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How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer's disease brain by a strain-relief mechanism

Authors: David Eisenberg, Ke Hou, Peng Ge, Michael Sawaya, Joshua Dolinsky, Yuan Yang, Yi Xiao Jiang, Liisa Lutter, David Boyer, Xinyi Cheng, Justin Pi, Jeffrey Zhang, Jiahui Lu, Shixin Yang, Zhiheng Yu, Juli Feigon

Journal: Res Sq

PubMed ID: 38766197

Doi: 10.21203/rs.3.rs-4152095/v1

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A vector system for single and tandem expression of cloned genes and multi-colour fluorescent tagging in

Authors: Solenne Ithurbide, Roshali T de Silva, Hannah J Brown, Vinaya Shinde, Iain G Duggin

Journal: Microbiology (Reading)

PubMed ID: 38787390

Doi: 10.1099/mic.0.001461

Products & Services: Proteins, Expression, Isolation and Analysis

Plasmodium falciparum Glutamic Acid-Rich Protein-Independent Polyclonal Antibodies Inhibit Malaria Parasite Growth in Human Erythrocytes

Authors: Christopher J Schwake, Rachel M Krueger, Toshihiko Hanada, Athar H Chishti

Journal: J Infect Dis

PubMed ID: 38298126

Doi: 10.1093/infdis/jiae050

Products & Services: Molecular Biology Reagents

mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models

Authors: Xuesong Wang, Christopher A Cottrell, Xiaozhen Hu, Rashmi Ray, Maria Bottermann, Paula Maldonado Villavicencio, Yu Yan, Zhenfei Xie, John E Warner, Jordan Renae Ellis-Pugh, Oleksandr Kalyuzhniy, Alessia Liguori, Jordan R Willis, Sergey Menis, Sebastian Rämisch, Saman Eskandarzade, Michael Kubitz, Ryan Tingle Nicole Phelps, Bettina Groschel, Sunny Himansu, Andrea Carfi, Kathrin H Kirsch, Stephanie R Weldon, Usha Nair, William R Schief, Facundo D Batista

Journal: Science immunology

PubMed ID: 38753808

Doi: 10.1126/sciimmunol.adn0622

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F Nucleatum enhances oral squamous cell carcinoma proliferation via E-cadherin/β-Catenin pathway

Authors: Zhengrui Li, Yuan Liu, Xufeng Huang, Qi Wang, Rao Fu, Xutao Wen, Ji'an Liu, Ling Zhang

Journal: BMC Oral Health

PubMed ID: 38698370

Doi: 10.1186/s12903-024-04252-3

Products & Services: Proteins, Expression, Isolation and Analysis

Immunogenicity Analysis and Identification of Potential T-Cell Epitopes in C129R Protein of African Swine Fever Virus

Authors: Wenzhu Zhai, Ying Huang, Yuheng He, Yuanyuan Chu, Chunhao Tao, Zhongbao Pang, Zhen Wang, Hongfei Zhu, Hong Jia

Journal: Microorganisms

PubMed ID: 38930438

Doi: 10.3390/microorganisms12061056

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Detection of SARS-CoV-2-Specific Secretory IgA and Neutralizing Antibodies in the Nasal Secretions of Exposed Seronegative Individuals

Authors: Jason S Chwa, Minjun Kim, Yesun Lee, Wesley A Cheng, Yunho Shin, Jaycee Jumarang, Jeffrey M Bender, Pia S Pannaraj

Journal: Viruses

PubMed ID: 38932145

Doi: 10.3390/v16060852

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and gene-edited human induced pluripotent stem cells for dissecting the functional roles of -GlcNAcylation in hematopoiesis

Authors: Sudjit Luanpitpong, Kantpitchar Tangkiettrakul, Xing Kang, Pimonwan Srisook, Jirarat Poohadsuan, Parinya Samart, Phatchanat Klaihmon, Montira Janan, Chanchao Lorthongpanich, Chuti Laowtammathron, Surapol Issaragrisil

Journal: Front Cell Dev Biol

PubMed ID: 38752196

Doi: 10.3389/fcell.2024.1361943

Products & Services: Custom DNA/RNA Oligos

Integrating cryo-OrbiSIMS with computational modelling and metadynamics simulations enhances RNA structure prediction at atomic resolution

Authors: Shannon Ward, Alex Childs, Ceri Staley, Christopher Waugh, Julie A Watts, Anna M Kotowska, Rahul Bhosale, Aditi N Borkar

Journal: Nat Commun

PubMed ID: 38777820

Doi: 10.1038/s41467-024-48694-3

Products & Services: Molecular Biology Reagents

Combinatorial Metabolic Engineering for Improving Betulinic Acid Biosynthesis in

Authors: Mei Tang, Xianhao Xu, Yanfeng Liu, Jianghua Li, Guocheng Du, Xueqin Lv, Long Liu

Journal: ACS Synth Biol

PubMed ID: 38748665

Doi: 10.1021/acssynbio.4c00104

Products & Services: Codon Optimization

Fluorescence Sensing of Eclampsia Biomarkers via the Immunosorbent Atom Transfer Radical Polymerization Assay

Authors: Nan Ma, Jian Zhang, Jinming Kong, Xueji Zhang

Journal: Anal Chem

PubMed ID: 38728011

Doi: 10.1021/acs.analchem.4c00110

Products & Services: Proteins, Expression, Isolation and Analysis

Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement

Authors: Seiji Watanabe, Kangsa Amporndanai, Raheela Awais, Caroline Latham, Muhammad Awais, Paul M O'Neill, Koji Yamanaka, S Samar Hasnain

Journal: Sci Rep

PubMed ID: 38802492

Doi: 10.1038/s41598-024-62903-5

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Molecular characteristics of Echinococcus multilocularis FABP1 and its regulatory functions on murine macrophages

Authors: Xiang Li, Peng Liao, Wenjing Zhou, Xinqi Yang, Bin Ye

Journal: Acta Trop

PubMed ID: 38729330

Doi: 10.1016/j.actatropica.2024.107247

Products & Services: Proteins, Expression, Isolation and Analysis

Development and application of a cycleave dual-probe fluorescence quantitative PCR method for simultaneous detection of Mycoplasma gallisepticum ts-11 vaccine strain and non-ts-11 strains

Authors: Xue Wang, Nana Sun, Meng Wang, Hui Wang, Yuhan Liu, Hao Shi, Hao Zhu, Peidong Li, Fuyou Zhang, Tianyao Yang, Zhaoyang Li, Chunguo Liu

Journal: Poult Sci

PubMed ID: 38878745

Doi: 10.1016/j.psj.2024.103907

Products & Services: PCR Cloning and Subcloning

Identification of a novel neurovirulence factor encoded by the cryptic orphan gene UL316 of herpes simplex virus 1

Authors: Akihisa Kato, Ryoji Iwasaki, Kousuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Tohru Natsume, Hideo Kusano, Shungo Adachi, Shuichi Kawano, Yasushi Kawaguchi

Journal: J Virol

PubMed ID: 38819171

Doi: 10.1128/jvi.00747-24

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Structural insights into the molecular mechanism of phytoplasma immunodominant membrane protein

Authors: Chang Yi Liu, Han Pin Cheng, Chan Pin Lin, Yi Ting Liao, Tzu Ping Ko, Shin Jen Lin, Shih Shun Lin, Hao Ching Wang

Journal: IUCrJ

PubMed ID: 38656311

Doi: 10.1107/S2052252524003075

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Mutation of SIVA, a candidate metastasis gene identified from clonally related bilateral breast cancers, promotes breast cancer cell spread in vitro and in vivo

Authors: Anke Vermehren-Schmaedick, Myron Peto, Wendy Wagoner, Kami E Chiotti, Elizabeth Ramsey, Xiaoyan Wang, Shauna Rakshe, Jessica Minnier, Rosalie Sears, Paul Spellman, Shiuh-Wen Luoh

Journal: PLoS ONE

PubMed ID: 38722955

Doi: 10.1371/journal.pone.0302856

Products & Services: PCR Cloning and Subcloning

A new strategy to generate nanobodies for the coumaphos based on the synthesized nanobody libraries

Authors: Ruyu Fang, Yingxue Li, Fei Liu, Yifan Liang, Yu Wang, Guohua Zhong, Zhenlin Xu, Bruce D Hammock, Hong Wang

Journal: Food Chem

PubMed ID: 38833869

Doi: 10.1016/j.foodchem.2024.139684

Imprinted lncRNA KCNQ1OT1 regulates CDKN1C expression through promoter binding and chromatin folding in pigs

Authors: Yongfeng Zhou, Hao Yu, Daoyu Zhang, Zhengzhu Wang, Qi Li, Xinglan An, Sheng Zhang, Ziyi Li

Journal: Gene

PubMed ID: 38772516

Doi: 10.1016/j.gene.2024.148590

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of phosphorylated small ORF-encoded peptides in Hep3B cells by LC/MS/MS

Authors: Mingbo Peng, Yutian Zhou, Cuihong Wan

Journal: J Proteomics

PubMed ID: 38823442

Doi: 10.1016/j.jprot.2024.105214

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Analysis of the molecular basis for the non-amylolytic and non-proteolytic nature of Aspergillus vadensis CBS 113365

Authors: Dujuan Liu, Sandra Garrigues, Helena Culleton, Vincent A McKie, Ronald P de Vries

Journal: N Biotechnol

PubMed ID: 38697469

Doi: 10.1016/j.nbt.2024.04.003

Products & Services: Gene Synthesis

Extracellular vesicles containing MFGE8 from colorectal cancer facilitate macrophage efferocytosis

Authors: Zhixin Ma, Yu Sun, Yang Yu, Wenjun Xiao, Zhijie Xiao, Tianyu Zhong, Xi Xiang, Zhigang Li

Journal: Cell Commun Signal

PubMed ID: 38802814

Doi: 10.1186/s12964-024-01669-9

Identification and characterisation of novel CAR-T cells to target IL13Rα2 positive human glioma in vitro and in vivo

Authors: Pamela Leland, Heba Degheidy, Ashley Lea, Steven R Bauer, Raj K Puri, Bharat H Joshi

Journal: Clin Transl Med

PubMed ID: 38685487

Doi: 10.1002/ctm2.1664

Products & Services: Codon Optimization

A potent Henipavirus cross-neutralizing antibody reveals a dynamic fusion-triggering pattern of the G-tetramer

Authors: Pengfei Fan, Mengmeng Sun, Xinghai Zhang, Huajun Zhang, Yujiao Liu, Yanfeng Yao, Ming Li, Ting Fang, Bingjie Sun, Zhengshan Chen, Xiangyang Chi, Li Chen, Cheng Peng, Zhen Chen, Guanying Zhang, Yi Ren, Zixuan Liu, Yaohui Li, Jianmin Li, Entao Li, Wuxiang Guan, Shanshan Li, Rui Gong, Kaiming Zhang, …Sandra Chiu

Journal: Nat Commun

PubMed ID: 38773072

Doi: 10.1038/s41467-024-48601-w

Products & Services: Proteins, Expression, Isolation and Analysis

Poc1 bridges basal body inner junctions to promote triplet microtubule integrity and connections

Authors: Marisa D Ruehle, Sam Li, David A Agard, Chad G Pearson

Journal: J Cell Biol

PubMed ID: 38743010

Doi: 10.1083/jcb.202311104

Products & Services: Molecular Biology Reagents

CRISPR/Cas9-Mediated Knockout of the Lycopene ε-Cyclase for Efficient Astaxanthin Production in the Green Microalga

Authors: Jacob Sebastian Kneip, Niklas Kniepkamp, Junhwan Jang, Maria Grazia Mortaro, EonSeon Jin, Olaf Kruse, Thomas Baier

Journal: Plants (Basel)

PubMed ID: 38794462

Doi: 10.3390/plants13101393

Products & Services: PCR Cloning and Subcloning Gene Synthesis

Structure and genome editing of type I-B CRISPR-Cas

Authors: Meiling Lu, Chenlin Yu, Yuwen Zhang, Wenjun Ju, Zhi Ye, Chenyang Hua, Jinze Mao, Chunyi Hu, Zhenhuang Yang & Yibei Xiao

Journal: Nat Commun

PubMed ID: 38750051

Doi: 10.1038/s41467-024-48598-2

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Thalidomide derivatives degrade BCL-2 by reprogramming the binding surface of CRBN

Authors: Jianhui Wang (王建辉) , Marcel Heinz, Kang Han (韩康), Varun J. Shah, Sebastian Hasselbeck, Martin P. Schwalm, Rajeshwari Rathore, Gerhard Hummer, Jun Zhou (周俊), Ivan Dikic, Xinlai Cheng (承辛来)

Journal: Cell Reports Physical Science

Doi: doi.org/10.1016/j.xcrp.2024.101960

Products & Services: Molecular Biology Reagents

A PACAP-activated network for secretion requires coordination of Ca influx and Ca mobilization

Authors: Xiaohuan Chen, Nicole A Bell, Breanna L Coffman, Agustin A Rabino, Rafael Garcia-Mata, Paul J Kammermeier, David I Yule, Daniel Axelrod, Alan V Smrcka, David R Giovannucci, Arun Anantharam

Journal: Mol Biol Cell

PubMed ID: 38758660

Doi: 10.1091/mbc.E24-02-0083

Products & Services: Molecular Biology Reagents

Polyglutamine-mediated ribotoxicity disrupts proteostasis and stress responses in Huntington's disease

Authors: Ranen Aviner, Ting-Ting Lee, Vincent B Masto, Kathy H Li, Raul Andino, Judith Frydman

Journal: Nat Cell Biol

PubMed ID: 38741019

Doi: 10.1038/s41556-024-01414-x

Products & Services: ORF cDNA Clones/MolecularCloud

Lysineless HiBiT and NanoLuc Tagging Systems as Alternative Tools Monitoring Targeted Protein Degradation

Authors: Hanfeng Lin, Kristin Riching, May Poh Lai, Dong Lu, Ran Cheng, Xiaoli Qi, Jin Wang

Journal: biorxiv

PubMed ID: 38798562

Doi: 10.1101/2024.05.14.594249

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Two-point immobilization of M3 muscarinic receptor: a method for recognizing receptor antagonists in natural products

Authors: Xiaomin Huang, Ting Wang, Ludan Wang, Yantao Sun, Ziru Zhang, Yajun Zhang

Journal: BMC Chem

PubMed ID: 38702791

Doi: 10.1186/s13065-024-01198-z

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Novel enzymes for biodegradation of polycyclic aromatic hydrocarbons identified by metagenomics and functional analysis in short-term soil microcosm experiments

Authors: Kinga K Nagy, Kristóf Takács, Imre Németh, Bálint Varga, Vince Grolmusz, Mónika Molnár, Beáta G Vértessy

Journal: Sci Rep

PubMed ID: 38773163

Doi: 10.1038/s41598-024-61566-6

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Nonspecific phospholipases C3 and C4 interact with PIN-FORMED2 to regulate growth and tropic responses in Arabidopsis

Authors: Teng Li, Shujuan Zhang, Shuaibing Yao, Xuebing Li, Qianru Jia, Jingya Yuan, Wenhua Zhang, Xuemin Wang, Qun Zhang

Journal: Plant Cell

PubMed ID: 38442314

Doi: 10.1093/plcell/koae071

Products & Services: Proteins, Expression, Isolation and Analysis

Single-molecule assay guided crRNA optimization enhances specific microRNA detection by CRISPR-Cas12a

Authors: Kaizhao Chen, Wenjun Sun, Mingtian Zhong, Jiaqi Xie, Yongkun Huo, Xiuqi Lu, Ziting Chen, Bo Sun, Xingxu Huang, Xinjie Wang， Ming Liu , Xiaodong Ma, Peixiang Ma

Journal: Sensors and Actuators B: Chemical

Doi: 10.1016/j.snb.2024.135389

Products & Services: Proteins, Expression, Isolation and Analysis

A Customized Biohybrid presenting Cascade Responses to Tumor Microenvironment

Authors: Feiyu Li, Peipei Zhu, Bingzhu Zheng, Zijie Lu, Chao Fang, Yike Fu, Xiang Li

Journal: Adv Mater

PubMed ID: 38723206

Doi: 10.1002/adma.202404901

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C9orf72-Associated Dipeptide Repeat Expansions Perturb ER-Golgi Vesicular Trafficking, Inducing Golgi Fragmentation and ER Stress, in ALS/FTD

Authors: Jessica Sultana, Audrey M G Ragagnin, Sonam Parakh, Sayanthooran Saravanabavan, Kai Ying Soo, Marta Vidal, Cyril Jones Jagaraj, Kunjie Ding, Sharlynn Wu, Sina Shadfar, Emily K Don, Anand Deva, Garth Nicholson, Dominic B Rowe, Ian Blair, Shu Yang, Julie D Atkin

Journal: Mol Neurobiol

PubMed ID: 38722513

Doi: 10.1007/s12035-024-04187-4

Products & Services: PCR Cloning and Subcloning

Disulfidptosis in head and neck squamous carcinoma: Integrative bioinformatic and in-vitro analysis

Authors: Xufeng Huang, Jinyan Yang, Qi Wang, Rao Fu, Xutao Wen, Zhengrui Li, Ling Zhang

Journal: Oral Dis

PubMed ID: 38696646

Doi: 10.1111/odi.14977

Products & Services: Molecular Biology Reagents

Arg-biodynamers as antibiotic potentiators through interacting with Gram-negative outer membrane lipopolysaccharides

Authors: Mohamed A M Kamal, Justine Bassil, Brigitta Loretz, Anna K H Hirsch, Sangeun Lee, Claus-Michael Lehr

Journal: Eur J Pharm Biopharm

PubMed ID: 38795784

Doi: 10.1016/j.ejpb.2024.114336

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Structural characterization of E22G Aβ fibrils H detected MAS NMR

Authors: Natalie C Golota, Brian Michael, Edward P Saliba, Sara Linse, Robert G Griffin

Journal: Phys Chem Chem Phys

PubMed ID: 38715538

Doi: 10.1039/d4cp00553h

Products & Services: Molecular Biology Reagents

Cysteine, sodium metabisulfite, and glutathione enhance crosslinking between proteins during high moisture meat analog extrusion processing and may improve the fibrousness of the products

Authors: Jana K Richter, Preston Watanabe, Josh Bernin, Brennan Smith, Rachel Mitacek, Girish M Ganjyal

Journal: J Sci Food Agric

PubMed ID: 38804791

Doi: 10.1002/jsfa.13569

Products & Services: Proteins, Expression, Isolation and Analysis

Nanobody-based immunosensor for the detection of H pylori in saliva

Authors: Mohammad Ia Ahmad, Célia G Amorim, Luay F Abu Qatouseh, Maria C B S M Montenegro

Journal: Biosens Bioelectron

PubMed ID: 38810413

Doi: 10.1016/j.bios.2024.116423

Products & Services: Gene Synthesis

for Deciphering Selenium-Encoded Peptide and a Pyrolysis-Thermolysis Dietary Model for Minimizing Loss of "KKSe(M)R" during Processing

Authors: Xin Wang, Wei Jia

Journal: J Agric Food Chem

PubMed ID: 38770928

Doi: 10.1021/acs.jafc.4c01638

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Deletion of Asb15b gene can lead to a significant decrease in zebrafish intermuscular bone

Authors: Minghui Niu, Huamin Whang, Zhichao Wu, Shouwen Jiang, Liangbiao Chen

Journal: Gene

PubMed ID: 38754570

Doi: 10.1016/j.gene.2024.148561

CYP116B5-SOX: An artificial peroxygenase for drug metabolites production and bioremediation

Authors: Daniele Giuriato, Gianluca Catucci, Danilo Correddu, Giovanna Di Nardo, Gianfranco Gilardi

Journal: Biotechnol J

PubMed ID: 38719620

Doi: 10.1002/biot.202300664

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Cellular metabolism of substance P produces neurokinin-1 receptor peptide agonists with diminished cyclic AMP signaling

Authors: Tamas Kriska, Jayashree Natarajan, Anja Herrnreiter, Sang-Kyu Park, Sandra L Pfister, Michael J Thomas, Alexander Widiapradja, Scott P Levick, William B Campbell

Journal: Am J Physiol Cell Physiol

PubMed ID: 38798270

Doi: 10.1152/ajpcell.00103.2024

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Cloning and functional characterization of novel human neutralizing anti-interferon-alpha and anti-interferon-beta antibodies

Authors: Emmanouil Papasavvas, Lily Lu, Matthew Fair, Isabela Oliva, Joel Cassel, Sonali Majumdar, Karam Mounzer, Jay R Kostman, Pablo Tebas, Amit Bar-Or, Kar Muthumani, Luis J Montaner

Journal: biorxiv

PubMed ID: 38746170

Doi: 10.1101/2024.05.05.591636

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Na,K-ATPase activity promotes macropinocytosis in colon cancer via Wnt signaling

Authors: Nydia Tejeda-Muñoz, Yagmur Azbazdar, Eric A Sosa, Julia Monka, Pu-Sheng Wei, Grace Binder, Kuo-Ching Mei, Yerbol Z Kurmangaliyev, Edward M De Robertis

Journal: Biol Open

PubMed ID: 38713004

Doi: 10.1242/bio.060269

Products & Services: PCR Cloning and Subcloning

Single-shot dendritic cell targeting SARS-CoV-2 vaccine candidate induces broad, durable and protective systemic and mucosal immunity in mice

Authors: Nicholas You Zhi Cheang, Kai Sen Tan, Peck Szee Tan, Kiren Purushotorma, Wee Chee Yap, Kirsteen McInnes Tullett, Benson Yen Leong Chua, Aileen Ying-Yan Yeoh, Caris Qi Hui Tan, Xinlei Qian, Huixin Chen, Douglas Jie Wen Tay, Irina Caminschi, Yee Joo Tan, Paul Anthony Macary, Chee Wah Tan, Mireille Hanna Lahoud, Sylvie Alonso

Journal: Mol Ther

PubMed ID: 38715364

Doi: 10.1016/j.ymthe.2024.05.003

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Nanoemulsions and nanocapsules as carriers for the development of intranasal mRNA vaccines

Authors: Mireya L Borrajo, Gustavo Lou, Shubaash Anthiya, Philipp Lapuhs, David Moreira Álvarez, Araceli Tobío, María Isabel Loza, Anxo Vidal, María José Alonso

Journal: Drug Deliv Transl Res

PubMed ID: 38811465

Doi: 10.1007/s13346-024-01635-5

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