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Expanding the Potential of Neoantigen Vaccines: Harnessing Bacille Calmette-Guérin Cell-Wall-Based Nanoscale Adjuvants for Enhanced Cancer Immunotherapy

Authors: Kangkang Liu, Jing Peng, Yunfei Guo, Yiming Li, Xiang Qi, Dengyi Duan, Taipeng Li, Jianmin Li, Yuanjie Niu, Gang Han, Yang Zhao

Journal: ACS Nano

PubMed ID: 38680054

Doi: 10.1021/acsnano.4c01691

Products & Services: Proteins, Expression, Isolation and Analysis

The use of Bacillus subtilis as a cost-effective expression system for production of Cholera Toxin B fused factor VIII epitope regions applicable for inducing oral immune tolerance

Authors: Vijay Elakkya Vijayakumar, Mookambeswaran A Vijayalakshmi, Sebastien Lacroix-Desmazes, Krishnan Venkataraman

Journal: Folia Microbiol (Praha)

PubMed ID: 38683262

Doi: 10.1007/s12223-024-01166-z

Products & Services: Molecular Biology Reagents

Mitochondria-Selective Dicationic Small-Molecule Ligand Targeting G-Quadruplex Structures for Human Colorectal Cancer Therapy

Authors: Bo-Xin Zheng, Wei Long, Wende Zheng, Yaoxun Zeng, Xiao-Chun Guo, Ka-Hin Chan, Meng-Ting She, Alan Siu-Lun Leung, Yu-Jing Lu, Wing-Leung Wong

Journal: J Med Chem

PubMed ID: 38624086

Doi: 10.1021/acs.jmedchem.3c02240

Products & Services: Gene Synthesis

The molecular immune modulator adenosine deaminase-1 enhances HIV specific humoral and cellular responses to a native-like HIV envelope trimer DNA vaccine

Authors: Michele A Kutzler, Gina Cusimano, David Joyner, Emily Konopka, Roshell Muir, Philip Barnette, Melanie Guderian, Iván Del Moral-Sánchez, Ronald Derking, Tom Bijl, Jonne Snitselaar, Photis Rotsides, Kyra Woloszczuk, Matthew Bell, Gabriela Canziani, Irwin Chaiken, Ann Hessell, Yannic Bartsch, Rogier Sanders, Elias Haddad

Journal: Res Sq

PubMed ID: 38746176

Doi: 10.21203/rs.3.rs-4139764/v1

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A new TROP2-targeting antibody-drug conjugate shows potent antitumor efficacy in breast and lung cancers

Authors: Dan-Dan Zhou, Xiao-Tian Zhai, Lan-Wen Zhang, Zi-Hui Xie, Ying Wang, Yong-Su Zhen, Rui-Juan Gao, Qing-Fang Miao

Journal: NPJ Precis Oncol

PubMed ID: 38654141

Doi: 10.1038/s41698-024-00584-z

Products & Services: Proteins, Expression, Isolation and Analysis

Combination of a TGF-β ligand trap (RAP-GRL) and TMPRSS6-ASO is superior for correcting β-thalassemia

Authors: Amaliris Guerra, Nolan Hamilton, Ariel Rivera, Perry Demsko, Shuling Guo, Stefano Rivella

Journal: Am J Hematol

PubMed ID: 38659383

Doi: 10.1002/ajh.27332

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening

Authors: Xing Li, Shiyu Sun, Wansong Zhang, Ziwei Liang, Yitong Fang, Tianhu Sun, Yong Wan, Xingcong Ma, Shuqun Zhang, Yang Xu, Ruilin Tian

Journal: Experimental & Clinical Cancer Research

PubMed ID: 38561797

Doi: 10.1186/s13046-024-03027-6

Products & Services: Recombinant Proteins

Cellugyrin (synaptogyrin-2) dependent pathways are used by bacterial cytolethal distending toxin and SARS-CoV-2 virus to gain cell entry

Authors: Kathleen Boesze-Battaglia, Gary H Cohen, Paul F Bates, Lisa M Walker, Ali Zekavat, Bruce J Shenker

Journal: Front Cell Infect Microbiol

PubMed ID: 38698905

Doi: 10.3389/fcimb.2024.1334224

Products & Services: Proteins, Expression, Isolation and Analysis

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication

Authors: Guy J Pearson, Harriet V Mears, Malgorzata Broncel, Ambrosius P Snijders, David L V Bauer, Jeremy G Carlton

Journal: SCIENCE ADVANCES

PubMed ID: 38569033

Doi: 10.1126/sciadv.adl5012

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Interplay of the Tfb1 pleckstrin homology domain with Rad2 and Rad4 in transcription coupled and global genomic nucleotide excision repair

Authors: Wenzhi Gong, Hannah Holmberg, Cheng Lu, Michelle Huang, Shisheng Li

Journal: Nucleic Acids Res

PubMed ID: 38634797

Doi: 10.1093/nar/gkae286

Products & Services: Catalog Antibody

Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway

Authors: Yan Yan, Jun Xiao, Fengtao Huang, Wei Xian, Bingbing Yu, Rui Cheng, Hui Wu, Xueling Lu, Xionglue Wang, Wenjing Huang, Jing Li, Greater Kayode Oyejobi, Carol V Robinson, Hao Wu, Di Wu, Xiaoyun Liu, Longfei Wang, Bin Zhu

Journal: Nat Microbiol

PubMed ID: 38649411

Doi: 10.1038/s41564-024-01684-z

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Minimizing the ratio of ionizable lipid in lipid nanoparticles for in vivo base editing

Authors: Qiubing Chen, Xuebin Wang, Yizhou Zhang, Ming Tian, Junyi Duan, Ying Zhang, Hao Yin

Journal: NSR

Doi: 10.1093/nsr/nwae135

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pH-dependent regulation of an acidophilic -acetylhomoserine sulfhydrylase from

Authors: Yasuyuki Matoba, Kosuke Oda, Maho Wataeda, Hina Kanemori, Koichi Matsuo

Journal: Appl Environ Microbiol

PubMed ID: 38568076

Doi: 10.1128/aem.00118-24

Products & Services: Mutagenesis Services

A conserved motif in the immune-subdominant RAP-1 related antigen of contains a B-cell epitope recognized by antibodies from protected cattle

Authors: Manuel J Rojas, Reginaldo G Bastos, Jinna Navas, Jacob M Laughery, Paul A Lacy, Carlos E Suarez

Journal: Front Immunol

PubMed ID: 38720894

Doi: 10.3389/fimmu.2024.1380660

Products & Services: Proteins, Expression, Isolation and Analysis

Food for Thought: The Effects of Feeding on Neurogenesis in the Ball Python, Python regius

Authors: Hannah Bow, Christina Dang, Katherine Hillsbery, Carly Markowski, Michael Black, Christine Strand

Journal: Brain Behav Evol

PubMed ID: 38657588

Doi: 10.1159/000539052

Products & Services: Polyclonal Antibody Services

Synthesis of site-specific Fab-drug conjugates using ADP-ribosyl cyclases

Authors: Hyo Sun Kim, Kimia Hariri, Xiao-Nan Zhang, Liang-Chieh Chen, Benjamin B Katz, Hua Pei, Stan G Louie, Yong Zhang

Journal: Protein Sci

PubMed ID: 38501590

Doi: 10.1002/pro.4924

Products & Services: Proteins, Expression, Isolation and Analysis

Development of an effective single-chain variable fragment recognizing a novel epitope in the hepatitis C virus E2 protein that restricts virus entry into hepatocytes

Authors: Soma Das, Padmanava Behera, Dipeshwari J Shewale, Janhavi Bodele, Saumitra Das, Anjali A Karande

Journal: Arch Virol

PubMed ID: 38683226

Doi: 10.1007/s00705-024-06024-4

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MiR-574-5p activates human TLR8 to promote autoimmune signaling and lupus

Authors: Tao Wang, Dan Song, Xuejuan Li, Yu Luo, Dianqiang Yang, Xiaoyan Liu, Xiaodan Kong, Yida Xing, Shulin Bi, Yan Zhang, Tao Hu, Yunyun Zhang, Shuang Dai, Zhiqiang Shao, Dahan Chen, Jinpao Hou, Esteban Ballestar, Jianchun Cai, Feng Zheng, James Y Yang

Journal: Cell Commun Signal

PubMed ID: 38589923

Doi: 10.1186/s12964-024-01601-1

Products & Services: Peptide Modifications

Searching for new plastic-degrading enzymes from the plastisphere of alpine soils using a metagenomic mining approach

Authors: Beat Frey, Margherita Aiesi, Basil M Rast, Joel Rüthi, Jérôme Julmi, Beat Stierli, Weihong Qi, Ivano Brunner

Journal: PLoS ONE

PubMed ID: 38578779

Doi: 10.1371/journal.pone.0300503

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A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells

Authors: Hema Preethi Subas Satish, Sweta Iyer, Melissa X Shi, Agnes W Wong, Karla C Fischer, Ahmad Z Wardak, Daisy Lio, Jason M Brouwer, Rachel T Uren, Peter E Czabotar, Michelle S Miller, Ruth M Kluck

Journal: Cell Death Differ

PubMed ID: 38582955

Doi: 10.1038/s41418-024-01289-3

Products & Services: Proteins, Expression, Isolation and Analysis

microRNA-2184 orchestrates Mauthner-cell axon regeneration in zebrafish via syt3 modulation

Authors: Xinghan Chen, Yueru Shen, Zheng Song, Xinliang Wang, Huaitong Yao, Yuan Cai, Zi-Ang Zhao, Bing Hu

Journal: J Genet Genomics

PubMed ID: 38582297

Doi: 10.1016/j.jgg.2024.03.016

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The proteomic analysis uncovers the cellular responses to the African swine fever virus membrane proteins p54, p17, and pB117L

Authors: Yuhong Chen, Jianqiang Ni, Chuanbin Wang, Xinyan Zhai, Tingrong Luo, Yi-Ping Li, Youchuan Wei, Yuliang Liu

Journal: Microbes Infect

PubMed ID: 38697277

Doi: 10.1016/j.micinf.2024.105348

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Interleukin-2 is required for NKp30-dependent NK cell cytotoxicity by preferentially regulating NKp30 expression

Authors: Nayoung Kim, Eunbi Yi, Eunbi Lee, Hyo Jin Park, Hun Sik Kim

Journal: Front Immunol

PubMed ID: 38698855

Doi: 10.3389/fimmu.2024.1388018

Products & Services: Molecular Biology Reagents

Amino Terminal Acetylation of HOXB13 Regulates the DNA Damage Response in Prostate Cancer

Authors: Duy T Nguyen, Urvashi Mahajan, Duminduni Hewa Angappulige, Aashna Doshi, Nupam P Mahajan, Kiran Mahajan

Journal: Cancers (Basel)

PubMed ID: 38730575

Doi: 10.3390/cancers16091622

Products & Services: Molecular Biology Reagents

Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity

Authors: Qiongqiong Zhou, Deshi Shi, Yan-Dong Tang, Longfeng Zhang, Boli Hu, Chunfu Zheng, Li Huang, Changjiang Weng

Journal: PLoS Pathog

PubMed ID: 38669242

Doi: 10.1371/journal.ppat.1012146

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of a linear B-cell epitope on the "puff" loop of the Senecavirus A VP2 protein involved in receptor binding

Authors: Hanrong Zhou, Mingxia Sun, Shibo Su, Liang Meng, Wei Yang, Lan Yang, Xinqi Shi, Xin Li, Haiwei Wang, Hongwei Ma, Xuehui Cai, Yan-Dong Tang, Tongqing An, Fandan Meng

Journal: Front Microbiol

PubMed ID: 38716170

Doi: 10.3389/fmicb.2024.1387309

Products & Services: Proteins, Expression, Isolation and Analysis

Non-Invasive Delivery of Negatively Charged Nanobodies by Anodal Iontophoresis: When Electroosmosis Dominates Electromigration

Authors: Phedra Firdaws Sahraoui, Oscar Vadas, Yogeshvar N Kalia

Journal: Pharmaceutics

PubMed ID: 38675200

Doi: 10.3390/pharmaceutics16040539

Products & Services: Molecular Biology Reagents

Fluctuation of flavor quality in roasted duck: The consequences of raw duck preform's repetitive freeze-thawing

Authors: Ziwu Gao, Dequan Zhang, Ruiyun Wu, Jinhua He, Jiale Ma, Xiangxiang Sun, Minghui Gu, Zhenyu Wang

Journal: Food Res Int

PubMed ID: 38763675

Doi: 10.1016/j.foodres.2024.114424

Products & Services: Proteins, Expression, Isolation and Analysis

Dynamically stiffening biomaterials reveal age- and sex-specific differences in pulmonary arterial adventitial fibroblast activation

Authors: Mikala C Mueller, Yanmei Du, Lori A Walker, Chelsea M Magin

Journal: Matrix Biol Plus

PubMed ID: 38699486

Doi: 10.1016/j.mbplus.2024.100145

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Developing a Novel Enzalutamide-Resistant Prostate Cancer Model via AR F877L Mutation in LNCaP Cells

Authors: Ruifeng Wang, Shuhua Ma, Nengwei Xu, Yumiao Gan, Pengya Li, Jingying Zhang, Zhixiang Zhang, Qingyang Gu, Jian Xiang

Journal: Curr Protoc

PubMed ID: 38652202

Doi: 10.1002/cpz1.1033

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Hymenopteran-specific TRPA channel from the Texas leaf cutter ant (Atta texana) is heat and cold activated and expression correlates with environmental temperature

Authors: Julia M York, Timothy N Taylor, Sarah LaPotin, Ying Lu, Ulrich Mueller

Journal: Insect Sci

PubMed ID: 38605428

Doi: 10.1111/1744-7917.13364

Products & Services: Molecular Biology Reagents

Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood

Authors: Mathias Jensen, Linn Stenfelt, Jennifer Ricci Hagman, Michael Jakob Pichler, Julia Weikum, Tine Sofie Nielsen, Annika Hult, Jens Preben Morth, Martin L Olsson, Maher Abou Hachem

Journal: Nat Microbiol

PubMed ID: 38684911

Doi: 10.1038/s41564-024-01663-4

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A DNA circuit that records molecular events

Authors: Mingzhi Zhang, Colin Yancey, Chao Zhang, Junyan Wang, Qian Ma, Linlin Yang, Rebecca Schulman, Da Han, Weihong Tan

Journal: SCIENCE ADVANCES

PubMed ID: 38578999

Doi: 10.1126/sciadv.adn3329

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Use of in silico approaches, synthesis and profiling of Pan-filovirus GP-1,2 preprotein specific antibodies

Authors: Maciej Wiśniewski, Peace Babirye, Carol Musubika, Eleni Papakonstantinou, Samuel Kirimunda, Michal Łaźniewski, Teresa Szczepińska, Moses L Joloba, Elias Eliopoulos, Erik Bongcam-Rudloff, Dimitrios Vlachakis, Anup Kumar Halder, Dariusz Plewczyński, Misaki Wayengera

Journal: Brief Funct Genomics

PubMed ID: 38605526

Doi: 10.1093/bfgp/elae012

Products & Services: Proteins, Expression, Isolation and Analysis

Antibody-blocking of a tick transporter impairs Anaplasma phagocytophilum colonization in Haemaphysalis longicornis ticks

Authors: Prachi Namjoshi, Donald M Lubembe, Hameeda Sultana, Girish Neelakanta

Journal: Sci Rep

PubMed ID: 38637614

Doi: 10.1038/s41598-024-59315-w

Products & Services: Polyclonal Antibody Services

Epitope mapping and a candidate vaccine design from canine distemper virus

Authors: Camila Pereira Dos Santos, Jerlane Tarcilia Gomes Telles, Georgia de Freitas Guimarães, Laura Helena Vega Gonzales Gil, Amanda Mota Vieira, Jose Wilton Pinheiro Junior, Carlos Eduardo Calzavara-Silva, Rita de Cássia CarvalhoMaia

Journal: Open Vet J

PubMed ID: 38808294

Doi: 10.5455/OVJ.2024.v14.i4.9

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Analysis of the Immunogenicity of African Swine Fever F317L Protein and Screening of T Cell Epitopes

Authors: Ying Huang, Wenzhu Zhai, Zhen Wang, Yuheng He, Chunhao Tao, Yuanyuan Chu, Zhongbao Pang, Hongfei Zhu, Hong Jia

Journal: Animals (Basel)

PubMed ID: 38731330

Doi: 10.3390/ani14091331

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Structural basis for the minimal bifunctional alginate epimerase AlgE3 from Azotobacter chroococcum

Authors: Takaaki Fujiwara, Eriko Mano, Eriko Nango

Journal: FEBS Lett

PubMed ID: 38649293

Doi: 10.1002/1873-3468.14886

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Flow Cytometry-Based Measurement of Antibodies Specific for Cell Surface-Expressed Folded SARS-CoV-2 Receptor-Binding Domains

Authors: Al Nasar Ahmed Sehgal, Jera Safran, Bernhard Kratzer, Pia Gattinger, Robert B Stieger, Laszlo Musiejovsky, Doris Trapin, Paul Ettel, Ulrike Körmöczi, Arno Rottal, Kristina Borochova, Yulia Dorofeeva, Inna Tulaeva, Milena Weber, Katharina Grabmeier-Pfistershammer, Thomas Perkmann, Ursula Wiedermann, Rudolf Valenta, Winfried F Pickl

Journal: Vaccines (Basel)

PubMed ID: 38675759

Doi: 10.3390/vaccines12040377

Products & Services: Proteins, Expression, Isolation and Analysis

The Ser/Thr protein kinase FonKin4-poly(ADP-ribose) polymerase FonPARP1 phosphorylation cascade is required for the pathogenicity of watermelon fusarium wilt fungus f sp

Authors: Jiajing Wang, Yizhou Gao, Xiaohui Xiong, Yuqing Yan, Jiajun Lou, Muhammad Noman, Dayong Li, Fengming Song

Journal: Front Microbiol

PubMed ID: 38690366

Doi: 10.3389/fmicb.2024.1397688

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Development of a novel monoclonal antibody-based competitive ELISA for antibody detection against bovine leukemia virus

Authors: Jing Wang, Chao Sun, Zhe Hu, Fang Wang, Jitao Chang, Ming Gao, Dandan Ye, Qi Jia, Hui Zou, Luc Willems, Zhigang Jiang, Xin Yin

Journal: Int J Biol Macromol

PubMed ID: 38621561

Doi: 10.1016/j.ijbiomac.2024.131446

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Edaravone Dexborneol mitigates pathology in animal and cell culture models of Alzheimer's disease by inhibiting neuroinflammation and neuronal necroptosis

Authors: Chong Xu, Yilan Mei, Ruihan Yang, Qiudan Luo, Jienian Zhang, Xiaolin Kou, Jianfeng Hu, Yujie Wang, Yue Li, Rong Chen, Zhengping Zhang, Yuyuan Yao, Jian Sima

Journal: Cell Biosci

PubMed ID: 38678262

Doi: 10.1186/s13578-024-01230-8

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Intratumoural delivery of TRAIL mRNA induces colon cancer cell apoptosis

Authors: Tingxuan Gu, Mengqiao Wang, Xiaorong Fu, Xueli Tian, Juanjuan Bi, Ning Lu, Chen Chen, Shijia Yan, Ang Li, Luyun Wang, Xiang Li, Kangdong Liu, Zigang Dong

Journal: Biomed Pharmacother

PubMed ID: 38636395

Doi: 10.1016/j.biopha.2024.116603

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Online monitoring of protein refolding in inclusion body processing using intrinsic fluorescence

Authors: Chika Linda Igwe, Don Fabian Müller, Florian Gisperg, Jan Niklas Pauk, Matthias Kierein, Mohamed Elshazly, Robert Klausser, Julian Kopp, Oliver Spadiut, Eva Přáda Brichtová

Journal: Anal Bioanal Chem

PubMed ID: 38573344

Doi: 10.1007/s00216-024-05249-1

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Immune response profiles from humans experimentally exposed to bites

Authors: Fernanda Fortes de Araujo, Maha Abdeladhim, Clarissa Teixeira, Kelly Hummer, Matthew D Wilkerson, Roseanne Ressner, Ines Lakhal-Naouar, Michael W Ellis, Claudio Meneses, Saule Nurmukhambetova, Regis Gomes, W David Tolbert, George W Turiansky, Marzena Pazgier, Fabiano Oliveira, Jesus G Valenzuela, Shaden Kamhawi, Naomi Aronson

Journal: Front Immunol

PubMed ID: 38633260

Doi: 10.3389/fimmu.2024.1335307

Products & Services: Proteins, Expression, Isolation and Analysis

High expression of PPP1CC promotes NHEJ-mediated DNA repair leading to radioresistance and poor prognosis in nasopharyngeal carcinoma

Authors: Ping Feng, Ying Wang, Na Liu, Yanming Chen, Yujun Hu, Zilu Huang, Ya Liu, Shuohan Zheng, Tongchao Jiang, Xiang Xiao, Wei Dai, Peng Huang, Yunfei Xia

Journal: Cell Death Differ

PubMed ID: 38589496

Doi: 10.1038/s41418-024-01287-5

Products & Services: Proteins, Expression, Isolation and Analysis

Determination of optimum levels of binding antibody units (BAU) of new quantitative chemiluminescent immuno-assay (CLIA) in COVID-19 vaccinated volunteer blood donors

Authors: Aseem Kumar Tiwari, Geet Aggarwal, Pratibha Kale, Neeti Yadav, Virendra Kumar, Gargi Singh, K Cheirmaraj, K Krishnan

Journal: Transfus Apher Sci

PubMed ID: 38678985

Doi: 10.1016/j.transci.2024.103937

Products & Services: Proteins, Expression, Isolation and Analysis

Lysine acetylation of Hsp163: Effect on its structure, chaperone function and influence towards the growth of Mycobacterium tuberculosis

Authors: Subhashree Barik, Alok Kumar Panda, Viplov Kumar Biswas, Sheetal Das, Ayon Chakraborty, Shibangini Beura, Rahul Modak, Sunil Kumar Raghav, Rajiv K Kar, Ashis Biswas

Journal: Int J Biol Macromol

PubMed ID: 38657928

Doi: 10.1016/j.ijbiomac.2024.131763

Products & Services: Proteins, Expression, Isolation and Analysis

Structural basis of exoribonucleasemediated mRNA transcription termination

Authors: Yuan Zeng, Hong-Wei Zhang, Xiao-Xian Wu, Yu Zhang

Journal: Nature

PubMed ID: 38538796

Doi: doi.org/10.1038/s41586-024-07240-3

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A long-acting FGF21 attenuates metabolic dysfunction-associated steatohepatitis-related fibrosis by modulating NR4A1-mediated Ly6C phenotypic switch in macrophages

Authors: Yue Ji, Yiliang Duan, Yuanyuan Li, Qingzhou Lu, Dingkang Liu, Yifan Yang, Ruilong Chang, Jing Tian, Wenbing Yao, Jun Yin, Xiangdong Gao

Journal: Br J Pharmacol

PubMed ID: 38679486

Doi: 10.1111/bph.16378

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