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A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells (TCR-T cells) against hepatocellular carcinoma

Authors: Wei Zhu, Zhiming Zhang, Jinzhang Chen, Xiaolan Chen, Lei Huang, Xiaoyong Zhang, Xuan Huang, Na Ma, Weikang Xu, Xuan Yi, Xinyu Lu, Xin Fu, Siwei Li, Guoheng Mo, Yiyue Wang, Guosheng Yuan, Mengya Zang, Qi Li, Xiaotao Jiang, Yajing He, Sha Wu, Yukai He, Yongyin Li, Jinlin Hou

Journal: Signal Transduct Target Ther

PubMed ID: 38643203

Doi: 10.1038/s41392-024-01792-6

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Dual mode of DDX3X as an ATP-dependent RNA helicase and ATP-independent nucleic acid chaperone

Authors: Yi-Ning He, Xiao-Rui Han, Dong Wang, Jia-Li Hou, Xi-Miao Hou

Journal: Biochem Biophys Res Commun

PubMed ID: 38669753

Doi: 10.1016/j.bbrc.2024.149964

Products & Services: DNA Sequencing

Ferroptosis and HMGB2 induced calreticulin translocation required for immunogenic cell death are controlled by the nuclear exporter XPO1

Authors: Ian Blair, Jingqi Fan, Kevin Gillespie, Clementina Mesaros

Journal: Res Sq

PubMed ID: 38496553

Doi: 10.21203/rs.3.rs-4009459/v1

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Protein localization of aquaporins in the adult female disease vector mosquito,

Authors: Britney Picinic, Jean-Paul V Paluzzi, Andrew Donini

Journal: Front Insect Sci

PubMed ID: 38699443

Doi: 10.3389/finsc.2024.1365651

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Validation for the function of protein C in mouse models

Authors: Ya Liu, Maoping Cai, Yan Chen, Guocai Wu, Songyu Li, Zhanghui Chen

Journal: PeerJ

PubMed ID: 38680896

Doi: 10.7717/peerj.17261

Products & Services: DNA Sequencing

Transmembrane conformation of the envelope protein of an alpha coronavirus, NL63

Authors: Iva Sučec, Yanina Pankratova, Mriganka Parasar, Mei Hong

Journal: Protein Sci

PubMed ID: 38501465

Doi: 10.1002/pro.4923

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The SARS-CoV-2 Spike Protein Receptor-Binding Domain Expressed in Rice Callus Features a Homogeneous Mix of Complex-Type Glycans

Authors: Guillermo Sobrino-Mengual, Victoria Armario-Nájera, Juliette Balieu, Marie-Laure Walet-Balieu, Andrea Saba-Mayoral, Ana M Pelacho, Teresa Capell, Paul Christou, Muriel Bardor, Patrice Lerouge

Journal: Int J Mol Sci

PubMed ID: 38674051

Doi: 10.3390/ijms25084466

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Selective Detection of Active Extracellular Granzyme A by Using a Novel Fluorescent Immunoprobe with Application to Inflammatory Diseases

Authors: Ana Senan-Salinas, Laura Comas, Patricia Esteban, Marcela Garzón-Tituaña, Zhiming Cheng, Llipsy Santiago, Maria Pilar Domingo, Ariel Ramírez-Labrada, José Ramón Paño-Pardo, Marc Vendrell, Julián Pardo, Maykel A Arias, Eva M Galvez

Journal: ACS Pharmacol Transl Sci

PubMed ID: 38751645

Doi: 10.1021/acsptsci.4c00065

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Identification and Quantification of a Pneumococcal Cell Wall Polysaccharide by Antibody-Enhanced Chromatography Assay

Authors: James Z Deng, Zhifeng Chen, James Small, Yue Yuan, Kara Cox, Aimin Tang, Jeanette Roman, Liming Guan, Katrina Feller, Frances Ansbro, Kalpit Vora

Journal: Vaccines (Basel)

PubMed ID: 38793720

Doi: 10.3390/vaccines12050469

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Catalytic specificity and crystal structure of cystathionine γ-lyase from Pseudomonas aeruginosa

Authors: Marco Pedretti, Carmen Fernández-Rodríguez, Carolina Conter, Iker Oyenarte, Filippo Favretto, Adele di Matteo, Paola Dominici, Maria Petrosino, Maria Luz Martinez-Chantar, Tomas Majtan, Alessandra Astegno, Luis Alfonso Martínez-Cruz

Journal: Sci Rep

PubMed ID: 38654065

Doi: 10.1038/s41598-024-57625-7

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Intestinal MAdCAM-1 imaging as biomarker for prognostic in murine models of multiple sclerosis

Authors: Erwan Baudron, Sara Martinez de Lizarrondo, Maxime Gauberti, Barbara Delaunay-Piednoir, Antoine P Fournier, Denis Vivien, Fabian Docagne, Isabelle Bardou

Journal: Brain Behav Immun

PubMed ID: 38604270

Doi: 10.1016/j.bbi.2024.04.006

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An improved system to generate recombinant canine distemper virus

Authors: Huai Cheng, Hewei Zhang, Huayun Zhang, Huanchang Cai, Min Liu, Mingen Yu, Meihua Xiang, Shubo Wen, Jingqiang Ren

Journal: BMC Vet Res

PubMed ID: 38678249

Doi: 10.1186/s12917-023-03830-x

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Reverse-Phase Protein Microarrays for Overexpressed Lysates Reveal a Novel Tyrosine Kinase

Authors: Batuhan Birol Keskin, Chien-Sheng Chen, Pei-Shan Tsai, Pin-Xian Du, John Harvey M Santos, Guan-Da Syu

Journal: Anal Chem

PubMed ID: 38683735

Doi: 10.1021/acs.analchem.4c00965

Products & Services: Proteins, Expression, Isolation and Analysis

MCT4 and CD147 colocalize with MMP14 in invadopodia and support matrix degradation and invasion by breast cancer cells

Authors: Signe Meng, Ester E Sørensen, Muthulakshmi Ponniah, Jeppe Thorlacius-Ussing, Roxane Crouigneau, Tanja Larsen, Magnus T Borre, Nicholas Willumsen, Mette Flinck, Stine F Pedersen

Journal: J Cell Sci

PubMed ID: 38661040

Doi: 10.1242/jcs.261608

Products & Services: Proteins, Expression, Isolation and Analysis

mARC1 in MASLD: Modulation of lipid accumulation in human hepatocytes and adipocytes

Authors: Amanda K Jones, Besnik Bajrami, Morgan K Campbell, Abdullah Mesut Erzurumluoglu, Qiusha Guo, Hongxing Chen, Xiaomei Zhang, Svetlana Zeveleva, David Kvaskoff, Andreas-David Brunner, Stefanie Muller, Vasudha Gathey, Rajvee M Dave, James W Tanner, Sophia Rixen, Michel A Struwe, Kathryn Phoenix, Kaitlyn J Klumph, Heather Robinson, Daniel Veyel, Annkatrin Muller, Boris Noyvert, Boris Alexander Bartholdy, Agnes A Steixner-Kumar, Jan Stutzki, Dmitriy Drichel, Steffen Omland, Ryan Sheehan, Jon Hill, Tom Bretschneider, Dirk Gottschling, Axel J Scheidig, Bernd Clement, Martin Giera, Zhihao Ding, John Broadwater, Curtis R Warren

Journal: Hepatol Commun

PubMed ID: 38619429

Doi: 10.1097/HC9.0000000000000365

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Characterization of genital chlamydia trachomatis infection among women attending infertility and gynecology clinics in Hunan, China

Authors: Qianting Zhou, Jiayan Li, Lipei Luo, Shuling Min, Li Wang, Lixiu Peng, Yinglan Hou, Ping He, Song He, Shixing Tang, Hongliang Chen

Journal: BMC Infect Dis

PubMed ID: 38622501

Doi: 10.1186/s12879-024-09254-8

Products & Services: Proteins, Expression, Isolation and Analysis

Structural basis for human Cav3.2 inhibition by selective antagonists

Authors: Jian Huang, Xiao Fan, Xueqin Jin, Chen Lyu, Qinmeng Guo, Tao Liu, Jiaofeng Chen, Amaël Davakan, Philippe Lory, Nieng Yan

Journal: Cell Research

PubMed ID: 38605177

Doi: 10.1038/s41422-024-00959-8

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Comparison of antibody-based immunotherapeutics for malignant hematological disease in an experimental murine model

Authors: Karin Frebel, Jörn C Albring, Anika Wohlgemuth, Christian Schwöppe, Stephan Hailfinger, Georg Lenz, Matthias Stelljes

Journal: Blood

PubMed ID: 38197968

Doi: 10.1182/bloodadvances.2023011647

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Somatic and intergenerational G4C2 hexanucleotide repeat instability in a human C9orf72 knock-in mouse model

Authors: Nada Kojak, Junko Kuno, Kristina E Fittipaldi, Ambereen Khan, David Wenger, Michael Glasser, Roberto A Donnianni, Yajun Tang, Jade Zhang, Katie Huling, Roxanne Ally, Alejandro O Mujica, Terrence Turner, Gina Magardino, Pei Yi Huang, Sze Yen Kerk, Gustavo Droguett, Marine Prissette, Jose Rojas, Teodoro Gomez, Anthony Gagliardi, Charleen Hunt, Jeremy S Rabinowitz, Guochun Gong, William Poueymirou, Eric Chiao, Brian Zambrowicz, Chia-Jen Siao, Daisuke Kajimura

Journal: Nucleic Acids Res

PubMed ID: 38597682

Doi: 10.1093/nar/gkae250

Products & Services: PCR Cloning and Subcloning

A hemoprotein with a zinc-mirror heme site ties heme availability to carbon metabolism in cyanobacteria

Authors: Nicolas Grosjean, Estella F Yee, Desigan Kumaran, Kriti Chopra, Macon Abernathy, Sandeep Biswas, James Byrnes, Dale F Kreitler, Jan-Fang Cheng, Agnidipta Ghosh, Steven C Almo, Masakazu Iwai, Krishna K Niyogi, Himadri B Pakrasi, Ritimukta Sarangi, Hubertus van Dam, Lin Yang, Ian K Blaby, Crysten E Blaby-Haas

Journal: Nature Communications

PubMed ID: 38609367

Doi: 10.1038/s41467-024-47486-z

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A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting

Authors: Connor Chain, Joseph P Sheehan, Xincheng Xu, Soodabeh Ghaffari, Aneesh Godbole, Hahn Kim, Joel S Freundlich, Joshua D Rabinowitz, Zemer Gitai

Journal: Nature Microbiology

PubMed ID: 38594311

Doi: 10.1038/s41564-024-01665-2

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Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency

Authors: Matthew B Johnson, Masato Ogishi, Clara Domingo-Vila, Elisa De Franco, Matthew N Wakeling, Zineb Imane, Brittany Resnick, Evangelia Williams, Rui Pedro Galão, Richard Caswell, James Russ-Silsby, Yoann Seeleuthner , Darawan Rinchai, Iris Fagniez, Basilin Benson, Matthew J Dufort, Cate Speake , Megan E Smithmyer, Michelle Hudson, Rebecca Dobbs; EXE-T1D consortium; Zoe Quandt, Andrew T Hattersley ,Peng Zhang, Stephanie Boisson-Dupuis , Mark S Anderson, Jean-Laurent Casanova, Timothy I Tree, Richard A Oram

Journal: Journal Of Experimental Medicine

PubMed ID: 38634869

Doi: 10.1084/jem.20231704

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Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade

Authors: Hao Nie, Pratima Saini, Taito Miyamoto, Liping Liao, Rafal J Zielinski, Heng Liu, Wei Zhou, Chen Wang, Brennah Murphy, Martina Towers, Tyler Yang, Yuan Qi, Toshitha Kannan, Andrew Kossenkov, Hiroaki Tateno, Daniel T Claiborne, Nan Zhang, Mohamed Abdel-Mohsen, Rugang Zhang

Journal: Nature Communications

PubMed ID: 38565883

Doi: 10.1038/s41467-024-47069-y

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Antisense oligonucleotide therapeutic approach for Timothy syndrome

Authors: Xiaoyu Chen, Fikri Birey,John Huguenard, Sergiu P Pașca

Journal: Nature

PubMed ID: 38658687

Doi: 10.1038/s41586-024-07310-6

Cryo-EM structure of the human Asc-1 transporter complex

Authors: Yaning Li , Yingying Guo, Angelika Bröer, Lu Dai, Stefan Brӧer , Renhong Yan

Journal: Nat Commun

PubMed ID: 38589439

Doi: 10.1038/s41467-024-47468-1

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Coiled-Coil Protein Hydrogels Engineered with Minimized Fiber Diameters for Sustained Release of Doxorubicin in Triple-Negative Breast Cancer

Authors: Dustin Britton, Jakub Legocki, Deven Paul, Olga Katsara, Orlando Aristizabal, Neelam Pandya, Orin Mishkit, Yingxin Xiao, Matias Aristizabal, Neha Rahman, Robert Schneider, Youssef Z Wadghiri, Jin Kim Montclare

Journal: ACS Biomater Sci Eng

PubMed ID: 38622760

Doi: 10.1021/acsbiomaterials.4c00349

Products & Services: Molecular Biology Reagents

Depolymerization of SUMO chains induces slender to stumpy differentiation in T brucei bloodstream parasites

Authors: Paula Ana Iribarren, Lucía Ayelén Di Marzio, María Agustina Berazategui, Andreu Saura, Lorena Coria, Juliana Cassataro, Federico Rojas, Miguel Navarro, Vanina Eder Alvarez

Journal: PLoS Pathog

PubMed ID: 38635823

Doi: 10.1371/journal.ppat.1012166

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FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy

Authors: Jack D Chan, Christina M Scheffler, Isabelle Munoz, Kevin Sek, Joel N Lee, Yu-Kuan Huang, Kah Min Yap, Nicole Y L Saw, Jasmine Li, Amanda X Y Chen, Cheok Weng Chan, Emily B Derrick, Kirsten L Todd, Junming Tong, Phoebe A Dunbar, Jiawen Li, Thang X Hoang, Maria N de Menezes, Emma V Petley, Joelle S Kim, Dat Nguyen, Patrick S K Leung, Joan So, Christian Deguit, Joe Zhu, Imran G House, Lev M Kats, Andrew M Scott, Benjamin J Solomon, Simon J Harrison, Jane Oliaro, Ian A Parish, Kylie M Quinn, Paul J Neeson, Clare Y Slaney, Junyun Lai, Paul A Beavis, Phillip K Darcy

Journal: Nature

PubMed ID: 38600376

Doi: 10.1038/s41586-024-07242-1

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Stepwise activation of a metabotropic glutamate receptor

Authors: Kaavya Krishna Kumar, Haoqing Wang, Chris Habrian, Naomi R Latorraca, Jun Xu, Evan S O'Brien, Chensong Zhang, Elizabeth Montabana, Antoine Koehl, Susan Marqusee, Ehud Y Isacoff, Brian K Kobilka

Journal: Nature

PubMed ID: 38632403

Doi: 10.1038/s41586-024-07327-x

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RATA: A novel class A carbapenemase with broad geographic distribution and potential for global spread

Authors: Hongyan Luo, Zhishuang Yang, Ting Lei, Caixia Li, Zuoyong Zhou, Mingshu Wang, Dekang Zhu, Pei Li, Anchun Cheng

Journal: Sci Total Environ

PubMed ID: 38692330

Doi: 10.1016/j.scitotenv.2024.172873

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Characterization of 35 novel NR5A1/SF-1 variants identified in individuals with atypical sexual development: The SF1next study

Authors: Rawda Naamneh Elzenaty, Idoia Martinez de Lapiscina, Chrysanthi Kouri, Kay-Sara Sauter, Grit Sommer, Luis Castaño, Christa E Flück

Journal: J Clin Endocrinol Metab

PubMed ID: 38623954

Doi: 10.1210/clinem/dgae251

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Development of a latex agglutination test based on VH antibody fragment for detection of Streptococcus suis serotype 2

Authors: Kiratika Chidkoksung, Nattihda Parakasikron, Suphachai Nuanualsuwan, Kannika Khantasup

Journal: PLoS ONE

PubMed ID: 38568909

Doi: 10.1371/journal.pone.0299691

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Antibacterial and Hemolytic Activity of Antimicrobial Hydrogels Utilizing Immobilized Antimicrobial Peptides

Authors: Edvin Blomstrand, Elin Posch, Annija Stepulane, Anand K Rajasekharan, Martin Andersson

Journal: Int J Mol Sci

PubMed ID: 38673786

Doi: 10.3390/ijms25084200

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Biophysical characterization and insights into the oligomeric nature of CD2-associated protein

Authors: Abrar H Qadri, Jyotsana Prajapati, Iqball Faheem, Utsa Bhattacharjee, Hari Krishnan Padmanaban, Sandeep Kn Mulukala, Anil K Pasupulati

Journal: Int J Biochem Mol Biol

PubMed ID: 38765876

Doi: 10.62347/UVSH8436

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Artemisinin Confers Cytoprotection toward Hydrogen Peroxide-Induced Cell Apoptosis in Retinal Pigment Epithelial Cells in Correlation with the Increased Acetylation of Histone H4 at Lysine 8

Authors: Chao Yang, Lijun Ge, Xiyong Yu, Philip Lazarovici, Wenhua Zheng

Journal: Molecules

PubMed ID: 38675608

Doi: 10.3390/molecules29081789

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Injectable self-assembled GDF5-containing dipeptide hydrogels for enhanced tendon repair

Authors: Ming Zhang, Hao Wang, Guan-Chun Dai, Pan-Pan Lu, Yu-Cheng Gao, Mu-Ming Cao, Ying-Juan Li, Yun-Feng Rui

Journal: Mater Today Bio

PubMed ID: 38600922

Doi: 10.1016/j.mtbio.2024.101046

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Identification and structural characterization of small molecule inhibitors of PINK1

Authors: Shafqat Rasool, Tara Shomali, Luc Truong, Nathalie Croteau, Simon Veyron, Bernardo A Bustillos, Wolfdieter Springer, Fabienne C Fiesel, Jean-François Trempe

Journal: Sci Rep

PubMed ID: 38565869

Doi: 10.1038/s41598-024-58285-3

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Evolutionarily conserved ovarian fluid proteins are responsible for extending egg viability in salmonid fish

Authors: Aurélie Gueho, Daniel Żarski, Hélène Rime, Blandine Guével, Emmanuelle Com, Régis Lavigne, Thaovi Nguyen, Jérôme Montfort, Charles Pineau, Julien Bobe

Journal: Sci Rep

PubMed ID: 38671194

Doi: 10.1038/s41598-024-60118-2

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Correlates of protection against symptomatic SARS-CoV-2 in vaccinated children

Authors: Youjia Zhong, Alicia Y H Kang, Carina J X Tay, Hui' En Li, Nurul Elyana, Chee Wah Tan, Wee Chee Yap, Joey M E Lim, Nina Le Bert, Kuan Rong Chan, Eugenia Z Ong, Jenny G Low, Lynette P Shek, Elizabeth Huiwen Tham, Eng Eong Ooi

Journal: Nat Med

PubMed ID: 38689059

Doi: 10.1038/s41591-024-02962-3

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A cAMP-biosensor-based assay for measuring plasma arginine-vasopressin levels

Authors: Kosuke Doi, Kouki Kawakami, Tatsuya Ikuta, Asuka Inoue

Journal: Sci Rep

PubMed ID: 38658606

Doi: 10.1038/s41598-024-60035-4

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Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein

Authors: Morgan L Pimm, Brian K Haarer, Alexander D Nobles, Laura M Haney, Alexandra G Marcin, Jessica L Henty-Ridilla

Journal: biorxiv

PubMed ID: 37205555

Doi: 10.1101/2023.05.04.539490

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Distinguishing individual photobodies using Oligopaints reveals thermo-sensitive and -insensitive phytochrome B condensation at distinct subnuclear locations

Authors: Juan Du, Keunhwa Kim, Meng Chen

Journal: Nat Commun

PubMed ID: 38684657

Doi: 10.1038/s41467-024-47789-1

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Tumor vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA): Suppresses macrophage capping protein beyond STING activation

Authors: Zhiyong Xiao, Xia Cui, Feng Liu, Ying Wang, Xiao Liu, Wenxia Zhou, Yongxiang Zhang

Journal: Biochim Biophys Acta Mol Basis Dis

PubMed ID: 38565383

Doi: 10.1016/j.bbadis.2024.167149

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Graphene oxide films as a novel tool for the modulation of myeloid-derived suppressor cell activity in the context of multiple sclerosis

Authors: Celia Camacho-Toledano, Isabel Machín-Díaz, Rafael Lebrón-Galán, Ankor González-Mayorga, Francisco J Palomares, María C Serrano, Diego Clemente

Journal: Nanoscale

PubMed ID: 38498071

Doi: 10.1039/d3nr05351b

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Structural analyses of the GI4 norovirus by cryo-electron microscopy and X-ray crystallography revealing binding sites for human monoclonal antibodies

Authors: Tomomi Kimura-Someya, Kazushige Katsura, Miyuki Kato-Murayama, Toshiaki Hosaka, Tomomi Uchikubo-Kamo, Kentaro Ihara, Kazuharu Hanada, Shin Sato, Kazutaka Murayama, Michiyo Kataoka, Mikako Shirouzu, Yuichi Someya

Journal: J Virol

PubMed ID: 38593321

Doi: 10.1128/jvi.00197-24

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Utility of accessible SARS-CoV-2 specific immunoassays in vaccinated adults with a history of advanced HIV infection

Authors: Ludovica Ferrari, Alessandra Ruggiero, Chiara Stefani, Livia Benedetti, Lorenzo Piermatteo, Eleonora Andreassi, Federica Caldara, Drieda Zace, Matteo Pagliari, Francesca Ceccherini-Silberstein, Christopher Jones, Marco Iannetta, Anna Maria Geretti

Journal: Sci Rep

PubMed ID: 38594459

Doi: 10.1038/s41598-024-58597-4

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Probing actin-activated ATP turnover kinetics of human cardiac myosin II by single molecule fluorescence

Authors: Albin Berg, Lok Priya Velayuthan, Sven Tågerud, Marko Ušaj, Alf Månsson

Journal: Cytoskeleton (Hoboken)

PubMed ID: 38623952

Doi: 10.1002/cm.21858

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Improving the Quality of Wheat Flour Bread by a Thermophilic Xylanase with Ultra Activity and Stability Reconstructed by Ancestral Sequence and Computational-Aided Analysis

Authors: Guoshuai Hu, Xizhi Hong, Meixin Zhu, Lei Lei, Zhenggang Han, Yong Meng, Jiangke Yang

Journal: Molecules

PubMed ID: 38675714

Doi: 10.3390/molecules29081895

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Peptide Inhibitor Targeting the Extraterminal Domain in BRD4 Potently Suppresses Breast Cancer Both and

Authors: Qi-Xuan Huang, Da-Meng Fan, Zao-Zao Zheng, Ting Ran, Ao Bai, Rong-Quan Xiao, Guo-Sheng Hu, Wen Liu

Journal: J Med Chem

PubMed ID: 38569135

Doi: 10.1021/acs.jmedchem.4c00141

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Development and performance evaluation of a novel elastic bacterial nanocellulose/polyurethane small caliber artificial blood vessels

Authors: Geli Li, Luhan Bao, Gaoquan Hu, Lin Chen, Xingping Zhou, Feng F Hong

Journal: Int J Biol Macromol

PubMed ID: 38641268

Doi: 10.1016/j.ijbiomac.2024.131685

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