: 10.1016/j.ijbiomac.2021.11.174

Products & Services: Recombinant Proteins

Overcome Chemoresistance: Biophysical and Structural Analysis of Synthetic FHIT-Derived Peptides

Authors: Maria Carmina Scala, Simone Di Micco, Delia Lanzillotta, Simona Musella, Veronica Di Sarno, Barbara Parrino, Stella Maria Casciofierro, Giuseppe Bifulco, Francesco Trapasso, Pietro Campiglia, Marina Sala

Journal: Front Mol Biosci

PubMed ID: 34901149

Doi: 10.3389/fmolb.2021.715263

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Molecular characterization of substrate-induced ubiquitin transfer by UBR7-PHD finger, a newly identified histone H2BK120 ubiquitin ligase

Authors: Anirban Dasgupta, Payel Mondal, Sambit Dalui, Chandrima Das, Siddhartha Roy

Journal: FEBS J

PubMed ID: 34739193

Doi: 10.1111/febs.16262

Products & Services: Recombinant Proteins

Gamma delta TCR anti-CD3 bispecific molecules (GABs) as novel immunotherapeutic compounds

Authors: Eline van Diest, Patricia Hernández López, Angelo D Meringa, Anna Vyborova, Froso Karaiskaki, Sabine Heijhuurs, Jan Gumathi Bormin, Sanne van Dooremalen, Mara J T Nicolasen, Lucrezia C D E Gatti, Inez Johanna, Trudy Straetemans, Zsolt Sebestyén, Dennis X Beringer, Jürgen Kuball

Journal: J Immunother Cancer

PubMed ID: 34815357

Doi: 10.1136/jitc-2021-003850

Products & Services: Peptide Synthesis

The impact of reductants on the catalytic efficiency of a lytic polysaccharide monooxygenase and the special role of dehydroascorbic acid

Authors: Anton A Stepnov, Idd A Christensen, Zarah Forsberg, Finn L Aachmann, Gaston Courtade, Vincent G H Eijsink

Journal: FEBS Lett

PubMed ID: 34845720

Doi: 10.1002/1873-3468.14246

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Structural characterization of the porcine adeno-associated virus Po1 capsid protein binding to the nuclear trafficking protein importin alpha

Authors: Mikayla Hoad, Justin A Roby, Jade K Forwood

Journal: FEBS Lett

PubMed ID: 34661283

Doi: 10.1002/1873-3468.14209

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A simple PCR-RFLP method for identification and detection of medicinal toad and its crude drug even with serious degradation of DNA

Authors: Jiao Liu, Xinyi Shao, Ziying Zhou, Miao Lei, Mingyu Xia, Dong Wang

Journal: J Pharm Biomed Anal

PubMed ID: 34864355

Doi: 10.1016/j.jpba.2021.114495

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1,800 MHz Radiofrequency Electromagnetic Irradiation Impairs Neurite Outgrowth With a Decrease in Rap1-GTP in Primary Mouse Hippocampal Neurons and Neuro2a Cells

Authors: Yanqi Li, Ping Deng, Chunhai Chen, Qinlong Ma, Huifeng Pi, Mindi He, Yonghui Lu, Peng Gao, Chao Zhou, Zhixin He, Yanwen Zhang, Zhengping Yu, Lei Zhang

Journal: Front Public Health

PubMed ID: 34881219

Doi: 10.3389/fpubh.2021.771508

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Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy

Authors: Cristina Gil-Cruz, Christian Perez-Shibayama, Angelina De Martin, Francesca Ronchi, Katrien van der Borght, Rebekka Niederer, Lucas Onder, Mechthild Lütge, Mario Novkovic, Veronika Nindl, Gustavo Ramos, Markus Arnoldini, Emma M C Slack, Valérie Boivin-Jahns, Roland Jahns, Madeleine Wyss, Catherine Mooser, Bart N Lambrecht, Micha T Maeder, Hans Rickli, Lukas Flatz, Urs Eriksson, Markus B Geuking, Kathy D McCoy, Burkhard Ludewig

Journal: Science

PubMed ID: 31727837

Doi: 10.1126/science.aav3487

Products & Services: Peptoid Synthesis Peptide Library Services

Two energy barriers and a transient intermediate state determine the unfolding and folding dynamics of cold shock protein

Authors: Haiyan Hong, Zilong Guo, Hao Sun , Ping Yu , Huanhuan Su , Xuening Ma & Hu Chen

Journal: Communications Chemistry

Doi: doi.org/10.1038/s42004-021-00592-1

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Performance Evaluation of the BZ COVID-19 Neutralizing Antibody Test for the Culture-Free and Rapid Detection of SARS-CoV-2 Neutralizing Antibodies

Authors: Bo Kyeung Jung, Jung Yoon, Joon-Yong Bae, Jeonghun Kim, Man-Seong Park, Suk Yong Lee, Chae Seung Lim

Journal: Diagnostics (Basel)

PubMed ID: 34943430

Doi: 10.3390/diagnostics11122193

Products & Services: Protein Reagents and Products

Picomolar inhibition of SARS-CoV-2 variants of concern by an engineered ACE2-IgG4-Fc fusion protein

Authors: Hristo L Svilenov, Julia Sacherl, Alwin Reiter, Lisa S Wolff, Cho-Chin Cheng, Marcel Stern, Vincent Grass, Martin Feuerherd, Frank-Peter Wachs, Nicole Simonavicius, Susanne Pippig, Florian Wolschin, Oliver T Keppler, Johannes Buchner, Carsten Brockmeyer, Ulrike Protzer

Journal: Antiviral Res

PubMed ID: 34774603

Doi: 10.1016/j.antiviral.2021.105197

Products & Services: Protein Reagents and Products

Kinetics of anti-SARS-CoV-2 neutralizing antibodies development after BNT162b2 vaccination in patients with amyloidosis and the impact of therapy

Authors: Efstathios Kastritis, Evangelos Terpos, Zoi Evangelakou, Foteini Theodorakakou, Despina Fotiou, Maria S Manola, Despoina D Gianniou, Tina Bagratuni, Nikolaos Kanellias, Magdalini Migkou, Maria Gavriatopoulou, Ioannis P Trougakos, Meletios A Dimopoulos

Journal: Am J Hematol

PubMed ID: 34778995

Doi: 10.1002/ajh.26406

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Backbone H, N, and C resonance assignments of the non-structural protein NS2B of Zika virus

Authors: Beatriz Rosa Penna, Danielle Maria P de Oliveira, Cristiane Dinis Anobom, Ana Paula Valente

Journal: Biomol NMR Assign

PubMed ID: 34817802

Doi: 10.1007/s12104-021-10055-2

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Cholecystokinin-B Receptor-Targeted Nanoparticle for Imaging and Detection of Precancerous Lesions in the Pancreas

Authors: Jill P Smith, Hong Cao, Elijah F Edmondson, Siva Sai Krishna Dasa, Stephan T Stern

Journal: Biomolecules

PubMed ID: 34944412

Doi: 10.3390/biom11121766

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The concentration of brain homogenates with the Amicon Ultra Centrifugal filters

Authors: Joshua Yang, Rachita K Sumbria

Journal: MethodsX

PubMed ID: 35004217

Doi: 10.1016/j.mex.2021.101584

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Biochemical basis for an interaction between SNX27 and the flexible SNX1 N-terminus

Authors: Mintu Chandra, Brett M Collins, Lauren P Jackson

Journal: Adv Biol Regul

PubMed ID: 34866035

Doi: 10.1016/j.jbior.2021.100842

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Endotoxin contamination in commercially available Cas9 proteins potentially induces T-cell mediated responses

Authors: Vijaya L Simhadri, Joseph R McGill, Zuben E Sauna

Journal: Gene Ther

PubMed ID: 34744169

Doi: 10.1038/s41434-021-00301-6

Products & Services: Proteins, Expression, Isolation and Analysis

JNK/Itch Axis Mediates the Lipopolysaccharide-Induced Ubiquitin-Proteasome-Dependent Degradation of Ferritin Light Chain in Murine Macrophage Cells

Authors: Shufen He, Jianqi Xue, Pengxiu Cao, Jianyuan Hou, Yan Cui, Jing Chang, Liying Huang, Yu Han, Xianglin Duan, Ke Tan, Yumei Fan

Journal: Inflammation

PubMed ID: 34837126

Doi: 10.1007/s10753-021-01603-y

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Characterization of Anti-Ana o 3 Monoclonal Antibodies and Their Application in Comparing Brazilian Cashew Cultivars

Authors: Christopher P Mattison, Barry Vant-Hull, Ana Cecilia Ribeiro de Castro, Heidi J Chial, Yvette Bren-Mattison, Peter J Bechtel, Edy Sousa de Brito

Journal: Antibodies (Basel)

PubMed ID: 34939998

Doi: 10.3390/antib10040046

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Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy

Authors: Sheng-Li Ming , Shuang Zhang , Qi Wang , Lei Zeng , Lu-Yu Zhou , Meng-Di Wang , Ying-Xian Ma , Li-Qiang Han , Kai Zhong , He-Shui Zhu , Yi-Lin Bai , Guo-Yu Yang , Jiang Wang , Bei-Bei Chu

Journal: Autophagy

PubMed ID: 34822318

Doi: 10.1080/15548627.2021.2002101

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Novel xylan-degrading enzymes from polysaccharide utilizing loci of Prevotella copri DSM18205

Authors: Javier A Linares-Pastén , Johan Sebastian Hero , José Horacio Pisa , Cristina Teixeira , Margareta Nyman , Patrick Adlercreutz , M Alejandra Martinez , Eva Nordberg Karlsson

Journal: Glycobiology

PubMed ID: 34142143

Doi: 10.1093/glycob/cwab056

Products & Services: Gene Synthesis

Phylogenetic Analysis of the Plant U2 snRNP Auxiliary Factor Large Subunit A Gene Family in Response to Developmental Cues and Environmental Stimuli

Authors: Shuai Lu, Cong Gao, Yongzhou Wang, Yingying He, Junrong Du, Moxian Chen, Hua Zhao, Hui Fang, Baohua Wang, Yunying Cao

Journal: Front Plant Sci

PubMed ID: 34868124

Doi: 10.3389/fpls.2021.739671

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Wilavidin - a novel member of the avidin family that forms unique biotin-binding hexamers

Authors: Orly Avraham, Edward A Bayer, Oded Livnah

Journal: FEBS J

PubMed ID: 34726340

Doi: 10.1111/febs.16259

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Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants

Authors: Matthew McCallum, Alexandra C Walls, Kaitlin R Sprouse, John E Bowen, Laura E Rosen, Ha V Dang, Anna De Marco, Nicholas Franko, Sasha W Tilles, Jennifer Logue, Marcos C Miranda, Margaret Ahlrichs, Lauren Carter, Gyorgy Snell, Matteo Samuele Pizzuto, Helen Y Chu, Wesley C Van Voorhis, Davide Corti, David Veesler

Journal: Science

PubMed ID: 34751595

Doi: 10.1126/science.abl8506

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Immune Responses to a Single Dose of the AZD1222/Covishield Vaccine at 16 Weeks in Individuals in Sri Lanka

Authors: Chandima Jeewandara, Dinuka Guruge, Pradeep Darshana Pushpakumara, Achala Kamaladasa, Inoka Sepali Aberathna, Shyrar Tanussiya Ramu, Banuri Gunasekera, Ayesha Wijesinghe, Osanda Dissanayake, Heshan Kuruppu, Thushali Ranasinghe, Deshni Jayathilaka, Shashika Dayarathna, Dinithi Ekanayake, Jeewantha Jayamali, Nayanathara Gamalath, Anushika Mudunkotiwa, Gayasha Somathilake, Madhushika Dissanayake, Michael Harvie, Thashmi Nimasha, Deshan Madusanka, Tibutius Jayadas, Ruwan Wijayamuni, Lisa Schimanski, Pramila Rijal, Tiong K Tan, Alain Townsend, Graham S Ogg, Gathsaurie Neelika Malavige

Journal: J Immunol

PubMed ID: 34750205

Doi: 10.4049/jimmunol.2100762

Products & Services: Recombinant Antibody Expression

α-Klotho released from HK-2 cells inhibits osteogenic differentiation of renal interstitial fibroblasts by inactivating the Wnt-β-catenin pathway

Authors: Zewu Zhu, Shuhao Ruan, Yingcheng Jiang, Fang Huang, Weiping Xia, Jinbo Chen, Yu Cui, Cheng He, Feng Zeng, Yang Li, Zhiyong Chen, Hequn Chen

Journal: Cell Mol Life Sci

PubMed ID: 34724098

Doi: 10.1007/s00018-021-03972-x

Products & Services: Proteins, Expression, Isolation and Analysis

Hydrolytically Stable Maleimide-End-Functionalized Polymers for Site-Specific Protein Conjugation

Authors: Thaiesha A Wright, Monica Sharfin Rahman, Camaryn Bennett, Madolynn R Johnson, Henry Fischesser, Natasha Ram, Amoni Tyler, Richard C Page, Dominik Konkolewicz

Journal: Bioconjug Chem

PubMed ID: 34730954

Doi: 10.1021/acs.bioconjchem.1c00487

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LDH nanoparticle adjuvant subunit vaccine induces an effective immune response for porcine epidemic diarrhea virus

Authors: Danyi Shi, Baochao Fan, Bing Sun, Jinzhu Zhou, Yongxiang Zhao, Rongli Guo, Zengjun Ma, Tao Song, Huiying Fan, Jizong Li, Li Li, Bin Li

Journal: Virology

PubMed ID: 34739917

Doi: 10.1016/j.virol.2021.10.010

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Polyactin A and CpG enhance inactivated Pseudomonas plecoglossicida vaccine potency in large yellow croaker (Larimichthys crocea)

Authors: Wenwen Wang, Wei Wang, Wenjun Xu, Qin Liu, Yuanxing Zhang, Xiaohong Liu

Journal: Fish Shellfish Immunol

PubMed ID: 34780977

Doi: 10.1016/j.fsi.2021.11.008

Products & Services: Plasmid DNA Preparation

STING inhibition accelerates the bone healing process while enhancing type H vessel formation

Authors: Xiaojun Chen, Wenxin He, Mengzhe Sun, Yingjie Yan, Yichuan Pang, Gang Chai

Journal: FASEB J

PubMed ID: 34694030

Doi: 10.1096/fj.202100069RR

Products & Services: Nucleic Acid Purification & Analysis

Structural basis and mechanism of activation of two different families of G proteins by the same GPCR

Authors: Kamela O Alegre, Navid Paknejad, Minfei Su, Jian-Shu Lou, Jianyun Huang, Kelsey D Jordan, Edward T Eng, Joel R Meyerson, Richard K Hite, Xin-Yun Huang

Journal: Nat Struct Mol Biol

PubMed ID: 34759376

Doi: 10.1038/s41594-021-00679-2

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Circular RNA hsa_circ_0043278 inhibits breast cancer progression via the miR-455-3p/EI24 signalling pathway

Authors: Yue Shi, Chong Liu

Journal: BMC Cancer

PubMed ID: 34800978

Doi: 10.1186/s12885-021-08989-w

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Mapping enzyme catalysis with metabolic biosensing

Authors: Linfeng Xu, Kai-Chun Chang, Emory M Payne, Cyrus Modavi, Leqian Liu, Claire M Palmer, Nannan Tao, Hal S Alper, Robert T Kennedy, Dale S Cornett, Adam R Abate

Journal: Nat Commun

PubMed ID: 34815408

Doi: 10.1038/s41467-021-27185-9

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SpSR-B2 functions as a potential pattern recognition receptor involved in antiviral and antibacterial immune responses of mud crab Scylla paramamosain

Authors: Jian Zhou, Jun-Fang Zhou, Yue Wang, Guang-Peng Feng, Wen-Hong Fang, Wei Kang, Ling-Bo Ma, Xin-Cang Li

Journal: Int J Biol Macromol

PubMed ID: 34780895

Doi: 10.1016/j.ijbiomac.2021.11.048

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Photoredox-Catalyzed Decarboxylative -Terminal Differentiation for Bulk- and Single-Molecule Proteomics

Authors: Le Zhang, Brendan M Floyd, Maheshwerreddy Chilamari, James Mapes, Jagannath Swaminathan, Steven Bloom, Edward M Marcotte, Eric V Anslyn

Journal: ACS Chem Biol

PubMed ID: 34734691

Doi: 10.1021/acschembio.1c00631

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Elevated Fab glycosylation of anti-hinge antibodies

Authors: J Koers, Nil Derksen, Wjj Falkenburg, P Ooijevaar-de Heer, M T Nurmohamed, G J Wolbink, T Rispens

Journal: Scand J Rheumatol

PubMed ID: 34726124

Doi: 10.1080/03009742.2021.1986959

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Using recombinant adhesive proteins as durable and green flame-retardant coatings

Authors: Weng I Leong, Owen Lok In Lo, Fong Tin Cheng, Wai Man Cheong, Leo Chi U Seak

Journal: Synth Syst Biotechnol

PubMed ID: 34786512

Doi: 10.1016/j.synbio.2021.10.005

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Structure and Function of a Dual Reductase-Dehydratase Enzyme System Involved in -Terphenyl Biosynthesis

Authors: Jonathan A Clinger, Yinan Zhang, Yang Liu, Mitchell D Miller, Ronnie E Hall, Steven G Van Lanen, George N Phillips, Jon S Thorson, Sherif I Elshahawi

Journal: ACS Chem Biol

PubMed ID: 34763417

Doi: 10.1021/acschembio.1c00701

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Biodegradation of diphenyl ether herbicide lactofen by Bacillus sp YS-1 and characterization of two initial degrading esterases

Authors: Na Shang, Lingling Chen, Minggen Cheng, Yanning Tian, Xing Huang

Journal: Sci Total Environ

PubMed ID: 34742792

Doi: 10.1016/j.scitotenv.2021.151357

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